THE HOT ZONE

Richard Preston
Random House
ISBN 0-679-43094-6

This book describes events between 1967 and 1993.  The incubation period 
of the viruses in this book is less than twenty-four days.  No one who 
suffered from any of the viruses or who was in contact with anyone 
suffering from them can catch or spread the viruses outside of the 
incubation period.  None of the living people referred to in this book 
suffer from a contagious disease.  The viruses cannot survive 
independently for more than ten days unless the viruses are preserved and 
frozen with special procedures and laboratory equipment.  Thus none of the locations in Reston or the Washington, D.C. area described in this book is infective or dangerous.

The second angel poured his bowl into the sea, and it became like the 
blood of a dead man.
						-APOCALYPSE

	PART ONE
	THE SHADOW OF MOUNT ELGON

SOMETHING IN THE FOREST

1980 NEW YEAR'S DAY

CHARLES MONET was a loner.  He was a Frenchman who lived by himself in a 
little wooden bungalow on the private lands of Nzoia Sugar Factory, a 
plantation in western Kenya what spread along the Nzoia River within sight 
of Mount Elgon, a huge, solitary extinct volcano that rises to a height of 
fourteen thousand feet near the edge of the Rift Valley.  Monet's history 
is a little obscure.  As with so many expatriates who end up in Africa, it 
is not clear what brought him there.  Perhaps he had been in some kind of 
trouble in France, or perhaps he had been drawn to Kenya by the beauty of 
the country.  He was an amateur naturalist, fond of birds and animals but 
not of humanity in general.  He was fifty-six years old, of medium height 
and medium build, with smooth, straight brown hair, a good-looking man.  
It seems that his only close friends were women who lived in towns around 
the mountain, yet even they could not recall much about him for the 
doctors who investigated his death.  His job was to take care of the sugar 
factory's water-pumping machinery, which drew water from the Nzoia River 
and delivered it to many miles of sugar-cane fields.  They say that he 
spent most of his day inside the pump house by the river, as if it pleased 
him to watch and listen to machines doing their work.
     So often in a case like this, it's hard to pin down the details.  The 
doctors remember the clinical signs, because no one who has seen the 
effects of a Biosafety Level 4 hot agent on a human being can ever forget 
them, but the effects pile up, one after the other, until they obliterate 
the person beneath them.  The case of Charles Monet emerges in a cold 
geometry of clinical fact mixed with flashes of horror so brilliant and 
disturbing that we draw back and blink, as if we are staring into a 
discolored alien sun.
     Monet came into the country in the summer of 1979, around the time 
that human immunodeficiency virus, or HIV, which causes AIDS, made a final 
breakout from the rain forest of central Africa and began its long burn 
through the human race.  AIDS had already fallen like a shadow over the 
population, although no one yet knew it existed.  It had been spreading 
quietly along the Kinshasa Highway, a transcontinental road that wanders 
across Africa from east to west and passes along the shores of Lake 
Victoria within sight of Mount Elgon.  HIV is a highly lethal but not very 
infective Biosafety Level 2 agent.  It does not travel easily from person 
to person, and it does not travel through the air.  You don't need to wear 
a biological suit while handling blood infected with HIV.
     Monet worked hard in the pump house during the week, and on his 
weekends and holidays he would visit forested areas near the sugar 
factory.  He would bring food with him, and he would scatter it around and 
watch while birds and animals ate it.  He could sit in perfect stillness 
while he observed an animal.  People who knew him recalled that he was 
affectionate with wild monkeys, that he had a special way with them.  They 
said that he would sit holding a piece of food while a monkey approached 
him, and the animal would eat from his hand.  
     On the evenings, he kept to himself in his bungalow.  He had a 
housekeeper, a woman named Johnnie, who cleaned up and prepared his meals. 
 He was teaching himself how to identify African birds.  A colony of 
weaverbirds lived in a tree near his house, and he spent time watching 
them build and maintain their baglike nests.  They say that one day near 
Christmas he carried a sick bird into his house, where it died, perhaps in 
his hands.  The bird may have been a weaverbird--no one knows--and it may 
have died of a Level 4 virus--no one knows.  He also had a friendship with 
a crow.  It was a pied crow, a black-and-white bird that people in Africa 
sometimes make into a pet.  This crow was a friendly, intelligent bird 
that liked to peek on the roof of Monet's bungalow and watch his comings 
and goings.  When the crow was hungry, it would land on the veranda and 
walk indoors, and Monet would feed it scraps of food from his table.
     He walked to work every morning through the cane fields, a journey of 
two miles.  That Christmas season, the workers had been burning the 
fields, and so the fields were scorched and black.  To the north across 
the charred landscape, twenty-five miles away, he could see Mount Elgon.  
The mountain displayed a constantly changing face of weather and shadow, 
rain and sun, a spectacle of African light.  At dawn, Mount Elgon appeared 
as a slumped pile of gray ridges receding into haze, culminating in a 
summit with two peaks, which are opposed lips of the eroded cone.  As the 
sun came up, the mountain turned silvery green, the color of the Mount 
Elgon rain forest, and as the day progressed clouds appeared and hid the 
mountain from view.  Late in the afternoon, near sunset, the clouds 
thickened and boiled up into an anvil thunderhead that flickered with 
silent lightning.  The bottom of the cloud was the color of charcoal, and 
the top of the cloud feathered out against the upper air and glowed a dull 
orange, illuminated by the setting sun, and above the cloud the sky was 
deep blue and gleamed with a few tropical stars.
     He had a number of women friends who lived in the town of Eldoret, to 
the southeast of the mountain, where the people are poor and live in 
shacks made of boards and metal.  He gave money to his women friends, and 
they, in return, were happy to love him.  When his Christmas vacation 
arrived, he formed a plan to go camping on Mount Elgon, and he invited one 
of the women from Eldoret to accompany him.  No one seems to remember her 
name.
     Monet and his friend drove in a Land Rover up the long, straight 
red-dirt road that leads to Endebess Bluff, a prominent cliff on the 
eastern side the volcano.  The road was volcanic dust, as red as dried 
blood.  They climbed onto the lower skirts of the volcano and went through 
cornfields and coffee plantations, which gave way to grazing land, and the 
road passed old, half-ruined English colonial farms hidden behind lines of 
blue-gum trees.  The air grew cool as they went higher, and crested eagles 
flapped out of cedar trees.  Not many tourists visit Mount Elgon, so Monet 
and his friend were probably the only vehicle on the road, although there 
would have been crowds of people walking on foot, villagers who cultivate 
small farms on the lower slopes of the mountain.  They approached the 
frayed outer edge of the Mount Elgon rain forest, passing by fingers and 
islands of trees, and they passed the Mount Elgon Lodge, an English inn 
built in the earlier part of century, now falling into disrepair, its 
walls cracked and its paint peeling off in the sun and rain.
     Mount Elgon straddles the border between Uganda and Kenya and is not 
far from Sudan.  The mountain is a biological island of rain forest in the 
center of Africa, an isolated world rising above dry plains, fifty miles 
across, blanketed with trees, bamboo, and alpine moor.  It is a knob in 
the backbone of central Africa.  The volcano grew up seven to ten million 
years ago, producing fierce eruptions and explosions of ash, which 
repeatedly wiped out the forests that grew on its slopes, until it 
attained a tremendous height.  Before Mount Elgon was eroded down, it may 
have been the highest mountain in Africa, higher than Kilmanjaro is today. 
 It is still the widest.  When the sun rises, it throws the shadow of 
Mount Elgon westward and deep into Uganda, and when the sun sets, the 
shadow reaches eastward across Kenya.  Within the shadow of Mount Elgon 
lie villages and cities inhabited by various tribal groups, including the 
Elgon Masai, a pastoral people who came from the north and settled around 
the mountain some centuries ago, and who raise cattle.  The lower slopes 
of the mountain are washed with gentle rains, and the air remains cool and 
fresh all year, and the volcanic soil produces rich crops of corn.  The 
villages form a ring of human settlement around the volcano, and the ring 
is steadily closing around the forest on its slopes, a noose that is 
tangling the wild habitat of the mountain.  The forest is being cleared 
away, the trees are being cut down for firewood or to make room for 
grazing land, and the elephant are vanishing.
     A small part of Mount Elgon is a national park.  Monet and his friend 
stopped at the park gate to pay their entrance fees.  A monkey or perhaps 
a baboon--no one seems to remember--used to hang out around the gate, 
looking for handouts, and Monet enticed the animal to sit on his shoulder 
by offering it a banana.  His friend laughed, but they stayed perfectly 
still while the animal ate.  They drove a short way up the mountain and 
pitched their tent in a clearing of moist green grass that sloped down to 
a stream.  The stream gurgled out of the rain forest, and it was a strange 
color, milky with volcanic dust.  The grass was kept short by Cape buffalo 
grazing it, and was spotted with their dung.
     The Elgon forest towered around their campsite, a web of gnarled 
African olive trees hung with moss and creepers and dotted with a black 
olive that is poisonous to humans.  They heard a scuffle of monkeys 
feeding in the trees, a hum of insects, an occasional low huh-huh call of 
a monkey.  They were colobus monkeys, and sometimes one would come down 
from a tree and scuttle across the meadow near the tent, watching them 
with alert, intelligent eyes.  Flocks of olive pigeons burst from the 
trees on swift downward slants, flying at terrific speed, which is their 
strategy to escape from harrier hawks that can dive on them and rip them 
apart on the wing.  There were camphor trees and teaks and African cedars 
and red stinkwood trees, and here and there a dark green cloud of leaves 
mushroomed above the forest canopy.  These were the crowns of podocarpus 
trees, or podos, the largest trees in Africa, nearly as large as 
California sequoias.  Thousands of elephants lived on the mountain then, 
and they could be heard moving through forest, making cracking sounds as 
they peeled bark and broke limbs from trees.
     In the afternoon, it would have rained, as it usually does on Mount 
Elgon, and so Monet and his friend would have stayed in their tent, and 
perhaps they made love while a thunderstorm hammered the canvas.  It grew 
dark; the rain tapered off.  They built a fire and cooked a meal.  It was 
New Year's Eve.  Perhaps they celebrated, drinking champagne.  The clouds 
would have cleared off in a few hours, as they usually do, and the volcano 
would have emerged as a black shadow under the Milky Way.  Perhaps Monet 
stood on the grass at the stroke of midnight and looked at the stars--neck 
bent backward, unsteady on his feet from the champagne.
     On New Year's morning, sometime after breakfast--a cold morning, air 
temperature in the forties, the grass wet and cold--they drove up the 
mountain along a muddy track and parked in a small valley below Kitum 
Cave.  They bushwhacked up the valley, following elephant trails that 
meandered besides a little stream that ran through stands of olive trees 
and grassy meadows. They kept an eye out for Cape buffalo, a dangerous 
animal to encounter in the forest.  The cave opened at the head of the 
valley, and the stream cascaded over its mouth.  The elephant trails 
joined at the entrance and headed inside.  Monet and his friend spent the 
whole of New Year's Day there.  It probably rained, and so they would have 
sat in the entrance for hours while the little stream poured down in a 
veil.  Looking across the valley, they watched for elephants, and they saw 
rock hyraxes--furry animals the size of groundhogs--running up and down 
the boulders near the mouth of the cave.
     Herds of elephants go inside Kitum Cave at night to obtain minerals 
and salts.  On the plains, it is easy for elephants to find salt in 
hardpans and dry water holes, but in the rain forest salt is precious 
thing.  The cave is large enough to hold as many as seventy elephant at a 
time.  They spend the night inside the cave, dozing on their feet or 
mining the rock with their tusks.  They pry and gouge rocks off the walls, 
and chew them to fragments between their teeth, and swallow the broken 
bits of rock.  Elephant dung around the cave is full of crumbled rock.
     Monet and his friend had a flashlight, and they walked back into the 
cave to see where it went.  The mouth of the cave is huge--fifty-five 
yards wide--and it opens out even wider beyond the entrance.  They crossed 
a platform covered with powdery dry elephant dung, their feet kicking up 
puffs of dust as they advanced.  The light grew dim, and the floor of the 
cave rose upward in a series of shelves coated with green slime.  The 
slime was bat guano, digested vegetable matter that had been excreted by a 
colony of fruit bats on the ceiling.
     Bats whirred out of holes and flicked through their flashlight beams, 
dodging around their heads, making high-pitched cries.  Their flashlights 
disturbed the bats, and more bats woke up.  Hundreds of bat eyes, like red 
jewels, looked down on them from the ceiling of the cave.  Waves of bat 
sound rippled across the ceiling and echoed back and forth, a dry, squeaky 
sound, like many small doors being opened on dry hinges.  Then they saw 
the most wonderful thing about Kitum Cave.  The cave is petrified rain 
forest.  Mineralized logs stuck out of the walls and ceiling.  They were 
trunks of rain-forest trees turned to stone--teaks, podo trees, 
evergreens.  An eruption of Mount Elgon about seven million years ago had 
buried the rain forest in ash, and the logs had been tranformed into opal 
and chert.  The logs were surrounded by crystals, white needles of 
minerals that had grown out of the rock.  The crystals were as sharp as 
hypodermic syringes, and they glittered in the beams of the flashlights.
     Monet and his friend wandered through the cave, shining their lights 
on the petrified rain forest.  Did he run his hands over the stone trees 
and prick his finger on a crystal?  They found petrified bones of ancient 
hippos and ancestors of elephants.  There were spiders hanging in webs 
among the logs.  The spiders were eating moths and insects.
     They came to a gentle rise, where the main chamber widened to more 
than a hundred yards across--wider than the length of a football field.  
They found a crevice and shined their lights down to the bottom.  There 
was something strange down there--a mass of gray and brownish material.  
It was the mummified corpses of baby elephants.  When elephants walk 
through the cave at night, they navigate by their sense of touch, probing 
the floor ahead of them with the tips of their trunks.  The babies 
sometimes fall into the crevice.
     Monet and his friend continued deeper into the cave, descending a 
slope, until they came to a pillar that seemed to support the roof.  The 
pillar was scored with hatch marks and grooves, the marks of elephant 
tusks.  If the elephants continued to dig away at the base of the pillar, 
it might eventually collapse, bringing down the roof of Kitum Cave with 
it.  At the back of the cave, they found another pillar.  This one was 
broken.  Over it hung a velvety mass of bats, which had fouled the pillar 
with black guano--a different kind of guano from the green slime near the 
mouth of the cave.  These bats were insect eaters, and the guano was an 
ooze of digested insects.  Did Monet put his hand in the ooze?
     Monet's friend dropped out of sight for several years after that trip 
to Mount Elgon.  Then, unexpectedly, she surfaced in a bar in Mombasa, 
where she was working as a prostitute.  A Kenyan doctor who had 
investigated the Monet case happened to be drinking a beer in the bar, and 
he struck up an idle conversation with her and mentioned Monet's name.  He 
was stunned when she said, "I know about that.  I come from western Kenya. 
 I was the woman with Charles Monet."  He didn't believe her, but she told 
him the story in enough detail that he became convinced she was telling 
the truth.  She vanished after that meeting in the bar, lost in the 
warrens of Mombasa, and by now she has probably died of AIDS.
     Charles Monet returned to his job at the pump house at the sugar 
factory.  He walked to work each day across the burned cane fields, no 
doubt admiring the view of Mount Elgon, and when the mountain was buried 
in clouds, perhaps he could still feel its pull, like the gravity of an 
invisible planet.  Meanwhile, something was making copies of itself inside 
Monet.  A life form had acquired Charles Monet as a host, and it was 
replicating.

THE HEADACHE BEGINS, typically, on the seventh day after exposure to the 
agent.  On the seventh day after his New Year's visit to Kitum 
Cave--January 8, 1980--Monet felt a throbbing pain behind his eyeballs.  
He decided to stay home from work and went to bed in his bungalow.  The 
headache grew worse.  His eyeballs ached, and then his temples began to 
ache, the pain seeming to circle around inside his head.  It would not go 
away with aspirin, and then he got a severe backache.  His housekeeper, 
Johnnie, was still on her Christmas vacation, and he had recently hired a 
temporary housekeeper.  She tried to take care of him, but she really did 
not know what to do.  Then, on the third day after his headache started, 
he became nauseated, spiked a fever, and began to vomit.  His vomiting 
grew intense and turned into dry heaves.  At the same time, he became 
strangely passive.  His face lost all appearance of life and set itself 
into an expressionless mask, with the eyeballs fixed, paralytic, and 
staring.  The eyelids were slightly droopy, which gave him a peculiar 
appearance, as if his eyes were popping out of his head and half-closed at 
the same time.  The eyeballs themselves seemed almost frozen in their 
sockets, and they turned bright red.  The skin of his face turned 
yellowish, with brilliant starlike red speckles. He began to look like a 
zombie.  His appearance frightened the temporary housekeeper.  She didn't 
understand the transformation in this man.  His personality changed.  He 
became sullen, resentful, angry, and his memory seemed to be blown away.  
He was not delirious.  He could answer questions, although he didn't seem 
to know exactly where he was.
     When Monet failed to show up for work, his colleagues began to wonder 
about him, and eventually they went to his bungalow to see if he was all 
right.  The black-and-white crow sat on the roof and watched them as they 
went inside.  They looked at Monet and decided that he needed to get to a 
hospital.  Since he was very unwell and no longer able to drive a car, one 
of his co-workers drove him to a private hospital in the city of Kisumu, 
on the shore of Lake Victoria.  The doctors at the hospital examined 
Monet, and could not come up with any explanation for what he might have 
some kind of bacterial infection, they gave him injections of antibiotics, 
but the antibiotics had no effect on his illness.
     The doctors thought he should go to Nairobi Hospital, which is the 
best private hospital in East Africa.  The telephone system hardly worked, 
and it did not seem worth the effort to call any doctors to tell them that 
he was coming.  He could still walk, and he had to get to Nairobi.  They 
put him in a taxi to the airport, and he boarded a Kenya Airways flight.
     A hot virus from the rain forest lives within a twenty-four-hour plan 
flight from every city on earth.  All of the earth's cities are connected 
by a web of airline routes.  The web is a network.  Once a virus hits the 
net, it can shoot anywhere in a day-Paris, Tokyo, New York, Los Angeles, 
wherever planes fly.  Charles Monet and the life form inside him had 
entered the net.
     The plane was a Fokker Friendship with propellers, a commuter 
aircraft that seats thirty-five people.  It started its engines and took 
off over Lake Victoria, blue and sparkling, dotted with dugout canoes of 
fishermen.  The Friendship turned and banked eastward, climbing over green 
hills quilted with tea plantations and small farms.  The commuter flights 
hat drone across Africa are often jammed with people, and this flight was 
probably full.  The plane climbed over belts of forest and clusters of 
round huts and villages with tin roofs.  The land suddenly dropped away, 
going down in shelves and ravines, and changed in color from green to 
brown.  The plane was crossing the Eastern Rift Valley.  The passengers 
looked out the windows at the place where the human species was born.  
They saw specks of huts clustered inside circles of thornbush, with cattle 
trails radiating from the huts.  The propellers moaned, and the Friendship 
passed through cloud streets, lines of puffy Rift clouds, and began to 
bounce and sway.  Monet became airsick.
     The seats are narrow and jammed together on these commuter airplanes, 
and you notice everything that is happening inside the cabin.  The cabin 
is tightly closed, and the air recirculates.  If there are any smells in 
the air, you perceive them.  You would not have been able to ignore the 
man who was getting sick.  He hunches over in his seat.  There is 
something wrong with him, but you can't tell exactly what is happening.
     He is holding an airsickness bag over his mouth.  He coughs a deep 
cough and regurgitates something into the bag.  The bag swells up.  
Perhaps he glances around, and then you see that his lips are smeared with 
something slippery and red, mixed with black specks, as if he has been 
chewing coffee grounds.  His eyes are the color of rubies, and his face is 
an expressionless mass of bruises.  The red spots, which a few days before 
had started out as starlike speckles, expanded and merged into huge, 
spontaneous purple shadows; his whole head is turning black-and-blue.  The 
muscles of his face droop.  The connective tissue in his face is 
dissolving, and his face appears to hang from underlying bone, as if the 
face is detaching itself from the skull.  He opens his mouth and gasps 
into the bag, and the vomiting goes on endlessly.  It will not stop, and 
he keeps bringing up liquid, long after his stomach should have been 
empty.  The airsickness bag fills up to the brim with a substance known as 
vomit negro, or the black vomit.  The black vomit is not really black; it 
is a speckled liquid of two colors, black and red, a stew of tarry 
granules mixed with fresh red arterial blood.  It is hemorrhage, and it 
smells like a slaughterhouse.  The black vomit is loaded with virus.  It 
is highly infective, lethally hot, a liquid that smell of the vomit negro 
fills the passenger cabin.  The airsickness bag is brimming with black 
vomit, so Monet closes the bag and rolls up the top.  The bag bulging and 
softening, threatening to leak, and he hands it to a flight attendant.
     When a hot virus multiplies in a host, it can saturate the body with 
virus particles, from the brain to the skin.  The military experts then 
say that the virus has undergone "extreme amplification".  This is not 
something like the common cold.  By the time an extreme amplification 
peaks out, an eyedropper of the victim's blood may contain a hundred 
million particles of virus.  During this process, the body is partly 
transformed into virus particles.  In other words, the host is possessed 
by a life form that is attempting to convert the host into itself.  The 
transformation is not entirely successful, however, and the end result is 
a great deal of liquefying flesh mixed with virus, a kind of biological 
accident.  Extreme amplification has occurred in Monet, and the sign of it 
is the black vomit.
     He appears to be holding himself rigid, as if any movement would 
rupture something inside him.  His blood is clotting up-his bloodstream is 
throwing clots, and the clots are lodging everywhere.  His liver, kidneys, 
lungs, hands, feet, and head are becoming jammed with blood clots.  In 
effect, he is having a stroke through the whole body.  Clots are 
accumulating in his intestinal muscles, cutting off the blood supply to 
his intestines.  The intestinal muscles are beginning to die, and the 
intestines are starting to go slack.  He doesn't seem to be fully aware of 
pain any longer because the blood clots lodged in his brain are cutting 
off blood flow.  His personality is being wiped away by brain damage.  
This is called depersonalization, in which the liveliness and details of 
character seem to vanish.  He is becoming an automaton.  Tiny spots in his 
brain are liquefying.  The higher functions of consciousness are winking 
out first, leaving the deeper parts of the brain stem (the primitive rat 
brain, the lizard brain) still alive and functioning.  It could be said 
that the who of Charles Mont has already died while the what of Charles 
Monet continues to live.
     The vomiting attack appears to have broken some blood vessels in his 
nose-he gets a nosebleed.  The blood comes from both nostrils, a shining, 
cloudless, arterial liquid that drips over his teeth and chin.  This blood 
keeps running, because the clotting factors have been used up.  A flight 
attendant gives him some paper towels, which he uses to stop up his nose, 
but the blood still won't coagulate, and the towels soak through.
     When a man is ill in an airline seat next to you, you may not want to 
embarrass him by calling attention to the problem.  You say to yourself 
that this man will be all right.  Maybe he doesn't travel well in 
airplanes.  He is airsick, the poor man, and people do get nosebleeds in 
airplanes, the air is so dry and thin ... and you ask him, weakly, if 
there is anything you can do to help.  He does not answer, or he mumbles 
words you can't understand, so you try to ignore it, but the flight seems 
to go on forever.  Perhaps the flight attendants offer to help him.  But 
victims of this type of hot virus have changes in behavior that can render 
them incapable of responding to an offer of help.  They become hostile, 
and don't want to be touched.  They don't want to speak.  They answer 
questions with grunts or monosyllables.  They can't seem to find words.  
They can tell you their name, but they can't tell you the day of the week 
or explain what has happened to them.
     The Friendship drones through the clouds, following the length of the 
Rift Valley, and Monet slumps back in the seat, and now he seems to be 
dozing ... Perhaps some of the passengers wonder if he is dead.  No, no, 
he is not dead.  He is moving.  His red eyes are open and moving around a 
little bit.
     It is late afternoon, and the sun is falling down into the hills to 
the west of the Rift Valley, throwing blades of light in all directions, 
as if the sun is cracking up on the equator.  The Friendship makes a 
gentle turn and crosses the eastern scarp of the Rift.  The land rises 
higher and changes in color from brown to green.  The Ngong Hills appear 
under the right wing, and the plane, now descending, passes over parkland 
dotted with zebra and giraffes.  A minute later, it lands at Jomo Kenyatta 
International Airport.  Monet stirs himself.  He is still able to walk.  
He stands up, dripping.  He stumbles down the gangway onto the tarmac.  
His shirt is a red mess.  He carries no luggage.  His only luggage is 
internal, and it is a load of amplified virus.  Monet has ben transformed 
into a human virus bomb.  He walks slowly into the airport terminal and 
through the building and out to a curving road where taxis are always 
parked.  The taxi drivers surround him--"Taxi?" "Taxi?"
     "Nairobi ... Hospital," he mumbles.
     One of them helps him into a car.  Nairobi taxi drivers like to chat 
with their fares, and this one probably asks if he is sick.  The answer 
should be obvious.  Monet's stomach feels a little better now.  It is 
heavy, dull, and bloated, as if he has eaten a meal, rather than empty and 
torn and on fire.
     The taxi pulls onto the Uhuru Highway and heads into Nairobi.  It 
goes through grassland studded with honey-acacia trees, and it goes past 
factories, and then it comes to a rotary and enters the bustling street 
life of Nairobi.  Crowds are milling on the shoulders of the road, women 
walking on beaten dirt pathways, men loitering, children riding bicycles, 
a man repairing shoes by the side of the road, a tractor pulling a 
wagonload of charcoal.  The taxi turns left onto the Ngong Road and goes 
past a city park and up a hill, past lines of tall blue-gum trees, and it 
turns up a narrow road and goes past a guard gate and enters the grounds 
of Nairobi Hospital.  It parks at a taxi stand beside a flower kiosk.  A 
sign by a glass door says CASUALTY DEPT.  Monet hands the driver some 
money and gets out of the tax and opens the glass door and goes over to 
the reception window and indicates that he is very ill.  He has difficulty 
speaking.  
     The man is bleeding, and they will admit him in just a moment.  He 
must wait until a doctor can be called, but the doctor will see him 
immediately, not to worry.  He sits down in the waiting room.
     It is a small room lined with padded benches.  The clear, strong 
ancient light of East Africa pours through a row of window and falls 
across a table heaped with soiled magazines, and makes rectangles on a 
pebbled gray floor that has a drain in the center.  The room smells 
vaguely of woodsmoke and sweat, and it is jammed with bleary-eyed people, 
Africans and Europeans sitting shoulder to shoulder.  There is always 
someone in Casualty who has a cut and is waiting for stitches.  People 
wait patiently, holding a washcloth against the scalp, holding a bandage 
pressed around a finger, and you may see a spot of blood on the cloth.  So 
Charles Monet is sitting on a bench in casualty, and he does not look very 
much different from someone else in the room, except for his bruised, 
expressionless face and his red eyes.  A sign on the wall warns patients 
to watch out for purse thieves, and
another sign says:

				 PLEASE MAINTAIN SILENCE
			YOUR COOPERATION WILL BE APPRECIATED.

			   NOTE: THIS IS A CASUALTY DEPARTMENT.
			EMERGENCY CASES WILL BE TAKEN IN PRIORITY.
			YOU MAY BE REQUIRED TO WAIT FOR SUCH CASES
				BEFORE RECEIVING ATTENTION

     Monet maintains silence, waiting to receive attention.  Suddenly he 
goes into the last phase.  The human virus bomb explodes. Military 
biohazard specialists have ways of describing this occurrence.  They say 
that the victim has "crashed and bled out".  Or more politely they say 
that the victim has "gone down".
     He becomes dizzy and utterly weak, and his spine goes limp and 
nerveless and he loses all sense of balance.  The room is turning around 
and around.  He is going into shock.  He leans over, head on his knees, 
and brings up an incredible quantity of blood from his stomach and spills 
it onto the floor with a gasping groan.  He loses consciousness and 
pitches forward onto the floor.  The only sound is a choking in his throat 
as he continues to vomit while unconscious.  Then come a sound like 
bedside being torn in half, which is the sound of his bowels opening and 
venting blood from sloughed his gut.  The linings of his intestines have 
come off and are being expelled along with huge amount of blood.  Monet 
has crashed and is bleeding out.
     The other patients in the waiting room stand up and move away from 
the man on the floor, calling for a doctor.  Pools of blood spread out 
around him, enlarging rapidly.  Having destroyed its host, the agent is 
now coming out of every orifice, and is "trying" to find a new host.

JUMPER

1980 JANUARY 15

NURSES AND AIDES came running, pushing a gurney along with them, and they 
lifted Charles Monet onto the gurney and wheeled him into the intensive 
care unit at Nairobi Hospital.  A call for a doctor went out over the 
loudspeakers: a patient was bleeding in the ICU.  A young doctor named 
Shem Musoke ran to the scene.  Dr. Musoke was widely considered to be one 
of the best young physicians at the hospital, an energetic man with a warm 
sense of humor, who worked long hours and had a good feel for emergencies. 
 He found Monet lying on the gurney.  He has no idea what was wrong with 
the man, except that he was obviously having some kind of massive 
hemorrhage.  There was no time to try to figure out what has caused it.  
He was having difficulty breathing-and then his breathing stopped.  He had 
inhaled blood and had a breathing arrest.
     Dr. Musoke felt for a pulse.  It was weak and sluggish.  A nurse ran 
and fetched a laryngoscope, a tube that can be used to open a person's 
airway.  Dr. Musoke ripped open Monet's shirt so that he could observe any 
rise and fall of the chest, and he stood at the head of the gurney and 
bent over Monet's face until he was looking directly into his eyes, upside 
down.
     Monet stared redly at Dr. Musoke, but there was no movement in the 
eyeballs, and the pupils were dilated.  Brain damage: nobody home.  His 
nose was bloody and his mouth was bloody.  Dr. Musoke tilted the patient's 
head back to open the airway so that he could insert the laryngoscope.  He 
was not wearing rubber gloves.  He ran his finger around the patient's 
tongue to clear the mouth of debris, sweeping out mucus and blood.  His 
hands became greasy with black curd.  The patient smelled of vomit and 
blood, but this was nothing new to Dr. Musoke, and he concentrated on his 
work.  He leaned down until his face was a few inches away from Monet's 
face, and he looked into Monet's mouth in order to judge the position of 
the scope.  Then he slid the scope over Monet's tongue and pushed the 
tongue out of the way so that he could see down the airway past the 
epiglottis, a dark hole leading inward to the lungs.  He pushed the scope 
into the hole, peering into the instrument.  Monet suddenly jerked and 
thrashed.
     Monet vomited.
     The black vomit blew up around the scope and out of Monet's mouth.  
Black-and-red fluid spewed into the air, showering down over Dr. Musoke.  
It struck him in the eyes.  It splattered over his white coat and down his 
chest, marking him with strings of red slime dappled with dark flecks.  It 
landed in his mouth.
     He repositioned his patient's head and swept the blood out of the 
patient's mouth with his fingers.  The blood had covered Dr. Musoke's 
hands, wrists and forearms.  It had gone everywhere-all over the gurney, 
all over Dr. Musoke, all over the floor.  The nurses in the intensive care 
unit couldn't believe their eyes, and they hovered in the background, not 
knowing quite what to do.  Dr. Musoke peered down into the airway and 
pushed the scope deeper into the lungs.  He saw that the airways were 
bloody.
     Air rasped into the man's lungs.  The patient had began to breathe 
again.
The patient was apparently in shock from loss of blood.  He had lost so 
much blood that he was becoming dehydrated.  The blood had come out of 
practically every opening in his body.  There wasn't enough blood left to 
maintain circulation, so his heartbeat was very sluggish, and blood 
pressure was dropping toward zero.  He needed a blood transfusion.
     A nurse brought a bag of whole blood.  Dr. Musoke hooked the bag on a 
stand an inserted the needled into the patient's arm.  There was something 
wrong with the patient's veins; his blood poured out around the needle.  
Dr. Musoke tried again, putting the needle into another place in the 
patient's arm and probing for the vein.  Failure.  More blood poured out.  
At every place in the patient's arm where he stuck the needle, the vein 
broke apart like cooked macaroni and spilled blood, and the blood ran from 
the punctures down the patient's arm and wouldn't coagulate.  Dr. Musoke 
abandoned his efforts to give his patient a blood transfusion for fear 
that the patient would bleed to death out of the small hole in his arm.  
The patient continued to bleed from the bowels, and these hemorrhages were 
now as black as pitch.
     Monet's coma deepened, and he never regained consciousness.  He died 
in the intensive care unit in the early hours of the morning.  Dr. Musoke 
stayed by his bedside the whole time.
     They has no idea what had killed him.  It was unexplained death.  
They opened him up for an autopsy and found that his kidneys were 
destroyed and that his liver was dead.  His liver had ceased functioning 
several days before he died.  It was yellow, and parts of it had 
liquefied-it looked like the liver of a three-day-old cadaver.  It was as 
if Monet had become a corpse before his death.  Sloughing of the gut, in 
which the intestinal ling comes off, is another effect that is ordinarily 
seen in a corpse that is days old.  What, exactly, was the cause of death? 
 It was impossible to say because there were too many possible causes.  
Everything had gone wrong inside this man, absolutely everything, any one 
of which could have been fatal: the clotting, the massive hemorrhages, the 
liver turned into pudding, the intestines full of blood.  Lacking words, 
categories, or language to describe what had happened, they called it, 
finally, a case of "fulminating liver failure".  His remain were placed in 
a waterproof bag and, according to one account, buried locally.  When I 
visited Nairobi, years later, no one 
remembered where the grave was.

1980 JANUARY 24

NINE DAYS AFTER the patient vomited into Dr. Shem Musoke's eyes and mouth, 
Musoke developed an aching sensation in his back.  He was not prone to 
backaches-really, he had never had a serious backache, but he was 
approaching thirty, and it occurred to him that he was getting into the 
time of life when some men begin to get bad backs.  He had been driving 
himself hard these past few weeks.  He had been up all night with a 
patient who had heart problems, and then, the following night, he had been 
up most of the night with that Frenchman with hemorrhages who ha come from 
somewhere upcountry.  So he had been going nonstop for days without sleep. 
 He hadn't thought much about the vomiting incident, and when the ache 
began to spread through his body, he still didn't think about it.  Then, 
when he looked in a mirror, he noticed that his eyes were turning red.
     Red eyes-he began to wonder if he had malaria.  He had a fever now, 
so certainly he had some kind of infection.  The backache had spread until 
all the muscles in his body ached badly.  He started taking malaria pills, 
but they didn't do any good, so he asked one of the nurses to give him an 
injection of an antimalarial drug.
     The nurse gave it to him in the muscle of his arm.  The pain of the 
injection was very, very bad.  He had never felt such pain from a shot; it 
was abnormal and memorable.  He wondered why a simple shot would give him 
this kind of pain.  Then he developed abdominal pain, and that made him 
think that he might have typhoid fever, so he gave himself a course of 
antibiotic pills, but that had no effect on his illness.  Meanwhile, his 
patients needed him, and he continued to work at the hospital.  The pain 
in his stomach and in his muscles grew unbearable, and he developed 
jaundice.
     Unable to diagnose himself, in severe pain, and unable to continue 
with his work, he presented himself to Dr. Antonia Bagshawe, a physician 
at Nairobi Hospital.  She examined him, observed his fever, his red eyes, 
his jaundice, his abdominal pain, and came up with nothing definite, but 
wondered if he had gallstones or a liver abscess.  A gall-bladder attack 
or a liver abscess could cause fever and jaundice and abdominal pain-the 
red eyes she could not explain-and she ordered an ultrasound examination 
of his liver.  She studied the images of his liver and saw that it was 
enlarged, but, other than that, she could see nothing unusual.  By this 
time, he was very sick, and they put him in a private room with nurses 
attending him around the clock.  His face set itself into an 
expressionless mask.
     This possible gallstone attack could be fatal.  Dr. Bagshawe 
recommended that Dr. Musoke have exploratory surgery.  He was opened up in 
the main operating theater at Nairobi Hospital by a team of surgeons 
headed by Dr. Imre Lofler.  They made an incision over his liver and 
pulled back the abdominal muscles.  What they found inside Musoke was 
eerie and disturbing, and they could not explain it.  His liver was 
swollen and red and did not look healthy, but they could not find any sign 
of gallstones.  Meanwhile, he would not stop bleeding.  Any surgical 
procedure will cut through blood vessels, and the cut vessels will ooze 
for a while and then clot up, or if the oozing continues, the surgeon will 
put dabs of gel foam on them to stop the bleeding.  Musoke's blood vessels 
would not stop oozing-his blood would not clot.  It was as if he had 
become a hemophiliac.  They dabbed gel foam all over his liver, and the 
blood cam through the foam.  He leaked blood like a sponge.  They had to 
suction off a lot of blood, but as they pumped it out, the incision filled 
up again.  It was like digging a hole below the water table; it fills up 
as fast as you pump it out.  One of the surgeons would later tell people 
that the team had been "up to the elbows in blood".  They cut a wedge out 
of his liver-a liver biopsy-and dropped the wedge into a bottle of 
pickling fluid and closed up Musoke as quickly as they could.
     He deteriorated rapidly after the surgery, and his kidneys began to 
fail.  He appeared to be dying.  At that time, Antonia Bagshawe, his 
physician, had to travel abroad, and he came under the care of a doctor 
named David Silverstein.  The prospect of kidney failure and dialysis for 
Dr. Musoke created a climate of emergency at the hospital-he was well 
liked by his colleagues, and they didn't want to lose him.  Silverstein 
began to suspect that Musoke was suffering from an unusual virus.  He 
collected some blood from his patient and drew off the serum, which is a 
clear, golden-colored liquid that remains when the red cells are removed 
from the blood.  He sent some tubes of frozen serum to laboratories for 
testing-to the National Institute of Virology in Sandringham, South 
Africa, and to the Centers for Disease Control in Atlanta, Georgia, U.S.A. 
 Then he waited for results.

DIAGNOSIS

DAVID SILVERSTEIN LIVES IN Nairobi, but he owns a house near Washington, 
D.C.  One day in the summer recently, when he was visiting the United 
States to tend to some business, I met him in a coffee shop in a shopping 
mall not far from his home.  We sat at a small table, and he told me about 
Monet and Musoke cases.  Silverstein is a slender, short man in his late 
forties, with a mustache and glasses, and he has an alert, quick gaze.  
Although he is an American, his voice carries a hint of Swahili accent.  
On the day that I met him, he was dressed in a denim jacket and blue 
jeans, and he was nicely tanned, looking fit and relaxed.  He is a pilot, 
and he flies his own plane.  He has the largest private medical practice 
in East Africa, and it has made him a famous figure in Nairobi.  He is the 
personal physician of Daniel arap Moi, the president of Kenya, he travels 
with President Moi when Moi goes abroad.  He treats all the important 
people in East Africa: the corrupt politicians, the actors and actresses 
who get sick on safari, the decayed English-African nobility.  He traveled 
at the side of Diana, Lady Delamere, as her personal physician when she 
was growing old, to monitor her blood pressure and heartbeat (she wanted 
to carry on with her beloved sport of deep-sea fishing off the Kenya 
coast, although she had a heart condition), and he was also Beryl 
Markham's doctor.  Markham, the author of West with the Night, a memoir of 
her years as an aviator in East Africa, used to hang out at the Nairobi 
Aero Club, where she had a reputation for being a slam-bang, two-fisted 
drinker.  ("She was a well-pickled old lady by the time I came to her.")
His patient Dr. Musoke has himself become a celebrity, in the annals of 
disease.  "I was treating Dr. Musoke with supportive care" Silverstein 
said to me.  "That was all I could do.  I tried to give him nutrition, and 
I tried to lower his fevers when they were high.  I was basically taking 
care of somebody without a game plan."
     One night, at two o'clock in the morning, Silverstein's telephone 
rang at his home in Nairobi.  It was an American researcher stationed in 
Kenya calling him to report that the South Africans had found something 
very queer in Musoke's blood: "He's positive for Marburg virus.  This is 
really serious.  We don't know much about Marburg."
     Silverstein had never heard of Marburg virus.  "After the phone call, 
I could not get back to sleep," he said to me. "I had kind of waking dream 
about it, wondering what Marburg was."  He lay in bed, thinking about the 
sufferings of his friend and colleague Dr. Musoke, fearful of what sort of 
organism had gotten loose among the medical staff at the hospital.  He 
kept hearing the voice saying, "We don't know much about Marburg."  Unable 
to sleep, he finally got dressed and drove to the hospital, arriving at 
his office before dawn.  He found a medical textbook and looked up Marburg 
virus.
     The entry was brief.  Marburg is an African organism, but it has a 
German name.  Viruses are named for the place where they are first 
discovered.  Marburg is an old city in central Germany, surrounded by 
forests and meadows, where factories nestle in green valleys.  The virus 
erupted there in 1967, in a factory called the Behring Works, which 
produced vaccines using kidney cells from African green monkeys.  The 
Behring Works regularly imported monkeys from Uganda.  The virus came to 
Germany hidden somewhere in a series of air shipment of monkeys totaling 
five or six hundred animals.  As few as two or three of the animals were 
incubating the virus.  They were probably not even visibly sick.  At any 
rate, shortly after they arrived at the Behring Works, the virus began to 
spread among them, and a few of them crashed and bled out.  Soon 
afterward, the Marburg agent jumped species and suddenly emerged in human 
population of the city.  This is an example of virus amplification.
     The first person known to be infected with Marburg agent was a man 
called Klaus F., an employee at Behring Works vaccine factory who fed the 
monkeys and washed their cages.  He broke with the virus on August 8, 
1967, and died two weeks later.  So little is known about the Marburg 
agent that only one book has been published about it, a collection of 
papers presented at a symposium on virus, held at the University of 
Marburg in 1970.  In the book, we learn that

	The monkey-keeper HEINRICH P. came back from his holiday on August 
13th 1967 and did his job of killing monkeys from 14th-23rd.  The first 
symptoms appeared on August 21st.  The laboratory assistant RENATE L. 
broke a test-tube that was to be sterilized, which had contained infected 
material, on August 28th, and fell ill on September 4th 1967.

     And so on.  The victims developed headaches at about day seven after 
their exposure and went downhill from there, with raging fevers, clotting, 
spurts of blood, and terminal shock.  For a few days in Marburg, doctors 
in the city thought the world was coming to an end.  Thirty one people 
eventually caught the virus; seven died in pools of blood.  The kill rate 
of Marburg turned out to be about one in four, which makes Marburg an 
extremely lethal agent: even in the best modern hospitals, where the 
patients are hooked up to life-support machines, Marburg kills a quarter 
of the patients who are infected with it.  By contrast, yellow fever, 
which is considered a highly lethal virus, kills only about one in twenty 
patients once they reach hospital.
     Marburg is one of a family of viruses known as the filoviruses.  
Marburg was the first filovirus to be discovered.  The word filovirus is 
Latin and means "thread virus".  The filoviruses look alike, as if they 
are sisters, and they resemble no other virus on earth.  While most 
viruses are ball-shaped particles that look like peppercorns, the thread 
viruses have been compared to strands of tangled rope, to hair, to worms, 
to snakes.  When they appear in a great flooding mess, as they so often do 
when they have destroyed a victim, they look like a tub of spaghetti that 
has been dumped on the floor.  Marburg particles sometimes roll up into 
loops.  The loops resemble Cheerios.  Marburg is the only ring-shaped 
virus known.
     In Germany, the effects of Marburg virus on the train were 
particularly frightening, and resembled the effects of rabies: the virus 
somehow damaged the central nervous system and could destroy the brain, as 
does rabies.  The Marburg particles also looked rather like rabies 
particles.  The rabies-virus particle is shaped like a bullet.  If you 
stretch out a bullet, it begins to look like a length of rope, and if you 
coil the rope into a loop, it becomes a ring, like Marburg.  Thinking that 
Marburg might be related to rabies, they called it stretched rabies.  
Later it became clear that Marburg belongs to its own family.
	Not long after Charles Monet died, it was established that the 
family of filoviruses comprised Marburg along with two types of virus 
called Ebola.  The Ebolas were named Ebola Zaire and Ebola Sudan.  Marburg 
was the mildest of the three filovirus sisters.  The worst of them was 
Ebola Zaire.  The kill rate in humans infected with Ebola Zaire is nine 
out of ten.  Ninety percent of the people who come down with Ebola Zaire 
die of it.  Ebola Zaire is a slate wiper in humans.
	Marburg virus (the gentle sister) affects humans somewhat like 
nuclear radiation, damaging virtually all of the tissues in their bodies.  
It attacks with particular ferocity the internal organs, connective 
tissue, intestines, and skin.  In Germany, all the survivors lost their 
hair-they went bald or partly bald.  Their hair died at the roots and 
fellout in clumps, as if they had received radiation burns.  Hemorrhage 
occurred from all orifices of the body.  I have seen a photograph of one 
of the men who died of Marburg, taken in the hours before his death.  He 
is lying in bed without any clothing on his upper body.  His face is 
expressionless.  His chest, arms, and face are speckled with blotches and 
bruises, and droplets of blood stand on his nipples.
	During the survivors' recovery period, the skin peeled off their 
faces, hands, feet, and genitals.  Some of the men suffered from blown up, 
semirotten testicles.  One of the worst cases of this appeared in a morgue 
attendant who had handled Marburg-infected bodies.  The virus also 
lingered in the fluid inside the eyeballs of some victims for many months. 
 No one knows why Marburg has a special affinity for the testicles and the 
eyes.  One man infected his wife with Marburg through sexual intercourse.
	Doctors noticed that the Marburg agent had a strange effect on the 
brain.  "Most of the patients showed a sullen, slight aggressive, or 
negativistic behavior," according to the book.  "Two patients (had) a 
feeling as if they were lying on crumbs."  One patient became psychotic, 
apparently as a result of brain damage.  The patient named Hans O.-V. 
showed no signs of mental derangement, and his fever cooled, and he seemed 
to be stabilizing, but then suddenly, without warning, he had an acute 
fall in blood pressure-he was crashing-and he died.  They performed an 
autopsy on him, and when they opened his skull, they found a massive, 
fatal hemorrhage at the center of the brain.  He had bled out into his 
brain.
	International health authorities were urgently concerned to find 
the exact source of the monkeys, in order to pin down where in nature the 
Marburg virus lived.  It seemed pretty clear that the Marburg virus did 
not naturally circulate in monkeys, because it killed them so fast it 
could not successfully establish itself in them as a useful host.  
Therefore, Marburg lived in some other kin of host-an insect? a rat? a 
spider? a reptile?  Where, exactly, had the monkeys been trapped?  That 
place would be the hiding place of the virus.  Soon after the outbreak in 
Germany, a team of investigators under the auspices of the World Health 
Organization flew to Uganda.  The team couldn't discover the exact source 
of the virus.
	There the mystery lingered for many years.  Then, in 1982, an 
English veterinarian came forward with new eyewitness information about 
the Marburg monkeys.  I will call this man Mr. Jones (today, he prefers to 
remain anonymous).  During the summer of 1967, when the virus erupted in 
Germany, Mr. Jones was working at a temporary job inspecting monkeys at 
the export facility in Entebbe from which the sick Marburg monkeys had 
been shipped, while regular veterinary inspector was on leave.  This 
monkey house, which was run by a rich monkey trader ("a sort of lovable 
rogue," according to Mr. Jones) was exporting about thirteen thousand 
monkeys a year to Europe.  This was a very large number of monkeys, and it 
generated big money.  The infected shipment was loaded onto an overnight 
flight to London, and from there it was flown to Germany-where the virus 
broke out of the monkeys and "attempted" to establish itself in the human 
population.
	After making a number of telephone calls, I finally located Mr. 
Jones in a town in England, where today he is working as a veterinary 
consultant.  He said to me: "All that animals got, before they were 
shipped off, was a visual inspection."
	"By whom?" I asked.
	"By me," he said. "I inspected them to see that they appeared 
normal.  On occasion, with some of these shipments, one or two animals 
were injured or had skin leisons."  His method was to pick out the 
sick-looking ones, which were removed from the shipment and presumably 
killed before the remaining healthy-looking animals were loaded onto the 
plane.  When, a few weeks later, the monkeys started the outbreak in 
Germany, Mr. Jones felt terrible.  "I was appalled, because I had signed 
the export certificate," he said to me.  "I feel now that I have the 
deaths of these people on my hands.  But that feeling suggests I could 
have done something about it.  There was no way I could have known."  He 
is right about that: the virus was then unknown to science, and as few as 
two or three not-visibly-sick animals could have started the outbreak.  
One concludes that the man should not be blamed for anything.
	The story becomes more disturbing.  He went on: "The sick ones 
were being killed, or so I thought."  But later he learned that they 
weren't being killed.  The boss of the company was having the sick monkeys 
put in boxes and shipped out to a small island in Lake Victoria, where 
they were released.  With so many sick monkeys running around it, the 
island could have become a focus for monkey viruses.  It could have been a 
hot island, an isle of plagues.  "Then, if this guy was a bit short of 
monkeys, he went out to the island and caught a few, unknown to me."  Mr. 
Jones thinks it is possible that the Marburg agent had established itself 
on the hot island, and was circulating among the monkeys there, an that 
some of the monkeys which ended up in Germany had actually come from that 
island.  But when the WHO team came later to investigate, "I was told by 
my boss to say nothing unless asked."  As it turned out, no one asked Mr. 
Jones any questions-he says he never met the WHO team.  The fact that the 
team apparently never spoke with him, the monkey inspector, "was bad 
epidemiology but good politics," he remarked to me.  If it had been 
revealed that the monkey trader was shipped off suspect monkeys collected 
on a suspect island, he could have been put out of business, and Uganda 
would have lost a source of valuable foreign cash.
	Shortly after the Marburg outbreak, Mr. Jones recalled a fact that 
began to seem important to him.  Between 1962 and 1965 he had been 
stationed in eastern Uganda, on the slopes of Mount Elgon, inspecting 
cattle for disease.  At some time during that period, local chiefs told 
him that the people who lived on the north side of the volcano, along the 
Greek River, were suffering from a disease that caused bleeding, death, 
and "a particular skin rash"-and that monkeys in the area were dying of a 
similar disease.  Mr. Jones did not pursue the rumors, and was never able 
to confirm the nature of the disease.  But it seems possible that in the 
years preceding the outbreak of Marburg virus in Germany, a hidden 
outbreak of the virus occurred on the slopes of Mount Elgon.

MR. JONES'S PERSONAL VISION of the Marburg outbreak reminds me of a 
flashlight pointed down a dark hole.  It gives a narrow but startling view 
of the larger phenomenon of the origin and spread of tropical viruses.  He 
told me that some of the Marburg monkeys were trapped in a group of 
islands in Lake Victoria known as the Sese Islands.  The Senses are a 
low-lying forested archipelago in the northwestern part of Lake Victoria, 
an easy boat ride from Entebbe.  The isle of plagues may have been 
situated among the Senses or near them.  Mr. Jones does not recall the 
name of the hot island.  He says it is close to Entebbe.  At any rate, Mr. 
Jones's then-boss, the Entebbe monkey trader, had arranged a deal with 
villagers in the Sese Islands to buy monkeys from them.  They regarded the 
monkeys as pests and were happy to get rid of them, especially for money.  
So the trader was obtaining wild monkeys from Sese Islands, and if the 
animals proved to be sick, he was releasing them on another island 
somewhere near Entebbe.  And some monkeys from the isle of plagues seemed 
to be ending up in Europe.
	In papyrus reeds and desolate flatlands on the western shore of 
Lake Victoria facing the Sese Islands, there is a fishing village called 
Kasensero.  You can see the Sese Islands from the village.  Kasensero was 
one of the first places in the world where AIDS appeared.  Epidemiologists 
have since discovered that the northwestern shore of Lake Victoria was one 
of the initial epicenters of AIDS.  It is generally believed that AIDS 
came originally from African primates, from monkeys and apes, and that it 
somehow jumped out of these animals into the human race.  It is thought 
that the virus went through a series of very rapid mutations at the time 
of its jump from primates to humans, which enabled it to establish itself 
successfully in people.  In the years since AIDS virus emerged, the 
village of Kasensero has been devastated.  The virus has killed a large 
portion of the inhabitants.  It is said that other villages along the 
shores of Lake Victoria have been essentially wiped off the map.
	The villagers of Kasensero are fishmen who were, and are, famous 
as smugglers.  In their wooden boats and motorized canoes they ferried 
illegal goods back and forth across the lake, using the Sese Islands as 
hiding places.  One can guess that if a monkey trader were moving monkeys 
around Lake Victoria, he might call on the Kasensero smugglers or on their 
neighbors.
	One general theory for the origin of AIDS goes that, during the 
late nineteen-sixties, a new and lucrative business grew up in Africa, the 
export of primates to industrialized countries for use in medical 
research.  Uganda was one of the biggest sources of these animals.  As the 
monkey trade was established throughout central Africa, the native workers 
in the system, the monkey trappers and handlers, were exposed to large 
numbers of wide monkeys, some of which were carrying unusual viruses.  
These animals, in turn, were being jammed together in cages, exposed to 
one another, passing viruses back and forth.  furthermore, different 
species of monkeys were mixed together.  It was a perfect setup for an 
outbreak of a virus that could jump species.  It was also a natural 
laboratory for rapid virus evolution, and possibly it led to the creation 
of HIV.  Did HIV crash into the human race as a result of the monkey 
trade?  Did AIDS come from an island in Lake Victoria?  A hot island?  Who 
knows.  When you begin probing into the origins of AIDS and Marburg, the 
light fails and things go dark, but you sense hidden connections.  Both 
viruses seem part of a pattern.

WHEN HE LEARNED what Marburg virus does to human being, Dr. David 
Silverstein persuaded the Kenyan health authorities to shut down Nairobi 
Hospital.  For a week, patients who arrived at the doors were turned away, 
while sixty seven people were quarantined inside the hospital, most 
medical staff.  They included the doctor who had done autopsy on Monet, 
nurses who had attended Monet or Dr. Musoke, the surgeons who had operated 
on Musoke, and aides and technicians who had handled any secretions from 
either Monet or Musoke.  It turned out that a large part of the hospital's 
staff had direct contact with either Monet or Musoke or with blood samples 
and fluids that came from the two patients.  The surgeons who had operated 
on Musoke, remembering only too well that they had been "up to the elbows 
in blood", sweated in quarantine for two weeks while they wondered if they 
were going to break with Marburg.  A single human virus bomb had walked 
into the Casualty waiting room and exploded there, and the event had put 
the hospital out of business.  Charles Monet had been an Exocet missile 
that stuck the hospital below the water line.
	Dr. Shem Musoke survived his encounter with a hot agent.  Ten days 
after he fell sick, the doctors noticed a change for the better.  Instead 
of merely lying in bed in a passive state, he became disoriented and angry 
and refused to take medicine.  One day, a nurse was trying to turn him 
over in bed, and he waved his fist at her and cried, "I have a stick, and 
I will beat you."  It was around that time that he began to get better, 
and after many days his fever subsided and his eyes cleared; his mind and 
personality came back, and he recovered slowly but completely.  Today he 
is one of the leading physicians at Nairobi Hospital, where he practices 
as a member of David Silverstein's group.  One day I interviewed him, and 
he said to me that he has almost no memory of the weeks he was infected in 
Marburg.  "I only remember bits and pieces," he said. "I remember having 
major confusion.  I remember, before my surgery, that I walked out of my 
room with my IV drip hanging out of me.  I don't remember much of the 
pain.  The only pain I can talk about is the muscle ache and the 
lower-back ache.  And I remember him throwing up on me."  Nobody else at 
the hospital developed a proven case of Marburg-virus disease.
	When a virus is trying, so to speak, to crash into the human 
species, the warning sign may be a spattering of breaks at different times 
and places.  These are microbreaks.  What had happened at Nairobi Hospital 
was an isolated emergence, a microbreak of a rain-forest virus with 
unknown potential to start an explosive chain of lethal transmission in 
the human race.
	Tubese of Dr. Musoke's blood went to laboratories around the world 
so that they could have samples of living Marburg for their collections of 
life forms.  The Marburg in his blood had come from Charles Monet's black 
vomit and perhaps originally from Kitum Cave.  Today this particular 
strain of Marburg virus is known as Musoke strain.  Some of it ended in 
glass vials in freezers owned by the United States Army, where it was kept 
immortal in 
a zoo of hot agents.

A WOMAN AND A SOLDIER

1983 SEPTEMBER 25, 1800 HOURS

THURMONT, MARYLAND, nearly four years after the death of Charles Monet.  
Evening, A typical American town.  On Catoctin Mountain, a ridge of the 
Appalachians that runs north to south through the western part of the 
state, the trees were brightening into soft yellows and golds.  Teenagers 
drove their pickup trucks slowly along the streets of the town, looking 
for something to happen, wishing that the summer had not ended.  Faint 
smells of autumn touched the air, the scent of ripening apples, a soreness 
of dead leaves, cornstalks drying in the fields.  In the apple groves at 
the edge of town, flocks of grackles settled into the branches for the 
night, squawking.  Headlights streamed north on the Gettysburg road.
	In the kitchen of a Victorian house near the center of town, Major 
Nancy Jaax, a veterinarian in the United States Army, stood at a counter 
making dinner for her children.  She slid a plate into the microwave oven 
and pushed a button.  Time to nuke up some chicken for the kids.  Nancy 
Jaax wore sweatpants and a T-shirt, and she was barefoot.  Her feet had 
calluses on them, the result of martial-arts training.  She had way auburn 
hair, which was cut above the shoulders, and greenish eyes.  Her eyes were 
actually two colors, green with an inner rim around the iris was amber.  
She was a former homecoming queen from Kansas-Miss Agriculture, Kansas 
State.  She had a slender, athletic build, and she displayed quick 
motions, flickery gestures, with her arms and hands.  Her children were 
restless and tired, and she worked as fast as she could to fix the dinner.
	Jaime, who was five, hung on Nancy's leg.  She grabbed the leg of 
Nancy's sweatpants and pulled, and Nancy lurched sideways, and then Jaime 
pulled the other way, and Nancy lurched to the other side.  Jaime was 
short for her age had greenish eyes, like her mother.  Nancy's son, Jason, 
who was seven, was watching television in the living room.  He was rail 
thin and quiet, and when he grew up he would probably be tall, like his 
father.
	Nancy's husband, Major Gerald Jaax, whom everyone called Jerry, 
was also a veterinarian.  He was a Texas at a training class, and Nancy 
was alone with the children.  Jerry had telephoned to say that it was hot 
as hell in Texas, and he missed her badly and wished he was home.  She 
missed him, too.  They had not been apart for more than a few days at a 
time ever since they had first started dating, in college.
	Nancy and Jerry Jaax-the name is pronounced JACKS-were both 
members of the Army Veterinary Corps, a tiny corps of "doggy doctors".  
They take care of Army's guard dogs, as well as Army horses, Army cow, 
Army sheeps, Army pigs, Army mules, Army rabbits, Army mice, and Army 
monkeys.  They also inspect the Army's food.
	Nancy and Jerry had bought the Victorian house not long after they 
had been assigned to Fort Detrick, which was nearby, within easy commuting 
distance.  The kitchen was small, and at the moment you could see plumbing 
and wires hanging out of the walls.  Not far from the kitchen, the living 
room had a bay window with a collection of tropical plants and ferns in 
it, and there was a cage among the plants that held an Amazon parrot named 
Herky.  The parrot burst into a song:
		Heigh-ho, heigh-ho, it's home from work we go!
"Mom! Mom!" he cried excitedly.  His voice sounded like Jason's. 
	"What?" Nancy said.  Then she realized it was the parrot.  "Nerd 
brain," she muttered.
	The parrot wanted to sit on Nancy's shoulder.  "Mom! Mom! Jerry! 
Jaime! Jason!" the parrot shouted, calling everyone in the family.  When 
he didn't get any response, he whistled the "Colonel Bogey March" from The 
Bridge on the River Kwai.  And then: "What? What? Mom! Mom!".
	Nancy did not want to take Herky out of his cage.  She worked 
quickly, putting plates and silverware out on the counter.  Some of the 
officers at Fort Detrick had noticed a certain abrupt quality in her hand 
motions and had accused her of having hands that were "too quick" to 
handle delicate work in dangerous situations.  Nancy had begun 
martial-arts training partly because she hoped to make her gestures cool 
and smooth and powerful, and also because he had felt the frustrations of 
a woman officer trying to advance her career in the Army.  She was five 
feet four inches tall.  She liked to spar with six-foot male solders, big 
guys.  She enjoyed knocking them around a little bit; it gave her a 
certain satisfaction to be able to kick higher than the guy's head.  She 
used her feet more than her hands when she sparred with an opponent, 
because her hands were delicate.  She could break four boards with a 
spinning back kick.  She had reached the point where she could kill a man 
with her bare feet, an idea that did not in itself give her much 
satisfaction.  On occasion, she had come home from her class with a broken 
toe, a bloody nose, or a black eye.  Jerry would just shake his head: 
Nancy with another shiner.
	Major Nancy Jaax did all the housework.  She could not stand 
housework.  Scrubbing grape jelly out of rugs didn't give her a feeling of 
reward, and in any case she did not have time for it.  Occasionally she 
would go into a paroxysm of cleaning, and she would race around the house 
for an hour, throwing things into closets.  She also did all the cooking 
for her family.  Jerry was useless in the kitchen.  Another point of 
contention was his tendency to buy things impulsively-a motorcycle, a 
sailboat.  Jerry had bought a sailboat when they were stationed at Fort 
Riley in Kansas.  And then there was that god-awful diesel Cadillac with a 
red leather interior.  She and Jerry had commuted to work together in it, 
but the car had started to lay smoke all over the road even before the 
payments were finished.  One day, she had finally said to Jerry, "You can 
sit in the driveway in those red leather seats all you want, but I'm not 
getting in there with you."  So they sold the Cadillac and bought a Honda 
Accord.
	The Jaaxes' house was the largest Victorian house in town, a pile 
of turreted brick with a slate roof and tall windows and a cupola and 
wooden paneling made of golden American chestnut.  It stood on a street 
corner near the ambulance station.  The sirens woke them up at night.  
They had bought the house cheap.  It had sat on the market a long time, 
and a story had been going around town that the previous owner had hanged 
himself in the basement.  After the Jaaxes bought it, the dead man's widow 
showed up at the door one day.  She was a wizened old lady, come to have a 
look around her old place, and she fixed a blue eye on Nancy and said, 
"Little girl, you are going to hate this house.  I did."
	There were other animals in the house besides the parrot.  In a 
wire cage in the living room lived a python named Sampson.  He would 
occasionally escape from his cage, wander around the house, and eventually 
climb up inside the hollow center post of the dining room table and go to 
sleep.  There he would stay for a few days.  It gave Nancy a creepy 
feeling to think that there was a python asleep inside the dining table.  
You wondered whether the snake was going to wake up while you were eating 
dinner.  Nancy had a study in the cupola at the top of the house.  The 
snake had once escaped from his cage and disappeared for a few days.  They 
pounded and knocked on the dining room table to try to flush him out, but 
he wasn't there.  Late one night when Nancy was in her study, the snake 
oozed out of the rafters and hung in front of her face, staring at her 
with lidless eyes, and she screamed.  The family also had an Irish setter 
and an Airelale terrier.  Whenever the Jaaxes were assigned to a different 
Army post, the animals moved with them in boxes and cages, a portable 
ecosystem of the Jaax family.
	Nancy loved Jerry.  He was tall and fine looking, a handsome man 
with prematurely gray hair.  She thought of his hair as silver, to go 
along with his silver tongue, which he used trying to talk her into buy 
diesel Cadillacs with red-leather interiors.  He had sharp brown eyes and 
a shape nose, like a hawk's, and he understood her better than anyone else 
on earth.  Nancy and Jerry Jaax had very little social life outside of 
their marriage.  They had grown up on farms in Kansas, twenty miles apart 
as the crow flies, but had not known each other as children.  They met in 
veterinary school at Kansas State University had gotten engaged a few 
weeks later, and they were married when Nancy was twenty.  By the time 
they graduated, they were broke and in debt, with no money to set up a 
practice as veterinarians, and so they had enlisted in the Army together.
	Since Nancy didn't have time to cook during the week, she would 
spend her Saturdays cooking.  She would make up a beef stew in a 
Crock-Pot, or she would broil several chickens.  Then she would freeze the 
food in bags.  On weekday nights, she would take a bag out of the freezer 
and heat it in the microwave.  Tonight, while she thawed chicken, she 
considered the question of vegetables.  How about canned green beans?  The 
children liked that.  Nancy opened a cabinet and pulled down a can of 
Libby's green beans.
	She searched through one or two drawers, looking for a can opener. 
 Couldn't find it.  She turned to the main junk drawer, which held all the 
utensils, the stirring spoons and vegetable peelers.  It was a jam-packed 
nightmare.
	The hell with the can opener.  She pulled a butcher knife out of 
the drawer.  Her father had always warned her not to use a knife to open a 
can, but Nancy Jaax had never mae a point of listening to her father's 
advice.  She jabbed the butcher knife into the can, and the point stuck in 
the metal.  She hit the handle with the heel of the right hand.  All of a 
sudden her hand slipped down the handle, struck the tang of the blade, and 
slid down the blade.  She felt the edge bit deep.
	The butcher knife clattered to the floor, an big drops of blood 
fell on the counter.  "Son of a bitch!" she said.  The knife had sliced 
through the middle of her right hand, on the palm.  It was a deep cut.  
She put pressure on the cut to stanch the bleeding and went over to the 
sink, turned on the faucet, and thrust her hand under the stream of water. 
 The sink turned red.  She wiggled her fingers.  They worked; so she had 
not sliced a tendon.  This was not such a bad cut.  Holding her hand over 
her head, she went into the bathroom and found a Band-Aid.  She waited for 
the blood to coagulate, and then she pressed the Band-aid over the cut, 
drawing the sides of the cut together to seal the wound.  She hated the 
sight of blood, even if it was her own blood.  She had a thing about 
blood.  She knew what some blood could contain.
	Nancy skipped the children's baths because of the cut on her hand 
and gave them their usual snuggle in bed.  That night, Jaime slept in bed 
with her.  Nancy didn't mind, especially because Jerry was out of town, 
and it made her feel close to her children.  Jaime seemed to need the 
reassurance.  Jaime was always a little edgy when Jerry was out of town.

PROJECT EBOLA

1983 SEPTEMBER 26

THE NEXT MORNING, Nancy Jaax woke up at four o'clock.  She got out of bed 
quietly so as not to wake Jaime and showered and put on her uniform.  She 
wore green Army slacks with a black stripe down the leg, a green Army 
shirt, an in the cold before sunrise she put on a black military sweater.  
The sweater displayed the shoulder bars of a major, with gold oak leaves.  
She drank a Diet Coke to wake herself up, and walked upstairs to her study 
in the cupola of the house.
	Today she might put on a biohazard space suit.  She was in 
training for veterinary pathology, the study of disease in animals.  Her 
specialty was turning out to be the effects Biosafety Level 4 hot agents, 
and in the presence of those kinds of agents you need to wear a space 
unit.  She was also studying for her pathology-board exams, which were 
coming up in a week.  As the sun rose that morning over the apple orchards 
and fields to the east of town, she opened her books and hunched over 
them.  Grackles began croaking in the trees, and trucks began to move 
along the streets of Thurmont, below her window.  The palm of her right 
hand still throbbed.
	At seven o'clock, she went down t the master bedroom and woke 
Jaime, who was curled up in the bed.  She went into Jason's room.  Jason 
was harder to wake, and Nancy had to shake him several times.  Then the 
babysitter arrived, an older woman named Mrs. Trapane, who got Jaime and 
Jason dressed and gave them their breakfasts while Nancy climbed back up 
to the cupola and returned to her books.  Mrs. Trapane would see Jason off 
to the school bus and would watch Jaime at home until Nancy came back from 
work that evening.
	At seven-thirty, Nancy closed her books and kissed her children 
goodbye.  She thought to herself, Have to remember to stop at the bank and 
get some money to pay Mrs. Trapane.  She drove the Honda alone to work, 
heading south on the Gettysburg road, along the foot of Catoctin Mountain. 
 As she approached Fort Detrick, in the city of Frederick, the traffic 
thickened and slowed.  She turned off the highway and arrived at the main 
gate of the base.  A guard waved her through. She turned right, drove past 
the parade grounds with its flagpole, and parked her car near a massive, 
almost windowless building made of concrete and yellow bricks that covered 
almost ten acres of ground.  Tall vent pipes on the roof discharged 
filtered exhaust air that was being pumped out of sealed biological 
laboratories inside the building.  This was the United States Army Medical 
Research Institute of Infectious Diseases, or USAMRIID.
	Military people often call USAMRIID the Institute.  When they call 
the place USAMRIID, they drawl the word in a military way, making it sound 
like "you Sam rid," which gives it some hang time in the air.  The mission 
of USAMRIID is medical defense.  The Institute conducts research into ways 
to protect soldiers again biological weapons and natural infectious 
diseases.  It specializes in drugs, vaccines, and biocontainment.  At the 
Institute, there are always a number of programs going on 
simultaneously-research into vaccines for various kind of bacteria, such 
as anthrax and botulism, research into the characteristics of viruses that 
might infect American troops, either naturally or in the form of a 
battlefield weapon.  Beginning with the Second World War, Army labs at 
Fort Detrick performed research into offensive biological weapons-the Army 
was developing strains of lethal bacteria and viruses that could be loaded 
into bombs and dropped on an enemy.  In 1969, President Richard M. Nixon 
signed an executive order that outlawed the development of offensive 
biological weapons in the United States.  From then on, the Army labs were 
converted to peaceful uses, and USAMRIID was founded.  It devoted itself 
to developing protective vaccines, and it concentrated on basic research 
into ways to control lethal micro-organisms.  The Institute knows ways to 
stop a monster virus before it ignites an explosive chain of lethal 
transmission in the human race.
	Major Nancy Jaax entered the building through the back entrance an 
showed her security badge to a guard behind a desk, who nodded and smiled 
at her.  She headed into the main block of containment zones, traveling 
through a maze of corridors.  There were soldiers everywhere, dressed in 
fatigues, and there were civilian scientists and technicians wearing ID 
badges.  People seemed very busy, and rarely did anyone stop to chat with 
someone else in the corridors.
	Nancy wanted to see what had happened to the Ebola monkeys during 
the night.  She walked along a Biosafety Level 0 corridor, heading for a 
Level 4 biocontainment area known as AA-5, or the Ebola suite.  The levels 
are numbered 0, 2, 3 and finally 4, the highest.  (For some reason, there 
is no Level 1.)  All the containment levels at the Institute, from Level 2 
to Level 4, are kept under negative air pressure, so that if a leak 
develops, air will flow into the zones rather than outward to the normal 
world.  The suite known as AA-5 was a group of negative-pressure 
biocontainment rooms that had been set up as a research lab for Ebola 
virus by a civilian Army scientist named Eugene Johnson.  He was an expert 
in Ebola and its sister, Marburg.  He had infected several monkeys with 
Ebola virus, and he had been giving them various drugs to see if they 
would stop the Ebola infection.  In recent days, the monkeys had begun to 
die.  Nancy had joined Johnson's Ebola project as the pathologist.  It was 
her job to determine the cause of death in the monkeys.
	She came to a window in a wall.  The window was made of heavy 
glass, like that in an aquarium, and it looked directly into the Ebola 
suite, directly into Level 4.  You could not see the monkeys through this 
window.  Every morning, a civilian animal caretaker put on a space unit 
and went inside to feed the monkeys and clean their cages and check on 
their physical condition.  This morning there was a piece of paper taped 
to the inside of the glass, with handwritten lettering on it.  It had been 
left there by a caretaker.  The note said that during the night two of the 
animals had "gone down".  This is, they had crashed and bled out.
	When she saw the note, she knew that she would be putting on a 
space suit and going in to dissect the monkeys.  Ebola virus destroyed an 
animal's internal organs, and the carcass deteriorated abruptly after 
death.  It softened, and the tissue turned into jelly, even if you put it 
in a refrigerator to keep it cold.  You wanted to dissect the animals 
quickly, before the spontaneous liquefaction began, because you can't 
dissect gumbo.

WHEN NANCY JAAX first applied to join the pathology group at the 
Institute, the colonel in charge it didn't want to accept her.  Nancy 
thought it was because she was a woman.  He said to her, "This work is not 
for a married female.  You can either going to neglect your work or 
neglect your family."  One day, she brought her resume into his office, 
hoping to persuade him to accept her.  He said, "I can have anybody I want 
in my group"-implying that he didn't want her because she wasn't good 
enough-and he mentioned the great Thoroughbred stallion Secretariat.  "If 
I want to have Secretariat in my group," he said, "I can get Secretariat."
	"Well, sir, I am no plow horse!" she roared at him, and slammed 
her resume on his desk.  He reconsidered the matter and allowed her to 
join the group.
	When you begin working with biological agents, the Army starts you 
in Biosafety Level 2, and then you move up to Level 3.  You don't go into 
Level 4 until you have a lot of experience, and the Army may never allow 
you to work there.  In order to work in the lower levels, you must have a 
number of vaccinations.  Nancy had vaccinations for yellow fever, Q fever, 
Rift Valley fever, the VEE, EEE, and WEE complex (brain viruses that live 
in horses), and tularemia, anthrax and botulism.  And, of course, she had 
a serious of shots for rabies, since she was a veterinarian.  Her immune 
system reacted badly to all the shots; they made her sick.  The Army 
therefore yanked her out of the vaccination program.  At this point, Nancy 
Jaax was essentially washed up.  She couldn't proceed with any kind of 
work with Level 3 agents, because she couldn't tolerate the vaccinations.  
There was only one way she could continue working with dangerous 
infectious agents.  She had to get her assigned to work in a space suit in 
Level 4 areas.  There aren't any vaccines for Level 4 hot agents.  A Level 
4 hot agent is a lethal virus for which there is no vaccine and no cure.

EBOLA VIRUS IS named for the Ebola River, which is the headstream of the 
Mongala River, a tributary of the Congo, or Zaire, River.  The Ebola River 
empties tracts of rain forest, winding past scattered villages.  The first 
known emergence of Ebola Zaire-the hottest type of Ebola virus-occurred 
September 1976, when it erupted simultaneously in fifty-five villages near 
the headwaters of the Ebola River.  It seemed to come out of nowhere, and 
killed nine out of ten people it infected.  Ebola Zaire is the most feared 
agent at the Institute.  The general feeling around USAMRIID has always 
been "Those people who work with Ebola are crazy."  to mess around with 
Ebola is an easy way to die.  Better to work with something safer, such as 
anthrax.
	Eugene Johnson, the civilian biohazard expert who was running the 
Ebola research program at the Institute, had a reputation for being a 
little bit wild.  He is something of a legend to the handful of people in 
the world who really know about hot agents and how to handle them.  He s 
one of the world's leading Ebola hunters.  Gene Johnson is a large man, 
not to say massive, with a broad, heavy face and loose-flying disheveled 
brown hair and bushy brown beard and a gut that hangs over his belt, and 
glaring, deep eyes.  If Gene Johnson were to put on a black leather 
jacker, he could pass for a roadie with Grateful Dead.  He does not look 
at all like a man who works for the Army.  He has a reputation for being a 
top-notch field epidemiologist (a person who studies viral diseases in the 
wild), but for some reason he does not often get around to publishing his 
work.  That explains his somewhat mysterious reputation.  When people who 
know Johnson's work talk about him, you hear things like "Gene Johnson did 
this, Gene Johnson did that," and it all sounds clever and imaginative.  
He is a rather shy man, somewhat suspicious of people, deeply suspicious 
of viruses, I think I have never met someone who is more afraid of viruses 
than Gene Johnson, and what makes his fear impressive is the fact that it 
is a deep intellectual respect, rooted in knowledge.  He spent years 
traveling across central Africa in search of the reservoirs of Ebola and 
Marburg viruses.  He had virtually ransacked Africa looking for these life 
forms, but despite his searches he had never found them in their natural 
hiding places.  No one knew where any of the filoviruses came from; no one 
knew where they lived in nature.  The trail had petered out in the forests 
and savannas of central Africa.  to find the hidden reservoir of Ebola was 
one of Johnson's great ambitions.
	No one around the Institute wanted to get involved with his Ebola 
project.  Ebola, the slate wiper, did things to people that you did not 
want to think about.  The organism was too frightening to handle, even for 
those who were comfortable and adept in space suits.  They did not care to 
do research on Ebola because they did not Ebola to do research on them.  
They didn't know what kind of host the virus lived in-whether it was a fly 
or a bat or a tick or a spider or a scorpion or some kind of reptile, or 
an amphibian, such as a grog or a newt.  Or maybe it lived in leopards or 
elephants.  And they didn't know exactly how virus spread, how it jumped 
from host to host.
	Gene Johnson had suffered recurrent nightmares about Ebola virus 
ever since he began to work with it.  He would wake up in a cold sweat.  
His dreams went more or less the same way.  He would be wearing his space 
unit while holding Ebola in his gloved hand, holding some kind of liquid 
tainted with Ebola.  Suddenly the liquid would be running all over his 
glove, and then he would realize that his glove was full of pinholes, and 
the liquid was dribbling over his bare hand and running inside his space 
suit.  He would come awake with a start, saying to himself, My God, 
there's been an exposure.  And then he would find himself in his bedroom, 
with his wife sleeping beside him.
	In reality, Ebola had not yet made a decisive, irreversible 
breakthrough into the human race, but seemed close to doing that.  It had 
been emerging in microbreaks here and there in Africa.  The worry was that 
a microbreak would develop into an unstoppable tidal wave.  If the virus 
killed nine of ten people it infected and there was no vaccine or cure for 
it, you could see the possibilities.  The possibilities were global.  
Johnson liked to say to people that we don't really know what Ebola has 
done in the past, and we don't know what it might do in the future.  Ebola 
was unpredictable.  An airborne strain of Ebola could emerge and circle 
around the worked in about six weeks, like the flu, killing large numbers 
of people, or it might forever remain a secret feeder at the margins, 
taking down humans a few at a time.
	Ebola is a rather simple virus-as simple as a firestorm.  It kills 
humans which swift efficiency and with a devastating range of effects.  
Ebola is distantly related to measles, mumps, and rabies.  It is also 
related to certain pneumonia viruses: to the parainfluenza virus, which 
causes colds in children, and to the respiratory syncytial virus, which 
can cause fatal pneumonia in a person who has AIDS.  In its own evolution 
through unknown hosts and hidden pathways in the rain forest, Ebola seems 
to have developed the worst elements of all the above viruses.  Like 
measles, it triggers a rash all over the body.  some of its effects 
resemble rabies-psychosis, madness.  Other of its effects look eerily like 
a bad cold.
	The Ebola virus particle contains only seven different 
proteins-seven large molecules.  Three of these proteins are vaguely 
understood, and four of the proteins are completely unknown-their 
structure and their function is a mystery.  Whatever these Ebola proteins 
do, they seem to target the immune system for special attack.  In this 
they are like HIV, which also destroys the immune system, but unlike the 
onset of HIV, the attack of Ebola is explosive.  As Ebola sweeps through 
you, you immune system fails, and you seem to lose your ability to respond 
to viral attack.  Your body becomes a city under seize, with its gates 
thrown open and hostile armies pouring in, making camp in the public 
squares and setting everything on fire; and from the moment Ebola enters 
your blood stream, the ware is already lost; you are almost certainly 
doomed.  You can't fight off Ebola the way you fight off a cold.  Ebola 
does in ten days what it takes AIDS ten years to accomplish.
	It is not really known how Ebola is transmitted from person to 
person.  Army researchers believed that Ebola virus traveled through 
direct contact with blood and bodily fluids (in the same way the AIDS 
virus travels).  Ebola seemed to have other routes of travel as well.  
Many of the people in Africa who came down with Ebola had handled 
Ebola-infected cadavers.  It seems that one of Ebola's paths goes from the 
dead to the living, winding in trickles of uncoagulated blood and slimes 
that come out of the dead body.  In Zaire during the 1976 outbreak, 
grieving relatives kissed and embraced the dead or prepared the body for 
burial, and then, three to fourteen days later, they broke with Ebola.
	Gene Johnson's Ebola experiment was simple.  He would infect a few 
monkeys with the virus, and then he would treat them with drugs in the 
hope that they would get better.  That way, he might discover a drug that 
would flight Ebola virus or possibly cure it.
	Monkeys are nearly identical to human beings in a biological 
sense, which is why they are used in medical experiments.  Humans and 
monkeys are both primates, and Ebola feeds on primates in same way that a 
predator consumes certain kinds of flesh.  Ebola can't tell the difference 
between a human being and a monkey.  The virus jumps easily back and forth 
between them.

NANCY JAAX VOLUNTEERED to work as the pathologist on Johnson's Ebola 
project.  It was Level 4 work, which she was qualified to do, because she 
didn't need to be vaccinated.  She was eager to prove herself and eager to 
continue working with lethal viruses.  However, some people around the 
Institute were skeptical of her ability to work in a space suit in Level 
4.  She was a "married female"-she might panic.  They claimed that her 
hands looked nervous or clumsy, not good for work with Level 4 hot agents. 
 People felt that she might cut herself or stick herself with a 
contaminated needle-or stick someone else.  Her hands became a safety 
issue.
	Her immediate superior was Lieutenant Colonel Anthony Johnson (he 
is not related to Gene Johnson, the civilian who was the head of the Ebola 
project).  Tony Johnson is a soft-spoken man and a cool customer.  Now he 
had to decide whether to allow her to go into Biosafety Level 4.  Wanting 
to be sure he understood the situation, he sent word around the Institute: 
 Who knows Nancy Jaax?  Who can comment on her strengths and weakness?  
Major Jerry Jaax, Nancy's husband, showed up in Lieutenant Colonel 
Johnson's office.  Jerry was against the idea of his wife putting on a 
space suit.  He argued strongly against it.  He said that there had been 
"family discussions" about Nancy working with Ebola virus.  "Family 
discussion" Jerry had said to Nancy, "You're the only wife I've got."  He 
did not wear a biological space suit himself at work, and he did not want 
his wife to wear one either.  His biggest concern was that she would be 
handling Ebola.  He could not stand the idea that his wife, the woman he 
loved, the mother of their children, and would hold in her hands a 
monstrous life form that is lethal and incurable.
	Lieutenant Colonel Tony Johnson listened to what Major Jerry Jaax 
had to say, and listened to what other people had t say, and then he felt 
he should speak with Nancy himself, and so he called her into his office.  
He could see that she was tense.  He watched her hands as she talked.  
They looked fine to him, not clumsy, and not too quick, either.  He 
decided that the rumors he had been hearing about her hands were 
unfounded.  She said to him, "I don't want any special favors."  Well, she 
was not going to get any special favors.  "I'm going to put you in the 
Ebola program," he said.  He told her that he would allow her to put on a 
space suit and go int the Ebola area, and that he would accompany her on 
the first few trips, to teach her how to do it and to observe her hands at 
work.  He would watch her like a hawk.  He believed that she was ready for 
total immersion in a hot zone.
	As he spoke, she broke down an cried in front of him-"had a few 
tears," as he would later recall.  They were tears of happiness.  At that 
moment, to hold Ebola virus in her hands was what she wanted more than 
anything else in the world.

1300 HOURS

NANCY SPENT the morning doing paperwork in her office.  After lunch, she 
removed her diamond engagement ring and her wedding band and locked them 
in her desk drawer.  She dropped by Tony Johnson's office and asked him if 
he was ready to go in.  They went downstairs and along a corridor to the 
Ebola suite.  There was only one locker room leading into it.  Tony 
Johnson insisted that Nancy Jaax go in first, to get changed.  He would 
follow.
	The room was small and contained a few lockers along one wall, 
some shelves, and a mirror over a sink.  She undressed, removing all of 
her clothing, including her underwear, and put everything in her locker.  
She left the Band-Aid stuck to her hand.  From a shelf, she took up a 
sterile surgical scrub suit-green pants and a green shirt, the clothing 
that a surgeon wears in an operating room-and she dragged on the pants and 
tied the drawstring at the waist, and snapped the shirt's snaps.  You were 
not allowed to wear anything under the scrub suit, no underwear.  She 
pulled a cloth surgical cap over her head and tucked her hair up into the 
cap while looking in the mirror.  She did not appear nervous, but she was 
starting to feel a little bit nervous.  This was only her second trip into 
a hot area.
	Standing in her bare feet, she turned away from the mirror and 
faced a door leading into Level 2.  A deep blue light streamed through a 
window in the door-ultraviolet light.  Viruses fall apart under 
ultraviolet light, which smashes their genetic material and makes them 
unable to replicate.
	As she opened the door and entered Level 2, she felt the door 
stick against her pull, sucked in by a difference of air pressure, and a 
gentle drag of air whispered around her shoulders and traveled inward, 
toward the hot zone.  This was negative air pressure, designed to keep hot 
agents from drifting outward.  The door closed behind her, and she was in 
Level 2.  The blue light bathed her face.  She walked through a 
water-shower stall that contained an ultraviolet light, a bar of soap, and 
some ordinary shampoo.  The shower stall led into a bathroom, where there 
was a shelf that held some clean white socks.  She put on a pair of socks 
and pushed through another door, into Level 3. 
	This was a room known as the staging area.  It contained a desk 
with a telephone and a sink.  A cylindrical waxed cardboard box sat on the 
floor beside the desk.  It was a biohazard container known as a "hatbox," 
or "ice-cream container."  A hatbox is blazed with bio-hazard symbols, 
which are red, spiky three-petaled flowers, and it is used for storing and 
transporting infectious waste.  This hatbox was empty.  It was only a 
makeshift chair.
	She found a box of latex rubber surgical gloves and a plastic 
shaker full of baby powder.  She shook baby powder onto her hands and 
pulled on the gloves.  Then she found a roll of sticky tape, and she tore 
off several strips of tape and hung them in a row on the edge of the desk. 
 Then she taped herself.  Taking up one strip at a time, she taped the 
cuffs of her gloves to the sleeves of her scrub shirt, running the tape 
around the cuff to make a seal.  She then tapped her socks to her 
trousers.  Now she wore one layer of protection between herself and the 
replicative Other.
	Lieutenant Colonel Johnson came in through Level 2 wearing a 
surgical scrub suit.  He put on rubber gloves and began taping them to his 
sleeves, and he taped his socks to his pants.
	Nancy turned to the right, into an antechamber, and found her 
space suit hanging on a rack.  It was Chemturion biological space suit, 
and it was marked in letters across the chest: JAAX.  A Chemturion is also 
known as a blue suit that meets government specifications for work with 
airborne hot agents.
	She opened up the space suit and laid it down on the concrete 
floor and stepped into it, feet first.  She pulled it up to her armpits 
and slid her arms into the sleeves until her fingers entered the gloves.  
The suit had brown rubber gloves that were attached by gaskets at the 
cuffs.  These were the space suit's main gloves, and they were made of 
heavy rubber.  They were the most important barrier between her and Ebola. 
 The hands were the weak point, the most vulnerable part of the suit, 
because of what they handled.  They handled needles, knives, and sharp 
pieces of bone.  You are responsible for maintaining you space unit in the 
same way that a paratrooper is responsible for packing and maintaining his 
own parachute.  Perhaps Nancy was in a bit of a hurry and did not inspect 
her space suit as closely as she should have.
	Lieutenant Colonel Johnson gave her a short briefing on procedures 
and then helped her lower the helmet over her head.  The helmet was made 
of soft, flexible plastic.  Johnson looked at her face, visible through 
the clear faceplate, to see how she was doing.
	She closed an oiled Ziploc zipper across the suit's chest.  The 
zipper made a popping sound as it snapped shut, pop, pop, pop.  The moment 
the space suit was closed, her faceplate fogged up.  She reached over to a 
wall and pulled down a coiled yellow air hose and plugged it into her 
suit.  Then came a roar of flowing air, and her suit bloated up, fat and 
hard, and a whiff of dry air clear away some tiny beads of sweat that had 
collected inside her faceplate.
	Around the Institute, they say that you can't predict who will 
panic inside a biological space unit.  It happens now and then, mainly to 
inexperienced people.  The moment the helmet does over their faces, their 
eyes begin to glitter with fear, they sweat, turn purple, claw at the 
suit, try to tear it open to get some fresh air, lose their balance and 
fall down on the floor, and they can start screaming or moaning inside the 
suit, which makes them sound as if they are suffocating in a closet.
	After he had helped Nancy Jaax put on her space suit, and had 
looked into her eyes for signs of panic, Tony Johnson put on his own suit, 
and when he was closed up and ready, he handed her a pack of dissection 
tools.  He seemed calm and collected.  They turned and faced the 
stainless-steel door together.  The door lead into an air lock and Level 
4.  The door was plastered with biohazard symbol and warning:

					   CAUTION

					  BIOHAZARD

					 DO NOT ENTER
				WITHOUT WEARING VENTILATED SUIT 

The international symbol for biohazard, which is pasted on doors at 
USAMRIID whenever they open through a major transition of zones, is a red 
trefoil that reminds me of a red trillium, or toadshade.
	The Level 4 air lock is a gray area, a place where two worlds 
meet, where the hot zone touches the normal world.  The gray area is 
neither hot nor cold.  A place that is neither provably sterile nor known 
to be infective.  At USAMRIID, toadshades bloom in the gray zones.  Nancy 
took a breath and gathered her thoughts into stillness, using her 
martial-arts training to get her breathing under control.  People 
performed all kinds of little rituals before they walked through that 
steel door.  some people crossed themselves.  Others carried amulets or 
charms inside their space suits, even though it was technically against 
the rules to bring anything inside the suit except your body and the 
surgical scrubs.  They hoped the amulets might help ward off the hot agent 
if there was a major break in their suit.
	She unplugged her air hose and unlatched the steel door and 
entered an air lock, and Tony Johnson followed her.  The air lock was made 
entirely of stainless steel, and it was lined with nozzles for spraying 
water and chemicals.  This was the decon shower.  Decon means 
"decontamination."  The door closed behind them.  Nancy opened the far 
door of the air lock, and they crossed over to the hot side.

TOTAL IMMERSION

1983 SEPTEMBER 26, 1330 HOURS

THEY WERE STANDING in a narrow cinder-block corridor.  Various rooms 
opened on either side.  The hot zone was a maze.  From the walls dangled 
yellow ar hoses.  There was an alarm strobe light on the ceiling that 
would be triggered if the air system failed.  The walls were painted with 
thick, gobby epoxy paint, and all the electrical outlets were plugged 
around the edges with a gooey material.  This was to seal any cracks and 
holes, so that a hot agent could not escape by drifting through hollow 
electrical conduits.  Nancy reached for an air hose and plugged it into 
her suit.  She could not hear anything except the roar of air in her 
helmet.  The air rumbled so loudly in their suits that they did not try to 
speak to each other.
	She opened a metal cabinet.  Blue light streamed out of it, and 
she removed a pair of yellow rubber boots.  They reminded her of barn 
boots.  She slid the soft feet of her space suit into the boots and 
glanced at Johnson and caught his eye.  Ready for action, boss.
	They unplugged their air hoses and proceeded down the hallway and 
entered the monkey room.  It contained two banks of cages, positioned 
facing each other along opposite walls of the room.  Jaax and Johnson 
replugged their hoses and peered into the cages.  One bank of cages 
contained two isolated monkeys.  They were the so-called control monkeys.  
They had not been infected with Ebola virus, and they were healthy.
	As soon as the two Army officers appeared in space suits, the 
healthy monkeys went nuts.  They rattled their cages and leaped around.  
Humans in space suits make monkeys nervous.  They hooted and grunted - 
"Ooo! Ooo! Haw, wah, haw!" And they uttered a high-pitched squeal: "Eek!". 
 The monkeys moved to the front of their cages and shook the doors or 
leaped back and forth, whump, whump, whump, watching Jaax and Johnson the 
whole time, following them with their eyes, alert to everything.  The 
cages had elaborated bolts on the doors to prevent fiddling by primate 
fingers.  These monkeys were creative little boogers, she thought, and 
they were bored.
	The other bank of cages was mostly quiet.  This was the bank of 
Ebola cages.  All the monkeys in these cages were infected with Ebola 
virus, and most of them were silent, passive and withdrawn, although one 
or two of them seemed queerly deranged.  Their immune systems had failed 
or gone haywire.  Most of the animals did not look very sick yet, but they 
did not display the alertness, the usual monkeys energy, the leaping and 
the cage rattling that you see in healthy monkeys, and most of them had 
not eaten their morning biscuits.  They sat almost motionless in their 
cages, watching the two officers with expressionless faces.
	They had been injected with the hottest strain of Ebola known to 
the world.  It was the Mayinga strain of Ebola Zaire.  This strain had 
come from a young woman named Mayinga N., who died of the virus on October 
19, 1976.  She was a nurse at a hospital in Zaire, and she had taken care 
of a Roman Catholic nun who died of Ebola.  The nun had bled to death all 
over Nurse Mayinga, and then, a few days later, Nurse Mayinga had broken 
with Ebola and died.  Some of Nurse Mayinga's blood had ended up in the 
United States, and the strain of virus that had once lived in Nurse 
Mayinga's blood now lived in small glass vials kept in superfreezers at 
the Institute, which were maintained at minus one hundred and sixty 
degrees Fahrenheit.  The freezers were fitted with padlocks and alarms and 
were plastered with biohazard flowers and sealed with bands of sticky 
tape, because it seals cracks.  It could be said that without sticky tape 
there would be no such thing as biocontainment.
	Gene Johnson, the civilian scientist, had thawed a little bit of 
Nurse Mayinga's frozened blood and had injected it into the monkeys.  
Then, as the monkeys became silk, he had treated them with a drug in hope 
that it would help them flight off the virus.  The drug did not seem to be 
working.
	Nancy Jaax and Tony Johnson inspected the monkeys, moving from 
cage to cage, until they found the two monkeys that had crashed and bled 
out.  Those animals were hunched up, each in its own cage.  They had 
bloody noses, and their eyes were half-open, glassy, and brilliant red, 
with dilated pupils.  The monkeys showed no facial expression, not even 
pain or agony.  The connective tissue under the skin had been destroyed by 
the virus, causing a subtle distortion of the face.  Another reason for 
the strange faces was that the parts of the brain that control facial 
expression had also been destroyed.  The masklike face, the red eyes, and 
the bloody nose were classic signs of Ebola that appear in all primates 
infected with the virus, both monkeys and humans.  It hinted at a vicious 
combination of brain damage and soft-tissue destruction under the skin.  
The classic Ebola face made the monkeys look as if they had seem something 
beyond comprehensive.  It was not a vision of heaven.
	Nancy Jaax felt a wave of unease.  She was distressed by the sight 
of the dead and suffering monkeys.  As a veterinarian, she believed that 
it was her duty to heal animals and relieve their suffering.  As a 
scientist, she believed that it was her obligation to perform medical 
research that would help alleviate human suffering.  Even though she had 
grown up on a farm, where her father had raised liverstock for food, she 
had never been able to bear easily the death of an animal.  As a girl, she 
had cried when her father had taken her 4-H Club prize steer to the 
butcher.  She liked animals better than many people.  In taking the 
veterinarian's oath, she had pledged herself to a code of honor that bound 
her to the care of animals but also bound her to the saving of human lives 
through medicine.  At times in her work, those two ideals clashed.  She 
told herself that this research was being done to help find a cure for 
Ebola, that t was medical research that would help save human lives and 
might possibly avert a tragedy for the human species.  That helped reduce 
her feeling of unease, but not completely, and she kept her emotions off 
to one side.
	Johnson watched Jaax carefully as she began the removal procedure. 
 Handling an unconscious monkey in Level 4 is tricky operation, because 
monkeys can wake up, and they have teeth and a powerful bit, and they are 
remarkably strong and agile.  The monkeys that are used in laboratories 
are not organ-grinder monkeys.  They are large, wild animals from the rain 
forest.  A bite by an Ebola-infected monkey would almost certainly be 
fatal.
	First Nancy inspected the monkey, looking through the bars.  It 
was a large male, and he looked as if he was really dead.  She saw that he 
still had his canine fangs, and that made her nervous.  Ordinarily the 
monkey would have had its fangs filed down for safety.  For some reason, 
this one had enormous natural fangs.  She stuck her gloved fingers through 
the bars and pinched the monkey's toe while she watched for an eye 
movement.  The eyes remained fixed and staring.
	"GO AHEAD AND UNLOCK THE CAGE," Lieutenant Colonel Johnson said.  
He had to shout to be heard above the roar of air in their space suits.
	She unlocked the door and slid it up until the cage gaped wide 
open.  She inspected the monkey again.  No muscle twitches.  The monkey 
was definitely down.
	"ALL RIGHT, GO AHEAD AND MOVE HIM OUT," Johnson said.
	She reached inside and caught the monkey by the upper arms and 
rotated him so that he was facing away from her, so that he couldn't bit 
her if he woke up.  She pulled his arms back and held them immobile, and 
she lifted the monkey out of the cage.
	Johnson took the monkey's feet, and together they carried him over 
to a hatbox, a biohazard container, and they slid the monkey into it.  
Then they carried the hatbox to necropsy room, shuffling slowly in their 
suits.  They were two human primates carrying another primate.  One was 
the master of the earth, or at least believed himself to be, and the other 
was a nimble dweller in trees, a cousin of the master of the earth.  Both 
species, the human and the monkey, were in the presence of another life 
form, which was older and more powerful than either of them, and was a 
dweller in blood.
	Jaax and Johnson moved slowly out of the room, carrying the 
monkey, and turned left and then turned left again, and entered the 
necropsy room, and laid the monkey down on a stainless-steel table.  The 
monkey's skin was rashly and covered with red blotches, visible through 
his sparse hair.
	"GLOVE UP," Johnson said.
	They put on latex rubber gloves, pulling them over the space suit 
gloves.  They now wore three layers of gloves: the inner-lining glove, the 
space suit glove, and the outer glove.  Johnson said, "WE'LL DO THE CHECK 
LIST.  SCISSORS, HEMOSTATS."  He laid the tools in a row at the head of 
the table.  Each tool was numbered, so he called the numbers out loud.
	They went to work.  Using blunt-ended scissors, Johnson opened the 
monkey while Jaax assisted with the procedure.  They worked slowly and 
with exquisite care.  They did not use any sharp blades, because a blade 
is a deadly object in a hot zone.  A scalpel can nick your gloves and cut 
your fingers, and before you even feel a sensation of pain, the agent has 
already entered your blood stream.
	Nancy handed tools to him, and she reached her fingers inside the 
monkey to tie off blood vessels and mop up excess blood with small 
sponges.  The animal's body cavity was a lake of blood.  It was Ebola 
blood, and it had run everywhere inside the animal: there had been a lot 
of internal hemorrhaging.  The liver was swollen, and she noticed some 
blood in the intestines.
	She had to tell herself to slow her hands down.  Perhaps her hands 
were moving too quickly.  She talked herself through the procedure, 
keeping herself alert and centered.  Keep it clean, keep it clean, she 
thought.  Okay, pick up the hemostat.  Clamp that artery 'cause it's 
leaking blood.  Break off and rinse gloves.  She could feel the Ebola 
blood through her gloves; it felt wet and slippery, even through her hands 
were clean and dry and dusted with baby powder.
	She withdrew her hands from the carcass and rinsed them in a pan 
of disinfectant called EnviroChem, which sat in a sink.  the liquid was 
pale green, the color of Japanese green tea.  It destroys viruses.  As she 
rinsed her gloves in it, the liquid turned brown with monkey blood.  All 
she could hear was the noise of the air blowing inside her suit.  It 
filled her suit with a roar like a subway train coming through a tunnel.

A VIRUS IS a small capsule made of membranes and proteins.  The capsule 
contains one or more strands of DNA or RNA, which are long molecules that 
contain the software program for making a copy of virus.  Some biologists 
classify viruses as "life forms," because they are not stricky known to be 
alive.  Viruses are ambiguously alive, neither alive nor dead.  They carry 
on their existence in the borderlands between life and nonlife.  They are 
dead.  They can even form crystals.  Virus particles that lie around in 
blood or mucus may seem dead, but the particles are waiting for something 
to come along.  They have a sticky surface.  If a cell comes along and 
touches the virus and the stickiness of the virus matches the stickiness 
of the cell, then the virus clings to the cell.  The cell feels the virus 
sticking to it and enfolds the virus and drags it inside.  Once the virus 
enters the cell, it becomes a Trojan horse.  It switches on and begins to 
replicate.
	A virus is a parasite.  It can't live on its own.  It can only 
make copies of itself inside a cell using the cell's materials and 
machinery to get the job done.  All living things carry viruses in their 
cells.  Even fungi and bacteria are inhabited by viruses and are 
occasionally destroyed by them.  That is, disease have their own disease.  
A virus makes copies of itself inside a cell until eventually the cell 
gets pigged with virus and pops, and the viruses spill out of the broken 
cell.  Or viruses can bud through a cell wall, like drips coming out of a 
faucet-drip, drip, drip, drip, copy, copy, copy, copy-that's the way the 
AIDS virus works.  The faucet runs and runs until the cell is exhausted, 
consumed, and destroyed.  If enough cells are destroyed, the host dies.  A 
virus does not "want" to kill its host.  That is not in the best interest 
of virus, because then the virus may also die, unless it can jump fast 
enough out of the dying host into a new host.
	The genetic code inside Ebola is a single strand of RNA.  This 
type of molecule is thought to be the oldest and most "primite" coding 
mechanism for life.  The earth's primordial ocean, which came into 
existence not long after the earth was formed, about four and a half 
billion years ago, may well have contained microscopic life forms based on 
RNA.  This suggested that Ebola is an ancient kind of life, perhaps nearly 
as old as the earth itself.  Another hint that Ebola is extremely ancient 
is the way in which it can seem neither quite alive nor quite unalive.
	Viruses may seem alive when they multiply, but in another sense 
they are obviously dead, are only machines, subtle ones to be sure, but 
strictly mechanical, no more alive than a jackhammer.  Viruses are 
molecular sharks, a motive without a mind.  Compact, hard, logical, 
totally selfish, the virus is dedicated to making copies of itself-which 
it can do on occasion with radiant speed.  The prime directive is to 
replicate.
	Viruses are too small to be seen.  Here is a way to imagine the 
size of a virus.  Consider the island of Manhattan shrunk to this size: /. 
 This Manhattan could easily hold nine million viruses.  If you could 
magnify this Manhattan and if it were fully of viruses, you would see 
little figures clustered like the lunch crowd on Fifth Avenue.  A hundred 
million crystallized polio viruses could cover the period at the end of 
this sentence.  There could be two hundred and fifty Woodstock Festivals 
of viruses sitting on that period-the combined populations of Great 
Britain and France-and you would never know it.

KEEP IT CLEAN, Nancy thought.  No blood.  No blood.  I don't like blood.  
Every time I see a drop of blood, I see a billion viruses.  Break off and 
rinse.  Break off and rinse.  Slow yourself.  Look at Tony's suit.  Check 
him.
	You watched your partner's suit for any sign of a hole or a break. 
 It was kind of like being a mother and watching your kid-a constant 
background check to see if everything is okay.
	Meanwhile, Johnson was checking her.  He observed her for any kind 
of mistake, any jerkiness with the tools.  He wondered if he would see her 
drop something.
	"RONGEUR," he said.
	"WHAT?" she asked.
	He pointed at her air hose to suggest that she crimp it so that 
she could hear him better.  She grabbed the hose and folded it.  The air 
stopped flowing, her suit deflated around her, and the noise died away.  
He put his helmet close to hers and spoke the work rongeur again, and she 
released her hose.  She handed him a pair of pliers called the rongeur.  
The word is French and means "gnawer."  It is used for opening skulls.
	Getting into a skull is always a bitch in Level 4.  A primate 
skull is hard and tough, and the bone plates are knitted together.  
Ordinarily you would whip through a skull with an electric bone saw, but 
you can't use a bone saw in Level 4.  It would throw a mist of bone 
particles and blood droplets into the air, and you do not want to create 
any kind of infective mist in a hot area, even if you are wearing a space 
suit; it is just too dangerous.
	They popped the skull with the pliers.  It made a loud cracking 
sound.  They removed the brain, eyes, and spinal cord and dropped them 
into a jar of preservative.
	Johnson was handing her a tube containing a sample when he stopped 
and looked at her gloved hands.  He pointed to her right glove.
	She glanced down.  Her glove.  It was drenched in blood, but now 
she saw the hole.  It was rip across the palm of the outer glove on her 
right hand.
	Nancy tore off the glove.  Now her main suit glove was covered 
with blood.  It spidered down the outer sleeve of her space suit.  Great, 
just great-Ebola blood all over my suit.  She rinsed her glove and arm in 
the disinfectant, and they came up clean and shiny wet.  Then she noticed 
that her hand, inside the two remaining gloves, felt cold and clammy.  
There was something wet inside her space suit glove.  She wondered if that 
glove was a leaker, too.  She wondered if she had sustained a breach in 
her right main glove.  She inspected that glove carefully.  Then she saw 
it.  It was a crack in the wrist.  She had a breach in her space suit.  
Her hand felt wet.  She wondered if there might be Ebola blood inside her 
space suit, somewhere close to that cut on the palm of her hand.  She 
pointed to her glove and said, "HOLE."  Johnson bent over and inspected 
her glove.  He saw the crack in the wrist.  She saw his face erupt in 
surprise, and then he looked into her eyes.  She saw he was afraid.
	That terrified her.  She jerked her thumb toward the exit.  "I'M 
OUTTA HERE, MAN.  CAN YOU FINISH?"
	He replied, "I WANT YOU TO LEAVE IMMEDIATELY.  I'LL SECURE THE 
AREA AND FOLLOW YOU OUT."
	Using only her left hand, her good hand, she unplugged her suit 
from the air hose.  She practically ran down the corridor to the air lock, 
her right arm hanging rigidly at her side.  She did not want to move that 
hand because every time she moved it she felt something squishing around 
in there, inside the glove.  Fear threatened to overwhelm her.  How was 
she going to remove her boots without using her bad hand?   She kicked 
them off.  They went flying down the corridor.  She threw open the 
air-lock door and stepped inside and slammed the door behind her.
	She pulled a chain that hung the ceiling of air lock.  That 
started the decon shower.  The decon shower takes seven minutes, and you 
are not permitted to leave during that period, because the shower needs 
time to work on viruses.  First came a blast of water jets, which washed 
traces of blood from her space suit.  The water jets stopped.  then came a 
spray of EnviroChem, coming out of nozzles all up and down the sides of 
the air lock, which deconned her space suit.  Of course, if something 
lived inside her glove, the chemical shower would not reach it.
	There were no lights in the air lock; it was dim, almost dark.  
The place was literally a gray zone.  She wished it had a clock.  Then you 
would know how long you would have to wait.  Five minutes to go?  four 
minutes?  Chemical mist drizzled down her faceplate.  It was like driving 
a car in the rain when the windshield wipers are broken; you can't see a 
thing.  Shit, shit, shit, she thought.
	At the Institute, there is a Level 4 biocontainment hospital 
called the Slammer, where a patient can be treated by doctors and nurses 
wearing space suits.  If you are exposed to a hot agent and you go into 
the Slammer and fail to come out alive, then you body is taken to a nearby 
Level 4 biocontainment morgue, known as the Submarine.  The soldiers 
around the Institute call the morgue the Submarine because its main door 
is made of heavy steel and looks like a pressure door in a submarine.
	Son of bitch! she thought.  Aw, fuck!  They'll put me into the 
Slammer.  And Tony will be filling out accident reports while I'm breaking 
with Ebola.  And a week later, I'll be in the Submarine.  Shit!  Jerry's 
in Texas.  And I didn't go to the bank today.  There's no money in the 
house.  The kids are home with Mrs. Trapane, and she needs to be paid.  I 
didn't go to the market today.  There's no food in the house.  How are the 
kids going to eat if I'm in the Slammer?  Who's going to stay with them 
tonight?  Shit, shit, shit!
	The shower stopped.  She opened the door and flung herself into 
the staging area.  She came out of the space suit fast.  She shucked it.  
She leaped out of it.  The space suit slapped to the concrete floor, wet, 
dripping with water.
	As her right arm came out of the suit, she saw that the sleeve of 
her scrub suit was dark wet and her inner glove was red.
	That space suit glove had been a leaker.  Ebola blood had run over 
her innermost glove.  It had smeared down on the latex, right against her 
skin, right against the Band-Aid.  Her last glove was thin and 
translucent, and she could see the Band-Aid through it, directly under the 
Ebola blood.  Her heart pounded, and she almost threw up-her stomach 
contracted and turned over, and she felt a gag reflex in her throat.  The 
puke factor.  It is a sudden urge to throw up when you find yourself 
unprotected in the presence of a Biosafety Level 4 organism.  Her mind 
raced: Oh, shit.  What now?  I've got an undeconned glove-Ebola blood in 
here.  Oh, Jesus.  What's the procedure here?  What do I have to do now?
	Tony Johnson's blue figure moved in the air lock, and she heard 
the nozzles begin to hiss.  He had begun the decon cycle.  It would be 
seven minutes before he could answer any questions.
	The main question was whether any blood had penetrated the last 
glove to the cut.  Five or ten Ebola-virus particles suspended in a 
droplet of blood could easily slip through a pinhole in a surgical glove, 
and that might be enough to start an explosive infection.  This stuff 
could amplify itself.  A pinhole in a glove might not be visible to the 
eye.  She went over to the sink and put her hand under the faucet to rinse 
off the blood and held there for a while.  The water carried the blood 
down the drain, where the waste water would be cooked in heated tanks.
	Then she pulled off the last glove, holding it delicately by the 
cuff.  Her right hand came out caked with baby powder, her fingernails 
short, no nail polish, no ring, knuckles scarred by a bite form a goat 
that had nipped her when she was child, and a Band-Aid on the palm.
	She saw blood mixed with the baby powder.
	Please, please, make it my blood.
	Yes-it was her own blood.  She had bled around the edges of the 
Band-Aid.  She did not see any monkey on her hand.
	She put the last glove under the faucet.  The water was running 
and it filled up the glove.  The glove swelled up like a water balloon.  
She dreaded the sudden appearance of a thread of water squirting from the 
glove, the telltale of a leak, a sign that her life was over.  The glove 
fattened and held.  No leaks.
	Suddenly her legs collapsed.  She fell against the cinder-block 
wall and slid down it, feeling as if she had been punched in the stomach.  
She came to rest on the hatbox, the biohazard box that someone had been 
using as a chair.  Her legs kicked out, and she went limp and leaned back 
against the wall.  That was how Tony Johnson found her when he emerged 
from the air lock.

THE ACCIDENT REPORT concluded that Major N. Jaax had not been exposed to 
Ebola virus.  Her last glove had remained intact, and since everyone 
believed that the agent was transmitted through direct contact with blood 
and bodily fluids, there did not seem to be any way for it to have entered 
her bloodstream, even though it had breached her space suit.  She drove 
home that night having escaped the Slammer by the skin of her last glove.  
She had almost caught Ebola from a dead monkey, who had caught t from a 
young woman named Mayinga, who had caught it from a nun who had crashed 
and bled out in the jungles of Zaire in years gone by.
	She called Jerry that night in Texas. "Guess what?  I had this 
little problem today.  I had a near-Ebola experience."  She told him what 
had happened.
	He was appalled. "God-damn it, Nancy!  I told you not to get 
involved with that Ebola virus!  That fucking Ebola!"  And he went into a 
ten-minute diatribe about the dangers of doing hot work in a space suit, 
especially with Ebola.
	She remained calm and did not argue with him.  She realized he 
wasn't angry with her, just scared.  She let Jerry run on, and when he had 
gotten it all out of his system and was starting to taper off, she told 
him that she felt confident that everything was going to be all right.
	Meanwhile, he was surprised at how calm his wife seemed.  He would 
have flown home that night if he had perceived any inkling of distress in 
her.

THE EBOLA EXPERIMENTS were not a success in the sense that the drugs had 
no effect on the virus.  All of Gene Johnson's infected monkeys died no 
matter what drugs they were given.  They all died.  The virus absolutely 
nuked the monkeys.  It was a complete slate wiper.  The only survivors of 
the experiment were the two control monkeys-the healthy, uninfected 
monkeys that lived in cages across the room from the sick monkeys.  The 
control monkeys had not been infected with Ebola, and so, as expected, 
they had not become sick.
	Then, two weeks after the incident with the bloody glove, 
something frightening happened in the Ebola rooms.  The two healthy 
monkeys developed red eyes and blood noses, and they crashed and bled out. 
 They had never been deliberately infected with Ebola virus, and they had 
not come near the sick monkeys.  They were separated from the sick monkeys 
by open floor.
	If a healthy person were placed on the other side of a room from a 
person who was sick with AIDS, the AIDS virus would not be able to drift 
across the room through the air and infect the healthy person.  But Ebola 
had drifted across a room.  It had moved quickly, decisively, and by an 
unknown route.  Most likely the control monkeys inhaled it into their 
lungs.  "It got there somehow," Nancy Jaax would say to me as she told me 
the story some years later.  "Monkeys spit and throw stuff.  And when the 
caretakers wash the cages down with water hoses, that can create an 
aerosol of droplets.  It probably traveled through the air in aerosolized 
secretion.  That was when I knew that Ebola can travel through the air." 

EBOLA RIVER

1976 SUMMER - AUTUMN

ONE JULY 6, 1976, five hundred miles northwest of Mount Elgon, in southern 
Sudan, near the fingered edge of the central-African rain forest, a man 
who is known to Ebola hunters as Yu. G. went into shock and died with 
blood running from the orifices of his body.  He is referred to only by 
his initials.  Mr. Yu. G. was the first identified case, the index case, 
in an outbreak of an unknown virus.
	Mr. Yu. G. was a storekeeper in a cotton factory in the town of 
Nzara.  The population of Nzara had grown in recent years-the town had 
experienced, in its own way, the human population explosion that is 
occurring through the equatorial regions of the earth.  The people of that 
area in southern Sudan are the Zande, a large tribe.  The country of the 
Zande is savanna mixed with riverine forest, beautiful country, where 
acacia trees cluster along the banks of seasonal rivers.  African doves 
perch in the trees and call their drawn-out calls.  The land between the 
rivers is a sea of elephant grass, which can grow ten feet height.  As you 
head south, toward Zaire, the land rises and forms hills, and the forest 
begins to spread away from the rivers and thickens into a closed canopy, 
and you enter the rain forest.  The land around the town of Nzara held 
rich planations of teak and fruit trees and cotton.  People were poor, but 
they worked hard and raised large families and kept to their tribal 
traditions.
	Mr. Yu. G. was a salaried man.  He worked at a desk in a room 
piled with cotton cloth at the back of the factory.  Bats roosted in the 
ceiling of the room near his desk.  If the bats were infected with Ebola, 
no one has been able to prove it.  The virus may have entered the cotton 
factory by some unknown route-perhaps in insects trapped in the cotton 
fibers, for example, or in rats that lived in the factory.  Or, possibly, 
the virus had nothing to do with the cotton factory, and Mr. Yu. G. was 
infected somewhere else.  He did not go to a hospital, and died on a cot 
in his family compound.  His family gave him a traditional Zande funeral 
and left his body under a mound of stones in a clearing of elephant grass. 
 His grave has been visited more than once by doctors from Europe and 
America, who want to see it and reflect on its meaning, and pay their 
respects to the index case of what later became known as Ebola Sudan.
	He is remembered today as a "quiet, unremarkable man."  No 
photograph was taken of him during his lifetime, and no one seems to 
remember what he looked like.  He wasn't well known, even in his hometown. 
 They say that his brother was tall and slender, so perhaps, he was, too.  
He passed through the gates of life unnoticed by anyone except his family 
and a few of his co-workers.  He might have made no difference except for 
the fact what he was a host.
	His illness began to copy itself.  A few days after he died, two 
other salaried men who worked at desks near him in the same room broke 
with bleeding, went into shock, and died with massive hemorrhages from the 
natural openings of the body.  One of the dead men was a popular fellow 
known as P.G.  Unlike the quiet Mr. Yu. G., he had a wide circle of 
friends, including several mistresses.  He spread the agent far and wide 
in the town.  The agent jumped easily from person to person, apparently 
through touching and sexual contact.  It was a fast spreader, and it could 
live easily in people.  It passed through as many as sixteen generations 
of infection as it jumped from person to person in Sudan.  It also killed 
many of its hosts.  While this is not necessarily in the best interest of 
the virus, if the virus is highly contagious, and can jump fast enough 
from host to host, then it does not matter, really, what happens to the 
previous host, because virus can amplify itself for quite a while, at 
least until it kills off much of the population of hosts.  Most of the 
fatal cases of Ebola Sudan can be traced back through chains of infection 
to the quiet Mr. Yu. G.  A hot strain radiated out of him and nearly 
devastated the human population of southern Sudan.  The strain burned 
through the town of Nzara and reached eastward to the town of Maridi, 
where there was a hospital.
	It hit the hospital like a bomb.  It savaged patients and snaked 
like chain lightning out from the hospital through patients' families.  
Apparently the medical staff had been giving patients injections with 
dirty needles.  The virus jumped quickly through the hospital via the 
needles, and then it hit the medical staff.  A characteristic of a lethal, 
contagious, and incurable virus is that it quickly gets into the medical 
people.  In some cases, the medical system may intensify the outbreak, 
like a lens that focuses sunlight on a heap of tinder.
	The virus tranformed the hospital at Maridi into a morgue.  As it 
jumped from bed to bed, killing patients left and right, doctors began to 
notice signs of mental derangement, psychosis, depersonalization, 
zombie-like behavior.  Some of the dying stripped off their clothes and 
ran out of the hospital, naked and bleeding, and wandered through the 
streets of the town, seeking their homes, not seeming to know what had 
happened or how they had gotten into this condition.  There is no doubt 
that Ebola damages the brain and causes psychotic dementia.  It is not 
easy, however, to separate brain damage from the effects of fear.  If you 
were trapped in a hospital where people dissolving in their beds, you 
might try to escape, and if you were a bleeder and frightened, you might 
take off your clothes, and people might think you had gone mad.
	The sudan strain was more than twice as lethal as Marburg 
virus-its case-fatality rate was 50 percent.  That is, fully half of the 
people who came down with it ended up dying, and quickly.  This was the 
same kind of fatality rate as was seen with the black plague during the 
Middle Ages.  If the Ebola Sudan virus had managed to spread out of 
central Africa, it might have entered Khartoum in a few weeks, penetrated 
Cairo a few weeks after that, and from there it would have hopped to 
Athens, New York, Paris, London, Singapore-it would have gone everywhere 
on the planet.  Yet that never happened, and the crisis in Sudan passed 
away unnoticed by the world at large.  What happened in Sudan could be 
compared to the secret detonation of an atomic bomb.  If the human race 
came close to a major biological accident, we never knew it.
	For reasons that are not clear, the outbreak subsided, and the 
virus vanished.  The hospital at Maridi had been the epicenter of 
emergence.  As the virus ravaged the hospital, the surviving medical staff 
panicked and ran off into the bush.  It was probably the wisest thing to 
do and the best thing that could have happened, because it stopped the use 
of dirty needles and emptied the hospital, which helped to break the chain 
of infection.
	There was another possible reason why the Ebola Sudan virus 
vanished.  It was exceedingly hot.  It killed people so fast that they 
didn't have much time to infect other people before they died.  
Furthermore, the virus was not airborne.  It was not quite contagious 
enough to start a full-scale disaster.  It traveled in blood, and the 
bleeding victim did not touch very many other people before dying, and so 
the virus did not have many chances to jump to a new host.  Had people 
been coughing the virus into the air ... it would have been a different 
story.  In any case, the Ebola Sudan virus destroyed a few hundred people 
in central Africa the way a fire consumes a pile of straw-until the blaze 
burns out at the center and ends in a heap of ash-rather than smoldering 
around the planet, as AIDS has done, like a fire in a coal mine, 
impossible to put out.  The Ebola virus, in its Sudan incarnation, 
retreated to the heart of the bush, where undoubtedly it lives to this 
day, cycling and cycling in some unknown host, able to shift its shape, 
able to mutate and become a new thing, with the potential to enter the 
human species in a new form.

TWO MONTHS AFTER the start of the Sudan emergence-the time was early 
September 1976-an even more lethal filovirus emerged five hundred miles to 
the west, in a district of northern Zaire called Bumba Zone, an ahead of 
tropical rain forest populated by scattered villages and drained by the 
Ebola River.  The Ebola Zaire strain was nearly twice as lethal as Ebola 
Sudan.  It seemed to emerge out of the stillness of an implacable force 
brooding on an inscrutable intention.  To this day, the first human case 
of Ebola Zaire has never been identified.
	In the first days of September, some unknown person who probably 
lived somewhere to the south of Ebola River perhaps touched something 
bloody.  It might have been monkey meat-people in that area hunt monkeys 
for food- or it might have been the meat of some other animal, such as an 
elephant or a bat.  Or perhaps the person touched a crushed insect, or 
perhaps he or she was bitten by a spider.  Whatever the original host of 
the virus, it seems that a blood-to-blood contact in the rain forest 
enabled the virus to move into the human world.  The portal into the human 
race may well have been a cut on this unknown person's hand.
	The virus surfaced in the Yambuku Mission Hospital, an upcountry 
clinic run by Belgian nuns.  The hospital was a collection of corrugated 
tin roofs and whitewashed concrete walls sitting besides a church in the 
forest, where bells rang and you heard a sound of hymns and the words of 
the high mass spoken in Bantu.  Next door, people stood in line at the 
clinic and shivered with malaria while they waited for a nun to give them 
an injection of medicine that might make them feel better.
	The mission in Yambuku also ran a school for children.  In later 
August, a teacher from the school and some friends went on a vacation trip 
to the northern part of Zaire.  They borrowed a Land Rover from the 
mission to make their journey, and they explored the country as they 
headed northward, moving slowly along rutted tracks, no doubt getting 
stuck in the mud from time to time, which is the way things go when you 
try to drive through Zaire.  The track was mostly a footpath enclosed by a 
canopy of trees, and it was always in shadow, as if they were driving 
through Zaire.  The track was mostly a footpath enclosed by a canopy of 
trees, and it was always in shadow, as if they were driving through a 
tunnel.  Eventually they came to the Ebola River and crossed it on a ferry 
barge and continued northward.  Near the Obangui River, they stopped at a 
roadside market, where the schoolteacher bought some fresh antelope meat.  
One of his friends bought a freshly killed monkey and put it in the back 
of the Land Rover.  Any of the friends could have handled the monkey or 
the antelope meat while they were bouncing around in the Land Rover.
	They turned back, and when the schoolteacher arrived home, his 
wife stewed the antelope meat, and everyone in the family ate it.  The 
following morning he felt unwell, and so before he reported to his 
teaching job at the school, he stopped off at the Yambuku Hospital, on the 
other side of the church, to get an injection of medicine from the nuns.
	At the beginning of each day, the nuns at Yambuku Hospital would 
lay out five hypodermic syringes on a table, and they would use them to 
give shots to patients all day long.  They were using five needles a day 
to give injections to hundreds of people in the hospital's outpatient and 
maternity clinics.  The nuns and staff occasionally rinsed the needles in 
a pan of warm water after an injection, to get the blood off the needle, 
but more often they proceeded from shot to shot without rinsing the 
needle, moving from arm to arm, mixing blood with blood.  Since Ebola 
virus is highly infective and since as few as five or ten particles of the 
virus in a blood-borne contact can start an extreme amplification in a new 
host, there would have been excellent opportunity for the agent to spread.
	A few days after schoolteacher received his injection, he broke 
with Ebola Zaire.  He was the first known case of Ebola Zaire, but he may 
well have contracted the virus from a dirty needle during his injection at 
the hospital, which means that someone else might have previously visited 
the hospital while sick with Ebola virus and earlier in the day received 
an injection from the same needle that was then used on the schoolteacher. 
 That unknown person probably stood in line for an injection just ahead of 
the schoolteacher.  That person would have started the Ebola outbreak in 
Zaire.  As in Sudan, the emergence of a life form that could in theory 
have gone around the earth began with one infected person.
	The virus erupted simultaneously in fifty-five villages 
surrounding the hospital.  First it killed people who had received 
injections, and then it moved through families, killing family members, 
particularly women, who in Africa prepare the dead for burial.  It swept 
through the Yambuku Hospital's nursing staff, killing most of the nurses, 
and then it hit the Belgian nuns.  The first nun to break with Ebola was a 
midwife who had delivered a stillborn child.  The mother was dying of 
Ebola and had given the virus to her unborn baby.  The fetus had evidently 
crashed and bled out inside the mother's womb.  The woman then aborted 
spontaneously, and the nun who assisted at this grotesque delivery came 
away from the experience with blood on her hands.  The blood of the mother 
and fetus was radiantly hot, and the nun must have had a small break or 
cut on the skin of her hands.  She developed an explosive infection and 
was dead in five days.
	There was a nun at the Yambuku Hospital who is known today as 
Sister M.E.  She became gravely ill with l'epidemie, or "the epidemic," as 
they had begun to call it.  A priest at Yambuku decided to try to take her 
to the city of Kinshasa, the capital of Zaire, in order to get her better 
medical treatment.  He and another nun, named Sister E.R., drove Sister 
M.E. in a Land Rover to the town of Bumba, a sprawl of cinder blocks and 
wooden shacks that huddles beside the Congo River.  They went to the 
airfield at Bumba and hired a small plane to fly to Kinshasa, an when they 
reached the city, they took Sister M.E. to Ngaliema Hospital, a private 
hospital run by Swedish nurses, where she was given a room of her own.  
There she endured her agonals and committed her soul to Christ.

EBOLA ZAIRE ATTACKS every organ and tissue in the human body except 
skeletal muscle and bone.  It is a perfect parasite because it transforms 
virtually every part of the body into a digested slime of virus particles. 
 The seven mysterious proteins that, assembled together, make up the 
Ebola-virus particle, work as a relentless machine, a molecular shark, and 
they consume the body as the virus makes copies of itself.  Small blood 
clots begin to appear in the bloodstream, and the blood thickens and 
slows, and the clots begin to stick to the walls of blood vessels.  This 
is known as pavementing, because the clots fit together in a mosaic.  The 
mosaic thickens and throws more clots, and the clots drift through the 
bloodstream into the small capillaries, where they get stuck.  This shuts 
off the blood supply to various part of the body, causing dead spots to 
appear in the brain, liver, kidneys, lungs, intestines, testicles, breast 
tissue (of men as well as women), and all through the skin.  The skin 
develops red spots, called petechiae, which are hemorrhages under the 
skin.  Ebola attacks connective tissue with particular ferocity; it 
multiplies in collagen, the chief constituent protein of the tissue that 
holds the organs together.  (The seven Ebola proteins somehow chew up the 
body's structural proteins.)  In this way, collagen in the body turns to 
mush, and the underlayers of the skin die and liquefy.  The skin bubbles 
up into a sea of tiny white blisters mixed with red spots known as a 
maculopapular rash.  The rash has been likened to tapioca pudding.  
spontaneous rips appear in the skin, and hemorrhagic blood pours from the 
rips.  The red spots on the skin grow and spread and merge to become huge, 
spontaneous bruises, and he skin goes soft and pulpy, and can tear off if 
it is touched with any kind of pressure.  You mouth bleeds, and you bleed 
around your teeth, and you may have hemorrhages from the salivary 
glands-literally every opening in the body bleeds, no matter how small.  
The surface of the tongue turns brilliant red and then sloughs off, and is 
swallowed or spat out.  It is said to be extraordinarily painful to lose 
the surface of one's tongue.  The tongue's skin may be torn off during 
rushes of the black vomit.  The back of the throat and the lining of the 
windpipe may also slough off, and the dead tissue slides down the windpipe 
into the lungs or is coughed up with sputum.  Your heart bleeds into 
itself; the heart muscle softens and has hemorrhages into its chambers, 
and blood squeezes out of the heart muscle as the heart beats, and it 
floods the chest cavity.  The brain becomes clogged with dead blood cells, 
a condition known as sludging of the brain.  Ebola attacks the lining of 
the eyeball, and the eyeballs may fill up with blood: you may go blind.  
Droplets of blood stand out on the eyelids: you may weep blood.  The blood 
runs from your eyes down your cheeks and refuses to coagulate.  You may 
have a hemispherical stroke, in which one whole side of the body is 
paralyzed, which is invariably fatal in a case of Ebola.  Even while the 
body's internal organs are becoming plugged with coagulated blood, the 
blood that streams out of the body cannot clot; it resembles when being 
squeezed out of curds.  The blood has been stripped of its clotting 
factors.  If you put the runny Ebola blood in a test tube and look at it, 
you see that the blood is destroyed.  Its red cells are broken and dead.  
The blood looks as if it has been buzzed in an electric blender.
	Ebola kills a great deal of tissue while the host is still alive.  
It triggers a creeping, spotty necrosis that spreads through all the 
internal organs.  The liver bulges up and turns yellow, begins to liquefy, 
and then it cracks apart.  The cracks run across the liver and deep inside 
it, and the liver completely dies and goes putrid.  The kidneys become 
jammed with blood clots and dead cells, and cease functioning.  As the 
kidneys fail, the blood becomes toxic with urine.  The spleen turns into a 
single huge, hard blood clot the size of a baseball.  The intestines may 
fill up completely with blood.  The lining of the gut dies and sloughs off 
into the bowels and is defecated along with large amounts of blood.  In 
men, the testicles bloat up and turn black-and-blue, the semen goes hot 
with Ebola, and the nipples may bleed.  In women, the labia turn blue, 
livid, and protrusive, and there may be massive vaginal bleeding.  The 
virus is a catastrophe for a pregnant woman: the child is aborted 
spontaneously and is usually infected with Ebola virus, born with red eyes 
and a bloody nose.
	Ebola destroys the brain more thoroughly than does Marburg, and 
Ebola victims often go into epileptic convulsions during the final stage.  
The convulsions are generalized grand mal seizures-the whole body twitches 
and shakes, the arms and legs thrash around, and the eyes, sometimes 
bloody, roll up into the head.  The tremors and convulsions of the patient 
may smear or splatter blood around.  Possibly this epileptic splashing of 
blood is one of Ebola's strategies for success-it makes the victim go into 
a flurry of seizures as he dies, spreading blood all over the place, thus 
giving the virus a chance to jump to a new host-a kind of transmission 
through smearing.
	Ebola (and Marburg) multiplies so rapidly and powerfully that the 
body's infected cells become crystal-like blocks of packed virus 
particles.  These crystals are broods of virus getting ready to hatch from 
the cell.  They are known as bricks.  The bricks, or crystals, first 
appear near the center of the cell and then migrate toward the surface.  
As a crystal reaches a cell wall, it disintegrates into hundreds of 
individual virus particles, and the bloodlings push through the cell wall 
like hair and float away in the bloodstream of the host.  The hatched 
Ebola particles cling to cells everywhere in the body, and get inside 
them, and continue to multiply.  It keeps on multiplying until areas of 
tissue all through the body are filled with crystalloids, which hatch, and 
more Ebola particles drift into the bloodstream, and the amplification 
continues inexorably until a droplet of host's blood can contain a hundred 
million individual virus particles.
	After death, the cadaver suddenly deteriorates: the internal 
organs, having been dead or partially dead for days, have already begun to 
dissolve, and a sort of shock-related meltdown occurs.  The corpse's 
connective tissue, skin, and organs, already peppered with dead spots, 
heated by fever, and damaged by shock, begin to liquefy, and the fluids 
that leak from the cadaver are saturated with Ebola-virus particles.

WHEN IT WAS all over, the floor, chair, and walls in Sister M.E's hospital 
room were stained with blood.  Someone who saw the room told me that after 
they took her body away for burial (wrapped in many sheets), no one at the 
hospital could bear to go into the room to clean it up.  The nurses and 
doctors didn't want to touch the blood on the walls and were frankly 
fearful of breathing the air in the room, too.  So the room was closed and 
locked, and remained that way for days.  The appearance of the nun's 
hospital room after her death may have raised in some minds one or two 
question about the nature of the Supreme Being, or, for persons not 
inclined to theology, the blood on the walls may have served as a reminder 
of the nature of Nature.
	No one knew what had killed the nun, but clearly it was a 
replicating agent, and the signs and symptoms of the disease were not easy 
to consider with a calm mind.  What also did not lead to calm thoughts 
were rumors coming out of the jungle to the effect that the agent was 
wiping out whole villages upriver on the Congo.  These rumors were not 
true.  The virus was hitting families selectively, but no one understood 
this because the flow of news coming from upriver was being choked off.  
Doctors at the hospital in Kinshasa examined the nun's case and began to 
suspect that she might have died of Marburg or a Marburg-like agent.
	Then Sister E.R., the nun who had traveled with Sister M.E. during 
the drive to Bumba and the plane flight to Kinshasa, broke with 
l'eoudenue,  They put her in a private room at the hospital, where she 
began to die with the same signs and symptoms that had preceded Sister 
M.E.'s death.
	There was a young nurse at the Ngaliema Hospital named Mayinga N.  
(Her first name was Mayinga and her last name is given as N.)  Nurse 
Mayinga had been caring for Sister M.E. when the nun had died in the 
bloodstained room.  She may have been splattered with the nun's blood or 
with black vomit.  At any rate, Nurse Mayinga developed a headache and 
fatigue.  she knew she was becoming sick, but she did not want to admit to 
herself what it was.  She came from a poor but ambitious family, and she 
had received a scholarship to go to college in Europe.  What worried her 
was the possibility that if she became ill, she would not be allowed to 
travel abroad.  When the headache came upon her, she left her job at the 
hospital and disappeared.  She dropped out of sight for two days.  During 
that time, she went into the city, hoping to get her travel permits 
arranged before she became visibly sick.  On the first day of her 
disappearance-the date was October 12, 1976-she spent a day waiting in 
lines at the offices of the Zairean foreign ministry, trying to get her 
papers straight.
	The next day, October 13, she felt worse, but instead of reporting 
to work, again she went into the city.  This time, she took a taxi to the 
largest hospital in Kinshasa, the Mama Yemo Hospital.  By now, as her 
headache became blinding and her stomach pain increased, she must have 
been terribly frightened.  Why didn't she go to the Ngaliema Hospital to 
seek treatment where she worked and where the doctors would have taken 
care of her?  It must have been a case of psychological denial.  She did 
not want to admit, even to herself, that she had been infected.  Perhaps 
she had a touch of malaria, she hoped.  So she went to Mama Yemo Hospital, 
the hospital of last resort for the city's poor, and spent hours waiting 
in a casualty ward jammed with ragged people and children.
	I can see her in my mind's eye-Nurse Mayinga, the source of the 
virus in the United States Army's freezers.  She was a pleasant, quiet, 
beautiful young African woman, about twenty years old, in the prime of her 
life, with a future and dreams, hoping somehow that what was happening to 
her could not be happening.  They say that her parents loved her dearly, 
that she was the apple of their eye.  Now she is sitting in the casualty 
ward at Mama Yemo among the cases of malaria, among the large-bellied 
children in rags, and no one is paying any attention to her because all 
she has is a headache and red eyes.  Perhaps the fact that she is crying 
has made her eyes red.  A doctor gives her a shot for malaria and tells 
her that she should be in quarantine for her illness.  But there is no 
room in the quarantine ward at Mama Yemo Hospital; so she leaves the 
hospital and hails another taxi.  She tells the driver to take her to 
another hospital, to University Hospital, where perhaps the doctors can 
treat her.  But when she arrives at University Hospital, the doctors can't 
seem to find anything wrong with her, except for possibly some sign of 
malaria.  Her headache is getting worse.  She is sitting in the waiting 
room of this hospital, and as I try to imagine her there, I am almost 
certain she is crying.  Finally she does the only thing left for her to 
do.  She returns to Ngaliema Hospital and asks to be admitted as a 
patient.  They put her in a private room, and there she falls into 
lethargy, and her face freezes into a mask.
	News of the virus and what it did to people had been trickling out 
of the forest, and now a rumor that a sick nurse had wandered around 
Kinshasa for two days, having face-to-face contact with many people in 
crowded rooms and public places, caused a panic in the city.  The news 
spread first along the mission grapevine and through government employees 
and among the diplomats at cocktail parties, and finally the rumors began 
to reach Europe.  When the story reached the offices of the World Health 
Organization in Geneva, the place went into a full-scale alert.  People 
who were there at the time said that you could feel fear in the hallways, 
and the director looked like a visibly shaken man.  Nurse Mayinga seemed 
to be a vector for an explosive claim of lethal transmission in a crowded 
third-world city with a population of two million people.  Officials at 
the WHO began to fear that Nurse Mayinga would become the vector for a 
world-wide plague.  European governments contemplated blocking flights 
from Kinshasa.  The fact that one infected person had wandered around the 
city for two days when she should have been isolated in a hospital room 
began to look like a species-threatening event.
	President Mobutu Sese Seko, the maximum leader of Zaire, sent his 
army into action.  He stationed soldiers around Ngaliema Hospital with 
orders to let no one enter or leave except doctors.  Much of the medical 
staff was no under quarantine inside the hospital, but the soldiers made 
sure that the quarantine was enforced.  President Mobutu also ordered army 
units to seal off Bumba Zone with roadblocks and to shoot anyone trying to 
come out.  Bumba's main link with the outside world was the Congo River.  
Captains of riverboats had heard about the virus by this time, and they 
refused to stop their boats anywhere along the length of the river in 
Bumba, even though people beseeched them from the banks.  Then all radio 
contact with Bumba was lost.  No one knew what was happening upriver, who 
was dying, what the virus was doing.  Bumba had dropped off the face of 
the earth into the silent heart of darkness.

AS THE FIRST nun at Ngaliema Hospital, Sister M.E., lay dying, her doctors 
had decided to give her a so-called agonal biopsy.  This is a rapid 
sampling of tissue, done close to the moment of death instead of a full 
autopsy.  She was a member of a religious order that prohibited autopsies, 
but the doctors very much wanted to know what was replicating inside her.  
As the terminal shock and convulsions came over her, they inserted a 
needle into her upper abdomen and sucked out a quantity of liver.  Her 
liver had begun to liquefy, and the needle was large.  A fair amount of 
the nun's liver traveled up the needle and filled a biopsy syringe.  
Possibly it was during this agonal biopsy that her blood squirted on the 
walls.  The doctors also took some samples of blood from her arm and put 
it in glass tubes.  The nun's blood was precious beyond measure, since it 
contained the unknown hot agent.
	The blood was flown to a national laboratory in Belgium and to the 
England natural laboratory, the Microbiological Research Establishment at 
Porton Down, in Wiltshire.  Scientists at both labs began racing to 
identify the agent.  Meanwhile, at the Centers for Disease Control in 
Atlanta, Georgia-the C.D.C.-scientists were feeling left out, and were 
still scrambling to get their hands on a little bit of the nun's blood, 
making telephone calls to Africa and Europe, pleading for the samples.
	There is a branch of the C.D.C. that deals with unknown emerging 
viruses.  It's called the Special Pathogens Branch.  In 1976, at the time 
of the Zaire outbreak, the branch was being run by a doctor named Karl M. 
Johnson, a virus hunter whose home terrain had been the rain forests of 
Central and South America.  (He is not related to Gene Johnson, the 
civilian virus hunter, or to Lieutenant Colonel Tony Johnson, the 
pathologist.)  Karl Johnson and his C.D.C. colleagues had heard almost 
nothing about the occurrences upriver in Zaire-all they knew was that 
people in Zaire were dying of a "fever" that had "generalized symptoms"-no 
details had come in from the bush or from the hospital where the nun had 
just died.  Yet it sounded like a bad one.  Johnson telephoned a friend of 
his at the English lab, in Porton Down, and reportedly said to him, "If 
you've got any little dregs to spare of that nun's blood, we'd like to 
have a look at it."  The Englishman agreed to send it to him, and what he 
received was literally dregs.
	The nun's blood arrived at C.D.C. in glass tubes in a box lined 
with dry ice.  The tubes had cracked and broken during shipment, and raw, 
rotten blood had run around inside the box.  A C.D.C. virologist named 
Patricia Webb-who was then married to Johnson-opened the box.  She found 
that the package was sticky with blood.  The blood looked like tar.  It 
was black and gooey, like Turkish coffee.  She put on rubber gloves, but 
other than that, she did not take any special precautions in handling the 
blood.  Using some cotton balls, she managed to dab up some of the black 
stuff, and then by squeezing the cotton between her fingertips, she 
collected a few droplets of it, just enough to begin testing it for 
viruses.
	Patrica Webb put some of the black blood droplets into flasks of 
monkey cells, and pretty soon the cells got sick and began to die-they 
burst.  The unknown agent could infect monkey cells and pop them.
	Another C.D.C. doctor who worked on the unknown virus was 
Frederick A. Murphy, a virologist who had helped to identify Marburg 
virus.  He was and is one of the world's leading electron-microscope 
photographers of viruses.  (His photographs of viruses have been exhibited 
in art museums.)  Murphy wanted to take a close look at those dying cells 
to see if he could photograph a virus in them.  On October 13-the same day 
Nurse Mayinga was sitting in the waiting rooms of hospitals in Kinshasa-he 
placed a droplet of fluid from the cells on a small screen and let it dry, 
and he put it in his electron microscope to see what he could see.
	He couldn't believe his eyes.  The sample was jammed with virus 
particles.  The dried fluid was shot through with something that looked 
like string.  His breath stopped in his throat.  He thought, Marburg.  He 
believed he was looking at Marburg virus.
	Murphy stood up abruptly, feeling strange.  The lab where he had 
prepared these samples-that lab was hot.  The lab was as hot as hell.  He 
went out of the microscope room, closing the door behind him, and hurried 
down a hallway to the laboratory where he had worked with the material.  
He got a bottle of Clorox bleach and scrubbed the room from top to bottom, 
washing countertops and sinks, everything, with bleach.  He really scoured 
the place.  After he had finished, he found Patricia Webb and told her 
what he had seen in his microscope.  She telephoned her husband and said 
to him, "Karl, you'd better come quick to the lab.  Fred has looked at a 
specimen, and he's got worms."
	Staring at the worms, they tried to classify the shapes.  They saw 
snakes, pigtails, branchy, forked things that looked like the letter Y, 
and they noticed squiggles like a small g, and bends like the letter U, 
and loopy 6s.  They also noticed a classic shape, which they began calling 
the shepherd's crook.  Other Ebola experts have taken to calling this loop 
the eyebolt, after a bolt of the same name that can be found in a hardware 
store.  It could also be described as a Cheerio with a long tail.
	The next day, Patrica Webb ran some tests on the virus and found 
that it did not react to any of the tests for Marburg or any other known 
virus.  Therefore, it was an unknown agent, a new virus.  She and her 
colleagues had isolated the strain and shown that it was something new.  
They had earned the right to name the organism.  Karl Johnson named it 
Ebola.
	Karl Johnson has since left the C.D.C., and he now spends a great 
deal of his time fly-fishing for trout in Montana.  He does consulting 
work on various matters, including the design of pressurized hot zones.  I 
learned that he could be reached at a fax number in Big Sky, Montana, so I 
sent him a fax.  In it, I said that I was fascinated by Ebola virus.  My 
fax was received, but there was no reply.  So I waited a day and then sent 
him another fax.  It fell away into silence.  The man must have been too 
busy fishing to bother to answer.  After I had given up hope, my fax 
machine suddenly emitted this reply:

	Mr. Preston:
		Unless you include the feeling generated by gazing into
	the eyes of a waving confrontational cobra, "fascination" is
	not what I feel about Ebola.  How about shit scared?"

Two days after he and his colleagues isolated Ebola virus for the first 
time, Karl Johnson headed for Africa in the company of two other C.D.C. 
doctors, along with seventeen boxes of gear, to try to organize an effort 
to stop the virus in Zaire and Sudan (the outbreak in Sudan was still 
going on).  They flew first to Geneva, to make contact with the World 
Health Organization, where they found that the WHO knew very little about 
the outbreaks.  So the C.D.C. doctors organized their equipment and packed 
more boxes, getting ready to go to the Geneva airport, from where they 
would fly to Africa.  But then, at the last possible moment, one of C.D.C. 
doctors panicked.  It is said he was the doctor assigned to go to Sudan, 
and it is said he was afraid to proceed any farther.  It was not an 
unusual situation.  As Karl Johnson explained to me, "I've seen young 
physicians run from these hemorrhagic viruses, literally.  They're unable 
to work in the middle of an outbreak.  They refuse to get off the plane."
	Johnson, one of the discoverers of Ebola virus, preferred to talk 
about these events while fly-fishing.  ("We've got to keep our priorities 
straight," he explained to me.)  So I flew to Montana and spent a couple 
of days with him fishing for brown trout ont the Bighorn River.  It was 
October, the weather had turned clear and warm, and the cottonwood trees 
along the banks were yellow and rattled in a south wind.  Standing 
waist-deep in a mutable slick of the river, wearing sunglasses, with a 
cigarette hanging from the corner of his mouth and a fly rod in his hand, 
Johnson ripped his line off the water and laid a cast upstream.  He was a 
lean, bearded man, with a soft voice that one had to listen for in the 
wind.  He is a great figure in the history of virus hunting, having 
discovered and named some of the most dangerous life forms on the planet.  
"I'm so glad nature is not benign," he remarked.  He studied the water, 
took a step downstream, and placed anther cast.  "But on a day like today, 
we can pretend nature is benign.  All monsters and beasts have their 
benign moments."
	"What happened in Zaire?" I asked.
	"When we got to Kinshasa, the place was an absolute mad house," he 
said.  "There was no news coming out of Bumba, no radio contact.  We knew 
it was bad in there, and we knew we were dealing with something new.  We 
didn't know if the virus could be spread by droplets in the air, something 
like influenza.  If Ebola had spread easily through the air, the world 
would be a very different place today."
	"How so?"
	"There would be a lot fewer of us.  It would have been exceedingly 
difficult to confirm that virus if it had any major respiratory component. 
 I did figure that if Ebola was the Andromeda strain-incredibly lethal and 
spread by droplet infection-there wasn't going to be any safe place in the 
world anyway.  It was better to be working at the epicenter than to get 
the infection at the London opera."
	"Are you worried about a species-threatening event?"
	He stared at me, "What the hell do you mean by that?"
	"I mean a virus that wipes us out."
	"Well, I think it could happen.  Certainly it hasn't happened yet. 
 I'm not worried.  More likely it would be a virus that reduces us by 
ninety percent."
	"Nine out of ten human killed?  And you're not bothered."
	A look of mysterious amusement crossed his face.  "A virus can be 
useful to a species by thinning it out," he said.
	A scream cut the air.  It sound nonhuman.
	He took his eyes off the water and looked around.  "Hear that 
pheasant?  That's what I like about the Bighorn River," he said.
	"Do you find viruses beautiful?"
	"Oh, yeah," he said softly. "Isn't true that if you stare into the 
eyes of a cobra, the fear has another side to it?  The fear is lessened as 
you begin to see the essence of the beauty.  Looking at Ebola under an 
electron microscope is looking at a gorgeously wrought ice castle.  The 
thing is cold.  So totally pure."
	Karl Johnson became the chief of an international WHO team that 
gathered in Kinshasa.

THE OTHER C.D.C. doctor, Joel Breman, who had flown with Johnson to Zaire, 
became a member of a field exploration team that boarded an aircraft bound 
for the interior to see what was going on in Bumba.  The airplane was a 
C-130 Buffalo troop-transport, an American-made military aircraft that 
belonged to the Zairmen Air Force.  It happened to be President Mobutu's 
private plane, equipped with leopard-skin seats, folding beds, and a wet 
bar, a sort of flying presidential palace that ordinarily took the 
president and his family on vacations to Switzerland, but now it carried 
the WHO team into the hot zone, following the Congo River north by east.  
They sat on the leopard-skin seats and stared out the windows at endless 
tracts of rain forest and brown river, a featureless blanket broken by the 
occasional gleam of an oxbow lake or a cluster of round huts strung like 
beads on a barely visible road or footpath.  As he leaned against the 
window and watched the terrain unfold into the heart of Africa, Breman 
became terrified of coming to earth.  It was safe in the air, high above 
the immeasurable forest, but down there ... It began to dawn on him that 
he was going to Burmba to die.  He had recently been assigned to Michigan 
as a state epidemiologist, and suddenly he had been called to Africa.  He 
ha left his wife back home in Michagan with their two children, and he 
began to suspect that he would never see them again.  He had brought an 
overnight bag with a toothbrush, and he had managed to pack a few paper 
surgical masks and some gowns and rubber gloves into the bag.  He did not 
have proper equipment for handling a hot agent.  The Buffalo descended, 
and the town of Bumba appeared, a rotting tropical port spread out along 
the Congo River.
	The Buffalo landed at an airstrip outside the town.  The plane's 
Zairmen crew was terrified, afraid to breathe the air, and they left the 
propellers idling while they showed the doctors down the gangway and 
heaved their bags out after them.  The doctors found themselves standing 
in the backwash of the Buffalo as it accelerated to take off.
	In the town, they met with the governor of Bumba Zone.  He was a 
local politician, quite distraught.  He had found himself in deep waters, 
in over his head.  "We are in a bad way," he told the doctors. "We have 
not been able to get salt or sugar."  His voice trembled on the edge of 
weeping as he added, "We have not even been able to get beer."
	A Belgian doctor on the team knew how to handle this situation.  
With a dramatic flourish, he placed a black airline pilot's bag on the 
table.  Then he turned the bag upside down, and wads of currency slapped 
out, making an impressive heap.  "Governor, perhaps this will make things 
a little better."    he said.
	"What are you doing?" Breman said to the Belgian.
	The Belgian shrugged.  "Look, this is the way things are done 
here."
	The governor scooped up the money and pledged his full cooperation 
together with all the extensive resources of government at his 
disposal-and he loaned them two Land Rovers.
	They pushed north toward the Ebola River.
	It was the rainy season, and the "road" was a string of mudholes 
cut by running streams.  Engines howling, wheels spinning, they proceeded 
through the forest at the pace of a wall, in continual rain and oppressive 
heat.  Occasionally they came to villages, and at each village they 
encountered a roadblock of fallen trees.  Having had centuries of 
experience with the smallpox virus, the village elders had instituted 
their own methods for controlling the virus, according to their received 
wisdom, which was to cut their villages off from the world, to protect 
their people from a raging plague.  It was reverse quarantine, an ancient 
practice in Africa, where a village bars itself from strangers during a 
time of disease, and drives away outside who appear.
	"Who are you?  What are you doing?" they shouted to the Land 
Rovers from behind a barrier of trees.
	"We are doctors!  We are coming to help!"
	Eventually the people would clear away the trees, and the team 
would proceed deeper into the forest.  In a long and desperate day of 
travel, they penetrated fifty miles away from the Congo River, and 
finally, toward evening, they came to a row of round, hatched African 
houses.  Beyond the houses stood a white church in the middle of the 
forest.  Around the church, there were two soccer fields, and in the 
middle of one field they noticed a heap of burned mattresses.  Two hundred 
yards farther on, they came to the Yambuku Mission Hospital, a complex of 
low, whitewashed buildings made of concrete, with corrugated tin roofs.
	The place was as silent as a tomb and appeared to be deserted.  
The beds were iron or wooden frames without mattresses-the blood-soaked 
mattresses had been burned in the soccer field-and the floors were clean, 
spotless, rinsed.  The team discovered three surviving nuns and one 
priest, along with a few devoted African nurses.  They had cleaned up the 
mess after the virus had wiped out everyone else, and now they were busy 
fogging the rooms with insecticide, in the hope that it might somehow 
disperse the virus.  One room in the hospital had not been cleaned up.  No 
one, not even the nuns, had the courage to enter the obstetric ward.  When 
Joel Breman and the team went in, they found basins of foul water standing 
among discarded, bloodstained syringes.  The room had been abandoned in 
the middle of childbirths, were dying mothers had aborted fetuses infected 
with Ebola.  The team had discovered the red chamber of virus queen at the 
end of the earth, where the life form had amplified through mothers and 
their unborn children.
	The rains continued all day and night.  Around the hospital and 
the church stood the beautiful ferocious trees, a complex of camphors and 
teaks.  Their crowns entwined and crisscrossed and whispered with rain, 
and bowed and shifted as troops of monkeys passed through them like 
currents of wind, leaping from crown to crown, crying their untranslatable 
cries.  The next day, the doctors set out deeper into the forest in their 
Land Rovers, and they made contact with infected villages, where they 
found people dying in huts.  Some of the victims had been put into 
isolation huts on the edge of the village-an old African technique for 
dealing with smallpox.  Some of the huts where people had died had been 
burned down.  Already the virus seemed to be petering out, and most of the 
people who were going to die were already dead, the virus having echoed so 
swiftly through Bumba.  A wave of emotion roled over Joel Breman as he 
realized, with the clarity of a doctor who suddenly sees into the heart of 
things, that the victims had received the infection from the hospital.  
The virus had taken root with the nuns and had done its work among those 
who had sought help from them.  In one village, he examined a man dying of 
Ebola.  The man sat in a chair, holding his stomach and leaning forward 
with pain, and blood streamed around his teeth.
	They tried to reach Kinshasa by radio, to tell Karl Johnson and 
the others that the epidemic had already peaked.  A week later, they were 
still trying to make radio contact, but they could not get through.  They 
traveled back to the town of Bumba and waited by the river.  One day an 
airplane droned overhead.  It circled the town once and touched down, and 
they ran for it.

AT THE NGALIEMA HOSPITAL in Kinshasa, Nurse Mayinga had been put into a 
private room, which was accessible through a kind of empty room, a gray 
zone, where the nurses and staff were supposed to put on bioprotective 
gear before they entered.  Mayinga was cared by a South African doctor 
named Margaretha Isaacson, who at first wore a military gas mask, but it 
became increasily uncomfortable in the tropical heat.  She thought to 
herself, I can't bear it.  I'll be surprised if I come out of this alive 
anyway.  That made her think about her own children.  She thought, My 
children are grown up, they are no great responsibility.  And she removed 
her mask and treated the dying girl face-to face.
	Dr. Isaacson did everything she could to save Mayinga, but she was 
as helpless before the agent as medieval doctors had been in the face of 
the black plague. ("This was not like AIDS," she would later recall. "AIDS 
is a child's play compared with this.")  She gave Nurse Mayinga ice cubes 
to suck on, which helped to ease the pain in her throat, and she gave her 
Valium to try to stave off her apprehension of what lay ahead.
	"I know I am dying," Mayinga said to her.
	"That's nonsense.  You ar not going to die." Dr. Isaacson replied.
	When Mayinga's bleeding began, it came from her mouth and nose.  
It never came in a rush, but the blood dripped and ran and would not stop 
and would not clot.  It was a hemorrhagic nose bleed, the kind that does 
not stop until the heart stops beating.  Eventually Dr. Isaacson gave her 
three transfusions of whole blood to replace what she lost in nosebleeds.  
Mayinga remained conscious and despondent until the end.  In the final 
stage, her heart developed a galloping beat.  Ebola had entered her heart. 
 Mayinga could feel her heart going blubbery inside her chest, and it 
frightened her unspeakably.  That night, she died of a heart attack.
	Her room was contaminated with blood, and there was also the 
question of the two nuns' rooms, both of which were still locked and 
bloodstrained.  R. Isaacson said to the staff, "I won't be of much use to 
you now," and she got a bucket and mop and wash the rooms.
	Medical teams fanned out into Kinshasa and managed to locate 
thirty-seven people who had face-to-face contact with Mayinga during the 
time when she had wandered around the city.  They set up two 
biocontainment pavilions at the hospital and shut the people up for a 
couple of weeks.  They wrapped like cadavers of the nuns an Nurse Mayinga 
in sheets soaked in chemicals, then double-bagged the mummies in plastic 
and put each one in an airtight coffin which a screw-down lid, and held 
the funeral services at the hospital, under the watch of doctors.
	Karl Johnson, having heard nothing from the team of doctors 
upriver in Bumba, wondered if they were dead, and assumed that the virus 
was about to go on a burn through the city.  He organized a floating 
hospital ship and had it moored in the Congo River.  It was an isolation 
ship for doctors.  The city would be the hot zone, and the floating ship 
would be the gray area, the place of refuge for the doctors.  
Approximately a thousand Americans were living in Zaire at the time.  In 
the United States, the Amy's Eighty-second Airborne Division went on alert 
and prepared to evacuate the Americans by air as soon as the first Ebola 
cases started popping up in the city.  But to the strange and wonderful 
relief of Zaire and the world, the virus never went on a burn through the 
city.  It subsides on the headwaters of the Ebola River and went back to 
its hiding place in the forest.  The Ebola agent seemed not to be 
contagious in face-to-face contacts.  It did not seem to be able to travel 
through the air.  No one caught the virus from Nurse Mayinga, even though 
she had been in close contact with at least thirty-seven people.  She had 
shared a bottle soda pop with someone, and not even that person became 
ill.  The crisis passed.

CARDINAL

1987 SEPTEMBER
	
AS WITH EBOLA, the secret hiding place of the Marburg agent was unknown.  
After erupting in Charles Monet and Dr. Shem Musoke, Marburg dropped out 
of sight, and no one could say where it had gone. It seemed to vanish off 
the face of the earth, but viruses never go away, they only hide, and 
Marburg continued to cycle in some reservoir of animals or insects in 
Africa.
	On the second of day of September 1987, around suppertime, Eugene 
Johnson, the civilian biohazard expert attached to USAMRIID, stood in a 
passenger-arrival area outside the customs gates at Dulles International 
Airport, near Washington.  He was waiting for a KLM flight from Amsterdam, 
which carried a passenger who had come from Kenya.  A man with a duffle 
bag passed through customs, and he and Johnson nodded to each other.  
("I'm going to leave this person's name out of it.  Let's just say he was 
someone I knew, someone I trust."  Johnson explained to me).  The man laid 
down the duffle bag at Johnson's feet, unzipped it, and pulled out a wad 
of bath towels wrapped around something.  Pulling off the towels, he 
revealed an unmarked cardboard box wound with tape.  He handed the box to 
Johnson.  They had little to say to each other.  Johnson carried the box 
out of the terminal building, put it in the trunk of his car, and drove to 
the Institute.  The box held blood serum from a ten-year-old Danish boy 
who will be called Peter Cardinal.  He had died a day or so earlier at 
Nairobi Hospital with a combination of extreme symptoms that suggested an 
unidentified Level 4 virus.
	As he drove to the Institute, Johnson wondered just what he was 
going to do with the box.  He was inclined to sterilize its contents in an 
oven and then incinerate it.  Just cook it and burn it, and forget it.  
Most of the samples that came into the Institute-and samples of blood and 
tissue arrived constantly from all parts of the world-contained nothing 
unusual, no interesting viruses.  In other words, most of the samples were 
false alarms.  Johnson wasn't sure he wanted to take the time to analyze 
this boy's blood serum, if, in all probability, nothing would be found in 
it.  By the time he pulled into the gates of Fork Detrick, he had decided 
to go ahead.  He knew the work would keep him up most of the night, but it 
had to be done immediately, before the blood serum deriorated.
	Johnson put on a surgical scrub suit and rubber gloves, and 
carried the box into the Level 3 staging area of the Ebola suite, where he 
opened the box, revealing a mass of foam peanuts.  Out of the peanuts he 
fished a metal cylinder sealed with tape and marked with a biohazard 
symbol.  Along the wall of the staging area was a row of stainless-steel 
cabinets with rubber gloves protruding into them.  They were Biosafety 
Level 4 cabinets.  They could be sealed off from the outside world while 
you handled a hot agent inside them with the rubber gloves.  These 
cabinets were similar in design to the safety cabinets that are used to 
handling nuclear-bomb parts.  Here the cabinets were designed to keep 
human beings from coming into direct contact with Nature.  Johnson 
unscrewed some wingnuts and opened a door in the cabinets, and placed the 
metal cylinder inside.  He closed and tightened the door.
	Next, he put his hands into the gloves, picked up the cylinder 
and, looking through a window to see what he was doing, peeled the tape 
off the cylinder.  The tape stuck to his rubber gloves, and he couldn't 
get it off.  Damn! he swore to himself.  It was now eight o'clock at 
night, and he would never get home.  Finally he got the cylinder open.  
Inside it was a wad of paper towel soaked in bleach.  He pulled apart the 
wad and found a Ziploc bag.  It contained a couple of plastic tubes with 
screw tops.  He unscrewed them and shook out two very small plastic vials 
containing golden liquid: Peter Cardinal's blood serum.
	The boy's mother and father worked for a Danish relief 
organization Kenya, and lived in a house in the town of Kisumu, on Lake 
Victoria.  Peter had been a student at a boarding school in Denmark.  That 
August, a few weeks before he died, he had gone to Africa to visit his 
parents and his older sister.  She was a student at a private school in 
Nairobi.  She and Peter were very close, and while Peter was visiting his 
family in Kenya, the two young people spent most of their time 
together-brother and sister, best friends.
	The Cardinal family went on vacation after Peter's arrival, and 
traveled by car through Kenya-his mother and father wanted to show him the 
beauty and sweetness of Africa.  They were visiting Mombasa, staying in a 
hotel by the sea, when Peter developed red eyes.  His parents took him to 
the hospital, where the doctors examined him an concluded that he had come 
down with malaria.  His mother did not believe it was malaria.  She began 
to perceive that her song was dying, and she became frantic.  She insisted 
that he be taken to Nairobi for treatment.  The Flying Doctors, an 
air-ambulance service, picked him up, and he was rushed to Nairbori 
Hospital, where he came under care of Dr. David Silverstein, who had also 
taken care of Dr. Musoke after Charles Monet had spewed the black vomit 
into Musoke's eyes.

"PETER CARDINAL WAS a blond-haired, blue-eyed guy, a tall, thin guy, a 
fit-looking ten-year-old," Dr. Silverstein recalled as we drank coffee and 
tea at a table in the shopping mall near his house outside Washington.  A 
small girl sitting burst into wails, and her mother hushed her.  Crowds of 
shoppers passed by our table.  I kept my eyes on Dr. Silverstein's 
face-steel-rimmed glasses, mustache, eyes that gazed into space-as he 
recalled the unusual death he had seen, which he spoke of a matter-of-face 
way. "When Peter came to me, he was febrile, but he was very with it, very 
alert and communicative.  We gave him an X-ray.  His lungs were fluffy."  
A kind of watery mucus had begun to collect in the boy's longs, which 
caused him difficulty in breathing.  "It was a typical ARDS picture-acute 
respiratory distress syndrome-like early pneumonia," Dr. Silverstein said. 
 "Shortly afterward, he started turning bluish on it.  He had blue in his 
fingertips.  Also, he had little red spots.  I had everybody glove up 
before they handled him.  We suspected he had Marburg, but we didn't have 
the paranoia we had with Dr. Musoke.  We just took precautions.  In 
twenty-four hours, he was on a respirator.  We noted that he bled easily 
from puncture sites, and he had deranged liver functions.  The small red 
spots became large, spontaneous bruises.  He turned black-and-blue.  Then 
his pupils dilated up on us.  That was a sign of brain death.  He was 
bleeding around the brain."
	He swelled up, and his filled with pockets of blood.  In some 
places, the skin almost separated from the underlying tissue.  This 
happened during the last phase, while he was on a respirator.  It is 
called third spacing.  If you bleed into the first space, you bleed into 
you lungs.  If you bleed into the second space, you bleed into your 
stomach and intestines.  If you bleed into the third space, you bleed into 
the space between the skin and the flesh.  The skin puffs up and separates 
from the flesh like a bag.  Peter Cardinal had bled out under his skin.

THE MORE ONE contemplates the hot viruses, the less they look like 
parasites and the more they begin to look like predators.  It is a 
characteristic of a predator to become invisible to its prey during the 
quiet and sometimes lengthy stalk that precedes an explosive attack.  The 
savanna grass ripples on the plains, and the only sound in the air is the 
sound of African doves calling from acacia trees, a pulse that goes on 
through the heat of the day and never slows and never ends.  In the 
distance, in the flickering heat, in the immense distance, a herd of 
zebras gaze.  Suddenly from the grass comes a streak of movement, and a 
lion is among them and hangs on a zebra's throat.  The zebra gives out a 
barking cry, choked off, and the two interlocked beings, the predator and 
the prey, spin around in a dance, until you lose sight of the action in a 
billow of dust, and the next day the bones have a surface of flies.  Some 
of the predators that feed on humans have lived on the earth for a long 
time, far longer than the human race, and their origins go back, it seems, 
almost to the formation of the planet.  When a human being is fed upon and 
consumed by one of them, especially in Africa, the event is telescoped 
against horizons of space and time, and takes on a feeling of immense 
antiquity.
	Peter Cardinal's parents and sister were stunned as they watched 
him being slowing torn apart by an invisible predator.  They could not 
comprehend his suffering or reach him to give him comfort.  As the blood 
poured into his third space, his eyes remained open and dilated, staring, 
bloody, deep, dark, and bottomless.  They didn't know if he could see 
them, and they couldn't tell what he saw or thought or felt behind the 
open eyes.  The machines hooked up to his scalp were showing flatlines in 
his brain.  There was little electrical activity in his brain, but now and 
then the flatlines gave a spooky twitch, as if something continued to 
struggle inside the boy, some destroyed fragment of his soul.
	They had to make a decision about whether to turn off the 
respirator.  Dr. Silverstein said to them, "We're much better off not 
letting him survive, because of brain death."
	"If they had only brought him in sooner from Mombasa," the mother 
said.
	"I'm sorry, but that would not have helped.  There was nothing 
that anyone could have done," Silverstein replied to her. "He was doomed 
from the beginning."

WORKING WITH HIS hands in the rubber gloves protruding into the cabinets, 
Gene Johnson took a little bit of the boy's blood serum and dropped it 
into flasks that contained living cells from a monkey.  If anything lived 
in Peter Cardinal's blood, it might begin to replicate in the monkey 
cells.  Then Johnson went home to get some sleep.  The procedure had taken 
him until three o'clock in the morning to finish.
	In the following days, Johnson watched the flasks to see if there 
were any changes in the monkey cells.  He saw that they were bursting and 
dying.  They were infected with something.  The Cardinal strain was 
definitely a hot agent-it killed the cells in vast numbers, and it killed 
them fast.
	Now for the next stage of the virus isolation.  He drew off a 
little bit of fluid from the flasks and injected it into three rhesus 
monkeys, to infect them with the Cardinal agent.  Two of the monkeys died 
and the third animal went into borderline shock, but somehow pulled 
through and survived.  So the Cardinal agent was viciously hot, a fast 
replicator, and it could kill monkeys.  "I knew god-damned well we had 
Marburg," Johnson would later say to me.
	He took some of the Cardinal strain and injected it into guinea 
pigs to see if it would infect them.  It killed them like flies.  Not only 
that, the testicles of the males swelled up to the size of golf balls and 
turned purple.  The Cardinal strain was a sophisticated organism that knew 
what they wanted.  It could multiply in many different kinds of meat.  It 
was an invasive life form, devastating and promiscuous.  It showed a kind 
of obscenity you see only in nature, an obscenity so extreme that it 
dissolves imperceptibly into beauty.  It made a living somewhere in 
Africa.  What made it particularly interesting was that it multiplied 
easily in various species, in monkeys, humans, guinea pigs.  It was 
extremely lethal in these species, which meant that its original host was 
probably not monkeys, humans or guinea pigs but some other animal or 
insect that it did not kill.  A virus does not generally kill its natural 
host.  The Marburg virus was a traveler: it could jump species; it could 
break through the lines that separate one species from another, and when 
it jumped into another species, it could devastate the species.  It did 
not know boundaries.  It did not know what humans are; or perhaps you 
could say that it knew only too well what humans are: it knew that humans 
are meat.
	As soon as he isolated the Cardinal strain and confirmed that it 
was Marburg, Johnson turned his attention to the question of where and how 
Peter Cardinal night have become infected.  Where had that kid been?  What 
had he been doing to get himself infected?  Exactly where had he traveled? 
 These questions haunted Johnson.  He had been trying to find the secret 
reservoirs of the thread viruses for years.
	He telephoned a friend and colleague in Kenya named Dr. Peter 
Turkei, who was a scientist at the Kenya Medical Research Institute in 
Nairobi.  "We know this is Marburg," Gene said to him.  "Can you get a 
history of the kid?  Find out where he was and what he did?"
	Dr. Tukei said he would locate the parents and interview them.  
	A week late, Gene's telephone rang.  It was Dr. Tukei on the line. 
 "You know where that kid was?" he said.  "He was in Kitum Cave on Mount 
Elgon."
	Gene felt a prickling sensation on his scalp.  The paths of 
Charles Monet and Peter Cardinal had crossed at only one place on earth, 
and that was inside Kitum Cave.  What had they done in the cave?  What had 
they found in there?  What had they touched?  What had they breathed?  
What lived in Kitum Cave?

GOING DEEP

EUGENE JOHNSON SAT at a picnic table at Fort Detrick near a duck pond, 
leaning forward and gazing at me.  It was hot day in the middle of summer. 
 He was wearing sunglasses.  He placed his large elbows on the table, took 
off his sunglasses, and rubbed his eyes.  He was six foot two, maybe two 
hundred and fifty pounds.  His eyes were brown and set deep in his bearded 
face, and there were dark circles under the lower lids.  He looked tired.
	"So Peter Tukei got on the phone to tell me that the boy had 
visited Kitum Cave," Johnson said. "I still get chills when I think about 
it.  A few weeks later, I flew to Nairobi, and I talked with David 
Silverstein, the kid's doctor.  Peter Tukei was with me.  Then we went 
everyplace in Kenya the kid went, even to his house.  His parents had a 
nice house in Kisumu, near Lake Victoria.  It was a stucco house with a 
wall around it, and there was a cook and groundskeepers and a driver.  The 
house was clean and neat, open and whitewashed.  We saw that there was a 
rock hyrax living on the roof.  It was a pet, and it lived in the gutters. 
 There were a couple of storks, and there were rabbits and goats and all 
kinds of birds.  I didn't see any bats around this house."
	He paused, thinking.  No one else was around.  A few ducks swam in 
the pond. "I was really nervous about talking with the parents," he said.  
"See, I am a field person.  My wife and I don't have children.  I'm not 
the kind of a guy who can console a mother, plus I work in the U.S. 
military.  I had no idea how to talk to them.  I tried to put myself in 
their place, and I remembered how I felt when my father died.  I let them 
talk about their son, Peter Cardinal and his sister had been inseparable 
from the moment he arrived in Kenya.  The kids had spent the whole time 
together, doing everything together.  So what was the difference in 
behavior?  Why did Peter Cardinal get the virus but not his sister?  There 
was one difference in their behavior.  The parents told me a story about 
the rocks in the cave.  They told me their kid was an amateur geologist.  
There was this issue: did he cut his hand on any crystals in the cave?  We 
went over that possibility with the parents, Peter had said to them that 
he wanted to collect some of the crystals in Kitum Cave.  So he beat on 
the walls of the cave with a hammer and collected some rocks with crystals 
in them.  The rocks were broken up by the driver and washed by the cook.  
We tested their blood, and they were not positive for Marburg."
	It seems possible that the point of contact had been the boy's 
hands, that the virus had entered Cardinal's bloodstream through a tiny 
cut.  Possibly he had pricked his finger on a crystal that had been 
contaminated with urine from some animal or the remains of a crushed 
insect.  But even if he had pricked his finger on a crystal, that didn't 
tell where the virus lived in nature; it didn't identify the virus's 
natural host.
	"We went to look at the cave," he said. "We had to protect 
ourselves when we went inside.  We knew that Marburg is transmitted by the 
aerosol route."
	In 1986-the year before Peter Cardinal died-Gene Johnson had done 
an experiment that showed that Marburg and Ebola can indeed travel through 
the air.  He infected monkeys with Marburg and Ebola by letting them 
breathe it into their lungs, and he discovered that a very small dose of 
airborne Marburg or Ebola could start an explosive infection in a monkey.  
Therefore, Johnson wanted the members of expedition to wear breathing 
apparatus inside the cave.
	"I brought with me these military gas masks with filters.  We 
needed some kind of covering to put over our heads, too, or we'd get bat 
shit in our hair.  We bought pillowcases at a local store.  They were 
white, with big flowers.  So the first time we went into the cave, it was 
a bunch of Kenyans and me wearing these military gas masks and these 
flowered pillowcases on our heads, and the Kenyans are just cracking up."
	They explored the cave and made a map of it.  After this scouting 
trip, Gene Johnson persuaded the Army to sponsor a major expedition to 
Kitum Cave.  Half a year after Peter Cardinal died, in the spring of 1988, 
Gene showed up in Nairobi with twenty shipping crates full of biohazard 
gear and scientific equipment.  It included several military body bags, 
for holding human cadavers, and the members of his team had a serious 
discussion among themselves about how to handle their own remains if one 
of them died of Marburg.  This time, Gene felt that he was closing in on 
the virus.  He knew it would be hard to find even if it lived inside Kitum 
Cave, but he felt he was getting too close to fail in his quest.  The 
monster lived in a cave, and he was going in there to find it.
	The Kenyan government agreed to close Kitum Cave to tourists while 
the joint Kenya-U.S. expedition searched it for viruses.  The head of the 
expedition was Dr. Peter Tukei of Kenya Medical Research Institute.  Gene 
Johnson conceived the idea and gathered the equipment and found the money 
to pay for t.  There were thirty-five team members, and most of them were 
Kenyans, including wildlife naturalists, scientists, doctors, and 
laborers.  They brought along a large number of guinea pigs, traveling in 
boxes, and seventeen monkeys in cages, including baboons, Sykes' monkeys, 
and African green monkeys.  The monkeys and guinea pigs were sentinel 
animals, like canaries in a coal mine: they would be placed in cages 
inside and near Kitum Cave in the hope that some of them would break with 
Marburg virus.  There are no instruments that can detect a virus.  The 
best way to find a virus in the wild, at the present time, is to place a 
sentinel animal at the suspected location of the virus and hope the animal 
gets sick.  Johnson figured that if any of his monkeys or guinea pigs 
crashed, he would be able to isolate the virus from the sick animals and 
would perhaps be able to discover how the animals had caught it.

1988 SPRING

THE KUTUM CAVE expedition set up headquarters in the Mount Elgon Lodge, a 
decayed resort dating from the nineteen twenties, when the English had 
ruled East Africa.  The lodge had been built for sporting people and trout 
fishermen.  It sat on a promontory overlooking the red-dirt road that 
wound up the mountain to Kitum Cave.  It had once been surrounded by 
English gardens, which had partly collapsed into clay and African weeds.  
Indoors there were hardwood floors, waxed daily to perfect gleam.  The 
lodge had turrets with round rooms and medieval doors, hand-carved from 
African olive wood, and the living room boasted an immense fireplace with 
a carved mantelpiece.  The staff spoke very little English, but they were 
intent on maintaining English hospitality for the rare guest who might 
happen to show up.  The Mount Elgon Lodge was a monument to the incomplete 
failure of the British Empire, which carried on automatically, like an 
uncontrollable tic, in the provincial backwaters of Africa long after it 
had died at the core.  In the evenings, as the frost-tinged night came on, 
the staff built fires of Elgon olive logs in the fireplaces, and the food 
in the dining room was horrible, in the best English tradition.  There 
was, however, a splendid bar.  It was a quaint hideaway in a round 
chamber, stocked with shining rows of Tusker-beer bottles and French 
aperitifs and obscure African brandies.  The men could sit at the bar and 
drink Tuskers or lean on the great mantel by the fire and tell stories 
after a hard day in the cave wearing a space suit.  A sign on the wall by 
the concierge's desk mentioned the delicate matter of money.  It announced 
that since Mount Elgon Lodge's suppliers had cut off all credit to the 
lodge, the lodge was unfortunately unable to extend any credit to its 
guests.
	They moved the animals up the mountain in stages, to let them get 
used to the climate.  When they got to the valley that leads to the cave, 
they cleared away some underbrush and put up blue tarpaulins.  The cave 
itself was considered to be a Level 4 hot zone.  The tarp closest to the 
cave covered a gray area, a place where the worlds met.  The men took 
chemical showers under the gray-area tarp, to decon their space suits 
after a visit to the cave.  Another tarp covered a Level 3 staging area, 
where the men changed in and out of their space suits.  Another tarp 
covered a Level 4 necropsy area.  Under that tarp, wearing space suits, 
they dissected any small animals that they had trapped, looking for signs 
of Marburg virus.
	"We were going where no one had gone before," Johnson said to me. 
"We brought the Biosafety Level 4 philosophy to the jungle."
	They wore orange Racal space suits inside the cave.  A Racal suit 
is a portable, positive-pressure space suit with a battery-powered air 
supply.  It is for use in fieldwork with extreme biohazards that are 
believed to be airborne.  A Racal suit is also known as an orange suit 
because it is bright orange.  It is lighter than a Chemturion, and unlike 
a Chemturion, it is fully portable, with a self-contained breathing 
apparatus.  The main body of the suit (apart from helmet and the blowers) 
is disposable, so that you can burn it after using it once or twice.
	Wearing their Racal space units, they laid out a trail that wound 
into Kitum Cave, marking the trail with avalanche poles so that people 
would not get lost.  Along the trail, they placed cages holding the 
monkeys and guinea pigs.  They surrounded the cages with electrified wire, 
powered by a battery, to discourage leopards from trying to eat the 
monkeys.  They placed some of the monkeys directly underneath bat colonies 
in the roof of the cave, hoping that something would drop on a monkey that 
would cause the animal to break with Marburg.
	They collected somewhere between thirty thousand and seventy 
thousand biting insects inside the cave-the cave is full of bugs.  "We put 
stickum paper over cracks in the cave, to catch crawling bugs," Johnson 
said to me. "We hung light traps inside the cave to collect flying 
insects.  The light traps were battery powered.  You know how to collect 
ticks?  They come out of the ground when they smell carbon dioxide from 
your breath.  They smell it and come up and bite your ass.  So we brought 
these huge tanks of carbon dioxide, and we used it to attract ticks.  We 
trapped all the rodents that went into the cave.  We used Havahart traps.  
Way at the back of the cave, by a pool of water, we found sand flies.  
These are biting flies.  We saw leopard tracks all over the place, and 
Cape-buffalo tracks.  We didn't take any food samples from large animals, 
nothing from leopards or buffalo.  Nothing from the antelopes."
	"Could Marburg live in large African cats?" I asked. "Could it be 
a leopard virus?"
	"Maybe.  We just didn't have permits to trap leopards.  We did 
collect genet cats, and it wasn't there."
	"Could it live in elephants?"
	"Did you ever try to draw blood from a wild elephant?  We didn't."
	The Kenyan naturalists trapped and netted hundreds of birds, 
rodents, hyaxes, and bats.  In the hot necropsy zone, under the tarp, they 
sacrificed the animals and dissected them while wearing Racal suits, 
taking samples of blood and tissue, which they froze in jars of liquid 
nitrogen.  Some local people-they were Elgon Masai-had lived inside some 
of the caves on Mount Elgon and had kept their cattle in the caves.  The 
Kenyan doctors drew blood from their cattle.  None of the local people or 
the cattle tested positive for Marburg antibodies-if they had tested 
positive, it would have shown that they had been exposed to Marburg.  
Despite the fact that nobody showed signs of having been infected, the 
Elgon Masai could tell stories of how a family member, a child or a young 
wife, had died bleeding in someone's arms.  They had seen family members 
crash and bleed out, but whether their illnesses were caused by Marburg or 
some other virus-who could tell?  Perhaps the local Masa people knew the 
Marburg agent in their own way.  If so, they had never given it a name.
	None of the sentinel monkeys became sick.  They remained healthy 
and bored, having sat in their cages in the cave for weeks.  The 
experiment required that they be sacrificed at the end of the time so that 
the researchers could take tissue samples and observe their bodies for any 
signs of infection.  At this point, the hard part of primate research 
began to torment Gene Johnson.  He could not being himself to euthanize 
the monkeys.  He couldn't stand the idea of killing them and couldn't go 
into the cave to finish the job.  He waited outside in the forest while 
another member of the team put on a space suit and went inside and gave 
the monkeys massive shots of sedative, which put them to sleep forever.  
"I don't like killing animals," he said to me. "That was a major issue for 
me.  After you've fed 'em bananas.  That was terrible.  It sucked."  He 
put on his orange Racal space suit and opened up the monkeys under 
necropsy tent, feeling frustrated and sad, especially when all the monkeys 
turned out to be healthy.
	The expedition was a dry hole.  All the sentinel animals remained 
healthy, and the blood and tissue samples from the other animals, insects, 
birds, Masai people, and their cattle showed no sign of Marburg virus.  It 
must have been a bitter disappointment for Gene Johnson, so disheartening 
that he was never able to bring himself to publish an account of the 
expedition and its findings.  There seemed to be no point in publishing 
the fact that he hadn't found anything in Kitum Cave.  All that he could 
say for sure is that Marburg lives in the shadow of Mount Elgon.
	What Johnson did not know at the time, but what he sensed almost 
instinctively after the failure of the Kitum Cave expedition, was that the 
knowledge and experience he gained inside a cover in Africa, and the space 
suits and biohazard gear he carried back with him to the Institute, might 
serve him well at another time and in another place.  He kept his African 
gear hidden away at the Institute, piled in olive-drab military trunks in 
storage rooms and in tractor trailers parked behind buildings and 
padlocked, because he did not want anyone else to touch his gear or use it 
or take it away from him.  He wanted to be ready to load it on an airplane 
at a moment's notice, in case Marburg or Ebola came to the surface again 
in Africa.  And sometimes he thought of a favorite saying, a remark by 
Louis Pasteur, "Chance favors the prepared mind."  Pasteur developed 
vaccines for anthrax and rabies.

1989 SUMMER

THE ARMY HAD always had a hard time figuring out what to do with Nancy and 
Jerry Jaax.  They were married officers at the same rank in a small corps, 
the veterinary Corps.  What do you do with a married pair of doggy doctors 
who need to be promoted?  What if one of them (the wife) is trained in the 
use of space suits?  Where do you send them?  The Army assigned the Jaaxes 
to the Institute of Chemical Defense, near Aberdeen, Maryland.  They sold 
their Victorian house and moved, bring their birds and animals with them.  
Nancy was not sorry to leave the house in Thurmont.  They moved into a 
tract house, which was more to her liking, and there they began to raise 
fish in tanks, as a hobby, and Nancy went to work in an Army program to 
study the effects of nerve gas on rat brains.  Her job was to open up the 
rat's head and figure out what the nerve gas has done to the brain.  This 
was safer and more pleasant than working with Ebola, but it was a little 
dull.  Eventually she and Jerry both received promotions to lieutenant 
colonel and wore silver oak leaves on their shoulders.  Jaime and Jason 
were growing up.  Jaime became a superb gymnast, short and wiry like 
Nancy, and Nancy and Jerry had hopes for her in the nationals, if not the 
Olympics.  Jason grew into a tall, quiet kid.  Herky, their parrot, did 
not change.  Parrots live for many years.  He went on shouting "Mom! Mom!" 
and whistling the march from The Bridge on The River Kwai.
	Colonel Tony Johnson, Nancy's commanding officer when she had 
worked at USAMRIID, remembered her competence in a space suit and wanted 
to get her back.  He felt she belonged at the Institute.  He was 
eventually appointed head of pathology at Walter Reed Army Medical Center, 
and when that happened, his old job came open, the job of chief of 
pathology at the Institute.  He urged the Army to appoint Nancy Jaax to 
the position, and the Army listened.  They agreed that she ought to be 
doing hot biological work, and she got the job in the summer of 1989.  At 
the same time, the Army appointed Jerry Jaax head of the veterinary 
division at the Institute.  So the Jaax became important and rather 
powerful figures.  Nancy went back to biological work in space suits.  
Jerry still didn't like it, but he had learned to live with it.
	With these promotions, the Jaax sold their house in Aberdeen and 
moved back to Thurmont, in August 1989.  This time, Nancy told Jerry it 
was not going to be a Victorian.  They bought a contemporary Cape house 
with dormer windows, with a lot of land around it, meadow and forest, 
where the dogs could run and the children could play.  Their house stood 
on the lower slope of Catoctin Mountain, overlooking the town, above a sea 
of apple orchards.  From their kitchen window, they could look into the 
distance over rolling farmland where armies had marched during the Civil 
War.  Central Maryland stretched away to the horizon in folds and hollows, 
in bands of trees and rumpled field, studded by silos that marked the 
presence of family farms.  High over the beautiful countryside, passenger 
jets crisscrossed the sky, leaving white contrails behind them.
??

 

PART TWO

THE MONKEY HOUSE

RESTON

1989 OCTOBER 4, WEDNESDAY

THE CITY OF Reston, Virginia, is a prosperous community about ten miles 
west of Washington, D.C., just beyond the Beltway.  On a fall day, when a 
western wind clears the air, from the upper floors of the office buildings 
in Reston you can see the creamy spike of Washington Monument, sitting in 
the middle of the Mall, and beyond it the Capitol dome.  The population of 
Reston has grown in recent years, and high-technology business and 
blue-chip consulting firms have moved into office parks there, where glass 
buildings grew up during the nineteen-eighties like crystals.  Before the 
crystals appeared, Reston was surrounded by farmland, and it still 
contains meadows.  In spring, the meadows burst into galaxies of 
yellow-mustard flowers, and robins and thrashers sing in stands of tullip 
tresses and white ash.  The town offers handsome residential 
neighborhoods, good schools, parks, golf courses, excellent day care for 
children.  There are lakes in Reston named American naturalists (like 
Thoreau, Lake Audubon), surrounded by expensive water-front homes.  Reston 
is situated within easy commuting distance of downtown Washington.  Along 
Leesburg Pike, which funnels traffic into the city, there are developments 
of executive homes with Mercedes-Benzes parked in crescent-shaped 
driveways.  Reston was once a country town, and its history still flights 
obliteration, like a nail that won't stay hammered down.  Among the 
upscale houses, you see the occasionally bungalow with cardboard stuffed 
in a broken window and a pickup truck parked in the side yard.  In the 
autumn, vegetable stands along Leeburg Pike sell pumpkins and butternut 
squash.
	Not far from Leesburg Pike there is a small office park.  It was 
built in nineteen-sixties, and is not as glassy or as fashionable as the 
newer office parks, but it is clean and neat, and it has been there long 
enough for sycamores and sweet-gum trees to grow up around it and throw 
shade over the lawns.  Across the street, a McDonald's is jammed at lunch 
hour with office workers.  In the autumn of 1989, a company called 
Hazleton Research Products was using a one-story building in the office 
park as a monkey house.  Hazleton Research Products is a division of 
Corning, Inc.  Corning's Hazleton unit is involved with the importation an 
sale of laboratory animals.  The Hazleton monkey house was known as the 
Reston Primate Quarantine Unit.
	Each year, about sixteen thousand wild monkeys are imported into 
the United States from the tropical regions of the earth.  Imported 
monkeys must be held in quarantine for a month before they are shipped 
anywhere else in the United States.  This is prevent the spread of 
infectious diseases that could kill other primates, including humans.
	Dan Dalgard, a doctor of veterinary medicine, was the consulting 
veterinarian at the Reston Primate Quarantine Unit.  He was on call to 
take care of the monkeys if they became sick or needed medical attention.  
He was actually a principal scientist at another company owned by Corning, 
called Hazleton Washington.  This company has its headquarters on Leesburg 
Pike not far from the monkey house, and so Dalgard could easily drive his 
car over to Reston to check on the monkeys if he was needed there.  
Dalgard was a tall man in his fifties, with metal-framed glasses, pale 
blue eyes, and a soft drawl that he had picked up in Tedas at veterinary 
school.  Generally he wore a gray business suit if he was working in his 
office, or a white lab coat if he was working with animals.  He had an 
international reputation as knowledgeable and skilled veterinarian who 
specialized in primate husbandry.  He was a calm even-tempered man.  On 
evenings and weekends, he repaired antique clocks as a hobby.  He liked to 
fix things with his hands; it made him feel peaceful and calm, and he was 
patient with a jammed clock.  He sometimes had longings to leave 
veterinary medicine and devote himself full-time to clocks.
	On Wednesday, October 4, 1989, Hazleton Research Products accepted 
a shipment of a hundred wild monkeys from the Philippines.  The shipment 
originated at Ferlite Farms, a monkey wholesale facility located not far 
from Manila.  The monkeys themselves came from coastal rain forests on the 
island of Mindanao.  The monkeys had been shipped by boat to Ferlite 
Farms, where they were grouped together in large cages known as gang 
cages.  The monkeys were then put into wooden crates and flown to 
Amsterdam on a specially fitted cargo airplane, and from Amersdam they 
were flown to New York City.  They arrived at JFK International Airport 
and were driven by truck down the eastern seaboard of the United Sates to 
Reston monkey house.
	The monkeys were crab-eating monkeys, a species that lives along 
rivers and in mangrove swamps in Southeast Asia.  Crab eaters are used as 
laboratory animals because they are common, cheap, and easily obtained.  
They have long, arching, whiplike tails, whitish fur on the chest, and 
cream-color fur on the back.  The crab eater is a type of macaque 
(pronounced ma-KACK).  It is sometimes called a long-tailed macaque.  The 
monkey has a protrusive, doglike snout with flaring nostrils and sharp 
canine teeth.  The skin is pinkish gray, close to the color of a white 
person.  The hand looks quite human, with a thumb and delicate fingers 
with fingernails.  The females have two breasts on the upper chest that 
look startlingly human, with pale nipples.
	Crab eaters do not like humans.  They have a competitive 
relationship with people who live in the rain forest.  They like 
vegetables, especially eggplants, and they like to raid farmers' crops.  
Crab-eating monkeys travel in a troop, making tumbling jumps through the 
trees, screaming, "Kra! Kra!".  They know perfectly well that after they 
have pulled off an eggplant rad they are likely to have a visit from a 
farmer, who will come around looking for them with a shotgun, and so they 
have to be ready to move out and head deep into the forest at a moment's 
notice.  The sight of a gun will set off their alarm cries: "Kra! Kra! 
Kra!".  in some parts of the world, these monkeys are called kras, because 
of the sound they make, and many people who live in Asian rain forests 
consider them to be obnoxious pests.  At the close of day, when night 
comes, the troop goes to sleep in a dead, leafless tree.  This is the 
troop's home tree.  The monkeys prefer to sleep in a dead tree so that 
they can see in all directions, keeping watch for humans and other 
predators.  The monkey tree usually hangs out over a river, so that they 
can relieve themselves from the branches without littering the ground.
	At sunrise, the monkeys stir and wake up, and you hear their cries 
as they greet the sun.  The mothers gather their children and herd them 
along the branches, and the troop moves out, leaping through trees, 
searching for fruit.  They like to eat all kinds of things.  In addition 
to vegetables and fruits, they eat insects, grass, roots, and small pieces 
of clay, which they chew and swallow, perhaps to get salt and minerals.  
They lust after crabs.  When the urge for crabs comes upon them, the troop 
will head for a mangrove swamp to have a feeding bout.  They descend from 
the trees and take up positions in the water beside crab holes.  A crab 
comes out of its hole, and the monkey snatches it out of the water.  The 
monkey has a way to deal with the crab's claws.  He grabs the crab from 
behind as it emerges from its hole and rips off the claws and throws them 
away and then devours the rest of the crab.  Sometimes a monkey isn't 
quick enough with the claws, and the crab latches onto the monkey's 
fingers, and the monkey lets out a shriek and shakes its hand, trying to 
get the crab off, and jumps around in the water.  You can always tell when 
crab eaters are having a feeding bout on crabs because you hear an 
occasionally string of shrieks coming out of the swamp as a result of 
difficulty with a crab.
	The troop has a strict hierarchy.  It is led by a dominant male, 
the largest, most aggressive monkey.  He maintains control over the troop 
by staring.  He stares down subordinates if they challenge him.  If a 
human stares at a dominant male monkey in a cage, the monkey will rush to 
the front of the cage, staring back, and will become exceedingly angry, 
slamming against the bars, trying to attack the person.  He will want to 
kill the human who stared at him: he can't afford to show fear when his 
authority is challenged by another primate.  If two dominant male monkeys 
are placed in the same cage, only one monkey will leave the cage alive.
	The crab-eating monkeys at the Reston monkey house were placed 
each in its own cage, under artificial lights, and were fed monkey 
biscuits and fruit.  There were twelve monkey rooms in the monkey house, 
and they were designated by the letters A through L.  Two of the monkeys 
that arrived on October 4 were dead in their crates.  That was not 
unusual, since monkeys die during shipments.  But in the next three weeks, 
an unusual number of monkeys began to die at the Reston monkey house.

ON OCTOBER 4, the same day the shipment of monkeys reached the Reston 
monkey house, something happened that would change Jerry Jaax's life 
forever.  Jerry had a brother named John, who lived in Kansas City with 
his wife and two small children.  John Jaax was a prominent businessman 
and a banker, and he was a partner in a manufacturing company that made 
plastic for credit cards.  He was a couple of years younger than Jerry, 
and the two men were as close as brothers can be.  They had grown up 
together on a farm in Kansas and had both gone to college at Kansas State. 
 They looked very much alike: tall, with prematurely gray hair, a beak 
nose, sharp eyes, a calm manner; and their voices sounded alike.  They 
only difference in appearance between them was John wore a mustache and 
Jerry did not.
	John Jaax and his wife planned to attend a parent-teachers' 
meeting on the evening of October 4 at their children's school.  Near the 
end of the day, John telephoned his wife from his office at the 
manufacturing plant to tell her that he would be working late.  She 
happened to be out of house when he called, so he left a message on the 
answering machine, explaining that he would go directly from the office to 
the meeting, and he would see her there.  When he did not show up, she 
became worried.  She drove over to the factory.
	The place was deserted, the machines silent.  She walked the 
length of the factory floor to a staircase.  John's office overlooked the 
factory floor from a balcony at the top of the staircase.  She climbed the 
stairs.  The door to his office was standing open a crack, and she went 
inside.  John had been shot many times, and there was blood all over the 
room.  It was a violent killing.
	The police officer who took the case at Kansas City Homicide was 
named Reed Buente.  He has know John personally and had admired him, 
having worked for him as a security guard at the Bank of Kansas City when 
John was president of the bank.  Officer Buente was determined to solve 
the case and bring the killer or killers to trial.  But as time went by 
and no breaks came along, the investigator became discouraged.  John Jaax 
had been having difficulties with his partner in the plastic business, a 
man named John Weaver, and Kansas City homicide looked at the partner as a 
suspect.  (When I called Officer Buente recently, he confirmed this.  
Weaver has since died of a heart attack, and the case remains open, since 
unsolved murder cases are never closed.)  There were few physical clues, 
and Weaver, as it turned out, had an alibi.  The investigator ran into 
more and more difficulties with the case.  At one point, he said to Jerry, 
"You can have someone killed pretty easy.  And it's cheap.  You can have 
someone killed for what you would pay for a desk."
	The murder of John Jaax threw Jerry into a paralysis of grief.  
Time is supposed to heal all things, but time opened an emotional gangrene 
in Jerry.  Nancy began to think that he was in a clinical depression.
	"I feel like my life is over," he said to her.  "It's just not the 
same anymore.  My life will never be the same.  It's just inconceivable 
that Johnny could have had an enemy."  At the funeral in Kansas City, 
Nancy and Jerry's children, Jaime and Jason, looked into coffin and said 
to their father, "Gee, Dad, he looks like you lying there."
	He called Kansas City Homicide nearly every day during October and 
November.  The investigator just couldn't break the case.  Jerry began to 
think about getting a gun and going out to Kansas City to kill John's 
business partner.  He thought.  If I do it, I'll be in jail, and what 
about my children?  An what if John's partner hadn't been behind the 
murder?  Then I'll have killed an innocent man.

NOVEMBER 1, WEDNESDAY

THE COLONY MANGER at the Reston monkey house will be called Bill Volt.  As 
he watched his monkeys die, Volt became concerned.  On November 1, a 
little less than a month after the shipment of monkeys had arrived, he put 
in a telephone call to Dan Dalgard, telling him that the monkeys that had 
recently arrived from the Philippines were dying in unusually large 
numbers.  He had counted twenty-nine deaths out of a shipment of a hundred 
monkeys.  That is, nearly a third of the monkeys had died.  At the same 
time, a problem had developed with the building's heating and air-handling 
system.  The thermostat had failed, and the heat would not go off.  The 
heaters dumped heat at full blast into the building, and the 
air-conditioning system would not kick in.  It had become awfully hot 
inside the building.  Volt wondered if the heat might be putting stress on 
the monkeys.  He had noticed that most of the deaths had taken place in 
one room, Room F, which was located on a long hallway at the back of the 
building.
	Dalgard agreed to drive over to the monkey house and have a look, 
but he became busy with other thing and did not get there until the 
following week.  When he arrived, Bill Volt took him to Room F, the focus 
of the deaths, so that Dalgard could inspect the monkeys.  They put on 
white coats and surgical masks, and the two men walked down a long 
cinder-block corridor lined on both sides with steel doors leading to 
monkey rooms.  The corridor was very warm, and they began to sweat.  
Through windows in the doors, they could see hundreds of monkey eyes 
looking at them as they passed.  The monkeys were exquisitely sensitive to 
the presence of humans.
	Room F contained only crab-eating monkeys from the October 
shipment from Ferlite Farms in the Philippines.  Each monkey sat on its 
own cage.  The monkeys were subdued.  A few weeks ago, they had been 
swinging in the trees, and they didn't like what had happened to them.  
Dalgard went from cage to cage, glancing at the animals.  He could tell a 
lot about a monkey from the look in its eyes.  He could also read its body 
language.  He searched for animals that seemed passive or in pain.
	Dalgard's staring into their eyes drove them berserk.  When he 
passed a dominant male and looked carefully at it, it rushed him, wanting 
to take him out.  He found a monkey whose eyes had a dull appearance, not 
shiny and bright but glazed and somewhat inactive.  The eyelids were down, 
slightly squinted.  Normally the lids would be retracted so that could see 
the entire iris.  A healthy monkey's eyes would be like two bright circles 
in the monkey's face.  This animal's eyelids had closed down slightly, and 
they dropped, so that the iris had become a squinting oval.
	He put on leather gauntlet gloves, opened the door of the cage, 
reached inside, and pinned the monkey down.  He slipped one hand out of a 
glove and quickly felt the monkey's stomach.  Yes-the animal felt warm to 
the touch.  It had a fever.  And it had a runny nose.  He let go of the 
monkey and shut the door.  He didn't think that the animal was suffering 
from pneumonia or a cold.  Perhaps the animal was affected by heat stress. 
 It was very warm in this room.  He advised Bill Volt to put some pressure 
on the landlord to get the heating system fixed.  He found a second animal 
that also had droopy eyelids, with that certain squint in the eyes.  This 
one also felt hot to the touch, feverish.  So there were two sick monkeys 
in Room F.

BOTH MONKEYS DIED during the night.  Bill Volt found them in the morning, 
hunched up in their cages, staring with glassy, half-open eyes.  This 
greatly concerned Volt, and he decided to dissect the animals, to try to 
see what had killed them.  He carried the two deceased monkeys into an 
examination room down the hallway and shut the door after him, out of 
sight of the other monkeys.  (You can't cut up a dead monkey in front of 
other monkeys-it will cause a riot.)  He opened the monkeys with a scalpel 
and began his inspection.  He did not like what he saw, and did not 
understand it, so he called Dalgard on the telephone and said, "I wonder 
if you could come over here and have a look at these monkeys."
	Dalgard drove over to the monkey house immediately.  His hands, 
which were so confident and skillful at taking apart clocks, probed the 
monkeys.  What he saw inside the animals puzzled him.  They appeared to 
have died of heat stress, brought on, he suspected, by the problems with 
the heating system in the building-but their spleens were weirdly 
enlarged.  Heat stress wouldn't blow up the spleen, would it?  He noticed 
something else that gave him pause.  Both animals had small amounts of 
blood in their intestines.  What could do that?
	Later that same day, another large shipment of crab-eating monkeys 
arrived from Ferlite Farms.  Bill Volt put the new monkeys in Room H, two 
doors down the hall from Room F.
	Dan Dalgard became very worried about the monkeys in Room F.  He 
wondered if there was some kind of infectious agent going around the room. 
 The blood in the gut looked like the effects of a monkey virus called 
simian hemorrhagic fever, or SHF.  This virus is deadly to monkeys, 
although it is harmless to people.  (It can't live in humans.)  Simian 
fever can spread rapidly through a monkey colony and will generally wipe 
it out.
	It was now Friday, November 10.  Dalgard planned to spend the 
weekend fixing his clocks in the family room of his house.  But as he laid 
out his tools and the pieces of an antique clock that needed fixing, he 
could not stop thinking about the monkeys.  He was worried about them.  
Finally he told his wife that he had to go out on company business, and he 
put on his coat and drove over to the monkey house and parked in front of 
the building and went in through the front door.  It was a glass door, and 
as he opened it, he felt the unnatural heat in the building wash over him, 
and he heard the familiar screeches of monkeys.  He went into Room F. 
"Kra! Kra!" the monkeys cried at him in alarm.  There were three more dead 
monkeys.  They were curled up in their cages, their eyes open, 
expressionless.  This was not good.  He carried the dead monkeys into the 
examination room and slit the animals open, and looked inside.

SOON AFTERWARD, DALGARD began to keep a diary.  He kept it on a personal 
computer, and he would type in a few words each day.  Working quickly and 
without much thought, he gave his diary a title, calling it, "Chronology 
of Events".  It was now getting close to the middle of November, and as 
the sun went down in the afternoon and traffic jams built up on Leesburg 
Pike near his office, Dalgard worked on his diary.  Tapping at the keys, 
he could recall in his mind's eye what he had seen inside the monkeys.
	
	The lesions by this time were showing a pattern of marked 	
splenomegaly (swollen spleen)-strikingly dry on cut surface,
	enlarged kidneys, and sporadic occurrences of hemorrhage in
	a variety of organs ... Clinically, the animals showed abrupt
	anorexia (loss of appetite), and lethargy.  When an animal 
	began showing signs of anorexia, its condition deteriorated
	rapidly.  Rectal temperatures taken on monkeys being sacrificed
	were not elevated.  Nasal discharge, epistaxis (blood nose) or
	bloody stools were not evident... Many of the animals were in
	prime condition and had more body fat than is customary for
	animals arriving from the wild.

	There was nothing much wrong with the dead animals, nothing that 
he could put his finger on.  They simply stopped eating and died.  They 
died with their eyes open, and with staring expressions on their faces.  
Whatever this disease was, the cause of death was not obvious.  Was it 
heart attack?  a fever?  What?
'	The spleen was inexplicably weird.  The spleen is a kind of bag 
that filters the blood, and it plays a role in the immune system.  A 
normal spleen is a soft sack with a drippy red center, which reminded 
Dalgard of a jerry doughnut.  When you cut into a normal spleen with a 
scalpel, it gives about as much resistance to the knife as a jelly 
doughnut, and it drips a lot of blood.  But these spleens had swelled up 
and turned as hard as a rock.  A normal monkey spleen would be about the 
size of a walnut.  These spleens were the size of a tangerine and were 
leathery.  They reminded him of a piece of salami-meaty, tough, dry.  His 
scalpel practically bounced off them.  He could actually tap the blade of 
the scalpel on the spleen, an the blade wouldn't dig in very much.  What 
he didn't realize-what he couldn't see because it was almost 
inconceivable-was that the entire spleen had become a solid clot of blood. 
 He was tapping his scalpel on a blood clot the size of a tangerine.
	On Sunday, November 12, Dalgard putted around the house in the 
morning, fixing things, doing little errands.  After lunch, he once again 
returned to the monkey house.  There was a mystery developing in the 
Reston Primate Quarantine Unit.  He found three more dead monkeys in Room 
F.  They were dying steadily, a handful every night.
	One of the dead animals had been given the name O53.  Dalgard 
carried the carcass of Monkey O53 int the examination room and opened it 
up and looked inside the body cavity.  With a scalpel, he removed a piece 
of Monkey O53's spleen.  It was huge, hard, and dry.  He took a Q-tip and 
rubbed it in the monkey's throat, collecting a little bit of mucus, a 
throat wash.  Then he swirled the Q-Tip in a test tube full of distilled 
water and capped the tube.  Anything alive in the mucus would be preserved 
temporarily.

INTO LEVEL 3

1989 NOVEMBER 13, MONDAY

BY MONDAY MORNING-the day after he dissected Monkey O53-Dan Dalgard had 
decided to bring the problem with his monkeys to the attention of 
USAMRIID, at Fort Detrick.  He had heard that the place had experts who 
could identify monkey diseases, and he wanted to get a positive 
identification of the sickness.  Fort Detrick was about an hour's drive 
northwest of Reston, on the other side of the Potomac River.
	Dalgard ended up talking by phone with a civilian virologist named 
Peter Jahrling, Jahrling had a reputation for knowing something about 
monkey viruses.  They had never talked before.  Dalgard said to Jahrling, 
"I think we've got some SHF (simian hemorrhagic fever) in our monkeys.  
The spleen looks like a piece of salami when you slice it."  Dalgard asked 
Jahrling if he would look at some samples and give a diagnosis, and 
Jahrling agreed to help.  The problem attracted Peter Jahrling's curiosity.
	Jahrling had worked at the Institute for most of his career, after 
an early period in which he had lived in Central America and hunted for 
viruses in the rain forest (he had discovered several previously known 
strains).  He had blond hair, beginning to go gray, steel-rimmed glasses, 
a pleasant, mobile face, and a dry sense of humor.  He was by nature a 
cautious, careful person.  Peter Jahrling spent large amounts of time in a 
Chemturion biological space suit.  He performed research on defenses 
against hot viruses-vaccines, drug treatments-and he did basic medical 
research on rain-forest viruses.  The killers and the unknowns were his 
specialty.  He deliberately kept his mind off the effects of hot agents.  
He told himself, If you did think about it, you might decide to make a 
living another way.
	Jahrling, his wife, and their three children lived in Thurmont, 
not far from Nancy and Jerry Jaax, in a brick ranch house with a white 
picket fence out front.  The fence surrounded a treeless yard, and there 
was a large brown car parked in the garage.  Although they lived near each 
other, the Jahrlings did not socialize with Jaax, since their children 
were of different ages and since the families had different styles.
	Pete Jahrling mowed his lawn regularly to keep the grass neat, so 
that his neighbors wouldn't think he was a slob.  Externally he lived a 
nearly featureless life among suburban neighbors, and very few of them 
knew that when he climbed into his mud-colored car he was headed for work 
in a hot zone, although the license plate on the car was a vanity plate 
that said LASSA.  Lassa is a Level 4 virus from West Africa, and it was 
one of Peter Jahrling's favorite life forms-he thought it was fascinating 
and beautiful, in certain ways.  He had held in his gloved hands virtually 
every hot agent known, except for Ebola and Marburg.  When people asked 
him why he didn't work with them, he replied, "I don't particularly feel 
like dying."

AFTER HIS TELEPHONE conversation with Dan Dalgard, Peter Jahrling was 
surprised and annoyed when, the next day, a few bits of frozen meat from 
Monkey O53 arrived at the Institute, brought by courier.  What annoyed him 
was the fact that the bits of meat were wrapped in aluminum foil, like 
pieces of leftover hot dog.
	The hot-dog-like meat was monkey spleen, and the ice around it was 
tinged with red and had begun to melt and drip.  The samples also included 
the tube containing the throat wash and some blood serum from the monkey.  
Jahrling carried the samples into a Level 3 laboratory.  Level 3 is kept 
under negative air pressure, to prevent things from leaking out, but you 
don't need to wear a space suit there.  People who work in Level 3 dress 
like surgeons in an operating room.  Jahrling wore a paper surgical mask, 
a surgical scrub suit, and rubber gloves.  He peeled off the tin foil.  A 
pathologist helped him do it, standing next to him.  The bit of spleen 
rolled about the tin foil as they poked it-a hard little pink piece of 
meat, just as Dalgard had described it.  He thought, Like the kind of 
mystery meat you get in a school lunchroom.  Jahrling turned to the other 
man and remarked, "Good thing this ain't Marburg" and they chuckled.
	Later that day, he called Dalgard on the telephone and said to him 
something like, "Let me tell you how to send a sample to us.  People 
around here may be slightly paranoid, but they get a little upset when you 
send a sample and it drips on the carpet."

ONE WAY TO identify a virus is to make it grow inside living cells in a 
flask of water.  You drop a sample of the virus into the flask, and the 
virus spreads through the cells.  If the virus likes the cells, it will 
multiply.  One or two viruses can become a billion viruses in a few days-a 
China of viruses in a bottle the size of one's thumb.
	A civilian technician named Joan Rhoderick cultured the unknown 
agent from Monkey O53.  She ground up a bit of the monkey's spleen with a 
mortar and pestle.  That made sort of bloody mush.  She dropped the mush 
into flasks that contained living cells from the kidney of a monkey.  She 
also took some of the throat mucus from Monkey O53 and put it into a 
flask, and she took some of the monkey's blood serum and put it into 
another flask.  Eventually she had a whole rack of flasks.  She put them 
into a warmer-an incubator, held at body temperature-and hoped that 
something would grow.  Growing up a virus in culture is a lot like making 
beer.  You follow the recipe, and you keep the brew nice and warm until 
something happens.

DAN DALGARD DID not visit the monkey house the next day, but he telephoned 
Bill Volt, the manager, to find out how things were going.  Volt reported 
that all animals looked good.  None of them had died during the night.  
The illness seemed to be fading away naturally.  It looked like things 
were quieting down in Reston, and Dalgard felt relieved that his company 
ha dodged a bullet.
	But what were those Army people doing with the samples of monkey?  
He called Jahrling and learned that it was too soon to know anything.  It 
takes several days to grow up a virus.
	A day later, Bill Volt called Dalgard with bad news.  Eight 
monkeys in Room F had stopped eating.  Eight monkeys were getting ready to 
die.  The thing had come back.
	Dalgard hurried over to the monkey house, where he found that the 
situation had deteriorated suddenly.  There were many more animals with 
squinting, glazed, oval-shaped eyes.  Whatever the thing was, it was 
steadily working its way through Room F.  By now, fully half the animals 
in the room had died.  It was going to kill the entire room if nothing was 
done to stop it.  Dalgard became extremely anxious for some news from 
Peter Jahrling.
	Thursday, November 16, arrived, and with it came news that monkeys 
had begun to die in rooms down the hallway from Room F.  Late in the 
morning, Dan Dalgard received a telephone call from Peter Jahrling.  A 
pathologist at the Institute had inspected the meat very carefully and had 
given it a tentative diagnosis of simian hemorrhagic fever-harmless to 
humans, lethal to monkeys.
	Dalgard now knew that he had to move fast to contain the outbreak 
before the virus spread through the monkey house.  Simian hemorrhagic 
fever is highly contagious in monkeys.  That afternoon, he drove up 
Leesburg Pike to the office park in Reston.  At five o'clock on a gray, 
rainy evening on the edge of winter, as commuters streamed home from 
Washington, he and another Hazleton veterinarian injected all the monkeys 
in Room F with lethal doses of anesthetic.  It was all over quickly.  The 
monkeys died in minutes.
	Dalgard opened up eight healthy-looking carcasses to see if he 
could find any signs of simian fever inside them.  He was surprised to see 
that there didn't seem to be anything wrong with them.  This greatly 
troubled him.  Sacrificing the monkeys had been a difficult, disgusting, 
and disheartening task.  He knew there was a disease in this room, and yet 
these monkeys were beautiful, healthy animals, and he had just killed 
them.  The sickness had been entrenched in the building since early 
October, and it was now the middle of November.  The Army had given him a 
tentative diagnosis, probably the best diagnosis he would ever get, and he 
had been left with the unpleasant task of trying to salvage the lives of 
the remaining animals.  He went home that evening feeling that he had a 
very bad day.  Later he would write in his diary:

	There was a notable absence of any hemorrhagic component.  In
	general, the animals were unusually well fleshed (butterballs),
	young (less than 5 years), and in prime condition.

	Before he left the monkey house, he and the other veterinarian 
placed the dead monkeys in clear plastic bags and carried some of them 
across the hall to a chest freezer.  A freezer can be as hot as hell.  
When a place is biologically hot, no sensors, no alarms, no instruments 
can tell the story.  All instruments are silent and register nothing.  The 
monkeys' bodies were visible in the clear bags.  They froze into contorted 
shapes, with their chest cavities spread wide and their intestines hanging 
out and dripping red icicles.  Their hands were clenched into fists or 
open like claws, as if they were grasping at something, and their faces 
were expressionless masks, their eyes glazed with frost, staring at 
nothing.

EXPOSURE

NOVEMBER 17, FRIDAY

THOMAS GEISBERT WAS an intern at the Institute, a kind of trainee.  He was 
twenty-seven years old, a tall man with dark blue eyes and longish brown 
hair parted in the middle and hanging over his forehead.  Geisbert was a 
skilled fisherman and a crack shot with a rifle, and he spent a lot of 
time in the woods.  He wore blue jeans and cowboy boots, and tended to 
ignore authority.  He was a local boy who had grown up near Fort Detrick.  
His father was the chief building engineer at the Institute, the man who 
repaired and operated the hot zones.  When Tom Geisbert was a boy, his 
father had taken him to visit the Institute, and Tom had stared through 
the heavy glass windows at people in space suits, thinking it would be 
cool to do that.  Now he was doing it, and it made him happy.
	The Institute hired him to operate its electron microscope, which 
uses a beam of electrons to make images of small objects, such as viruses. 
 It is an essential tool to have around a virus lab because you can use it 
to make a photograph of a tiny piece of meat and find viruses in the meat. 
 For Geisbert, identifying hot strains and classifying the tribes of 
viruses was like sorting butterflies or collecting flowers.  He liked the 
loneliness of inner space, the sense of being forgotten by the world.  He 
felt quiet and at peace with himself when he was padding around a hot zone 
carrying a rack of test tubes that held an unknown agent.  He liked to go 
into the Level 4 suites alone, rather than with a buddy, especially in the 
middle of the night, but his tendency to spend large amounts of time at 
his work had begun to affect his personal life, and his marriage was 
breaking up.  He and his wife had separated in September.  His troubles at 
home only reinforced his tendency to bury himself in Level 4.
	One of Geisbert's greatest happiness in life, apart from his work, 
came from being in the outdoors, fishing for black bass and hunting for 
deer.  He hunted for meat-he gave the venison to members of his family-and 
then, when he had got the meat he needed, he hunted for trophies.  Every 
year around Thanksgiving, he went hunting in West Virginia, where he and 
some buddies rented a house for the opening of deer season.  His friends 
did not know much about what he did for a living, and he made no effort to 
tell them about it.
	Geisbert tried to look at many samples of virus as a way of 
sharpening his skills with an electron microscope.  He was learning how to 
identify hot agents by eye, by looking at photographs of the particles.  
When the samples of the Cardinal boy had arrived from Africa, Geisbert 
spent days gazing at them.  They attracted him.  The Cardinal strain was a 
tangled mass of 6s, Us, gs, Ys, snakes, and Cheerios mixed up with partly 
liquefied human flesh.  Geisbert spent so much time staring at the virus, 
one of the true horrors of nature, that the shapes became implanted in his 
mind.

TOM GEISBERT HAD HEARD about the sick monkeys in Virginia, and he wanted 
to take photographs of the meat to see if he could identify any 
simian-fever-virus particles in it.  On Friday morning, November 17, the 
day after Dan Dalgard had killed all the animals in Room F, Geisbert 
decided to take a look at the flasks of monkey cell that were ripening.  
He wanted to examine them with a light microscope before he went on his 
Thanksgiving hunt, to see if he could observe any changes.  A light 
microscope is a standard microscope that uses lens to focus light.
	At nine o'clock on that Friday morning, he put on a surgical scrub 
suit and a paper mask and went into the Level 3 lab where the flasks were 
being kept warm.  There he met Joan Rhoderick, the technician who had 
started the Reston culture.  She was staring through the binocular 
eyepieces of the microscope at a small flask.  The flask contained cells 
that had been infected with the simian-fever-virus that came from Monkey 
O53.
	She turned to Geisbert. "There's something flaky going on in this 
flask," she said.
	The flask was a typical virus flask.  It was about the size of a 
person's thumb and was made of clear plastic so that you could place it in 
a microscope and look into the flask.  It had a black screw cap.
	Geisbert stared through the eyepieces of the microscope.  He saw a 
complicated world in the flask.  As always in biology, the problem was to 
know what you were looking at.  The patterns of nature are keep and 
complex, constantly changing.  He saw cells all over the place.  They were 
tiny bags, each containing a nucleus, which was a darker blob near the 
center.  The cells looked a little bit like fried eggs, sunny-side up.  
The egg yolk would be the cell's nucleus.
	Living cells ordinarily stick to the bottom of a flask to form a 
living carpet-cells prefer to cling to something when they grow.  This 
carpet had been eaten by moths.  The cells had died and drifted away, 
leaving holes in the carpet.
	Geisbert checked all the flasks, and most of them looked the same 
way, like moth-eaten carpet.  They looked real bad, they looked sick.  
Something was killing these cells.  They were swollen and puffy, fat 
looking, as if they were pregnant.  Tom could see that they contained 
granules or specks.  The specks looked like pepper.  As if someone had 
shaken pepper over fried eggs.  He may have seen reflection of light in 
the pepper, as if light was gleaming through crystals.  Crystals?  These 
cells were unrecognizably sick.  And they were very sick, because the 
fluid was milky and clouded with dead cells, cells that had exploded.
	They decided that their boss, Peter Jahrling, should have a look.  
Geisbert went to find Jahrling.  He exited Level 3-removed his scrub suit 
and took a water shower and dressed in civilian clothes-and went to 
Jahrling's office.  Then he and Jahrling returned to the Level 3 lab.  It 
took a few minutes for both of them to change in the locker room and put 
on scrub suits.  When they were ready to go in-dressed like surgeons-they 
entered and sat down at the eyepieces of the microscope.  Geisbert said to 
him, "There's something very strange going on in that flask, but I'm not 
sure what it is.  This isn't like SHF."
	Jahrling looked.  He saw that the flask had turned milky, as if it 
had gone rotten.  "This is contaminated," he said.  "These cells are blown 
away.  They're crud."  The cells were exploded and dead.  "They're off the 
plastic," he remarked.  By off the plastic he meant that the dead cells 
had detached from the surface of the flask, and had floated away in the 
broth.  He thought that a wild strain of bacteria had invaded the cell 
culture.  This is an annoying and common occurrence when you are trying to 
grow virus, and it wipes out the flask.  The wild bacteria consume the 
cell culture, eat it up, and make a variety of different smells in the air 
while they're growing, whereas viruses kill cells without releasing an 
odor.  Jahrling guessed that the flask had been wiped out by a common soil 
bacterium called pseudomonas.  It lives in dirt.  It lives in everyone's 
backyard and under fingernails.  It is one of the most common forms of 
life on the planet, and it often gets into cell cultures and wrecks them.
	Jahrling unscrewed the little black cap and waved his hand over 
the flask to bring the scent to his nose, and then he took a whiff.  Hm.  
Funny.  No smell.
	He said to Tom Geisbert, "Have you ever smelled pseudomonas?"
	"No," Tom replied.
	"It smells like Welch's grape juice.  Here-" He offered the flask 
to Tom.
	Tom sniffed it.  There was no smell.
	Jahrling took back the flask and whiffed it again.  His nose 
registered nothing.  But the flask was milky, and the cells were blown 
away.  He was puzzled.  He handed the flask back to Tom and said, "Put it 
in the beam, and let's look at it." By put it in the beam, he meant "look 
at it using the electron microscope," which is much more powerful than a 
light microscope, and can see deeper into the universe within.
	
GEISBERT POURED SOME of the milky fluid out of the flask into a test tube 
and then spun it in a centrifuge machine.  A button grayish ooze collected 
at the bottom of the test tube-a tiny pill of dead and dying cells.  The 
pill was the size of a pinhead, and it had a pale brownish color.  
Geisbert thought it looked like a dab of mashed potato.  He lifted out the 
button with a wooden stick and soaked the button in plastic resin to 
preserve it.  But now, what was on his mind was the hunting season.  Later 
that afternoon-Friday-he went home to get packed.  He had been planning to 
drive his Ford Bronco, but it had broken down; so one of his hunting 
buddies met him in a pickup truck and they loaded Geisbert's duffel bag 
and gun case into it and set off on his hunting trip.  When a filovirus 
begins to amplify itself in a human being, the incubation period is from 
three to eighteen days, while the number of virus particles climbs 
steadily in the bloodstream.  Then comes the headache.

THANKSGIVING

NOVEMBER 20-25

FOR NANCY AND Jerry Jaax, it was the worst Thanksgiving of their lives.  
On Wednesday, November 22, they put their children in the family van and 
drove straight through the night to Kansas.  Jaime was no twelve, and 
Jason was thirteen.  They were used to long drives to Kansas, and they 
slept peacefully.  Jerry had almost lost his ability to sleep since the 
murder of his brother, and Nancy stayed awake with him, trading places 
behind the steering wheel.  They arrived in Wichita on Thanksgiving Day 
and ate a meal of turkey with Nancy's father, Curtis Dunn, who was living 
with Nancy's brother.
	Nancy's father was dying of cancer.  He had gone through life 
fearing that he might come down with cancer-he once took to his bed for 
eight months while claiming he had cancer when, in fact, he did not-and 
now he had come down with real cancer.  He had lost a lot of weight that 
fall.  He was like a human skeleton, down to less than a hundred pounds, 
but he was still a relatively young man, and his hair was black and curly 
and oiled with Vitalis.  He looked so terrible that the children were 
afraid of him.  He did his best to show sympathy for Jerry.  "How awful it 
was, what happened to you Jaaxes," he said to Jerry.  Jerry did not want 
to talk about it.
	Nancy's father sat and slept in a reclining chair most of the day. 
 At night, he couldn't sleep on account of the pain, and he would wake up 
at three o'clock in the morning, and get out of bed, and rummage around 
the house, looking for something.  He smoked cigarettes continually, and 
complained that he couldn't taste his food, that he had lost his appetite. 
 Nancy felt sorry for him, but she felt a distance from him that she could 
not overcome.  He was man of strong opinions, and lately, from the way he 
had been talking while he wandered about the house at night, it seemed 
that he was going to try to sell the family farm in Kansas and use the 
money to get himself to Mexico for a cure involving peach pits.  Nancy was 
angry with him for having such ideas, and that anger was mixed with pity 
for him in his illness.
	After they had finished their turkey with Nancy's father, they 
drove out to Andale, Kansas, a town northwest of Wichita, and ate another 
dinner, with Jerry's mother, Ada, and the rest of the Jaax family in Ada's 
house on he edge of town, near the grain elevator.  Ada was a widow who 
lived alone in a ranch house that looked out across beautiful wheat 
fields.  The fields were bare and planted with winter wheat, and Ada sat 
in her chair in the living room and stared outdoors.  She could not watch 
television because she was afraid she would see a gun.  They sat around 
the living room and talked, telling stories about the old days on Ada's 
farm, laughing and joking and trying to have a good time, and suddenly 
John's name would come up.  The conversation would flag into silence, and 
everyone would look at the floor, not knowing what to say, and someone 
would start crying, and then they would see tears running down Ada's face. 
 She had always been a strong woman, and none of her children had ever 
seen her cry.  When she felt she could not stop it, she would get up and 
leave the room, and go into her bedroom and close the door.
	They set up tables in the kitchen and served roast beef-the Jaaxes 
did not like turkey.  After a while, people drifted into the living room 
with plates in their hands and watched a football game.  The women, 
including Nancy, cleaned up around the kitchen and helped with the 
children.  Afterward, Nancy and Jerry stayed on in Wichita for a few days 
to help Nancy's father get to the hospital for his cancer treatments.  
Then they drove back to Maryland in the van with their children.
	
DAN DALGARD SPENT an uneasy Thanksgiving week.  On Monday, he called Peter 
Jahrling at the Institute to find out if Jahrling had any further news 
about what had been killing the monkeys at Reston.  Jahrling now had a 
tentative diagnosis.  It looked like they really did have SHF.  Bad for 
monkeys, no problem for humans.  He said to Dalgard that he felt strongly 
that it was simian fever, but he was reluctant to say so categorically.  
He wanted to play it carefully until the final tests were finished.
	Dalgard hung up the phone believing that his decision to sacrifice 
the monkeys in Room F had been correct.  Those monkeys had been inflected 
with simian fever and would have died anyway.  What now worried Dalgard 
was the possibility that the virus had somehow escaped from Room F.  It 
might be quietly working his way through the building, in which case 
monkeys might start dying in other rooms.  And then the virus would be 
very hard to control.
	On Thanksgiving morning, Dan and his wife drove to Pittsburgh, to 
be with Dan's wife's parents.  They drove back to Virginia on Friday, and 
Dan headed over to the monkey house to see if there had been any changes.  
He was shocked by what he found.  Over Thanksgiving, five monkeys had died 
in Room H, two doors down the hall from Room F.  So the virus was moving, 
and what was worse, it was skipping rooms as it moved.  How could it do 
that?  Five dead monkeys in one room during the night ... He felt very 
uneasy.

MEDUSA

NOVEMBER 27, 0700 HOURS, MONDAY

EARLY ON MONDAY morning of the week following Thanksgiving, Tom Geisbert 
went to work at the Institute wearing blue jeans, a flannel shirt, and 
cowboy boots, as a kind of memento of his time in the woods.  He was 
anxious to check up on the button of dead monkey cells that he had 
harvested from the little flask just before he had gone hunting.  He 
wanted to look at the cells in his electron microscope to try to find some 
visual evidence that they were inflected with simian fever.
	The button was a dot the size of toast crumb, embedded in a tiny 
plug of yellow plastic.  He unlocked a filing cabinet and removed his 
diamond knife.  A diamond knife is a metal object no larger than a small 
pocket-size pencil sharpener-about an inch long.  It costs about four 
thousand dollars.  It has a diamond edge-a large, flawless prism-sharp 
diamond, a gem-quality stone.
	He carried the diamond knife and the plug of plastic containing 
the toast crumb of cells into the cutting room.  He sat down at a table, 
facing the cutting machine, and fitted his diamond knife into it, taking 
extreme care not to let his fingers touch the edge of the knife.  One 
touch of a fingertip would destroy it.  The diamond would also cut your 
fingertip, perhaps badly.  The knife is extraordinarily sharp.  It has the 
sharpest cutting edge of any tool on earth.  It is sharp enough to split a 
virus cleanly in half, like a razor blade going through a peanut.  If you 
consider the idea that a hundred million viruses could cover the dot on 
this i, then you get an idea of the sharpness of a diamond knife.  If you 
happened to cut yourself with it, it would go through you skin without 
resistance, as if your skin were air-and it would split individual blood 
cells as it went through your finger.  And then the knife edge would be 
covered with skin oil and blood cells, and would be ruined.
	Tom looked into the eyepieces of a microscope that was attached to 
the cutting machine.  Now he could see the toast crumb clearly.  He threw 
a switch, and the machine hummed, and the sample began to move back and 
forth, the toast crumb sliding across the edge of the diamond knife.  The 
cutting machine worked like a deli slicer, peeling off slices about this 
size:
						.
The slices fell onto a droplet of water, and rested on the surface.  Each 
contained as many as ten thousand cells, and the cells themselves were 
split by the knife.  The blade peeled off slice after slice.  They spread 
out like lily pads.
	He took his eyes away from the microscope and looked around the 
table until he found a wooden stick that had a human eyelash glued to it 
with a droplet of nail polish.  It was a device for handling the slices.  
The eyelash had come from one of the women in the lab-it was generally 
believed that she had superior eyelashes for this kind of work, not too 
thick and not too thin, tapered, ending in fine points.  He poked the 
eyelash into the water droplet and stirred it, separating the slices from 
one another.  With the tip of the eyelash, he then lifted a few damaged 
slices out of the water and wiped them on a piece of tissue paper to get 
rid of them.
	Next, using a pair of tweezers, he picked up a small metal grid.  
The grid was this size-*-and it was made of copper.  Holding the grid with 
his tweezers, he dipped it into the water and brought it up slowly 
underneath a floating slice, like a fisherman lifting up a dip net.  The 
slice was now stuck
to the grid.  Still holding the grid with his tweezers, he put it into a 
tiny box.  He carried the box down the hall to a darkened room.  In the 
middle of the room stood a metal tower taller than a person.  This was his 
electron microscope.  My scope, he thought; he was very fond of it.  He 
opened the tiny box, lifted out the grid with tweezers, and fitted it into 
a steel rod the size of a tire iron-the sample holder, as it was called.  
He slid the rod into the microscope until it clanked, locked in place.  
Now the slice, sitting on the grid, which was held in place by the tire 
iron, was positioned in the microscope, centered in the beam of electrons.
	He switched off the lights in the room and sat down at a console 
that was covered with dials and digital readouts.  In the middle of the 
console there was a viewing screen.  The room had become the command deck 
of a starship, and the viewing screen was a window that looked down into 
the infinity within.
	He hit a switch, hunched down in his chair, and put his head close 
to the viewing screen.  His face glowed greenish in the light of the 
screen, and was reflected in the glass: long hair, serious expression, 
deep-set eyes that scanned the terrain.  He was looking into a corner of 
one cell.  It was like looking at a landscape from high altitude.  It was 
a cellscape.  What loomed before his eyes was a huge complicated vista, 
crowded with more detail than the mind could absorb.  You could spend days 
scanning cells, looking for a virus.  In one slice, there might be 
thousands of cells that needed to be searched-and you still might not find 
what you were looking for.  The incredible thing about living systems is 
that no matter how small the view, it is just as complicated as ever.  He 
could see forms and shapes that resembled rivers and streams and oxbow 
lakes, and he could see specks that might be towns, and he could see belts 
of forest.  It was an aerial view of rain forest.  The cell was a world 
down there, and somewhere in that jungle hid a virus.
	He turned a knob, and the cellscape drifted across his field of 
view, and he wandered through it.  He zoomed in.  The scene rushed up 
toward him.
	His breath stopped.  Wait a minute-there was something wrong with 
this cell.  This cell was a mess.  It wasn't just dead-it had been 
destroyed.  It was blown apart.  And it was crawling with worms.  The cell 
wall-to-wall with worms.  Some parts of the cell were so thick with virus 
they looked like buckets of rope.  There was only one kind of virus that 
looked like rope.  A filovirus.
	He though, Marburg.  This stuff looks like Marburg.  He hunched 
over the screen.  His stomach screwed up into a knot and turned over, and 
he felt an unpleasant sensation.  The puke factor.  He almost panicked, 
almost ran out of the room shouting, "Marburg!  We've got Marburg!"  He 
thought,  Is this really happening?  He sucked in his breath.  He didn't 
know if this thing was Marburg, but it sure as hell looked like a 
filovirus, a thread virus.  Then an image came into his mind-an image of 
Peter Cardinal's liver cells exploded and flooded with snakes.  He brought 
the image into mental focus and compared it with what he saw on the 
screen.  He knew exactly what the Cardinal strain looked like because he 
had memorized its curlicues and Cheerio shapes.  What the virus did to 
that boy ... the devastating effect on that boy's tissue ... oh, man!-oh, 
man!-Peter and I smelled this stuff.  Peter and I have been handling this 
stuff, and this is a Biosafety Level agent, Marburg ... oh, man ... A foul 
feeling washed over him, a sudden awareness of male reproductive glands 
hanging on the exterior of the body between the legs ... testicles the 
size of pears, black and putrid, the skin peeling off them.
	He began snapping photographs with his microscope.  Several 
negatives came out of the machine.  He carried them into a dark room and 
switched out the lights and began developing them.  In pitch-darkness, he 
had time to think.  He counted the days back to the date of his exposure.  
Let's see, he had sniffed that flask on the Friday before he went hunting. 
 That would have been ... ten days ago.  What's the incubation period for 
Marburg?  He didn't know offhand.  Let's see-monkeys that inhaled Marburg 
virus took a long time to develop the disease, from six to eighteen days.  
He was on day ten.
	I am in the window to be sick.  I am in prime time to be dropping 
over!  Did I have a headache yesterday?  Do I have a headache now?  Do I 
have a fever?  He placed his hand on his forehead.  Feels okay.  Just 
because I don't get a headache on day ten doesn't mean I won't get a 
headache on day twelve.  How deep did I breathe when I sniffed that flask? 
 Did I snap the cap?  That would spray stuff around.  I can't remember.  
Did I rub my eye with my finger afterward?  I can't remember.  Did I touch 
my mouth with my finger?  I might have, I don't know.
	He wondered if he had made a mistake.  Maybe this wasn't Marburg.  
He was only an intern; he was just learning this stuff.  Finding major 
Biosafety Level 4 agents on the outskins of Washington, D.C., is not the 
kind of things interns do everyday.  Maybe this isn't a filovirus.  How 
sure am I?  If you go and tell you boss that you've found Marburg an you 
are wrong, your career goes down the tubes.  If you make a bad call, then 
first of all you start a panic.  Second, you become a laughingstock.
	He switched on the darkroom light and pulled the negatives out of 
the bath and held them up to the light.
	He saw virus particles shaped like snakes, in negative images.  
They were white cobras tangled among themselves, like the hair of Medusa.  
They were face of Nature herself, the obscene goddess revealed naked.  
This thing was breathtakingly beautiful.  As he stared at it, he found 
himself being pulled out of the human world into a world where moral 
boundaries blur and finally dissolve completely.  He was lost in wonder 
and admiration, even though he knew that he was the prey.  Too bad he 
couldn't bring it down with a clean shot from a rifle.
	He saw something else in the pictures that left him frightened and 
filled with awe.  The virus had altered the structure of the cell almost 
beyond recognition.  It had transformed the cell into something that 
resembled a chocolate-chip cookie that was mostly chocolate chips.  The 
"chips" were crystal-like blocks of pure virus.  He knew them as 
"inclusion bodies."
	They were broods of virus getting ready to hatch.  As the virus 
grows inside a cell, crystalloids, or bricks, appear at the center.  Then 
they move outward, toward the surface of the cell.  When a brick touches 
the inner surface of the cell wall, it breaks apart into hundred of 
individual viruses.  The viruses are shaped like threads.  The threads 
push through the cell wall and grow out of the cell, like grass rising 
from seeded loam.  As the bricks appear and move outward, they distort the 
cell, causing it to bulge and change shape, and finally the cell pops-it 
bursts and dies.  The threads break away from the cell and drift into the 
bloodstream of the host, multiplying and taking over more cells and 
forming bricks and bursting the cells.
	As he looked at the bricks, he realized that what he had thought 
was "pepper" when he had looked at the cells in the flask ten days 
ago-those specks in the cells-were really inclusion bodies.  That was also 
why the cells had looked swollen and fat.  Because they were pregnant and 
jammed with bricks of virus.  Because they were getting ready to burst.

THE FIRST ANGEL

NOVEMBER 27, 1000 HOURS, MONDAY

TOME GEISBERT PRINTED the negatives on eight-by-ten glossy paper, and 
headed for the office of his boss, Peter Jahrling.  He carried his 
photographs down a long hallway, went downstairs, and through a security 
door, swiping his ID card across a sensor, and entered a warren of rooms.  
He nodded to a solider-there were soldiers everywhere, going about their 
business-and went up another flight of stairs and past a conference room 
that displayed a map of the world on the wall.  In this room, Army people 
discussed outbreaks of virus.  A meeting was in progress in the room.  
Beyond it, he came to a cluster of offices.  One of them was an 
awe-inspiring mess, papers everywhere.  It belonged to Gene Johnson, the 
biohazard expert who had led the expedition to Kitum Cave.  Across the way 
was Peter Jahrling's office.  It was neatly kept and small, but it had a 
window.  Jahrling had placed his desk under the window to get some extra 
light.  On the walls he had hung drawings done by his children.  There was 
a drawing by his daughter that showed a rabbit under a shining yellow sun. 
 A shelf held an African sculpture of a human hand holding an egg on the 
tips of its fingers, as if the egg contained something interesting about 
to hatch.
	"What's up, Tom?" Jahrling asked.
	"We have a big problem here." Geisbert placed the photographs in a 
row on Jahrling's desk.  It was a gray November day, and the light from 
the window fell gently on the images of Medusa.  "This came from the 
Reston monkeys," Geisbert said, "I think it's a filovirus, and there may 
be a good chance it's Marburg."
	Jahrling remembered sniffing the flask and said, "You're playing a 
joke on me.  This isn't funny."
	"This is no joke, Peter."
	"Are you sure?" Jahrling asked.
	Geisbert said he felt very sure.
	Jahrling looked carefully at the photographs.  Yes, he could see 
worms.  Yes, he and Geisbert might have breathed it into their lungs.  
Well, they didn't have headaches yet.  He remembered remarking to the 
pathologist, as he cut up the little pink chunk of mystery meat in the 
tine foil, "Good thing this ain't Marburg." Yeah, right.
	"Is this stuff the right size?" Jahrling asked.  He got a ruler 
and measured the particles.
	"It looks a little long to be Marburg," Geisbert said.  Marburg 
particles form loops like Cheerios.  This stuff was more like spaghetti.  
They opened a textbook and compared Geisbert's pictures with the textbook 
pictures.
	"It looks good to me," Jahrling said. "I'm going to show it to 
C.J. Peters."

JAHRLING, A CIVILIAN, had decided to notify the military chain of command. 
 It started with Colonel Clarence James Peter, MD.  He was the chief of 
the disease-assessment division at the Institute, the doctor who dealt 
with the dangerous unknowns.  ("The interesting stuff," as he called it.)  
Peters had built up this division almost singlehandedly, and he ran it 
singlehandedly.  He was a strange sort of military man, easygoing and 
casually brilliant.  He had wire-rimmed glasses, a round, ruddy, pleasant 
face with mustache, a light Texas drawl.  He was not a large man, but he 
liked to eat, and he believed himself to be overweight.  He spoke fluent 
Spanish, which he had learned during his years in the jungles of Central 
and South America, hunting for hot agents.  He was required by Army 
regulations to show up for work at eight o'clock in the morning, but he 
usually drifted in around ten o'clock.  He disliked wearing a uniform.  
Usually he wore faded blue jeans with a flaming Hawaiian shirt, along with 
sandals and dweebish white socks, looking like he had just spent the night 
in a Mexican hotel.  His excuse for his lack of uniform was that he 
suffered from athlete's foot, an incurable tropical strain that he had 
picked up in Central America and could never quite get rid of, and so he 
had to wear socks with sandals in order to keep air circulating around his 
toes, and the jeans and flaming shirt were part of the package.  Peters 
worked twelve-hour days and left work at night, often long after everyone 
else had gone home.
	C.J. Peters could swim through a bureaucracy like a shark.  He 
inspired great loyalty in his staff, and he made enemies easily and 
deliberately, when it suited him.  He drove a red Toyota that had seen 
better days.  On his travels in rain forests and tropical savannas, he ate 
with pleasure whatever the locals were eating.  He had consumed frogs, 
snakes, zebra meat, jellyfish, lizards, and toads cooked whole in their 
skin, but he thought he had never eaten salamanders, at least none that he 
had been able to identify in a soup.  He had eaten boiled monkey thigh, 
and he had drunk banana beer fermented with human saliva.  In central 
America, while leading an expedition in search of Ebola virus, he had 
found himself in termite country during swarming season, and he had waited 
by termite nest and collected the termites as they swarmed out and had 
eaten them raw.  He thought they had a nice sort of nutty taste.  He liked 
termites so much that he refrigerated them with his blood samples, to keep 
the termites fresh all day so that he could snack on them like peanuts 
with his evening gin as the sun went down over the African plains.  He was 
fond of suffocated guinea pig baked in its own blood and viscera.  The 
guinea pig is split open like a book, offering treasures, and he enjoyed 
picking out and eating the guinea pig's lungs, adrenal glands, and brain.  
And then, inevitably, he would pay a price.  "I always get sick, but it's 
worth it," he once said to me.  He was a great believer in maps, and his 
offices always contained many maps hung on the walls, showing locations of 
outbreaks of virus.
	Jahrling put Geisbert's photographs in a folder.  He didn't want 
anyone to see them.  He found Peters at a meeting in the conference room 
that held the map of the world.  Jahrling tapped him on the shoulder.  "I 
don't know what you are doing right now, C.J., but I've got something more 
important."
	"What is it?"
	Jahrling held the folder closed. "It's a little sensitive.  I 
really don't want to flash it here."
	"What's so sensitive?"
	Jahrling opened the folder slightly, just enough to give C.J. a 
glimpse of spaghetti, and snapped it shut.
	The colonel's face took on a look of surprise.  He stood up, and 
without a word to the others, without even excusing himself, he walked out 
of the room with Jahrling.  They went back to Jahrling's office and closed 
the door behind them.  Geisbert was there, waiting for them.
	Jahrling spread the photographs on his desk.  "Take a look at 
these, C.J."
	The colonel flipped through the photographs.  "What's this from, 
anyway?" he asked.
	"It's from those monkeys in Reston.  It doesn't look good to me.  
Tom thinks it's Marburg."
	"We've been fooled before," C.J. said.  "A lot of things look like 
worms."  He stared at the photographs.  The worms were unmistakable-and 
there were the crystalloids-the bricks.  It looked real.  It felt real.  
He experienced what he would later describe as a major pucker factor 
setting in.  He thought, This is going to be an awful problem for that 
town in Virginia and these people there. "The first question," he went on, 
"is what are the chances of laboratory contamination?"  The stuff could be 
the Army's own Cardinal strain-it might have somehow leaked out of a 
freezer and gotten into those flasks.  But that seemed impossible.  And 
the more they pondered, the more impossible it seemed.  The Cardinal 
strain was kept in a different area of the building, behind several walls 
of biocontainment, a long distance from the monkey flasks.  There were 
multiple safeguards to prevent the accidental release of a virus like 
Marburg Cardinal.  That just wasn't possible.  It could not be a 
contamination.  But it might be something other than a virus.  It might be 
a false alarm.
	"People around here see something long and stringy, and they think 
they've got a filovirus," C.J. Peters said.  "I'm skeptical.  A lot of 
things look like Marburg."
	"I agree," Jahrling replied. "It could be nothing.  It could be 
just another Loch Ness monster."
	"What are you doing to confirm it?" the colonel asked him.
	Jahrling explained that he was planning to test the cells with 
human blood samples that would make them glow if they were infected by 
Marburg.
	"Okay, you're testing for Marburg," C.J. said.  "Are you going to 
include a test for Ebola?"
	"Sure, I already thought of that."
	"When will your tests be done?  Because if those Monkeys have 
Marburg, we have to figure out what to do."
	Dan Dalgard, for example, was a prime candidate for coming down 
with Marburg, because he had dissected that monkey.
	"I'll have a definite yes or no on Marburg by tomorrow," Jahrling 
said.
	C.J. Peters turned to Tom Grisbert and said that he wanted more 
proof-he wanted pictures of the agent actually growing in monkey liver 
from a monkey that had died in the monkey house.  That would prove that it 
lived in the monkeys.
	C.J. could see that a military and political crisis was brewing.  
If the public found out what Marburg does, there could be panic.  He stood 
up with a photograph of snakes in his hand and said, "If we are going to 
announce that Marburg has broken out near Washington, we had better be 
damned sure we are right." Then he dropped the photograph on Jahrling's 
desk and returned to his meeting under the map of the world.
	
AFTER C.J. PETERS left Jahrling's office, a delicate conversation occurred 
between Peter Jahrling and Tom Geisbert.  They shut the door and talked 
quietly about the whiffing incident.  It was something they had better get 
straight between them.  Neither of them had mentioned to Colonel C.J. 
Peters that they had whiffed that flask.
	They counted the days back to their exposure.  Ten days had passed 
since they had uncapped the flask and whiffed what could be eau de 
Marburg.  Tomorrow would be day eleven.  The clock was ticking.  They were 
in the incubation period.  What were they going to do?  What about their 
families?
	They wondered what Colonel Peters would do if he found out what 
they had done.  He might order them into the Slammer-the Level 4 
biocontainment hospital.  They could end up in the Slammer behind air 
locks and double steel doors, tended by nurses and doctors wearing space 
suits.  A month in the Slammer while the doctors hovered over you in space 
suits drawing samples of your blood just waiting for you to crash.
	The doors of the Slammer are kept locked, the air is kept under 
negative pressure, and your telephone calls are monitored-because people 
have emotional breakdowns in the Slammer and try to escape.  They start 
flaking out by the second week.  They become clinically depressed.  
Noncommunicative.  They stare at the walls, speechless, passive, won't 
even watch television.  Some of them become agitated and fearful.  Some of 
them need to have a continual drip of Valium in the arm to keep them from 
pounding on the walls, smashing the viewing windows, tearing up the 
medical equipment.  They sit on death row in solitary confinement, waiting 
for the spiking fevers, horrible pain in the internal organs, brain 
strokes, and finally the endgame, with its sudden, surprising, 
uncontrollable gushes of blood.  Most of them claim loudly that they have 
not be exposed to anything.  They deny that anything could go wrong with 
them, and ordinarily nothing does go wrong with them, physically, in the 
Slammer, and they come out healthy.  Their minds are another story.  In 
the Slammer, they become paranoid, convinced that the Army bureaucracy has 
forgotten about them, has left them to rot.  When they come out, they are 
disoriented.  They emerge through the air-lock door, pale, shaken, 
tentative, trembling, angry with the Army, angry with themselves.  The 
nurses, trying to cheer them up, give them a cake studded with the number 
of candles equal to the number of days they've been living in the Slammer. 
 They blink in confusion and terror at a mass of flaming candles on their 
Slammer cake, perhaps more candles than they've ever seen on one of their 
own birthday cakes.  One guy was locked in the Slammer for forty-two days. 
 Forty-two candles on his Slammer cake.
	Many people who have been isolated in the Slammer choose to cut 
down on their work in Level 4, begin to find all kinds of excuses for why 
they really can't put on a space suit today or tomorrow or the day after 
that.  Many of the people who have been in the Slammer end up quitting 
their jobs and leaving the Institute altogether.
	Peter Jahrling felt that, on the whole, he was not at much risk of 
contracting virus , nor was Tom.  If he did contract it, he would know 
soon enough.  His blood west test positive, or he would get a headache 
that wouldn't go away.  In any case, he believed very strongly that 
Marburg wasn't easy to catch, and he didn't think there was any danger to 
his family or to anyone else around town.
	But think about Dan Dalgard cutting into monkeys.  Bending over 
and breathing monkey when he opened their abdomens.  He was bending over 
their intestines, over a pool of Marburg blood.  So then, why isn't 
Dalgard dead?  Well, he reasoned, nothing's happened to him, so maybe 
nothing will happen to us.
	Where had it come from?  Was it a new strain?  What was it capable 
of doing to human?  The discoverer of a new strain of virus gets to name 
it.  Jahrling thought about that, too.  If he and Tom were locked up in 
the Slammer, they would not be able to carry out any research on this 
virus.  They were on the verge of a major discovery, and the glory of it 
perhaps tantalized them.  To find a filovirus near Washington was the 
discovery of a lifetime.
	For all these reasons, they decided to keep their mouths shut.
	They decided to test their blood for the virus.  Jahrling said 
something to Geisbert like, "We are going to get blood samples drawn from 
ourselves like right now."  If their blood went positive, they could 
immediately report to the Slammer.  If their blood remained negative and 
they didn't develop other symptoms, then there are little chance they 
could infect anyone else.
	Obviously they did not want to go to the regular clinic to have an 
Army nurse take their blood.  So they found a friendly civilian technician 
and he twisted a rubber band around their arms, and they watched while he 
filled some tubes with their blood.  He understood what had happened, and 
he said he would keep his mouth shut.  Jahrling then put on a space suit 
and carried his own blood into his Level 4 hot lab.  He also took with him 
Geisbert's blood and the flasks of milky stuff.  It was very strange, 
handling your own blood while wearing a space suit.  It seemed, however, 
quite risky to let his blood lie around where someone might be 
accidentally exposed to it.  His blood had to be biocontained in a hot 
zone.  If it was infected with Marburg, he didn't want to be responsible 
for it killing anyone.  He said to himself, Given that this was a piece of 
mystery meat sniffed out of a monkey carcass, I should have been a little 
more careful...
	Tom Geisbert went off to collect some pickled monkey liver that he 
could photograph for viruses, hoping to prove that the Marburg-like agent 
lived in the monkeys.  He found a plastic jug that contained sterilized 
pieces of liver from Monkey O53.  He fished some liver out of the jug, 
clipped a few bits of it, and fixed the bit in plastic.  This was a slow 
job and took many hours to finish.  He left the plastic to cure overnight 
and went home for a couple of hours to try to get some sleep.

THE SECOND ANGEL

NOVEMBER 28, TUESDAY

TOM GEISBERT LIVED in a small town in West Virginia, across the Potomac 
River.  After his separation from his wife, his two children had stayed 
with her for a time, and now they were staying with him, or rather, they 
were staying with his parents in their house down the road.  Both his 
children were toddlers.
	He got up at four o'clock in the morning, drank a cup of coffee, 
and skipped breakfast.  He drove his Bronco in pitch darkness across the 
Potomac River and through Antietam National Battlefield, a broad ridge of 
cornfields and farmland scattered with stone monuments to the dead.  He 
passed through the front gate of Fort Detrick, parked, and went past the 
security desk and into his microscope area.
	The dawn came gray, gusty, and warm.  As light the color of old 
aluminum glimmered around the Institute, Tom sliced pieces of monkey liver 
with his diamond knife and put them into the electron microscope.  A few 
minutes later, he took a photograph of virus particles budding directly 
out of cells in the liver of Monkey O53.  The animal's liver was full of 
snakes.  These photographs were definite proof that the virus was 
multiplying the Reston monkeys-that it was not a laboratory contamination. 
 He also found inclusion bodies inside the monkey's liver cells.  The 
animal's liver was being transformed into crystal bricks.
	He carried his new photographs to Peter Jahrling's office.  Then 
they both went to see Colonel C.J. Peters.  The colonel stared at the 
photographs.  Okay-he was convinced, too.  The agent was growing in those 
monkeys.  Now they would have to wait for Jahrling's test results, because 
that would be the final confirmation that it was indeed Marburg.
	Jahrling wanted to nail down this Marburg as fast as he could.  He 
spent most of the day in a space suit, working in his hot lab, putting 
together his tests.  In the middle of the day, he decided that he had to 
call Dan Dalgard.  He couldn't wait any longer, even without test results. 
 He wanted to warn Dalgard of the danger, yet he wanted to deliver the 
warning carefully, so as not to cause a panic in the monkey house.  "You 
definitely have SHF in the monkey house," he said.  "We have definitely 
confirmed that.  However, there is also the possibility of a second agent 
in at least some of the animals."
	"What agent?  Can you tell me what agent?" Dalgard asked.
	"I don't want to identify the agent right now," Jahrling said, 
"because I don't want to start a panic.  But there are serious potential 
public health hazards associated with it, if, in fact, we are dealing with 
this particular agent."
	Somehow, the way Jahrling used the words panic and particular made 
Dalgard think of Marburg virus.  Everyone who handled monkeys knew about 
Marburg.  It was a virus that could easily make people panic.
	"Is it Marburg or some similar agent?" Dalgard asked.
	"Yes, something like that," Jahrling said.  "We'll have 
confirmation later in the day.  I'm working on the tests now.  I feel it's 
unlikely the results will be positive for this second agent.  But you 
should take precautions not to do any necropsies on any animals until 
we've completed the tests.  Look, I don't want to set off too many 
whistles and bells, but I don't want you and your employees walking into 
that room unnecessarily."
	"How soon can you get back to me with definite yes or no about 
this second agent?  We need to know as soon as possible."
	"I'll call you back today.  I promise," Jahrling said.
	Dalgard hung up the phone highly disturbed, but he maintained his 
usual calm manner.  A second agent, and it sounded as if it was Marburg.  
The people who had died in Germany, he knew, had been handling raw, blood 
monkey meat.  The meat was full of virus, and they got it on their hands, 
or they rubbed it on their eyelids.  He and other people at the company 
had been cutting into sick monkeys since October-and yet no one had become 
sick.  Everyone had worn rubber gloves.  He wasn't afraid for himself-he 
felt fine-but he began to worry about the others.  He thought, Even if the 
virus is Marburg, the situation is still no different from before.  We're 
still stuck in a pot.  The question is how to get ourselves out of this 
pot.  He called Bill Volt and ordered him not to cut into any more 
monkeys.  Then he sat in his office, getting more and more annoyed as the 
day darkened and Peter Jahrling did not call him back.  He wondered if any 
of the men had cut themselves with a scalpel while performing a dissection 
of diseased monkey.  Chances were they wouldn't file an accident report.  
He knew for sure that he had not cut himself.  But he had performed a mass 
sacrifice of approximately fifty animals.  He had been in contact with 
fifty animals.  How long had it been since then?  He should be showing 
some symptoms by now.  Bloody nose, fever, something like that.
	At five-thirty, he called Jahrling's office and got a soldier on 
the phone, who answered by saying, "How can I help you, sir or ma'am? ... 
I'm sorry, sir, Dr. Jahrling is not in his office ... No sir, I don't know 
where he is, sir ... No, he has not left work.  May I take a message, 
sir?"  Dalgard left a message for Jahrling to call him at home.  He was 
felling steadily more annoyed.

1500 HOURS

JAHRLING WAS IN his space suit.  He worked steadily all afternoon in his 
own lab, hot zone AA-4, at the center of the building, where he fiddled 
with the flasks of virus culture from the monkey house.  It was a slow, 
irritating job.  His tests involved making samples glow under ultraviolet 
light.  If he could make the samples glow, then he knew he had the virus.
	In order to do this, he needed to use blood serum from human 
victims.  The blood serum would react to viruses.  He went to the 
freezers, and got out vials of frozen blood serum from three people.  Two 
of the people had died; and one had survived.  They were:

	1.	Musoke - A test for Marburg.  Serum from the blood of Dr. 
Shem Musoke, a survivor.  (Presumably reactive against the Kitum Cave 
strain, which had started with Charles Monet and jumped into Dr. Musoke's 
eyes in the black vomit.)

	2.	Boniface - A test for Ebola Sudan.  From a man named 
Boniface who died in Sudan.

	3.	Mayinga - A test for Ebola Zaire.  Nurse Mayinga's blood 
serum.

The test was delicate, and took hours to complete.  It was not made easier 
by the fact that he was shuffling around in his space suit the whole time. 
 First he put droplets of cells from the monkey culture onto glass slides, 
and let them dry, and treated them with chemicals.  Then he put drops of 
the blood serum on the slides.  They would glow in the presence of target 
virus.
	Now it was time to look.  This had to be done in total darkness, 
because the glow would be faint.  He shuffled over to a storage closet, 
and went inside it, and closed the door behind him.  A microscope sat on a 
table in the closet, and there was a chair, and from the wall hung an air 
hose.  He plugged the hose into his space suit and put the slides into the 
microscope.  Then he turned out the lights.  He felt around in the 
darkness for the chair, and sat down.  This was not a fun place to be if 
you happened to have a touch of claustrophobia-sitting in a pitch-black 
Level 4 closet while wearing a space suit.  Peter Jahrling had made his 
peace with suffocation and darkness a long time ago.  He waited for a 
minute to give his eye time to adapt to the dark, and the little sparkles 
of light in his eyes as they adjusted to the darkness eventually faded 
away, while cool, dry air roared around his face and whiffled the hair on 
his forehead.  Then he looked through the binocular eyepieces of the 
microscope.  He wore his eyeglasses inside his space suit, and that made 
it particularly difficult to see.  He pressed the faceplate against his 
nose and squinted.  He moved his face from side to side.  His nose left a 
greasy streak inside his faceplate.  He twisted his helmet unit it was 
turned nearly sideways.  Finally he saw through the eyepieces.
	Two circles drifted into his sight, and he focused his eyes, 
bringing the circles together.  He was looking down into vast terrain.  He 
saw cells dimly outlined in a faint glow.  It was like flying over a 
country at night, over thinly populated lands.  It was normal to see a 
faint glow.  He was looking for a bright glow.  He was looking for a city. 
 He scanned the slides with his eyes, back and forth, back and forth, 
moving across the microscopic world, looking for a telltale greenish glow.
	The Musoke did not glow.
	The Boniface glowed weakly.
	To his horror, the Mayinga glowed brightly.
	He jerked his head back.  Aw, no!  He adjusted his helmet and 
looked again.  The Mayinga blood serum was still glowing.  The dead 
woman's blood was reacting to the virus in the monkey house.  He got an 
ugly feeling in the pit of his stomach.  Those monkeys didn't have 
Marburg.  They had Ebola.  Those animals were dying of Ebola Zaire.  His 
stomach lurched and turned over, and he sat frozen in the dark closet, 
with only the sound of his air and the thud of his heart.

CHAIN OF COMMAND

1600 HOURS, TUESDAY

THIS CAN'T BE Ebola Zaire, Peter Jahrling thought.  Somebody must have 
switched the samples by accident.  He looked again.  Yeah, the Mayinga 
blood serum was definitely glowing.  It meant he and Tom could be infected 
with Ebola Zaire, which kills nine out of ten victims.  He decided that he 
had made a mistake in his experiment.  He must have accidentally switched 
around his samples or gotten something mixed up.
	He decided to do the test again.  He turned on the lights in the 
closet and scuffled out into his lab, this time keeping careful track of 
his vials, bottles, and slides to make sure that nothing got mixed up.  
Then he carried the new samples back into the closet and turned out the 
lights and looked again into the his microscope.
	Once again, the Mayinga blood glowed.
	So maybe it really was Ebola Zaire or something closely related to 
it-the dead woman's blood "knew" this virus, and reacted to it.  Good 
thing this ain't Marburg-well, guess what, it ain't Marburg.  This is the 
honker from Zaire, or maybe its twin sister.  Ebola had never seen outside 
Africa.  What was it doing near Washington?  How in the hell had it gotten 
here?  What would it do?  He thought, I'm onto something really hot.
	He was wearing his space suit, but he didn't want to take the time 
to decon out through the air lock.  There was an emergency telephone on 
the wall in his lab.  He disconnected his air hose to extinguish the roar 
of air so that he could hear through the receiver, and he punched C.J. 
Peters' phone number.
	"C.j.!" he shouted through his helmet.  "IT'S PETER JAHRLING.  
IT'S REAL, AND IT'S EBOLA."
	"Naw!" C.J. replied.
	"YEAH."
	"Ebola?  It's gotta be a contamination," C.J. said.
	"no, IT ISN'T A CONTAMINATION."
	"Could you have gotten the samples mixed up?"
	"YEAH, I KNOW-MY FIRST THOUGHT WAS THAT SOMEBODY HAD SWITCHED THE 
SAMPLES.  BUT THEY WEREN'T SWITCHED, C.J.-BECAUSE I DID THE TEST TWICE."
	"Twice?"
	"EBOLA ZAIRE BOTH TIMES.  I'VE GOT THE RESULTS RIGHT HERE.  I CAN 
PASS THEM TO YOU.  TAKE A LOOK FOR YOURSELF."
	"I'm coming down there," C.J. said.  He hung up the phone and 
hurried downstairs to Jahrling's hot lab.
	Jahrling, meanwhile, picked up a sheet of waterproof paper on 
which he had written the results of his tests.  He slid the paper into a 
tank full of EnviroChem.  The tank went through the wall to a Level 0 
corridor outside the hot zone.  The tank worked on the same principle as a 
sliding cash drawer in a teller's window.  You could pass an object from 
the hot zone through a tank into the normal world.  It would be 
disinfected on its way through the tank.
	C.J. stood at a thick glass window on the other side, looking in 
at Jahrling.  They waited for several minutes while the chemicals 
penetrated the paper and sterilized it.  Then C.J. opened the tank from 
his side and removed the paper, dripping with chemicals, and held it in 
his hands.  He motioned to Jahrling through the window: Go back to the 
phone.
	Jahrling shuffled back to the emergency telephone and waited for 
it to ring.  It rang, and there was C.J.'s voice on the line: "Get out of 
there, and let's go see the commander!"
	It was time to move this thing up the chain of command.
	Jahrling deconned out through the air lock, got dressed in his 
street clothes, and hurried to C.J. Peters's office, and they both went to 
the office of the commander of USAMRIID, a colonel named David Huxsoll.  
They brushed past his secretary-told her it was an emergency-and sat down 
at a conference table in his office.
	"Guess what?" C.J. said. "It looks like we've found a filovirus in 
a bunch of monkeys outside Washington.  We've recovered what we think is 
Ebola."
	Colonel David Huxsoll was an expert in biohazards, and this was 
the sort of situation he thought the Institute was prepared to handle.  
Within minutes, he telephoned Major General Philip K. Russell, MD, who was 
the commander of the United States Army Medical Research and Development 
Command, which has authority over USAMRIID, and had set up a meeting in 
Russell's office in another building at Fort Detrick.
	Huxsoll and C.J. Peters spent a few moments talking about who else 
should be brought in.  They hit upon Lieutenant Colonel Nancy Jaax, the 
Institute's chief of pathology.  She could identify the signs of Ebola in 
a monkey.  Huxsoll picked up his phone.  "Nancy, it's David Huxsoll.  Can 
you get over to Phil Russell's office right now?  It's damned important."
	"It was a dark November evening, and the base was beginning to 
quiet down for the night.  At the moment of sundown that day, there was no 
sun visible, only a dying of the light behind clouds that flowed off 
Catoctin Mountain.  Jaax met Jahrling and the two colonels on their way 
across the parade ground beside the Institute.  A detail of marching 
soldiers stopped before the flagpole.  The group of people from the 
Institute also stopped.  From a loudspeaker came a roar of a cannon and 
then the bugle music of "Retreat," cracklish and cheap-sounding in the 
air, and the soldiers lowered the flag while the officers came to 
attention and saluted.  C.J. Peters felt both embarrassed and oddly moved. 
 "Retreat" ended, and the soldiers folded up the flag, and the Institute 
people continued on their way.
	General Russell's office occupied a corner of a low-slung Second 
World War barracks that had been recently plastered with stucco into a 
hopeless effort to make it look new.  It had a view of the legs of Fort 
Detrick's water tower.  Consequently, the general never opened his 
curtains.  The visitors sat on a couch and hairs, and the general settled 
behind his desk.  He was a medical doctor who had hunted viruses in 
Southeast Asia.  He was in his late fifties, a tall man with hair thinning 
on top and gray at the temples, lined cheeks, a long jaw, pale blue eyes 
that gave him a look of intensity, and a booming, deep voice.
	C.J. Peters handed the general a folder containing the photographs 
of the life form in the monkey house.
	General Russell stared, "Holy shit," he said.  He drew a breath.  
"Man.  That's filovirus.  Who the hell took this picture?"  He flipped to 
the next one.
	"These were done by my microscopist, Tom Geisbert," Jahrling said. 
"It could be Ebola.  The tests are showing positive for Ebola Zair."
	C.J. then gave an overview of the situation, telling the general 
about the monkeys in Reston, and finishing with these words: "I'd say we 
have a major pucker factor about the virus in those monkeys."
	"Well, how certain are you that it's Ebola?" General Russell 
asked. "I'm wondering if this could be Marburg."
	Jahrling explained why he didn't think it was Marburg.  He had 
done his test twice, he said, and both times the samples were positive to 
the Mayinga strain of Ebola Zaire.  As he spoke to the general, he was 
very careful to say that test did not in itself prove that the virus was 
Ebola Zaire.  It showed only that is was closely related to Ebola Zaire.  
It might be Ebola, or it might be something else-something new and 
different.
	C.J. said, "We have to be very concerned and very puckered if it 
is of the same ilk as Ebola."
	They had to be very puckered, Russell agreed. "We have a natural 
emergency on our hands," he said. "This is an infectious threat of major 
consequences."  He remarked that this type of virus had never been seen 
before in the United States, and it was right outside Washington.  "What 
the hell are we going to do about it?"  he said.  Then he asked them if 
there was any evidence that the virus could travel through air.  That was 
a crucial question.
	There was evidence, horrifying but incomplete, that Ebola could 
travel through the air.  Nancy Jaax described the incident in which her 
two healthy monkeys had died of presumably airborne Ebola in the weeks 
after the bloody-glove incident, in 1983.  There was more evidence, and 
she described that, too.  In 1986, Gene Johnson had infected monkeys with 
Ebola and Marburg by letting them breathe it into their lungs, and she had 
been the pathologist for that experiment.  All of the monkeys exposed to 
airborne virus had died except for one monkey, which managed to survive 
Marburg.  The virus, therefore, could infect the lungs on contact.  
Furthermore, the lethal dose was fairly small: as small as five hundred 
infectious virus particles.  That many particles of airborne Ebola could 
easily hatch out of a single cell.  A tiny amount of airborne Ebola could 
nuke a building full of people if it got into the airconditioning system.  
The stuff could be like plutonium.  The stuff could be worse than 
plutonium because it could replicate.
	C.J. said, "We know it's infectious by air, but we don't know how 
infectious."
	Russell turned to Jaax and asked, "Has this been published?  Did 
you publish it?"
	"No, sir," she said.
	He glared at her.  She could see him thinking, Well, Jaax, why the 
hell hasn't it been published?
	There were plenty of reasons, but she didn't feel like giving them 
just now.  She believed that Gene Johnson, her collaborator, had 
difficulty writing papers.  And, well, they just had not gotten around to 
publishing it, that was all.  It happens.  People sometimes just don't get 
around to publishing papers.
	Hearing the discussion, Peter Jahrling chose not to mention to the 
general that he might have sniffed just a little bit of it.  Anyway, he 
hadn't sniffed it, he had only whiffed it.  He had kind of like waved his 
hand over it, just to bring the scent to his nose.  He hadn't inhaled it.  
He hadn't like jammed the flask up in his nostril and snorted it or 
anything like that.  Yet he had a feeling he knew what the general might 
do if he found out about it-the general would erupt in enough profanity to 
lift Jahrling off his feet and drop him into the Slammer.
	Then there was the additional frightening possibility that this 
virus near Washington was not Ebola Zaire.  That it was something else.  
Another hot strain from the rain forest.  An unknown emerger.  And who 
could say how it moved or what it could do to humans?  General Russell 
began to think out loud.  "We could be in for a hellacious event," he 
said. "Given that we have an agent with a potential to cause severe human 
disease, and given that it appears to be uncontrolled in the monkey house, 
what do we do?  We need to do the right thing, and we need to do it fast.  
How big is this sucker?  And are people going to die?"  He turned to 
Colonel C.J. Peters and asked, "So what are our option here?"
	C.J. had been thinking about this already.  There are three ways 
to stop a virus-vaccines, drugs and biocontainment.  For Ebola, there was 
only one way to stop it.  There was no vaccine for Ebola.  There was no 
drug treatment for Ebola.  That left only biocontainment.
	But how to achieve biocontainment?  That was tricky.  As far as 
C.J. could see, there were only two options.  The first option was to seal 
off the monkey colony and watch the monkey die-and also keep a close watch 
on the people who had handled the monkeys and possibly put them into 
quarantine as well.  The second option was to go into the building and 
sterilize the whole place.  Kill the monkeys-give them lethal 
injections-burn their carcasses, and drench the entire building with 
chemicals and fumes-a major biohazard operation.
	General Russell listened and sad, "So option one is to cut the 
monkeys off from the rest of the world and let the virus run its course in 
them.  And option two is to wipe them out.  There aren't any more options."
	Everyone agreed that there were no other options.
	Nancy Jaax was thinking.  It may be in the monkey house now, but 
it ain't going to stay there very damn long.  She had never seen a monkey 
survive Ebola.  And Ebola is a species jumper.  All of those monkeys were 
going to die, and they were going to die in a way that was almost 
unimaginable.  Very few people on earth had seen Ebola do its work on a 
primate, but she knew exactly what it could do.  She did not see how the 
virus could be contained unless the monkey house was set up for quarantine 
with an independently filtered air supply.  She said, "How ethical is it 
to let these animals go a long time before they die?  And how do we assure 
the safety of people in the meantime?  I've watched these guys  die of 
Ebola, and it's not a fun way to go-they're sick, sick, sick animals."  
She said that she wanted to go into the monkey house to look at the 
monkeys.  "The lesions are easy to miss unless you know what you are 
looking for," she said, "and then it's as plain as the nose on you face."
	She also wanted to go there to look at pieces of tissue under a 
microscope.  She wanted to look for crystalloids, or "inclusion bodies"  
Bricks.  If she could find them in the monkey meat, that would be another 
confirmation that the monkeys were hot.
	Meanwhile, there was the larger question of politics.  Should the 
Army become involved?  The Army has a mission, which is to defend the 
country against military threats.  Was this virus a military threat?  The 
sense of the meeting ran like this: military threat or not, if we are 
going to stop this agent, we've got to throw everything at it that we've 
got.
	That would create a small political problem.  Actually it would 
create a large political problem.  The problem had to do with the Centers 
for Disease Control in Atlanta, Georgia.  The C.D.C. is the federal agency 
that deals with emerging diseases.  It has a mandate from Congress to 
control human disease.  This is the C.D.C.'s lawful job.  The Army does 
not exactly have a mandate to flight viruses on American soil.  Yet the 
Army has the capability and the expertise to do it.  Everyone in the room 
could see that a confrontation might boil up with the C.D.C. if the Army 
decided to move in on the monkey house.  There were people at C.D.C. who 
could be jealous of their turf.  "The Army doesn't have the statutory 
responsibility to take care of this situation," General Russell pointed 
out, "but the Army has the capability.  The C.D.C. doesn't have the 
capability.  We have the muscle but not the authority.  The C.D.C. has the 
authority but not the muscle.  And there's going to be a pissing contest."
	In the opinion of General Russell, this was a job for soldiers 
operating under a chain of command.  There would be a need for people 
trained in biohazard work.  They would have to be young, without families, 
willing to risk their lives.  They would have to know each other and be 
able to work in teams.  They had to be ready to die.
	In fact, the Army had never before organized a major field 
operation against a hot virus.  The whole thing would have to be put 
together from scratch.
	Obviously there were legal questions here.  Lawyers were going to 
have to be consulted.  Was this legal?  Could the Army simply put together 
a biohazard SWAT team and move in on the monkey house?  General Russell 
was afraid the Army's lawyers would tell him that it could not, and should 
not, be done, so he answered the legal doubts with these words: "A policy 
of moving out and doing it, an asking forgiveness afterward, is much 
better than a policy of asking permission and having it denied.  You never 
ask a lawyer for permission to do something.  We are going to do the 
needful, and the lawyers are going to tell us why it's legal."
	By this time, the people in the room were shouting and 
interrupting one another.  General Russell, still thinking out loud, 
boomed, "So the next question is, Who the fuck is going to pay for it?"  
Before anyone had a chance to speak, he answered the question himself.  
"I'll get the money.  I'll beat it out of somebody."
	More shouting.
	The general's voice rose above the noise.  "This is a big one 
coming, so let's not screw it up, fellas," he said. "Let's write the right 
game plan and then execute it."  In the Army, an important job is called a 
mission, and a mission is always carried out by a team, and every team has 
a leader.  "We have to agree on who is going to be in charge of this 
operation," the general continued. "C.J. Peters has got this action here.  
He's in charge of the operation.  He's the designated team leader.  Okay?  
Everybody agreed on that?
	Everybody agreed.
	"C.J., what we need is a meeting," the general said. "Tomorrow 
we're going to have a meeting.  We have to call everybody."
	He looked at the clock on the wall.  It was five-thirty, rush 
hour.  People were leaving work, and monkeys were dying in Reston, and the 
virus was on the move.  "We've got to pull the chain on this whole thing,' 
the general said. "We'll have to inform everybody simultaneously, as soon 
as possible.  I want to start with Fred Murphy at the C.D.C.  I don't want 
him to be sandbagged by this."
	Frederick A. Murphy was one of the original discovers of Ebola 
virus, the wizard with an electron microscope who had first photographed 
the virus and whose work had hung in art museums.  He was an old friend of 
General Russell's.  He was also an important official at C.D.C., the 
director of the National Center for Infectious Diseases.
	Russells put his hand on the telephone on his desk.  He stared 
around the room.  "One last time: are you sure you've got what you think 
you've got?  Because I'm gonna to make this phone call.  If you don't have 
a filovirus, we will look like real assholes."
	Around the room, one by one, they told him they were convinced it 
was a thread virus.
	"All right.  Then I'm satisfied we've got it."
	He dialed Murphy's number in Atlanta.
	"Sorry-Dr. Murphy has gone home for the day."
	He pulled out his black book and found Murphy's home phone number. 
 He reached Murphy in his kitchen, where he was chatting with his wife.  
"Fred, It's Phil Russell ... Great, how about yourself? ... Fred, we've 
isolated an Ebola-like agent outside Washington ... Yeah.  Outside 
Washington."
	A grin spread over Russell's face, and he held the phone away from 
his ear and looked around the room.  Evidently Murphy was having some kind 
of a noisy reaction.  Then General Russell said into the receiver, "No, 
Fred, we're not smoking dope.  We've got an Ebola-like virus.  We've seen 
it ... Yeah, we have pictures."  There was a pause, and he put his hand 
over the mouthpiece and said to the room, "He thinks we've got crud in our 
scope."
	Murphy wanted to know who took the pictures and who analyzed them.
	"It was a kid who took the pictures.  Young guy named-what's his 
name?-Geisbert.  And we're looking at them right here."
	Murphy said he would fly up to Fort Detrick tomorrow morning to 
look 
at the pictures and review the evidence.  He took it extremely seriously.

1830 HOURS, TUESDAY

DAN DALGARD HAD to called, and they had to notify Virginia state health 
authorities.  "I'm not even sure who the state authorities are," Russell 
said. "And we've got to get them on the phone right now."  People were 
leaving work.  "We'll have to call people at home.  It's going to be a 
bunch of phone calls."  What county was that monkey house located in?  
Fairfax County, Virginia.  My, oh my, a nice place to live.  Fairfax 
County-beautiful neighborhoods, lakes, golf course, expensive homes, good 
schools, and Ebola.  "We'll have to call the county health department," 
the general said.  They would also have to call the U.S. Department of 
Agriculture, which has control over imported monkeys.  They would have to 
call the Environmental Protection Agency, which has jurisdiction in cases 
of environmental contamination by an extreme biohazard.  General Russell 
also decided to call an assistant secretary of defense, just to get the 
Pentagon noticed.
	People left the room and fanned out along the hallways, going into 
empty offices and making the calls.  C.J. Peters, now the team leader, 
went into another office down the hall and called Dan Dalgard's office, 
with Peter Jahrling on an extension line.  Dalgard had gone home.  They 
called Dalgard's home, and Dalgard's wife told him that Dan hadn't arrived 
yet.  At about half past six, they called Dalgard's house again, and this 
time they got him.  "This is Colonel C.J. Peters, up at USAMRIID.  I'm the 
chief of the disease-assessment division ... How do you do? ... Anyway, 
I'm calling to report that the second agent is apparently not Marburg.  
The second agent is Ebola virus."
	"What is Ebola?" Dalgard asked.  He had never heard of Ebola.  The 
word had no meaning for him.
	In his smoothest Texas voice, C.J. Peters said, "It's a rather 
rare viral disease that has been responsible for human fatalities in 
outbreaks in Zaire and Sudan within the past ten or twelve years."
	Dalgard was starting to feel relieved-good thing it isn't Marburg. 
 "What is the nature of Ebola virus?" he asked.
	C.J. described the virus in vague terms.  "It is related to 
Marburg.  It is transmitted the same way, through contact with infected 
tissue and blood, and the signs and symptoms are much the same."
	"How bad is it?"
	"The case-fatality rate is fifty to ninety percent."
	Dalgard understood exactly what that meant.  The virus was much 
worse than Marburg.
	C.J. continued, "With the information we have, we are going to 
notify state and national public health officials."
	Dalgard spoke carefully, "Would you, ahem, would you please wait 
until seven p.m., to allow me to apprise my corporate head-quarters of 
recent development?"
	C.J. agreed to wait before pulling the trigger, through in fact 
General Russell had already called the C.D.C.  Now C.J. had a favor to ask 
of Dalgard.  Would it be all right if he sent someone down to Reston 
tomorrow to have a look at some sample of dead monkeys?
	Dalgard resisted.  He had sent a little bit of blood and tissue to 
the Army for diagnosis-and look what was happening.  This thing could go 
way out of control.  He sensed that Colonel Peters was not telling him all 
there was to know about this virus called Ebola.  Dalgard feared he could 
lose control of the situation in a hurry if he let the Army get its foot 
in the door.  "Why don't we meet by phone early tomorrow and discuss this 
approach?"  Dalgard replied.
	After the phone call, C.J. Peters found Nancy Jaax and asked her 
if she would come with him to meet Dalgard the next day and look at some 
monkey tissue.  He assumed Dalgard would give permission.  She agreed to 
go with him.

NANCY JAAX WALKED across the parade ground back to the Institute and found 
Jerry in his office.  He looked up at her with a pained expression on his 
face.  He had been staring out the window and thinking about his brother.  
It was dark; there was nothing to see out there except a blank wall.
	She closed the door.  "I've got something for you.  This is close 
hold.  This is hush-hush.  You are not going to believe this.  There's 
Ebola virus in a monkey colony in Virginia."
	They drove home, talking about it, traveling north on the road 
that led to Thurmont along the foot of Catoctin Mountain.
	"This is killing me-I'll never get away from this bug," she said 
to him.
	It seemed clear that they both were going to be involved in the 
Army action.  It wasn't clear what kind of an action it would be, but 
certainly something big was going to go down.  She told Jerry that 
tomorrow she would probably visit the monkey house with C.J. and that she 
would be looking at monkey tissues for signs of Ebola.
	Jerry was profoundly surprised: so this was what Nancy's work with 
Ebola had come to.  He was impressed with his wife and bemused by the 
situation.  If he was worried about her, he didn't show it.
	They turned up a gentle swing of road that ran along the side of 
the mountain, and passed through apple orchards, and turned into their 
driveway.  It was eight o'clock, and Jason was home.  Jaime had gone off 
to her gymnastic practice.  The kids were latchkey children now.
	Jason was doing his homework.  He had made himself a microwave 
dinner of God knows what.  Their son was a self-starter, a little bit of a 
loner, and very self-sufficient.  All he needed was food and money, and he 
ran by himself.
	The two colonels changed out of their uniforms into sweat clothes, 
and Nancy put a frozen chunk of her homemade stew into the microwave and 
thawed it.  When the stew was warm, she poured it into a Thermos jar.  She 
put the dog and the Thermos into a car, and she drove out to get Jaime at 
her gymnastics practice.  The gym was a half hour's drive from Thurmont.  
Nancy picked up Jaime and gave her the stew to eat in the car.  Jaime was 
an athletic girl, short, dark haired, sometimes inclined to worry about 
things-and she was exhausted from her workout.  She ate the stew and fell 
asleep on the back seat while Nancy drove her home.
	The Colonel Jaaxes had a water bed, where they spent a lot of 
time.  Jaime got into her pajama and curled up on the water bed next to 
Nancy and fell asleep again.	
	Nancy and Jerry read books in bed for a while.  The bedroom had 
red wallpaper and a balcony that overlooked the town.  They talked about 
the monkey house, and then Nancy picked up Jaime and carried her into her 
own bedroom and tucked her into her bed.  Around midnight, Nancy fell 
asleep.
	Jerry continued to read.  He liked to read military history.  Some 
of the most brutal combat in history had occurred in the rolling country 
around Catoctin Mountain: at the cornfield at Antietam, where every 
individual stalk of corn had been slashed away by bullets, and where the 
bodies had lain so thick a person could walk on them from one end of the 
cornfield to the other.  He could look out his bedroom window and imagine 
the blue and gray armies crawling across the land.  That night he happened 
to be reading The Killer Angels, a novel by Michael Shaara about the 
Battle of Gettysburg:
	Then Lee said slowly, "Soldiering has one great trap."
	Longstreet turned to see his face.  Lee was riding slowly ahead,
	without expression.  He spoke in that same slow voice.
	"To be a good soldier you must love the army.  But to be a good
	officer you must be willing to order the death of the thing you
	love.  That is ... a very hard thing to do.  No other profession
	requires it.  That is one reason why there are so few very good
	officers.  Although there are many good men."

	He switched out the light, but he could not sleep.  He rolled 
over, and the water bed gurgled.  Every time he closed his eyes, he 
thought about his brother, John, and he saw in his mind's eye an office 
splattered with blood.  Eventually it was two o'clock in the morning and 
he was still awake, thinking to himself, I'm just laying here in the dark, 
and nothing's happening.

GARBAGE BAGS

NOVEMBER 29, WEDNESDAY

DAN DALGARD SLEPT peacefully that night, as he always did.  He had never 
heard of Ebola virus, but the brief conversation with Colonel C.J. Peters 
had given him the basic picture.  He had been around monkeys and monkey 
diseases for a long time, and he was not particularly frightened.  Many 
days had passed during which he had been exposed to infected blood, and he 
certainly had not become sick yet.
	Early in the morning, his telephone rang at home.  It was Colonel 
Peters calling.  Again Peters asked him if he could send some people down 
to look at specimens of tissue from the monkeys.  Dalgard said that would 
be all right.  Peters then repeated his request to see the monkey house.  
Dalgard turned away the question and wouldn't answer it.  He didn't know 
Peters, and he wasn't going to open any doors to him until he had met the 
man and had a chance to size him up.
	He drove down Leesburg Pike to work, turned through a gate, parked 
his car, and went into the main building of Hazleton Washington.  His 
office was a tiny cubicle with a glass wall that looked across the lawn; 
his door looked back to a secretarial pool, a cramped area where you could 
hardly move around with bumping into people.  There was no privacy in 
Dalgard's office, it was a fishbowl.  He tended to spend a lot of time 
looking out the window.  Today he behaved with deliberate calm.  No one in 
the office detected any unusual emotion, any fear.
	He called Bill Volt, the manager of the monkey house.  Volt gave 
him a shocking piece of news.  One of the animal caretakers was very sick, 
might be dying.  During the night, the man had a heart attack and had been 
taken to London Hospital, not far away.  There's no further information, 
Volt said, and we're still trying to find out what happened.  He's in the 
cardiac-care unit, and no one can talk to him.  (The man's name will be 
given here as Jarvis Purdy.  He was one of four workers in the monkey 
house, not including Volt.)
	Dalgard was extremely dismayed and couldn't rule out the 
possibility that the man was breaking with Ebola.  A heart attack is 
usually caused by a blood clot in the heart muscle.  Had he thrown a clot? 
 Was Jarvis Purdy clotting up?  Suddenly Dalgard felt as if he was losing 
control of the situation.
	He told Bill Volt that he was to suspend all unnecessary activity 
in the monkey rooms.  As he later recorded in his diary:
	
	All operations other than feeding, observation and cleaning were
	to be suspended.  Anyone entering the rooms was to have full pro-
	taction-Tyvek suit, respirator, and gloves.  Dead animals were to
	be double-bagged and placed in a refrigerator.

He also mentioned to Volt that the news media were almost certainly going 
to get onto this story.  He told Volt that he didn't want any employees to 
go outside the building wearing their biohazard gear.  If pictures of 
Hazleton workers wearing face masks and white suits wound up on the 
evening news, it could cause panic.
	Dalgard called the hospital and reached Purdy's doctor.  The 
doctor said that Purdy's condition was guarded but stable.  Dalgard told 
the doctor that if any aspect of Purdy's heart attack wasn't typical, he 
should please call Colonel C.J. Peters at Fort Detrick.  He was careful 
not to mention the word Ebola.

LATER THAT MORNING, C.J. Peters and Nancy Jaax headed out from Fort 
Detrick for Virginia, and Gene Johnson came with them.  The officers wore 
their uniforms, but they drove in civilian cars so as not to attract 
attention.  The traffic moved slowly.  It was a clear, cold, windy day.  
The grass along the road was wet and green, still growing, untouched by 
frost.  They turned off Leesburg Pike at the Hazleton offices.  Dalgard 
met them in the lobby and escorted them to another building, which was a 
laboratory.  There a pathologist had prepared a set of slides for Nancy to 
look at.  The slides contained slices of liver from monkeys that had died 
in the monkey house.
	She sat down at a microscope, adjusted the eyepieces, and began to 
explore the terrain.  She zoomed around and paused.  The terrain was a 
mess.  Something had ravaged these cells.  They were blitzed and 
pock-marked, as if the liver had been carpet bombed.  Then she saw the 
dark blobs in the cells-the shadows that did not belong there.  They were 
crystalloids.  And they were huge.
	This was extreme amplification.
	"Oh, fuck," she said in a low voice.
	The bricks did not look like crystals.  Ebola bricks come in all 
kinds of shapes-horsehoes, blobs, lumps, even rings.  Some of the cells 
consisted of a single brick, a huge mother of a brick, a brick that had 
grown so fat that the whole cell had plumped up.  Shed saw rotten pockets 
where all the cells had popped and died, forming a liquefied spot that was 
packed with wall-to-wall bricks.
	While she looked at the slides, C.J. Peters and Gene Johnson took 
Dan Dalgard aside and questioned him closely about the use of needles at 
the monkey house.  The Ebola virus had spread in Zaire through dirty 
needles.  Had the company ben giving monkeys shots with dirty needles?
	Dalgard was not sure.  The company had an official policy of 
always using clean needles. "Our policy is to change needles after every 
injection," he said.  "Whether it is done religiously is anybody's guess."
	Nancy collected some pieces of sterilized liver and spleen that 
were embedded in wax blocks, and she put the blocks in a Styrol-foam cup 
to take back to Fort Detrick for analysis.  These samples were exceedingly 
valuable to her and to the Army.  What would be even more valuable would 
be a sample containing live virus.
	C.J. Peters asked Dalgard again if they could all go see the 
monkey house.
	"Well-let's not go there now," Dalgard replied.  He made it clear 
to the officers that the building was a private property.
	"What about some samples of monkey?  Can we get some samples?" 
they asked.
	"Sure," Dalgard said.  He told them to drive out Leesburg Pike in 
the direction of the monkey house.  There was an Amoco gas station on the 
pike, he said, and the colonels were to park their cars there and wait. "A 
guy is going to come and meet you.  He'll bring some samples with him.  
And he can answer your questions," he said.
	"The samples ought to be wrapped in plastic and put in boxes for 
safety," C.J. said to Dalgard.  "I want you to do that."
	Dalgard agreed to wrap the samples in plastic.
	Then C.J., Nancy and Gene drove out to the gas station, where they 
parked in a cul-de-sac by the highway, near some pay telephones.  By now 
it was early afternoon, and they were hungry-they had missed lunch.  Nancy 
went into the gas station and bought Diet Cokes for everyone and a pack of 
cheddar-cheese crackers for herself, and she bought C.J. some 
peanut-butter crackers.  The Army people sat in their two cars, eating 
junk food, feeling cold, and hoping that someone would show up soon with 
samples of monkey.
	C.J. Peters observed the comings and goings at the gas station.  
It gave him a sense of life and time passing, and he enjoyed the pleasant 
normality of the scene.  Truckers stopped for diesel and Cokes, and 
businesspeople stopped for cigarettes.  He noticed an attractive woman 
park her car and go over to one of the pay telephones, where she spoke at 
length to someone.  He whiled away the time imagining that she was a 
housewife talking to a boyfriend.  What would these people think if they 
knew what had invaded their town?  He had begun to think that the Army 
might have to act decisively to put out this fire.  He had been in Bolivia 
when a hot agent called Machupo had broken out, and he had seen a young 
woman die, covered with blood.  North America had not yet seen an 
emergence of an agent that turned people into bleeders.  North America was 
not ready for that, not yet.  But the possibilities for a huge break of 
Ebola around Washington were impressive when you thought about it.
	He wondered about AIDS.  What would have happened if someone had 
noticed AIDS when it first began to spread?  It had appeared without 
warning, secretly, and by the time we noticed it, it was too late.  If 
only we had the right kind of research station in central Africa during 
the nineteen-seventies ... we might have seen it hatching from the forest. 
 If only we had seen it coming ... we might have been abe to stop it, or 
at least slow it down; ... we might have been able to save at least a 
hundred million lives.  At least.  Because the AIDS virus's penetration of 
the human species was still in its early stages, and the penetration was 
happening inexorably.  People didn't realize that the AIDS thing had only 
just began.  No one could predict how many people were going to die of 
AIDS, but he believed that the death toll, in the end, could hit hundreds 
of millions-and that possibility had not sunk in with the general public.  
On the other hand, suppose AIDS had been noticed?  Any "realistic" review 
of the AIDS virus when it was first appearing in Africa would probably 
have led experts and government officials to conclude that the virus was 
of little significance for human health and that scarce research funds 
should not be allocated to it-after all, it was just a virus that infected 
a handful of Africans, and all it did was suppress their immune systems.  
So what?  And then the agent had gone on a tremendous amplification all 
over the planet, and it was still expanding its burn, with no end in sight.
	We didn't really know what Ebola virus could do.  We didn't know 
if the agent in the monkey house was, in fact, ebola Zaire or it was 
something else, some new strain of Ebola.  An agent that could travel in a 
cough?  Probably not, but who could tell?  The more he thought about it, 
the more he wondered,  Who is going to take out those monkeys?  Because 
someone is going to have to go in there and take them out.  We can't just 
walk away from that building and let it self-destruct.  This is a 
human-lethal virus.  Who is going to sack the monkeys?  The guys who work 
for the company?
	He ha begun to wonder whether the Army should move in with a 
military biohazard SWAT team.  His own term for this type of action was 
NUKE.  To nuke a place means to sterilize it, to render it lifeless.  If 
the hosts are people, you evacuate them and put them in the Slammer.  If 
the hosts are animals, you kill them and incinerate the carcasses.  Then 
you drench the place with chemicals and fumes.  He wondered if the Army 
would have to nuke the monkey house.
	Gene Johnson sat in the passenger seat next to C.J. Peters.  His 
mind was somewhere else.  His mind was in Africa.  He was thinking about 
Kitum Cave.
	Gene was very worried about this situation, not to say shit 
scared.  He thought to himself, I don't know how we are going to get out 
of this one without people dying.  His worry was growing all the time, 
every minute.  The U.S. military, he thought, is stepping into a crisis 
that is already full-blown, and if something goes wrong and people die, 
the military will be blamed.
	Suddenly he turned to C.J. and spoke his mind.  He said, "It looks 
inevitable that we're going to have to take out all the monkeys.  A Level 
4 outbreak is not a game.  I want to warn you about just how detailed and 
major an effort this is going to be.  It's going to be very complex, it's 
going to take some time, and we have to be very fucking careful to do it 
right.  If we are going to do it right, the gist of what I'm saying, C.J., 
is that we cannot have amateurs in key positions.  We need to have 
experienced people who knows what they are doing.  Do you understand 
what's going to happen if something goes wrong?"  And he was thinking: 
Peters-Peters-he's never been in an outbreak this complicated-none of us 
has-the only thing like it was Kitum Cave.  And Peters wasn't there.
	C.J. Peters listened to Gene Johnson in silence, and didn't reply. 
 He felt that it was sort of irritating to get this kind of advice from 
Gene-when he's telling you the obvious, telling you what you already know.
	C.J. Peters and Gene Johnson had a stressful, complicated 
relationship.  They had journeyed together in a truck expedition across 
central Africa, looking for Ebola virus, and a lot of tension had built up 
between the two men by the end of the trip.  The traveling had been 
brutal, as hard as any on earth-roads didn't exists, bridges were gone, 
the maps must have been drawn by a blind monk, the people spoke languages 
not even the native translators could understand, and the expedition had 
not been able to find enough food and water.  Worst of all, they ran into 
difficulty finding human cases of Ebola-they were not able to discover the 
virus in a natural host or in people.
	It was during that trip, perhaps as a result of the chronic food 
shortage, that C.J. had taken to eating termites.  The ones that swarmed 
out of their nests.  They had wings.  Gene, who was more fastidious than 
C.J., had not been quite so eager to try them.  Popping termites in his 
mouth, C.J. would make remarks like, "they have this extra...mmm...," and 
he would smack his lips, smack, smack, and you'd hear a mouthful of 
termites crunching between his teeth, and he'd spit out the wings, pah, 
ptah.  The African members of expedition, who liked termites, had pushed 
Gene to try them, too, and finally he did.  He placed a handful of them in 
his mouth, and was surprised to find that they tasted like walnuts.  C.J. 
had spoken longingly of finding the African termite queen, the glistening 
white sac that was half a foot long and as thick as bratwurst, bursting 
with eggs and creamy insect fat, the queen you ate alive and whole, and 
she was said to twitch as she went down your throat.  Although snacking on 
termites had amused them, they had argued with each other about how to do 
the science, how to search for the virus.  In Africa, Gene had felt that 
C.J. was trying to run the show, and it irritated Gene to no end.

SUDDENLY A BLUE, windowless, unmarked van turned off the road and pulled 
through the gas station and parked next to them.  The van parked in such a 
way that no one on the road or at the gas station could see what went on 
between the two vehicles.  A man swung heavily out of the driver's seat.  
It was Bill Volt.  He walked over to the Army people, and they got out of 
their cars.
	"I've got'em right back here," he said, and he threw open the side 
door of the van.
	They saw seven black plastic garbage bags sitting on the floor of 
the van.  They could see the outlines of limbs and heads in the bags.
	C.J. said to himself, What is this?
	Nancy gritted her teeth and silently pulled in a breath.  She 
could see how the bags bulged in places, as if liquid had pooled inside 
them.  She hoped it wasn't blood.  "What on earth is all of that?" she 
exclaimed.
	"They died last night," Volt said. "They're in double bags."
	Nancy was getting a nasty feeling in the pit of her stomach.  "Has 
anybody cut himself fooling around with these monkeys?" she asked.
	"No," Volt replied.
	Then Nancy noticed that C.J. was looking sideways at her.  It was 
a significant look.  The message was, So who's going to drive the dead 
monkeys back to Fort Detrick?
	Nancy stared back at C.J.  He was pushing her, and she knew it.  
They were both division chiefs at the Institute.  He outranked her, but he 
was not her boss.  He can push me just so far, and I can push him right 
back.  "I'm not putting that shit in the trunk of my car, C.J.," she said. 
"As a veterinarian, I have certain responsibilities with regard to the 
transportation of dead animals, sir.  I can't just knowingly ship a dead 
animal with an infectious disease across state lines."
	Dead silence.  A grin spread over C.J.'s face.
	"I agree that it needs to be done," Nancy went on. "You're a doc.  
You can get away with this."  She nodded at his shoulder boards.  "This is 
why you put on those big eagles."
	They burst into nervous laughter.
	Time was slipping away while the virus was amplifying inside the 
monkey house.  C.J. inspected the bags-it was a relief to see that the 
monkeys were double-bagged or triple-bagged-and he decided to take them 
back to Fort Detrick and worry about health laws afterward.  His 
reasoning, as he explained to me later, went like this: "If the guy drove 
them back to the Reston monkey facility, I felt there would be a certain 
added risk to the population just from his driving them around in the van, 
and there would be a delay in diagnosing them.  We felt that we could 
quickly get a definite diagnosis of Ebola it would be in everyone's 
favor."  Surely some smart Army lawyers could figure out why the act of 
carrying Ebola-ridden dead monkeys across state lines in the trunk of a 
private automobile was so completely legal that there had never ever been 
any question about it.
	His read Toyota was not in the best of shape, and he had lost any 
interest in its resale value.  He popped the trunk.  It was lined with 
carpet, and he didn't see any sharp edges anywhere that might puncture a 
plastic bag.
	They didn't have rubber gloves.  So they would do the lifting 
bare-handed.  Nancy, keeping her face well away from the enclosed air of 
the van, inspected the outside of the bags for any droplets of blood.  
"Have the exteriors of the bags been disinfected?" she asked Volt.
	Volt said he'd washed the outsides of the bags with Clorox bleach.
	She held her breath, fighting the puke factor, and picked up a 
bag.  The monkey kind of slid around inside it.  They piled the bags one 
by one gently in the Toyota's trunk.  Each monkey weighed between five and 
twelve pounds.  The total weight came to around fifty pounds of Biohazard 
Level 4 liquefying primate.  It depressed the rear end of the Toyota.  
C.J. closed the trunk.
	Nancy was anxious to dissect the monkeys right away.  If you left 
an Ebola monkey inside a plastic bag for a day, you'd end up with a bag of 
soup.
	"Follow behind me, and watch for drips," C.J. joked.

SPACE WALK

1400 HOURS, WEDNESDAY

THEY ARRIVED AT the Institute in midafternoon.  C.J. Peters parked beside 
a loading dock on the side of the building and found some soldiers to help 
him carry the garbage bags to a supply air lock that led to the Ebola 
suite.  Nancy went to the office of a member of her staff, a lieutenant 
colonel named Ron Trotter, and told him to suit up and go in; and she 
would follow.  They would be buddies in the hot zone.
	As she always did before going into Level 4, she took off her 
engagement ring and her wedding band, and locked them away in her desk.  
She and Trotter walked down the hall together, and he went first into the 
small locker room that led to AA-5 while she waited in the corridor.  A 
light went on, telling her that he had gone on to the next level, and she 
swiped her security card across a sensor, which opened the door into the 
locker room.  She took off all of her clothes, put on a long-sleeved scrub 
suit, and stood before the door that led inward, blue light falling on her 
face.  Beside the door there was another security sensor.  This one was a 
numerical key pad.  You can't bring your security card with you into the 
higher levels.  A security card would be melted or ruined by chemicals 
during the decontamination process.  Therefore you memorize your security 
code.  She punched a string of numbers on the key pad, and the building's 
central computer noticed that JAAX, NANCY, was attempting entry.  Finding 
that she was CLEARED TO ENTER AA-5, the computer unlocked the door and 
beeped to let her know that she could proceed inward without setting off 
alarms.  She walked through the shower stall into the bathroom, put on 
white socks, and continued inward, opening a door that led to the Level 3 
staging area.
	There she met Lieutenant Colonel Trotter, a stocky, dark haired 
man whom Nancy had worked with for many years.  They put on their inner 
gloves and taped the cuffs.  Nancy put a pair of hearing protectors over 
her ears.  She had started wearing them a while back, when people had 
begun to suspect that the roar of air in you suit might be loud enough to 
damage your hearing.  They edged around each other as they fiddled with 
their suits.  People wearing biohazard space suits tend to step around on 
another like two wrestlers at the beginning of a match, watching the other 
person's every move, especially watching the hands to make sure they don't 
hold a sharp object.  This cringing becomes instinctive.
	They closed up their suits and lumbered across the staging area to 
a larger air-lock door.  This was a supply air lock.  It did not lead into 
the hot zone.  It led to the outside world.  They opened it.  On the floor 
of the air lock sat the seven garbage bags.
	"TAKE AS MANY AS YOU CAN CARRY," she sad to Lieutenant Colonel 
Trotter.
	He picked up a few bags, and so did she.  They shuffled back 
across the staging area to the air-lock door that led to Level 4.  She 
picked up a metal pan containing tools.  She was getting warm, and her 
faceplate fogged up.  They opened air-lock door and stepped in together.  
Nancy took a breath and gathered her thoughts.  She imagined that passing 
through the gray-zone door into Level 4 was like a space walk, except that 
instead of going into outer space, you went into inner space, which was 
full of pressure of life trying to get inside you suit.  People went into 
Level 4 areas all the time at the Institute, particularly the civilian 
animal caretakers.  But going into a containment zone to perform a 
necropsy on an animal that had died of an amplified unknown hot agent was 
something a little different.  This was high-hazard work.
	Nancy centered herself and brought her breathing under control.  
She opened the far door and went through to the hot side.  Then she 
reached back inside the air lock and pulled the chain in the chemical 
shower.  That started a decon cycle running in the air lock that would 
eliminate any hot agents that might have leaked into the air lock as they 
were going through.
	They put on their boots and headed down the cinder-block hallway, 
lugging the monkeys.  Their air was going stale inside their space suits, 
and they needed to plug in right away.
	They came to a refrigerator room, and put all the bags in the 
refrigerator except for one.  This bag they carried into the necropsy 
room.  Stepping around each other cautiously, they plugged in their air 
hose, and dry air cleared their faceplates.  The air thundered distantly 
beyond Nancy's hearing protectors.  They gloved up, pulling surgical 
gloves over their space-suit gloves.  She laid her tools and specimen 
container at the head of the table, counting them off one by one.
	Trotter untwisted some ties on the garbage bag and opened it, and 
the hot zone inside the bag merged with the hot zone of the room.  He and 
Nancy together lifted the monkey out and laid it on the dissection table.  
She switched on a surgical lamp.
	Unclouded brown eyes stared at her.  The eyes looked normal.  They 
were not red.  The whites were white, and the pupils were clear and black, 
dark as night.  She could see a reflection of the lamp in the pupils.  
Inside the eyes, behind the eyes, there was nothing.  No mind, no 
existence.  The cells had stopped working.
	Once the cells in a biological machine stop working, it can never 
be started again.  It goes into a cascade of decay, falling toward 
disorder and randomness.  Except in the case of viruses.  They can turn 
off and go dead.  Then, if they come in contact with a living system, they 
switch on and multiply.  The only thing that "lived" inside this monkey 
was the unknown agent, and it was dead, for the time being.  It was not 
multiplying or doing anything, since the monkey's cells were dead.  But if 
the agent touched living cells, Nancy's cells, it would come alive and 
begin to amplify itself.  In theory, it could amplify itself around the 
world in the human species.
	She took up a scalpel and slit the monkey's abdomen, making a slow 
and gentle cut, keeping the blade well away from her gloved fingers.  The 
spleen was puffed up and tough, leathery, like a glob of smoke salami.  
She did not see any bloody leisons inside this monkey.  She had expected 
that the monkey's interior would be a lake of blood, but no, this monkey 
looked all right, it had not bled into itself.  If the animal had died of 
Ebola, this was not a clear case.  She opened up the intestine.  There was 
no blood inside it.  The gut looked okay.  Then she examined the stomach.  
There she found a ring of bleeding spots at the junction between the 
stomach and the small intestine.  This could be a sign of Ebola, but it 
was not a clear sign.  It could also be a sign of simian fever, not Ebola 
virus in this animal based on a visual inspection of internal organs 
during necropsy.
	Using a pair of blunt scissors, she clipped wedges out of the 
liver and pressed them on glass slides.  Slides and blood tubes were the 
only glass objects allowed in a hot zone, because of the danger of glass 
splinters if something broke.  All laboratory beakers in the room were 
made of plastic.
	She worked slowly, keeping her hands out of the body cavity, away 
from blood as much as possible, rinsing her gloves again and again in a 
pan of EnviroChem.  She changed her gloves frequently.
	Trotter glanced at her once in a while.  He held the body open for 
her and clamped blood vessel, handing her tools when she asked for them.  
They could read each other's lips.
	"FORCEPS," she mouthed silently, pointing to it.  He nodded and 
handed her a forceps.  They did not talk.  She was alone with the sound of 
her air.
	She was beginning to think that this monkey did not have Ebola 
virus.  In biology, nothing is clear, everything is too complicated, 
everything is a mess, and just when you think you understand something, 
you peel off a layer and find deeper complications beneath.  Nature is 
anything but simple.  This emerging virus was like a bat crossing the sky 
at evening.  Just when you thought you saw it flicker through your field 
of view, it was gone.

SHOOT-OUT

1400 HOUR, WEDNESDAY

WHILE NANCY JAAX was working on the monkeys, C.J. Peters was in the 
conference room at Fort Detrick's headquarters building.  Careers were at 
stake in this room.  Almost all of the people in the world who understood 
the meaning of Ebola virus were sitting around a long table.  General 
Russell sat at the head of the table, a tall, tough-looking figure in 
uniform; he chaired the meeting.  He did not want the meeting to turn into 
a power struggle between the Centers for Disease Control and the Army.  He 
also did not want to let the C.D.C. take over this thing.
	Dan Dalgard was there, wearing a dark suit, seeming reserved and 
cool; in fact, he churned with nervousness.  Gene Johnson glowered over 
the table, bearded and silent.  There were officials from the Virginia 
Department of Health and from Fairfax County.  Fred Murphy-the 
codiscoverer of Ebola virus, the C.D.C. official whom General Russell ha 
called-sat at the table beside another official from C.D.C., Dr. Joseph B. 
McCormick.
	Joe McCormick was the chief of the Special Pathogens Branch of the 
C.D.C., the branch that had been run by Karl Johnson, another codiscoverer 
of Ebola.  Joe McCormick was the successor to Karl Johnson-he had been 
appointed to the job when Johnson retired.  He had lived and worked in 
Africa.  He was a handsome, sophisticated medical doctor with curly dark 
hair and round Fiorucci spectacles, a brilliant, ambitious man, charming 
and persuasive, with a quick, flaring temper, who had done extraordinary 
things in his career.  He had published major research articles on Ebola.  
Unlike anyone else in the room, he had seen and treated human cases of 
Ebola virus.
	It happened that Joe McCormick and C.J. Peters couldn't stand each 
other.  There was bad blood between these two doctors that went back many 
years.  They had both rifled the darkest corners of Africa searching for 
Ebola, and neither of them had found its natural hiding place.  Like 
Peters, Joe McCormick evidently felt that now, finally, he was closing in 
on the virus and getting ready to make a spectacular kill.

THE MEETING BEGAN with Peter Jahrling, the codiscoverer of the strain that 
burned in the monkeys.  Jahrling stood up and spoke, using charts and 
photographs.  Then he sat down.
	Now it was Dalgard's turn to speak.  He was exceedingly nervous.  
He described the clinical signs of disease that he had seen at the monkey 
house, and by the end he felt that no one had noticed his nervousness.
	Immediately afterward, Joe McCormick got up and spoke.  What he 
said remains a matter of controversy.  There s an Army version and there 
is another version.  According to Army people, he turned to Peter Jahrling 
and said words to this effect: Thanks very much, Peter.  Thanks for 
alerting us.  The big boys are here now.  You can just turn this thing 
over to us before you hurt yourselves.  We've got excellent containment 
facilities in Atlanta.  We'll just take all your materials and your 
samples of virus.  We'll take care of it from here.
	In other words, the Army people thought McCormick tried to present 
himself as the only real expert on Ebola.  They thought to be tried to 
take over the management of the outbreak and grab the Army's samples of 
virus.
	C.J. Peters fumed, listening to McCormick.  He heard the speech 
with a growing sense of outrage, and thought it was "very arrogant and 
insulting."
	McCormick remembers something different.  "I'm sure I offered some 
help or assistance with the animal situation at Reston," he recalled, when 
I telephoned him. "I don't know that there was any conflict.  If there was 
any animosity, it came from their side, not ours, for reasons they know 
better than I.  Our attitude was, Hey guys, good work."
	In the past, McMormick had publicly criticized Gene Johnson, the 
Army's Ebola expert, for spending a lot of money to explore Kitum Cave and 
then not publishing his findings.  McCormick expressed his feelings to me 
this way: "They want to tell you about their experiments, but the way to 
tell people about them is to publish them.  That's not an unreasonable 
criticism.  They're spending taxpayers' money."  And besides, "None of 
them had spent as much time in the field as I had.  I was the one of those 
who had dealt with human case of Ebola.  No one else there had done that."
	What McCormick had done was this.  In 1979, reports reached the 
C.D.C. that Ebola had come out of hiding and was burning once again in 
southern Sudan, in the same places where it had first appeared, in 1976.  
The situation was dangerous, not only because of the virus but because a 
civil war was going on in Sudan at the time-the areas where Ebola raged 
was also a war zone.  McCormick volunteered to try to collect some human 
blood and bring strain back alive to Atlanta.  No one else wanted to go to 
Sudan with him, so he went there alone.  (It will be recalled that in 1976 
Sudan outbreak, three years earlier, a C.D.C. doctor had allegedly become 
too frightened to get on the plane to Sudan.)  McCormick arrived in 
southern Sudan in a light plane flown by tow terrified bush pilots.  
Around sunset, they landed at an airstrip near a Zande village.  The 
pilots were too scared to get out of the plane.  It was getting dark, and 
the pilots decided to spend the night in the cockpit, sitting on the 
airstrip.  They warned McCormick they would leave the next morning at 
sunrise.  He had until dawn to find the virus.
	McCormick shouldered his backpack and walked into the village, 
looking for Ebola.  He arrived at a mud hut.  Villagers stood around the 
hut, but they wouldn't go inside.  He heard sounds of human agony.  A dark 
doorway led inside.  He couldn't see into the hunt, but he know that Ebola 
was in there.  He rummaged in his backpack and found his flashlight, but 
it was dead, and he realized that he had forgotten to bring batteries.  He 
asked the crowd if anyone had a light, and someone brought him a lantern.  
Holding the lantern in front of him, he entered the hut.
	He would never forget the sight.  The first thing he saw was a 
number of red eyes staring at him.  The air inside the hut reeked of 
blood.  People lay on straw mats on the floor.  some were having 
convulsion-the final phase, as death sets in-their bodies rigid and 
jerking, their eyes rolled up into the head, blood streaming out of the 
nose and flooding from the rectum.  Others had gone into termina comas, 
and were motionless and bleeding out.  The hut was a hot zone.
	He opened his backpack and fished out rubber gloves, a paper gown, 
a paper surgical mask, and paper boots to cover his shoes, to keep them 
from becoming wet with blood.  After he had dressed himself, he laid out 
his blood tubes and syringes on a mat.  Then he began drawing blood from 
people.  He worked all night in the hut on his knees, collecting blood 
samples and taking care of the patients as best he could.
	Sometime during the night, he was drawing blood from an old woman. 
 Suddenly she jerked and thrashed, having a seizure.  Here arm lashed 
around, and the bloody needle cam out of her arm and jabbed into his 
thumb.  Uh, oh, he thought.  That would be enough to do it.  The agent had 
entered his bloodstream.	
	At dawn, he gathered up his tubes of blood serum and ran to the 
airplane and handed the samples to the pilots.  The question was what to 
do with himself, now that he had been pricked with a bloody needle.  That 
was a massive exposure to Ebola virus.  He probably had three to four days 
before he broke with Ebola.  Should he leave Sudan now, get himself to a 
hospital?  He had to make a decision-whether to leave with the pilots or 
stay with the virus.  It seemed obvious that the pilots would not come 
back later to pick him up.  If he planned to leave and medical help for 
himself, the time to do it was now.  There was an additional factor.  He 
was a physician, and those people in the hut were his patients.
	He returned to the village.  He thought he might be infected with 
Ebola virus, but he wanted to get more samples, and he figured that if he 
developed a headache, he could radio for help, and perhaps a plane would 
come and get him.  He rested that day in a hut, and gave himself a 
transfusion of two bags of blood serum that supposedly contained 
antibodies that might protect him from Ebola virus-he had carried the bags 
with him, chilled on ice, and now he hoped they would save his life.  That 
night he could not sleep, thinking about the needle jabbing his thumb, 
thinking about the agent beginning its massive replication in his 
bloodstream.  He drank half a bottle of scotch whisky to put himself to 
sleep.
	He worked with Ebola patients for the next four days inside the 
hut, and still he did not have a headache.  Meanwhile, he watched the old 
lady like a hawk to see what happened to her.  On the fourth day, to his 
surprise, the old lady recovered.  She had not had Ebola.  She had 
probably been suffering from malaria.  She had not been having an Ebola 
seizure but, rather, had been shivering from a fever.  He had walked away 
from a firing squad.
	Now, at the meeting at Fort Detrick, Joe McCormick of the C.D.C. 
was convinced that Ebola virus does not travel easily, especially not 
through the air.  He had not become sick, even though he had breathed the 
air inside an Ebola-ridden hut for days and nights on end.  He felt 
strongly that Ebola is a disease that is not easy to catch.  Therefore, in 
his view, it was not as dangerous as perhaps the Army people believed.
	Dan Dalgard asked a question of the assembled experts.  He said, 
"How soon after we give you samples can you tell us whether they have 
virus in them?"
	C.J. Peters replied, "It may take a week.  This is all we know."
	Joe McCormick spoke up.  Wait a minute, he said-he had a new, fast 
probe test for Ebola virus that would work in twelve hours.  He argued 
that the C.D.C. should have the virus and the samples.
	C.J. Peters turned and stared at McCormick.  C.J. was furious.  He 
didn't believe McCormick had any quick test for Ebola.  He thought it was 
Joe McCormick blowing smoke, trying to get his hands on the virus.  He 
thought it was a poker bluff in a high-stakes game for control of the 
virus.  It was a delicate situation, because how could he say in front of 
all these state health officials, "Joe, I just don't believe you?"  He 
raised his voice and said, "An ongoing epidemic is not the time to try to 
field-test a new technique."  He argued that Fort Detrick was closer to 
the outbreak than was the C.D.C., in Atlanta, and therefore it was 
appropriate for the Army to have the samples and try to isolate the virus. 
 What he did not say-no reason to rub it in-was that seven dead monkeys 
were at that very moment being examined by Nancy Jaax.  Even as they 
argued, she was exploring the monkeys.  What's more, the Army was growing 
the virus in cultures.  Possession is nine tenths of the law, and the Army 
had the meat and the agent.
	Fred Murphy, the other C.D.C. man, was sitting next to McCormick.  
He began to realize that the C.D.C. was not in a good position to argue 
the matter.  He leaned over and whispered, "Joe!  Calm you jets.  Stifle 
it, Joe.  We're outnumbered here."
	General Philip Russell had been sitting back, watching the 
argument, saying nothing.  Now he stepped in.  In a calm but almost 
deafeningly loud voice he suggested that they work out a compromise.  He 
suggested that they split the management of the outbreak.
	A compromise seemed to be the best solution.  The general and Fred 
Murphy quickly worked out the deal, while McCormick and Peters stared at 
each other with little to say.  It was agreed that the C.D.C. would manage 
the human-health aspects of the outbreak and would direct the car of any 
human patients.  The Army would handle the monkeys and the monkey house, 
which was the nest of the outbreak.

THE MISSION

1630 HOURS, WEDNESDAY

COLONEL C. J. PETERS now felt that he had permission to get the action 
under way.  As soon as the meeting broke up, he began to line up his 
ducks.  the first thing he needed was field officer who could lead a team 
of soldiers and civilians into the monkey house.  He needed to form a 
military-action unit.
	He had already decided who was going to lead the mission.  It was 
going to be Colonel Jerry Jaax, Nancy's husband.  Jerry had never worn a 
space suit, but he was the chief of the veterinary division at the 
Institute, and he understood monkeys.  His people, both soldiers and 
civilians, were certainly going to be needed.  No one else had the 
training to handle monkeys.
	He found Jerry in his office, staring out the window and chewing 
on a rubber band.  C.J. said, "Jerry,  I believe we have a situation down 
in Reston."  A situation.  Code for a hot agent.  "It looks like we're 
going to have to go down and take those monkeys out, and we're going to do 
it in Biosafety Level 4 conditions."  He asked Jerry to assemble teams of 
soldiers and civilian employees to be ready to move out with space suits 
in twenty-four hours.
	Jerry walked over to Gene Johnson's office and told him that he'd 
been put in charge of the mission.  The office was a mess.  He wondered 
how Gene, as large a man as he was, could even fit himself in among the 
stacks of paper.
	Jerry and Gene immediately began to plan a biohazard operation.  
There had been a general decision to take out one room of monkeys, and see 
how that worked, see how things went-see if the virus was spreading.  They 
set up their priorities.

	Priority One - Safety of the human population.

	Priority Two - Euthanasia of the animals with a minimum of 
suffering.

	Priority Three - Gathering of scientific samples.  Purpose: to
	identify the strain and determine how it travels.

	Gene felt that if the team did its job properly, the human 
population of Washington would be safe.  He put on his glasses and hunched 
over and fished through his papers, his beard crushed on his chest.  He 
knew already that he was not going to go inside that building.  No way in 
hell.  He had seen monkeys die too many times, and he could not bear it 
anymore.  In any case, his job was to gather equipment and people and move 
them into the building, and then to extract the people and equipment and 
dead animals safely.
	He had saved lists, long lists of all the gear he had brought to 
Kitum Cave.  He pawed through his papers, swearing gently.  He had 
literally tons of African gear.  He had squirreled it away in all kinds of 
hiding places at the Institute, where other people couldn't find it and 
rip it off.
	Gene was terribly excited, and also afraid.  His nightmares about 
Ebola virus, the bad dreams of liquid running through pinholes into his 
space suit, had never really gone away.  He would still wake up thinking, 
My god, there's been an exposure.  He had spent almost ten years hunting 
Ebola and Marburg in Africa, with little success, and suddenly one of the 
bastards had reared its head in Washington.  His favorite saying came back 
to him: "Chance favors the prepared mind."  Well, the chance had come.  If 
a piece of gear had been handy in Kitum Cave, it would be handy in the 
monkey house.  As Gene thought about it, he realized that the building was 
very much like Kitum Cave.  It was an enclosed air space.  Dead air.  
Air-handling system broken, failed.  During all over the place.  Monkey 
urine in pools.  A hot cave near Washington.  And there were people who 
had been inside the cave who might be infected with virus by now.  How 
would you move your teams in and out of the cave?  You would have to set 
up a staging area.  You would have to have a gray area-an air lock with a 
chemical shower of some kind.  Somewhere inside that building lived a 
Level 4 life form, and it was growing, multiplying, cooking inside hosts.  
The hosts were monkeys and, perhaps, people.

2000 HOURS, WEDNESDAY

DAN DALGARD LEFT USAMRIID and drove back to his office on Leesburg Pike, 
arriving there around eight o'clock.  The office was deserted; everyone 
had gone home.  He straightened up his desk, shut down his computer, and 
removed a floppy disk that contained his diary, his "Chronology of 
Events."  He put the disk into his brief case.  He said good night to a 
security guard at the front desk and drove home.  On the road, he realized 
that he had forgotten to call his wife to tell her that he would be late.  
He stopped at a Giant Food supermarket and bought her a bunch of cut 
flowers, carnations and mums.  When he arrived home, he reheated his 
dinner in the microwave and joined his wife in the family room, where he 
ate sitting in a recliner chair.  He was exhausted.  He put another log 
into the wood stove and sat down at his personal computer, which was 
located next to his clock-repair bench.  He inserted the floppy disk and 
began typing.  He was bringing his diary up to date.
	So much had happened that he had difficulty keeping it all 
straight in his mind.  In the morning, he had learned that the monkey 
caretaker named Jarvis Purdy was in the hospital, reportedly with a heart 
attack.  Jarvis was resting comfortably, and there had been no reports 
that his condition was getting worse.  Should I have notified the hospital 
that Jarvis might be infected with Ebola?  If he does have Ebola, and it 
spreads within the hospital, am I liable?  Jesus!  I'd better get someone 
to go over to the hospital first thing tomorrow and tell Jarvis what's 
going on.  If he hears on the news first, he's liable to have another 
heart attack!
	He had gotten all the other monkey caretakers fitted with 
respirators, and he had briefed them on what was known about the 
transmission of Ebola and Marburg to humans, and he had suspended all 
daily operations in the building other than feeding once a day, 
observation, and cleaning of the animal rooms.  He had briefed the staff 
in the laboratory on Leesburg Pike-which had been handling monkey blood 
and tissue samples-about the need to handle these specimens as if they 
were infected with the AIDS virus.
	I must remember to inform labs that have received animal shipments 
from us to notify the C.D.C. if any unusual animal deaths occur.  What 
about the exposure to those people who had been working on the 
air-handling system?  What about the laundry service?  Wasn't there a 
telephone repairman in recently?  Perhaps last week-I can't remember just 
when that was.  Holy Christ!  Have I missed anything?
	While he was updating the day's events on the computer, the 
telephone rang.  It was Nancy Jaax on the line.  She sounded tired.  She 
told him that her findings were consistent with either SHF or Ebola.  She 
said it could be either one or both.  Her results were ambiguous.

RECONNAISSANCE

NOVEMBER 30, THURSDAY

BY THE TIME Dan Dalgard woke up the next morning-it was now Thursday, 
exactly a week after Thanksgiving Day-he had made up his mind to invite 
the Army in to clean up one room, Room H, where the outbreak now seemed to 
be centered.  He telephoned C.J. Peters and gave the Army permission to 
enter the monkey house.  The news that they had the green light for a 
biohazard operation spread instantly through USAMRIID.
	Colonel Jerry Jaax called a meeting of all the commissioned 
officers on his staff, along with two sergeants.  They were Major 
Nathaniel (Nate) Powell, Captain Mark Haines, Captain Steven Denny, 
Sergeant Curtis Klages, and Sergeant Thomas Amen, and he invited a 
civilian animal caretaker named Merhl Gibson to attend.  These people were 
the core of his team.  He put it casually to them: "Do you want to go to 
Reston? "  Some of them had not heard of Reston.  He explained what was 
going on, saying, "There are some monkeys that need to be euthanized.  
We'd like for you to play.  Do you want in?  Do you want to go?"  They all 
said they wanted to play.  He also figured that Nancy was going to play.  
That meant that he and Nancy would be inside the building at the same 
time.  The children would be on their own tomorrow.
	They were going to make an insertion into the monkey house, go 
into one room, kill the monkeys in that room, and take samples of tissue 
back to the Institute for analysis.  They were going to do the job in 
space suits, under condition of Level 4 biocontainment.  The team would 
move out at 0500 hours tomorrow morning.  They had less than twenty-four 
hours to get ready.  Gene Johnson was gathering his biohazard equipment 
right now.

GENE DROVE DOWN to Virginia and arrived at the monkey house in midmorning 
for a reconnaissance, to get a sense of the layout of the building and to 
figure out where to put the air lock and gray zone, and how to insert the 
team into the building.  He went with Sergeant Klages, who was wearing 
fatigues.  As they turned into the parking lot, they saw a television van 
parked in front of the monkey house, the newscaster and his crew drinking 
coffee and waiting for something to happen.  It made Gene nervous.  The 
news media had begun to circle around the story early one, but they 
couldn't seem to get a handle on it, and USAMRIID was trying to keep it 
that way.
	Gene and sergeant parked under a sweet-gum tree by the low brick 
building and went in through the front door.  As they opened the door, the 
smell of monkey almost knocked them over.  Whoa, Sergeant Klages thought, 
Whoa-we shouldn't even be in here without a space suit.  The building 
stank of monkey.  something ugly was happening here.  The whole god-damned 
place could be hot; every surface could be hot.  The monkey workers had 
stopped cleaning the cages, because they did not want to go into the 
monkey rooms.
	They found Bill Volt and told him they wanted to scout the 
building to determine the best way for the teams to enter tomorrow.  Volt 
offered them a chair in his office while they talked.  They didn't want to 
sit down, didn't want to touch any surfaces in his office with their bare 
hands.  They noticed that Volt had a candy habit.  He offered them a box 
full of Life Savers, Bit-O-Honeys, and Snickers bars-"Help yourselves," he 
said.  Sergeant Klanges stared at the candy with horror and mumbled, "No, 
thank you."  He was afraid to touch it.
	Gene wanted to go into the monkey area and see Room H, the hot 
spot.  It was at the back of the building.  He did not want to walk 
through the building to get to that room.  He did not want to breathe too 
much of the building's air.  Poking around, he discovered another route to 
the back of the building.  The office space next door was empty and had 
been vacated some time ago; the electric power was cut off, and ceiling 
panels were falling down.  He got a flashlight and circled around through 
these dark rooms.  This is like a bombed-out area, he thought.
	He found a door leading back into the monkey house.  It led to a 
storeroom, and there was a closed corridor that headed deeper into the 
monkey house.  Now he could see it all in his mind's eye.  The closed 
corridor would be the air lock.  The storeroom would be the staging area.  
The team could put their space suits in this storeroom, out of sight of 
the television cameras.  He drew a map on a sheet of paper.
	When he understood the layout of the building, he circled to the 
front and told the monkey workers that he wanted the back areas of the 
building completely sealed off-airtight.  He didn't want an agent from 
Room H to drift to the front of the building and get into the offices.  He 
wanted to lower the amount of contaminated air flowing into those offices.
	There was a door that led to the back monkey rooms.  They taped it 
shut with military brown sticky tape: the first line of defense against a 
hot agent.  From now on, as Gene explained to the monkey workers, no one 
was to break the sticky tape, no one was to go inside those back rooms 
except Army people until Room H had been cleaned out.  What Gene did not 
realize was that there was another way into the back rooms.  You could get 
there without breaking the sticky tape on the door.

AT ELEVEN-THIRTY in the morning, Leutenant Colonel Nancy Jaax and Colonel 
C.J. Peters arrived at the corporate offices of Hazleton Washington on 
Leesburg Pike to meet with Dan Dalgard and to speak to a group of Hazleton 
lab workers who had been exposed to tissues and blood from sick monkeys.  
Since C.D.C. now had charge of the human aspects of the Ebola outbreak, 
Joe McCormick also arrived at the Hazleton offices at the same time as 
Jaax and Peters.
	The lab employees had been handling tissue and blood from the 
monkeys, running tests on the material.  They were mainly women, and some 
of them were extremely frightened, nearly in a panic.  That morning, there 
had been radio reports during rush hour, as the women were coming to work, 
that Ebola virus had killed hundred of thousand of people in Africa.  This 
was a wild exaggeration.  But the radio newscasters had no idea what was 
going on, and now the women thought they were going to die.  "We've been 
hearing about this on the radio," they said to Jaax and McCormick.
	Nancy Jaax claims that Joe McCormick did his best to calm them 
down, but that as he talked to the women about his experiences with Ebola 
in Africa, they seemed to become more and more frightened.
	A woman got up and said, "We don't care if he's been to Africa.  
We want to know if we're going to get sick!"
	McCormick doesn't have any recollection of speaking to the women.  
He said to me, "I never talked to them.  Nancy Jaax talked to them about 
Ebola."
	Nancy thinks that they began to calm down when they saw a female 
Army colonel in a uniform.  She asked the women, "Did any of you break a 
test tube?  Do we have anyone here who stuck himself with a needle or cut 
himself?"
	No one raised a hand.
	"Then you'll be all right," she said to them.
	A few minutes afterward, Dan Dalgard turned to C.J. Peters and 
said something like, "Why don't you come over to the primate facility with 
me to look at the monkeys?"
	Now they would finally get a chance to see the building.
	They drove to the monkey house.  By this time, Gene Johnson had 
closed off the back rooms and sealed the main entry door with sticky tape. 
 Nancy and C.J., along with Dan Dalgard, circled around to the back of the 
building, put on rubber gloves and paper surgical masks, and went into 
Room H to look at the sick monkeys.  Nancy and C.J. noticed with some 
concern that the monkey workers around the building were not wearing 
respirators, despite Dalgard's order.  No one offered a respirator to 
Nancy or C.J. either.  This made them both nervous, but they did not say 
anything.  When in a monkey house, do as the monkey workers do.  They did 
not want to give offense by asking for breathing equipment, no at this 
delicate moment, not when they had finally gotten their first chance to 
look at the building.
	In Room H, Dalgard picked out the sick animals, pointing to them.  
"This one is sick, this one looks sick, this one over here looks sick," he 
said.  The monkeys were quiet and subdued, but they rattled their cages 
now and then.  Nancy stood well back from the cages and took shallow 
breaths, not wanting to let the smell of monkey get too deep into her 
lungs.  A number of animals had already died-there were many empty cages 
in the room-and many of the other animals were obviously sick.  They sat 
at the backs of their cages, passive and blank faced.  They were not 
eating their monkey biscuits.  She saw that some had runny noses.  She 
averted her eyes and behaved respectfully around the monkeys, because she 
did not want a monkey to get a notion in its head to spit at her.  They 
have good aim when they spit, and they aim for your face.  She worried 
more about her eyes than anything else.  Ebola has a special liking for 
the eyes.  Four or five virus particles on the eyelid would probably do it.
	She noticed something else that made her fearful.  These monkeys 
had their canine teeth.  The company had not filed down the monkeys' 
fangs.  The canines on these hummers were as big as the canines on any 
guard dog you'll ever see, and that was a rude awakening.  A monkey can 
run amazingly fast, t can jump long distances, and it uses its tail as a 
gripper or a hook.  It also has a mind.  Nancy thought, An angry monkey is 
like a flying pit bull terrier with five prehensile limbs-these critters 
can do a job on you.  A monkey directs its attacks toward the face and 
head.  It will grab you by the head, using all four limbs, and then it 
will wrap its tail around your neck to get a good grip, and it will make 
slashing attacks all over your face with its teeth, aiming especially for 
the eyes.  This is not a good situation if the monkey happens to be 
infected with Ebola virus.  A six-foot-tall man and a ten-pound monkey are 
pretty evenly matched in a stand-up fight.  The monkey will be all over 
the man.  By the end of the fight, the man may need hundreds of stitches, 
and could be blinded.  Jerry and his team would have to be exquisitely 
careful with these monkeys.

THAT EVENING, JERRY drove home alone.  Nancy had put on a space suit and 
gone back into her lab to continue analyzing the monkey samples, and he 
had no idea when she would finish.  He changed out of his uniform, and the 
telephone rang.  It was Nancy's brother on the line, calling from Kansas, 
saying that Nancy's father was slipping, and that it looked as if the end 
was near.  Nancy might be called home at any time for her father's 
funeral.  Jerry said that he would pass the word along to Nancy, and 
explained that she was working late.
	Then he and Jason drove for half an hour in the direction of 
Washington and picked up Jaime at her gym.  They decided to have supper at 
McDonald's.  The Jaax family, minus the mother, sat at a table, and while 
they ate, Jerry explained to the children why Mom was working late.  He 
said, "Tomorrow morning, we're going to be going down to a civilian place 
in space suits.  There's an important thing going on there.  There are 
some monkeys that are sick.  The situation has kind of emergency feel to 
it.  We'll be gone real early, and we may not get back until real late.  
You kids will be on your own."  They didn't react much to what he said.
	Jerry went on, "It's possible that humans could get sick from the 
monkeys."
	"well, there's not really any danger," Jaime said, chewing her 
chicken nuggets.
	"Well, no, it's not really dangerous," he said. "It's more 
exciting than dangerous.  And anyway, it's just what your mom and I are 
doing right now."
	Jason said that he had seen something on television about it.  It 
was on the news.
	"I think what your mom does is something pretty unusual," Jerry 
said to his son.  And he thought, I'll never convince him of that.
	They returned home around nine-thirty, and Jerry had trouble 
making the kids go to bed.  Perhaps they were afraid of what was happening 
but didn't know how to express it; he wasn't sure.  More likely, they 
sensed an opportunity to have their own way when their mother wasn't 
around.  They said they wanted to wait up for her.  He thought he would 
wait up for her, too.  He made them put on their pajamas, and he brought 
them into bed with him, and they curled up on Nancy's side of the water 
bed.  There was a television in the room, and he watched the 
eleven-o'clock news.  A newscaster was standing in front of the monkey 
house, and he was talking about people dying in Africa.  By this time, the 
children had fallen asleep.  He thought about John for a while, and then 
he picked up a book to try to read.
	He was still awake when Nancy arrived home at one o'clock in the 
morning, looking fresh and clean, having taken a shower and shampooed her 
hair on her way out of Level 4.
	As she looked around the house to see what needed to be done, she 
saw that Jerry had not tended to the animals.  She put out food for the 
cats and dogs, and changed their water.  She checked on Herky, the parrot, 
to see how he was doing.  He started making noise the moment he perceived 
that the cats were being fed.  He wanted some attention, too.
	"Mom! Mom!" Herky hung upside down and laughed like a maniac, and 
cried, "Bad bird! Bad bird!"  She took him out of his cage and stroked him 
on the head.  He moved onto her shoulder and she preened his feathers.
	Upstairs in the bedroom, she found the children asleep next to 
Jerry.  She picked up Jaime and carried her into her own bedroom and 
tucked her into bed.  Jerry picked up Jason and carried him to his bed-he 
was getting too big for Nancy to haul around.
	Nancy settled into bed with Jerry.  She said to him, "I have a gut 
feeling they're not going to be able to contain the virus in that one 
room."  She told him she was worried that it could be spreading into other 
rooms through the air.  That virus was just so damned infective she didn't 
see how it would stay in one room.  Something that Gene Johnson had once 
said to her came into her mind: "We don't really know what Ebola has done 
in the past, and we don't know what it might do in the future."
	Then Jerry broke the news to her about her father.  Nancy was 
beginning to feel extremely guilty about not going home to be with him as 
he lay dying.  She felt the tug of her last obligation to him.  She 
wondered if she should bag this monkey thing and fly to Kansas.  But she 
felt that it was her duty to go through with the operation.  She decided 
to take a chance that her father would live awhile longer.
??

 

PART THREE

SMASHDOWN

INSERTION

DECEMBER 1, FRIDAY

THE ALARM WENT off at four-thirty.  Jerry Jaax got up, shaved, brushed his 
teeth, threw on clothes, and was out of there.  The teams were going to 
wear civilian clothes.  No one wanted to attract attention.  Soldiers in 
uniform and camouflage, putting on space suits ... it could set off a 
panic.
	It was five o'clock by the time he arrived at the Institute.  
There was no sign of dawn in the sky.  A crowd of people had already 
gathered by a loading dock on the side of the building, under 
flood-lights.  There had been a hard freeze during the night, and their 
breath steamed in the air.  Gene Johnson, the Ajax of this biological war, 
paced back and forth across the loading dock among a pile of camouflaged 
military trunks-his stockpile of gear from Kitum Cave.  The trunks 
contained field space suits, battery packs, rubber gloves, surgical scrub 
suits, syringes, needles, drugs, dissection tools, flashlights, one or two 
human surgery packs, blunt scissors, sample bags, plastic bottles, 
pickling preservatives, biohazard bags marked with red flowers, and 
hand-pumped garden sprayers for spraying beach on space suits and objects 
that needed to be decontaminated.  Holding a cup of coffee in his fist, 
Gene grinned at the soldiers and rumbled, "Don't touch my trunks."
	A white unmarked supply van showed up.  Gene loaded his trunks 
into the van by himself and set off for Reston.  He was the first wave.
	By now, copies of The Washington Post were hitting driveways all 
over the region.  It contained a front-page story about the monkey house:

			DEADLY EBOLA VIRUS FOUND IN VA.
				LABORATORY MONKEY

		One of the deadliest known human viruses has turned up for 
the first time in the United States, in a shipment of monkeys imported 
from the Philippines by a research laboratory in Reston.
		A task force of top-level of yesterday devising a detailed 
program to trace the path of the rare Ebola virus and who might have been 
exposed to it.  That includes interviews with the four or five laboratory 
workers who cared for the animals, which have since been destroyed as a 
precaution, and any other people who were near the monkeys.
		Federal and state health officials played down the 
possibility that any people had contracted the virus, which has a 50 to 90 
percent mortality rate and can be highly contagious to those coming into 
direct contact with its victims.  There is no known vaccine. "There's 
always a level of concern, but I don't think anybody's	panicked," said 
Col. C.J. Peters, a physician and expert on the virus.

	C.J. knew that if people learned what this virus could do, there 
would be traffic jams heading out of Reston, with mothers screaming at 
television cameras, "Where are my children?"  When he talked to the 
Washington Post reporters, he was careful not to discuss the more dramatic 
aspects of the operation.  ("I thought it would not be a good idea to talk 
about space suits," he explained to me much later.)  He was careful not to 
use scary military terms such as amplification, lethal chain of 
transmission, crash and bleed, or major pucker factor.  A military 
biohazard operation was about to go down in a suburb of Washington, and he 
sure as hell didn't want the Post to find out about it.
	Half of this biocontainment operation was going to be news 
containment.  C.J. Peter's comments to The Washington Post were designed 
to create an impression the situation was under control, safe, and not all 
that interesting.  C.J. was understating the gravity of the situation.  
But he could be very smooth when he wanted, and he used his friendliest 
voice with the reporters, assuring them over the telephone that there 
really was no problem, just kind of a routine technical situation.  
Somehow the reporters concluded that the sick monkeys had been "destroyed 
as a precaution" when in fact the nightmare, and the reason for troops, 
was that the animals hadn't been destroyed.
	As to whether the operation was safe, the only way to know was to 
try it.  Peters felt that the larger danger could come from sitting back 
and watching the virus burn through the monkeys.  There were five hundred 
monkeys inside that building.  That was about three tons of monkey meat-a 
biological nuclear reactor having a core meltdown.  As the core of monkeys 
burned, the agent would amplify itself tremendously.

C.J. ARRIVED AT the loading dock of the Institute at five o'clock in the 
morning.  He would accompany the group down to the monkey house to see 
Jerry's team inserted, and then he would drive back to the Institute to 
deal with the news media and government agencies.
	At six-thirty, he gave an order to move out, and the column of 
vehicles left Fort Detrick's main gate and headed south, toward the 
Potomac River.  It consisted of a line of ordinary automobiles-the 
officer's family cars, with the officers inside wearing civilian clothes, 
looking like commuters.  The line of cars followed behind two unmarked 
military vehicles.  One was a snow-white ambulance and the other was a 
supply van.  It was an unmarked Level 4 biocontainment ambulance.  Inside 
it there were an Army medical-evacuation team and a biocontainment pod 
known as a bubble stretcher.  This was a combat medical stretcher enclosed 
by a biocontainment bubble made of clear plastic.  If someone was bitten 
by a monkey, he would go into the bubble, and from there he would be 
transferred  to the Slammer, and perhaps from there he would go to the 
Submarine, the Level 4 morgue.  The supply van was a white unmarked 
refrigerator truck.  This was to hold dead monkeys and tubes of blood.
	There was not a uniform in the group, although a few members of 
ambulance team wore camouflage fatigues.  The caravan crossed the Potomac 
River at Point of Rocks and hit Leesburg Pike just as rush hour began.  
The traffic became bumper to bumper, and the officers began to get 
frustrated.  It took them two hours to reach the monkey house, contending 
the whole way with ill-tempered commuters.  Finally the column turned into 
the office park, which by that time was filling up with workers.  The 
supply van and the ambulance were driven along the side of the monkey 
house, up onto a lawn, and were parked behind the building, to get them 
out of sight.  The back of the building presented a brick face, some 
narrow windows, and a glass door.  The door was the insertion point.  They 
parked the supply van up close to the door.
	At the edge of the lawn, behind the building, there was a line of 
underbrush and trees sloping down a hillside.  Beyond that, there was a 
playground next to a day-care center.  They could hear shouts of children 
in the air, and when they looked through the underbrush, they could see 
bundled-up four-years-olds swinging on swings and racing around a 
playhouse.  The operation would be carried out near children.
	Jerry Jaax studied a map of the building.  He and Gene Johnson had 
decided to have all the team members put on their space suits inside the 
building rather than out on the lawn so that if any television crews 
arrived there would be nothing to film.  The men went through the 
insertion door and found themselves in an empty storage room.  It was the 
staging room.  They could hear faint cries of monkeys beyond a 
cinder-block wall.  There was no sign of any human being in the monkey 
house.
	Jerry Jaax was going to be the first man in, the point man.  He 
had decided to take with him one of his officers, Captain Mark Haines, a 
former Green Berets' scuba-diving school.  He had jumped out of airplanes 
at night into the open sea, wearing scuba gear.  ("I'll tell you one 
thing," Haines once said to me.  "I don't do scuba diving as a civilian.  
The majority of my diving has been in the Middle East.")  Captain Haines 
was not a man who would get claustrophobia and go into a panic in a space 
suit.  Furthermore, Captain Haines was a veterinarian.  He understood 
monkeys.
	Jaax and Haines climbed into the supply van and pulled a plastic 
sheet across the van's back door for privacy, and stripped naked, 
shivering in the cold.  They put on surgical scrub suits and then walked 
across the lawn, opened the glass door, and went into the storage room, 
the staging area, where an Army support team-the ambulance team, led by a 
captain named Elizabeth Hill-helped them into their space suits.  Jerry 
knew nothing about field biological suits, and neither did Captain Haines.
	The suits were orange Racal suits, designed for field use with 
airborne biological agents, and they were the same type of suit that had 
been used in Kitum Cave-in fact, some of them had come back from Africa in 
Gene Johnson's trunks.  The suit has a clear, soft plastic bubble for a 
helmet.  The suit is pressurized.  Air pressure is supplied by an electric 
motor that sucks air from outside and passes it through virus filters and 
then injects it into the suit.  This keeps the suit under positive 
pressure, so that any airborne virus particles will have a hard time 
flowing into it.  A Racal suit performs the same job as a heavy-duty 
Chemturion space suit.  It protects the entire body from a hot agent, 
surrounds the body with superfiltered air.  Army people generally don't 
refer to Racals as space suits.  They call them Racals or field biological 
suits; but they are, in fact, biological space suits.
	Jaax and Haines put on rubber gloves, and the support team taped 
the gloves to the sleeves of the suits while they held their arms out 
straight.  On their feet, they wore sneakers, and over the sneakers they 
pulled bright yellow rubber boots.  The support team taped the boots to 
the legs of the suits to make an airtight seal above the ankle.
	Jerry was terribly keyed up.  In the past he had lectured Nancy on 
the dangers of working with Ebola in a space suit, and now he as leading a 
team into an Ebola hell.  At the moment, he didn't care what happened to 
himself, personally.  He was expendable, and he knew it.  Perhaps he could 
forget about John for a while in there.  He switched on his electric 
blower, and his suit puffed up around him.  It didn't feel too bad, but it 
made him sweat profusely.  The door was straight ahead.  He held the map 
of the monkey house in his hand and nodded to Captain Haines.  Haines was 
ready.  Jerry opened the door, and they stepped inside.  The sound of the 
monkeys became louder.  They were standing in a windowless, lightless, 
cinder-block corridor that had doors had either end: this was the 
makeshift air lock, the gray zone.  The rule inside the air lock was that 
the two doors, the far door and the near door, could never be open at the 
same time.  This was to prevent a backflow of contaminated air from coming 
into the staging room.  The door closed behind them, and the corridor went 
dark.  It went pitch-dark.  Aw, son of bitch.  We forgot to bring 
flashlights.  Too late now.  They proceeded forward, feeling their way 
down the walls to the door at the far end.

NANCY JAAX WOKE up her children at seven-thirty.  She had to shake Jason, 
as always, to get him out of bed.  It didn't work, so she turned one of 
the dogs loose on him.  He hit the bed flying and climbed all over Jason.
	She put on sweatpants and a sweat shirt and went downstairs to the 
kitchen and flipped on the radio and turned it to a rock-and-roll station 
and popped a Diet Coke.  The music fired up the parrot.  Herky began to 
scream along with John Cougar Mellencamp.  Parrots really respond to 
electric guitar, she thought.
	The children sat at the kitchen table, eating instant oatmeal.  
She told them that she would be working late, so they would be on their 
own at suppertime.  She looked in the freezer and found a stew.  It would 
do fine for kids.  They could defrost it in the microwave.  She watched 
from the kitchen window as they walked down the driveway to the bottom of 
the hill to wait for the school bus ... "This work is not for a married 
female.  You are either going to neglect your work or neglect your family" 
were the words of a superior officer long ago.
	She cut a bagel for herself, and brought along an apple, and ate 
them in the car on the way to Reston.  By the time she arrived at the 
monkey house, Jerry had already suited up and gone inside.	
	The staging room was crowded, warm, loud, confused.  The experts 
on the use of space suits were giving advice to team members as they 
suited up.  Nancy herself had never worn a Racal field suit, but the 
principles are the same as with a heavy-duty Chemturion.  The main 
principle is that the interior of the space suit is a cocoon housing the 
normal world, which you bring with you into the hot area.  If there were a 
break in the suit, the normal world would vanish, merging with the hot 
world, and you would be exposed.  She spoke to the soldiers as they suited 
up.  "Your suits are under pressure," she said. "If you get a rip in your 
suit, you have to tape it shut right away, or you'll lose your pressure, 
and contaminated air could flow inside the suit."  She held up a roll of 
brown sticky tape.  "Before I go in, I wrap extra tape around my ankle, 
like this."  She demonstrated how to do it: she wound the roll around her 
ankle several times, the way you tape up a sprained ankle.  "You can tear 
off a length of tape from you ankle and use it to patch a hole in your 
suit," she said.  "A hundred chancy things can happen to rip your suit."
	She told them about Ebola in monkeys.  "If these monkey are 
infected with Ebola, then they are so full of virus that a bit from one of 
them would be a devastating exposure," she said. "Animals that are 
clinically ill with Ebola shed a lot of virus.  Monkeys move real quick.  
A bite would be a death warrant.  Be exquisitely careful.  Know where your 
hands and body are at all the times.  If you get blood on your suit, stop 
what you are doing and clean it off right away.  Don't let blood stay on 
your gloves.  Rinse them off right away.  With bloody gloves, you can't 
see a hole in the glove.  Also, one other thing.  You really don't want to 
drink a lot of coffee or liquids before going in.  You will be in your 
space suit for a long time."
	The batteries that pressurized the suit had a life span of six 
hours.  People would have to leave the hot area and be deconned out before 
their batteries failed, or they would be in trouble.

JERRY JAAX AND Captain Mark Haines felt their way down the dark corridor, 
toward the door that led into the hot zone.  They opened it and found 
themselves standing at the junction of two corridors, bathed in a 
cacophony of monkey cries.  The air-handling equipment still wasn't 
working, and the temperature in the place seemed as if it was above ninety 
degrees.  Jerry's head bubble fogged up.  He pushed the bubble against his 
face to rub the moisture off the faceplate, and now he could see.  The 
walls were gray cinder block, and the floor was painted concrete.
	Just then, he noticed a blur of motion on his left, and he turned 
and saw two Hazleton workers walking towards him.  They weren't supposed 
to be in here!  The area was supposed to be sealed off, but they had come 
in by another route that led through a storeroom.  They wore respirators, 
but nothing covered their eyes.  When they saw the two men in space suits, 
they froze, speechless.  Jerry could not see their mouths, but he could 
see their eyes, wide with astonishment.  It was as if they had suddenly 
discovered that they were standing on the moon.
	Jerry didn't know what to say.  Finally he said, "WHICH WAY TO 
ROOM H?"-shouting to be heard over his blowers.
	The workers led him down the corridor to the infected room.  It 
was at the far end of the hall.  Then they retreated to the front of the 
building and found Dan Dalgard, who had been sitting in an office, waiting 
for the Army to come in.  He showed up at Room H moments later, wearing a 
respirator, to find out what was going on.  Jerry looked at him as if he 
was insane.  It was as if you went to a meeting with someone, and the 
person showed up naked.
	Dalgard was not happy with the space suits.  Apparently he had not 
realized how the Army would be outfitted.  Dalgard gave them a tour of 
Room H, feeling exceptionally nervous.  "Looks like we have some sick 
monkeys in here," he said.  Some of the monkeys went berserk when they saw 
the space suits.  They spun in circles in their cages or cowered in the 
corners.  Others stared at the humans with fixed expressions on their 
faces.
	"You see the clinical signs," Dalgard said, pointing to a monkey.  
"I feel pretty confident I can tell when a monkey is getting sick.  They 
got a little bit depressed, they go off their feed, and in a day or two 
they are dead."
	Jerry wanted to look at all the monkeys in the monkey house.  He 
and Captain Haines went back out into the corridor and went from room to 
room through the entire building.  They found other monkeys that seemed 
depressed, with the same glazed expression on their faces.  Jaax and 
Haines, both of whom knew a lot about monkeys, didn't like the feel of 
this whole building.  Something lived in here other than monkeys and 
people.

NANCY JAAX GOT ready to go inside.  She changed into a scrub suit in the 
van, ran across the lawn, and entered the staging area.  The support team 
helped her suit up.  She gathered several boxes of syringes and went in 
with Captain Steven Denny.  They walked down the air-lock corridor and 
came to the far door.  She opened the door and found herself in the long 
corridor.  It was empty.  Everyone was down the hall in Room H.  Jerry 
thought his wife looked like the Pillsbury dough boy.  Her suit was too 
large for her, and it billowed around her when she walked.
	Nancy noticed mucus and slime on the noses of some of the monkeys. 
 That scared her, because it seemed so much like the flu or a cold, when 
it wasn't.  Dan Dalgard, wearing a respirator and a jumpsuit, selected 
four sick monkeys for sacrifice, the ones he thought looked the sickest.  
He reached into the cages and gave the monkeys their shots.  When they 
crumpled and fell asleep, he gave them a second round of shots, and that 
stopped their hearts.
	The room was jammed with people in space suits.  They kept coming 
in pairs, and they milled around with nothing to do.  One of them was 
Sergeant Curtis Klages.  He turned to someone and said, "WELL, THIS IS A 
BIG CHARLIE FOXTROT."  That's code for CF, which means "cluster fuck".  
This is an Army operation that winds up in confusion, with people bumping 
into one another and demanding to know what's going on.
	Nancy happened to glance at the sergeant, checking his suit 
instinctively, and she saw that he had a tear across hip.  She touched the 
sergeant's arm and pointed.  She reached down to her ankle, where she kept 
her extra tape, and taped the hole for him.
	She removed the four dead monkeys from their cages, holding them 
by the backs of the arms, and loaded them into plastic biohazard bags.  
She carried the bags to the entry door, where someone had left a garden 
sprayer full of Clorox bleach along with more bags.  She double-bagged the 
monkeys, spraying each bag with bleach, and then she loaded the bags into 
cardboard biohazard containers-hatboxes-and sprayed them to decon them.  
Finally she loaded each hatbox into a third plastic bag and spray it.  She 
pounded on the door.  "IT'S NANCY JAAX.  I'M COMING OUT."   The door was 
opened by a sergeant standing on the other side, a member of the decon 
team.  He was wearing a Racal suit, and he had a pump sprayer filled with 
bleach.  She went into the air lock, pushing the hatboxes ahead of her.
	In the darkness and in the whine of their blowers, he shouted to 
her, "STAND WITH YOUR ARMS OUT, AND TURN AROUND SLOWLY."  He sprayed her 
for five minutes, until the air lock stank of bleach.  It felt wonderfully 
cool, but the smell leaked through her filters and made her throat sting.  
He also sprayed the bags.  Then he opened the door to the staging area, 
and she blinked at the light and came out, pushing the bags ahead of her.
	The support team peeled off her suit.  She was drenched with 
sweat.  Her scrubs were soaked.  Now it was freezing cold.  She ran across 
the lawn and changed into her civilian clothes in the back of the van.
	Meanwhile, people loaded the bags into boxes, and loaded the boxes 
into the refrigerator truck, and Nancy and a driver headed off for Fort 
Detrick.  She wanted to get those monkeys into Level 4 and opened up as 
fast as possible.

JEERY JAAX COUNTED sixty-five animals in the room, after the four that 
Nancy had removed.  Gene Johnson had brought a special injector back from 
Africa.  Jerry used this device to give shots to the monkeys.  It was a 
pole that had a socket on one end.  You fitted a syringe into the socket, 
and you slid the pole into the cage and gave the monkey a shot.  You also 
needed a tool to pin the monkey down, because monkeys don't like needles 
coming at them.  They used a mop handle with a soft U-shaped pad on the 
end.  Captain Haines held the mop handle against the monkey to immobilize 
it, and Jerry ran the pole into the cage and hit the monkey's thigh with a 
double dose of ketamine, a general anesthetic.  They went through the room 
from cage to cage, hitting all the monkeys with the drug.  Pretty soon the 
monkeys began to collapse in their cages.  Once a monkey was down, Jerry 
gave it a shot of a sedative called Rompun, which put it into a deep sleep.
	When all the monkeys were down and asleep, they set up a couple of 
stainless-steel tables, and then, one monkey at a time, they took blood 
samples from the unconscious monkeys and gave them a third injection, this 
time of a lethal drug called T-61, which is a euthanasia agent.  After a 
monkey was clinically dead, it was opened by Captain Steve Denny.  He took 
samples of liver and spleen, using scissors, and he dropped the samples 
into the plastic bottles.  They bagged the dead monkeys, loaded them into 
hatboxes, and piled the hatboxes along the corridor.  Dan Dalgard, 
meanwhile, left the room and remained in an office at the front of the 
building for the rest of the day.
	By late afternoon, all the monkeys in Room H had been put to 
death.  Behind the building, through the trees and down the hill, children 
ran in circles around their playhouse.  Their shouts carried far in the 
December air.  The mothers and fathers arrived in cars and picked them up. 
 The team exited from the hot zone in pairs, and stood around on the grass 
in their civilian clothes, looking pale, weak, and thoughtful.  In the 
distance, floodlights began to light up the monuments and buildings of 
Washington.  It was the Friday evening at the end of the week following 
Thanksgiving, the start of a quiet weekend that precedes the Christmas 
season.  The wind strengthened and blew paper cups and empty cigarette 
packs in eddies around the parking lots.  In a hospital not far from 
there, Jarvis Purdy, the monkey worker who had a heart attack, rested 
comfortably, his condition stable.
	
BACK AT THE Institute, Nancy Jaax again stayed up until one o'clock in the 
morning, dissecting monkeys with her hot-zone buddy, Ron Trotter.  When 
they had suited up and gone in, there had been five monkey carcasses 
waiting for them in the air lock.
	This time, the signs of Ebola were obvious.  Nancy saw what she 
described as "horrendous gut lesions" in some of the animals, caused 
sloughing of the intestinal lining.  That sloughing of the gut was a class 
sign.  The intestine was blitzed, completely full of uncoagulated, runny 
blood, and at the same time the monkey had massive blood clotting in the 
intestinal muscles.  The clotting had shut off blood circulation to the 
gut, and the cells in the gut subsequently died-that is, the intestines 
had died-and then the gut had filled up with blood.  Dead intestine-this 
is the kind of thing you saw in a decayed carcass.  In her words, "It 
looked like the animals had been dead for three or four days."  Yet they 
had been dead only for hours.  Some of the monkeys were so badly liquefied 
that she and Trotter didn't even bother to do a necropsy, they just yanked 
samples of liver and spleen from the dead animal.  Some of the monkeys 
that were dying in Room H had become essentially a heap of mush and bones 
in a skin bag, mixed with huge amounts of amplified virus.

DECEMBER 4, 0730 HOURS, MONDAY

MONDAY ARRIVED COLD and raw, with a rising wind that brought a smell of 
snow from a sky the color of plain carbon steel.  In the shopping malls 
around Washington, Christmas lights had been hung.  The parking lots were 
empty, but later in the day they would fill up with cars, and the malls 
would fill up with parents and children, and the children would line up to 
see Santa Clauses.  Dan Dalgard drove to the primate building, one more 
commuter in a sea of morning traffic.
	He turned into the parking lot.  As he got closer to the building, 
he saw a man was standing by the front door near the sweet-gum tree, 
wearing a white Tyvek jumpsuit.  It was one of the monkey caretakers.  
Dalgard was furious.  He had instructed them not to come out of the 
building wearing a mask or a protective suit.  He jumped out of his car, 
slammed the door, and hurried across the parking lot.  As he got closer, 
he recognized the man as someone who will be called Milton Frantig.  
Frantig was standing bent over with his hands on his knees.  He didn't 
seem to notice Dalgard-he was staring at the grass.  Suddenly Frantig's 
body convulsed, and liquid spewed out of his mouth.  He vomited again and 
again, and the sound of his retching carried across the parking lot.

A MAN DOWN

AS DAN DALGARD watched the man spill his stomach out onto the lawn, he 
felt, in his words, "scared shitless".  Now, perhaps for the first time, 
the absolute horror of the crisis at the primate building washed over him. 
 Milton Frantig was doubled over, gasping and choking.  When his vomiting 
subsides, Dalgard helped him to his feet, took him indoors, and made him 
lie down on a couch.  Two employees were now sick-Jarvis Purdy was still 
in the hospital, recovering from a heart attack.  Milton Frantig was fifty 
years old.  He had a chonic, hacking cough, although he didn't smoke.  He 
had been working with monkeys and with Dalgard at Hazleton for more than 
twenty-five years.  Dalgard knew the man well and liked him.  Dalgard felt 
shaken, sick with fear and guilt.  Maybe I should have evacuated the 
building last week.  Did I put the interests of the monkeys ahead of the 
interest of the human beings?
	Milton Frantig was pale and shaky, and felt faint.  He developed 
the dry heaves.  Dalgard found a plastic bucket for him.  Between heaves, 
interrupted by coughing speels, Frantig apologized for leaving the 
building while wearing a jump suit.  He said he had just been putting on 
his respirator to go inside a monkey room when he began to feel sick to 
his stomach.  Perhaps the bad smell in the building had nauseated him, 
because the monkey room weren't cleaned as regularly as usual.  He could 
feel he was about to vomit, and he couldn't find a bucket or anything to 
throw up into, and it was coming on so fast that he couldn't get to the 
rest room, so he had run outdoors.
	Dalgard wanted to take Frantig's temperature, but nobody could 
find a thermometer that hadn't been used rectally on monkeys.  He sent 
Bill Volt to a drugstore to buy one.  When he returned, they discovered 
that Frantig had a fever of a hundred and one.  Bill Volt hovered in the 
room, almost shaking with fear.  Volt was not doing well-"almost spastic 
in his terror,"  Dalgard would later recall, but it wasn't any different 
from the way Dalgard felt.
	Milton Frantig remained the calmest person in the room.  Unlike 
Dalgard and Volt, he did not seem afraid.  He was a devout Christian, 
comfortable with telling people that he had been saved.  If the lord saw 
fit to take him home with a monkey disease, he was ready.  He prayed a 
little, remembering his favorite passages in the Bible, and his dry heaves 
subsided.  Soon he was resting quietly on the couch and said he felt a 
little better.
	"I want you to stay where you are," Dalgard said to him.  "Don't 
leave the building."  He got into his car and drove as fast as he could to 
the Hazleton Washington offices on Leesburg Pike.  The drive didn't take 
long, and by the time he got there, he had made up his mind: the monkey 
facility had to be evacuated.  Immediately.
	There had been four workers employed in the building, and two of 
them were now going to be in the hospital.  One man had heart problems, 
and now the other had a fever with vomiting.  From what Dalgard knew about 
Ebola virus, either of these illnesses could be signs of infection.  They 
had shopped at malls and visited friends and eaten in restaurants.  
Dalgard thought they were probably having sexual intercourse with their 
wives.  He didn't even want to think about the consequences.
	When he arrived at Hazleton Washington, he went directly to the 
office of the general manager.  He intended to brief him about the 
situation and get his approval to evacuate the monkey house.  "We've got 
two guys who are sick," Dalgard said to him.  He began to describe what 
had happened, and he started crying.  He couldn't control it.  He broke 
down and wept.  Trying to pull himself together, he said, "I recommend 
that-the entire operation-we close it down and turn it over to the Army.  
We've had this god-damned disease since October, we haven't gotten 
injured, and all of a sudden we've got two guys sick, one in the hospital, 
one who's going there.  I kept on thinking that if there was a real human 
risk, we would have seen something by now.  We've played with fire for too 
long."
	The general manager sympathized with Dalgard and agreed with him 
that the monkey facility ought to be evacuated and shut down.  Then, 
holding back his tears, Dalgard hurried to his own office, where he found 
a group of officials from C.D.C. waiting for him.  He felt as if the 
pressure would never let up.  The C.D.C. people had arrived at Hazleton to 
begin surveillance of all employees who had been exposed to the virus.  
Dalgard told them what had just happened at the monkey house, that a man 
had gone down with vomiting.  He said, "I have recommended that the 
facility be evacuated.  I feel that the building and the monkeys should be 
turned over to the people from USAMRIID, who have the equipment and 
personnel to handle it safely."
	The C.D.C. people listened and did not disagree.
	Then there was the question of what to do with Milton Frantig, who 
was still lying on the couch under orders from Dalgard not to move.  Since 
the C.D.C. was in charge of the human aspects of the outbreak, the C.D.C. 
was in charge of Frantig-and the C.D.C. wanted him taken to Fairfax 
Hospital, inside the Washington Beltway.
	It was now nine-twenty in the morning.  Dalgard sat in his office 
and sweated it out, managing the crisis by telephone.  He called C.J. 
Peters at Fort Detrick and told him that he had a monkey caretaker who was 
sick.  In his dry, calm voice, now without any hint that he had recently 
been weeping, he said to Peters, "You have permission to consider the 
facility and all the animals to be the responsibility of USAMRIID."
	Colonel C.J. Peters was a little distrustful of the phrase "the 
responsibility of USAMRIID."  It implied that if anything went wrong and 
people died, the Army could be held responsible and could be sued.  He 
wanted to take control of the building and nuke it, but he didn't want 
lawsuits.  So he said to Dalgard that the safety of his people and the 
safety of the general public were the most important things to him but 
that he would have to clear this with his command.  He said he would get 
back to Dalgard as soon as possible.
	Then they talked about the sick man, and C.J. learned that he was 
being taken to Fairfax Hospital.  That disturbed him greatly.  He felt 
that it should be assumed that the guy was breaking with Ebola-and do you 
really want to bring a guy like that into a community hospital?  Look at 
what Ebola had done in hospitals in Africa.  C.J. thought the man belonged 
in the Slammer at the Institute.
	As soon as he got off the line with Dalgard, C.J. Peters 
telephoned Joe McCormick, who was in charge of the C.D.C. effort.  He said 
to Mccormick something like, "I know you have this idea that a surgical 
mask and gown are all you need to handle an Ebola patient, but I think you 
need to use a higher level of containment," and he offered to pick up the 
sick man in an Army ambulance-put him in an Army biocontainment pod-and 
carry the pod to the Army's facilities at the Institute.  Put him in the 
Slammer.
	C.J. Peters recalls that McCormick said to him something like, "I 
want the guy at Fairfax Hospital."  C.J. replied, "All right, I believe 
this, Joe, and you believe that, and we don't agree.  Regardless-what is 
going to happen to the medical personnel at Fairfax Hospital or to you.  
Joe, if Ebola virus gets into that hospital?"
	McCormick would not budge on his decision: he had been 
face-to-face with Ebola in Africa, and he hadn't gotten sick.  He had 
worked for days inside a mud hut that was smeared with Ebola blood, on his 
knees among people who were crashing on and bleeding out.  You didn't need 
a space suit to handle an Ebola patient.  They could be handled by skilled 
nurses in a good hospital.  The guy was going to Fairfax Hospital.  C.J. 
Peters, in spite of his strong dislike for McCormick, found himself 
admiring him for making strong decisions in a very difficult situation.

A TELEVISION-NEWS VAN arrived at the monkey house from Channel 4 in 
Washington.  The workers peered through curtains at the van, and when the 
reporter came to the door and pushed the buzzer, no one answered.  Dalgard 
had made it clear to them that no one was to talk to the media.  Just 
then, an ambulance from Fairfax Hospital arrived to take Frantig away.  
Channel 4's timing could not have been better.  The news team turned on 
their lights and started filming the action.  The door of the monkey house 
swung open and Milton Frantig stumbled out, still wearing his Tyvek suit, 
looking embarrassed.  He walked over to the ambulance, the medical team 
opened the back doors of the vehicle, and Frantig climbed in by himself 
and lay down on the gurney.  They slammed the doors and took off with 
Channel 4 following them.  A few minutes later, the ambulance and Channel 
4 pulled into Fairfax Hospital.  Frantig was put in an isolation room, 
with access restricted to doctors and nurses wearing rubber gloves, gowns, 
and surgical masks.  He said he felt better.  He prayed to the Lord and 
watched a little television.
	Back at the monkey house, the situation had become unbearable for 
the remaining workers.  They had seen people in space suits, they had seen 
their colleague puking the grass, they had seen Channel 4 chasing the 
ambulance.  They left the building in a real hurry, locking it after 
themselves.
	There were four hundred and fifty monkeys alive in the building, 
and their hoots and cries sounded in the empty hallways.  It was eleven 
o'clock in the morning.  A snow flurry came and went.  The weather was 
turning colder.  In the monkey house, the air-handling equipment had 
failed for good.  The air temperature in the building had soared beyond 
ninety degrees, and the place had turned steamy, odorous, alive with 
monkey calls.  The animals were hungry now, because they had not been fed 
their morning biscuits.  Here and there, in rooms all over the building, 
some of the animals stared from glazed eyes in masklike faces, and some of 
them had blood running from their orifices.  It landed on metal trays 
under their cages ... ping, ping, ping.

91-TANGOS

1030 HOURS, MONDAY

THE CRISIS WAS getting worse at Reston.  Dan Dalgard felt he was losing 
control of everything.  He set up a conference call with all the senior 
managers in his company and informed them of the situation-two employees 
were down, and the second man could be breaking with Ebola-and he told the 
managers that had offered to turn the monkey house over to the Army.  They 
approved his action, but they said they wanted the oral agreement with the 
Army to be put in writing.  Furthermore, they wanted the Army to agree to 
take legal responsibility for the building.
	Dalgard then called C.J. Peters and asked that the Army assume 
responsibility for any liability that would arise after the Army took 
over.  C.J. flatly rejected that proposal.  He saw a need for clarity, 
speed, and no lawyers.  He felt that the outbreak had ballooned to the 
point where a decision had to be made.  Dalgard agreed to fax him a simple 
letter turning the monkey over to the Army.  They worked up some language, 
and C.J. carried the letter by hand to the office of General Philip 
Russell.  He and the general pored over the letter, but they did not 
choose to show it any Army lawyers.  Russell said, "We have to convince 
the lawyers of the path of righteousness."  They signed the letter, faxed 
it back to Dalgard, and the monkey house fell into the hands of the Army.
	Jerry Jaax would have to lead a much larger biohazard team back 
into the monkey house.  The number of animals that needed to be dealt with 
was staggering.  His troops were untested, and he himself had never been 
in combat.  He didn't know, couldn't know, how he or his people would 
perform a chaotic situation involving intense fear of an unpleasant death.
	Jerry was the commanding officer of the 91-Tangos at the 
Institute.  The Army's animal-care technicians are classified 91-T, which 
in Army jargon becomes 91-Tango.  The younger 91-Tangos are eighteen years 
old and privates.  While the ambulance was taking Milton Frantig to the 
hospital, Jerry called a meeting of his 91-Tangos and civilian staff in a 
conference room in the Institute.  Although most of the soldiers were 
young and had very little or no experience in space suits, the civilians 
were old men, and some were Level 4 specialists who had worn Chemturions 
on a daily basis.  The room was jammed, and people sat on the floor.
	"The virus is Ebola or Ebola-like agent," he said to them.  "We 
are going to be handling large amount of blood.  And we will be handling 
sharp instruments.  We are going to use the disposable biocontainment 
suits."
	The room was silent while he spoke.  He didn't mention that a man 
was down, because he didn't know about it-C.J. Peters hadn't told him 
about that.  For the time being, Peters was staying quiet about the 
development.
	Jerry said to his people, "We are looking for volunteers.  Is 
there anyone in this room who does not want to go?  We can't make you go."
	When no one backed out, Jerry looked around the room and picked 
his people: "Yep, he's going.  She's going, and, yep, you're going."  In 
the crowd, there was a sergeant named Swiderski, and Jerry decided that 
she could not go because she was pregnant.  Ebola has particularly nasty 
effects on pregnant women.
	No combat unit in the Army could handle this work.  There would be 
no hazard pay, as there is in a war zone.  The Army has a theory regarding 
biological space suits.  The theory is that work inside a space suit is 
not hazardous, because you are wearing a space suit.  Hell, if you handled 
hot agents without a space suit, that would be hazardous work.  The 
privates would get their usual pay: seven dollars an hour.  Jerry told 
them that they were not to discuss the operation with anyone, not even 
members of their families.  "If you have any tendency to claustrophobia, 
consider it now," he said.  He told them to wear civilian clothes and to 
show up at the Institute's loading dock at 0500 hours the next morning.

DECEMBER 4-5, MONDAY-TUESDAY

THE SOLDIERS DIDN'T sleep much that night, and neither did Gene Johnson.  
He was terrified for the "kids", as he called them.  He had fair share of 
scares with hot agents.  Once in Zaire, he had stuck himself with a bloody 
needle while taking blood from a mouse.  There was reason to believe the 
mouse was hot, and so they had airlifted him to the Institute and put him 
in the Slammer for thirty days.  "That was not a fun trip," as he put it.  
"They treated me as if I would die.  They wouldn't give me scissors to cut 
my beard because they thought I would be suicidal.  And they locked me in 
at night."  At Kitum Cave, while wearing a space suit and dissecting 
animals, he had been nicked three times with bloody tools.  Three times 
his space suit had been punctured and his skin broken and cut smeared with 
animal blood.  He regarded himself as lucky not to have picked up Marburg 
or something else at Kitum Cave.  Having had some close calls, he was 
deeply afraid of what had invaded the monkey house.
	Johnson lived in a rambling house on the side of Catoctin 
Mountain.  He sat in his study most of the night, thinking about 
procedures.  Every movement of the body in a hot area has to be controlled 
and planned.  He said to himself,  Where's this virus going to get you?  
It's going to get you through the hands.  The hands are the weak point.  
Above all, the hands must be under control.
	He sat in an easy chair and held up one hand and studied it.  Four 
fingers and an apposed thumb.  Exactly like a monkey's hand.  Except that 
it was wired to a human mind.  And it could be enclosed and shielded by 
technology.  The thing that separated the human hand from Nature was the 
space suit.
	He stood up and went through motions in the air with his hands.  
Now he was giving a monkey an injection.  Now he was carrying the monkey 
to a table.  He was putting the monkey on the table.  He was in a hot 
zone.  He was opening the monkey up, and now he was putting his hands into 
a bloody lake of amplified hot agent.  His hands were covered with three 
layers of rubber and then smeared with blood and hot agent.
	He paused and jotted notes on paper.  Then he turned back to his 
imaginary hot zone.  He inserted a pair of scissors into the money and 
clipped out part of the spleen.  He handed it to someone.  Where would 
that person be standing?  Behind him?  Now he imagined himself holding a 
needle in his hand.  Okay, I have a needle in my hand.  It's lethal 
object.  I'm holding it in my right hand if I'm right-handed.  Therefore, 
my buddy should stand to my left, away from the needle.  Now my buddy's 
hands.  What will my buddy's hands be doing?  What will everyone's hands 
be doing?  By early in the morning, he had written many pages of notes.  
It was a script for a biohazard operation.

JEERY JAAX LEFT home at four o'clock in the morning, while Nancy was still 
asleep.  He met Gene Johnson at the loading dock, where they went over 
Gene's script.  Jerry memorized it, and meanwhile the team members began 
to show up, soldiers in Jerry's unit.  Many of them arrived on foot, 
having walked over from their barracks.  They stood around, waiting for 
their orders.  It was pitch-dark, and only the floodlights illuminated the 
scene.  Jerry had decided to use a buddy system inside the building, and 
he began deciding who would be paired with whom.  On a piece of paper, he 
drew up a roster of buddies, and he wrote down the order of entry, the 
sequence in which they would be inserted into the building.  He stood 
before them and read the roster, and they got into their vehicles-a white 
refrigerator truck, a couple of unmarked passenger vans, an unmarked 
pickup truck, the white ambulance containing the bubble stretcher, and a 
number of civilian cars-and headed for Reston.  They became trapped in 
rush-hour traffic again, surrounded by half-asleep yuppies in suits who 
were sucking coffee from foam cups and listening to traffic reports and 
easy rock and roll.

WHEN ALL THE vehicles had arrived at the back of the monkey house, the 
teams assembled on the lawn, and Gene Johnson asked for their attention.  
His eyes were sunken and dark, suggesting he had not slept in days.  "We 
are not playing games here," he said. "This is the real thing.  A 
biological Level 4 outbreak is not a training session.  There's been a 
development I want you all to know about.  There is a possibility that 
transmission of this virus to human has taken place.  There are two people 
who are ill and are hospitalized.  Both of them are animal caretakers who 
worked in this building.  There is one guy we are especially worried 
about.  Yesterday morning, he became sick.  He vomited and spiked a fever. 
 He is now in the hospital.  We don't know if he is breaking with Ebola.  
The thing I want you to understand is that he was not bitten by an animal 
and he did not cut himself or stick himself with a needle.  So if he has 
Ebola, there is a possibility he got it through airborne transmission."
	Jerry Jaax listened to the speech with a rising sense of horror.  
He hadn't known about this man getting sick!  Nobody had told him about 
this!  Now he had a feeling that there were going to be casualties.
	It was an icy, gray day.  The trees behind the monkey house had 
lost their leaves, and dead leaves rustled across the lawn.  At the 
day-care center down the hill, parents had been dropping off their 
children, and the children were playing on swings.  Gene Johnson continued 
his speech.  "Everyone is to proceed on the assumption risks, and you are 
experienced"-and his eyes rested on a private first class named Nicole 
Berke.  She was quite beautiful, long blond hair, eighteen years old-and 
he thought, Who is she?  I've never seen her before.  Must be one of 
Jerry's people.  They're just kids, they don't know what they're up 
against.  "You must follow the procedures exactly," he went on. "If you 
have any questions, you must ask."
	Jerry got up and said to them, "No question is too stupid.  If you 
have a question, ask."
	Private Nicole Berke was wondering if she would get a chance to go 
into the building.  "How long are we going to be doing this, sir?" she 
asked him.
	"Until the monkeys are dead," he replied. "There are four hundred 
and fifty monkeys in there."
	Oh, God, she thought, four hundred fifty monkeys-this is going to 
take forever.
	The questions were few.  People were tense, silent, turned inward. 
 Jerry Jaax entered the staging room, and the support team helped him put 
on his Racal Suit.  They fitted the bubble over his head, and his blowers 
started to roar.  He told the teams he'd see them inside, and he and his 
buddy, Sergeant Thomas Amen, entered the air lock.  The door closed behind 
them, and they stood in darkness.  They felt their way down the dark 
air-lock corridor, opened the far door, and crossed over to the hot side.
	The area was trashed.  It had not been cleaned in many days.  The 
workers had left in a big hurry.  There were monkey biscuits scattered all 
over the floor, and papers were scattered everywhere, an there were 
overturned chairs in the offices.  It looked as if the humans had fled 
from here.  Jerry and the sergeant began exploring the building.  They 
moved slowly and carefully in their suits, as if they were wreck divers 
operating in deep water.  Jerry found himself in a small corridor that 
opened into more monkey rooms.  He saw a room full of monkeys, and every 
one of the animals was looking at him.  Seventy pairs of monkey eyes fixed 
on a pair of human eyes in a space suit-and the animals went nuts.  They 
were hungry and were hoping to be fed.  They had trashed their room.  Even 
locked inside cages, monkey could really do a job on a room.  They had 
been throwing their biscuits all over the place, and they had been 
finger-painting the walls with dung.  The wall were scribbled all the way 
up to the ceiling with monkey writing.  It was a cryptic message to the 
human race that came out of the primate soul.
	Jerry and the sergeant found some bags of monkey biscuits and went 
into each room in the building, and fed the monkeys.  The animals were 
going to die soon, but Jerry didn't want them to suffer more than they had 
to.  While he fed them, he inspected them for signs of Ebola.  In many of 
the rooms, he found animals that seemed dull-eyed and listless.  Some of 
them had runny noses, or there was a kind of blood-spattered green crust 
caked around the nostrils.  He saw puddles of blood in some of the pans 
under their cages.  These sights disturbed him deeply because they told 
him that the agent had gone all through the building.  He could see some 
of the animals coughing and sneezing, as if they had the flu.  He wondered 
if he was seeing a mutant form of Ebola-a kind of airborne Ebola flu.  He 
shrank from the idea and tried to turn his mind away from it, for it was 
too awful to contemplate.  You could no more imagine it than you could 
imagine a nuclear war.  A layer of sweat built up inside his plastic head 
bubble, making it difficult for hm to see the monkeys clearly.  But he 
could hear them, shrieking and calling distantly beyond the sound of his 
blowers.  So far, he had not felt any claustrophobia or panic.  He wasn't 
going to lose it in here.

SEVERAL MEMBERS OF the team spent the next half hour in staging room.  
They were shucking syringes, removing them from a sterile envelope, and 
fitting each syringe with a needle.  Now the syringes were ready to be 
filled with drugs.
	A few feet from the soldiers, Captain Mark Haines began to suit 
up.  While the support team got him dressed, he gave a speech.  He wanted 
the soldiers to keep certain things in mind as they followed him in.  He 
said, "You are going to euthanize a whole building full of animals.  This 
is not a fun operation.  Don't get attached to the animals.  They are 
going to die anyway.  They're all going to have to go, every last one of 
them.  Don't think of it as killing something.  Think of it as stopping 
the virus here without letting it get anywhere else.  Don't play with the 
monkeys.  I don't want to hear laughing and joking around the animals.  I 
can be hard.  Remember the veterinarian's creed: you have a responsibility 
to animals, and you have a responsibility to science.  These animals gave 
their lives to science.  They were caught up in this thing, and it's not 
their fault.  They had nothing to do with it.  Keep an eye on you buddy.  
Never hand a used needle to another person.  If a needle comes out of its 
cap, it goes straight into an animal.  Put the used syringe into a sharps 
container.  If you get tired, tell your supervisor, and we'll decon you 
out."  He turned away from them and went in with his buddy.
	"Who's next?" Gene Johnson said, reading the roster, "Godwin!  
You're next."
	A private first class named Charlotte Godwin hurried outdoors to 
the van and climbed inside, and took off all her clothes, and put on a 
surgical scrub suite, socks, sneakers, and a hair cap.  It was brutally 
cold in the van.  She felt embarrassed and vulnerable.
	In the staging room they began to suit her up.  Someone said to 
her, "You're kind of small.  We've got a special suit for you."  It wasn't 
special.  It was a large suit, sized for a big man, and she was five feet 
tall.  It hung around her like a bag.  The supper team was taping her now, 
running brown sticky tape around her ankles and wrists, and her blowers 
came on.
	An Army photographer took some photographs for the action file, 
and as the flash went off she thought, God, I would be swearing a hair 
cap.  It's a clown cap.  It's a Bozo hat.  You won't see my hair in the 
picture, and my space suit is too large for me.  Makes me look fat.  Just 
my luck to be the one looking like a dork in the action photographs.
	She staggered into the gray zone, carrying boxes of supplies, and 
felt a sweeping adrenal rush, and thought.  I'm too young to be going 
through this.  She was eighteen.  Then she noticed the smell.  A really 
bad smell was creeping through her filters.  Her buddy pounded on the far 
door, and they entered.  Ripples in the faceplate of her head bubble 
distorted the view, as if she was in a house of mirrors.  The smell of 
monkey was overpowering inside her space suit.  It was also too quiet, and 
monkey houses are not quiet places.  The quiet bothered her even more than 
the smell or the heat.
	A door swung open, and Colonel Jaax appeared.  He said, "START 
LOADING SYRINGES.  DOUBLE DOSES OF KETAMINE."
	"YES, SIR," she replied.
	"THE SERGEANT AND I WILL BE KNOCKING DOWN MONKEYS IN HERE," he 
said.
	Charlotte started filling syringes with ketamine, the anesthetic.  
Jerry Jaax carried a loaded syringe into the monkey room and fitted it to 
the socket of a pole syringe.  The sergeant fished his mop handle into a 
cage and pinned a monkey.  Then Jerry opened the door of the cage.  
Watching the monkey carefully to make sure it didn't try to rush at him, 
he slid the pole syringe through the open door and gave the monkey an 
injection of anesthetic, and then pulled out the syringe, and slammed the 
door shut.  It was the most dangerous job because of the open door.  The 
animal could attack or try to escape.  Jerry and the sergeant went from 
cage to cage, and the monkeys began to go to sleep under the anesthesia.
	The rooms contained double banks of monkey cages.  The lower bank 
was near the floor and was dark.  Jerry had to get down on his knees to 
peer inside.  He could hardly see anything through his head bubble.  His 
knees were killing him.  He would open a cage door, and the sergeant would 
slide the mop handle into the cage.  The monkey would scrabble around, try 
to escape, and the sergeant would say, "OKAY, I GOT HIM.  HE'S PINNED."  
Jerry would slide the pole syringe toward the monkey, aiming the needle 
for the thigh.  There would be screeches and a wild commotion, the monkey 
shrieking "Kra! Kra!" and the needle would sink in.  This was turning out 
to be one of the hardest things he'd ever done in his career as a 
veterinarian.
	More team members came into the building, Jerry assembled them in 
the hallway and said to them: "STOP EVERY FIVE OR TEN MINUTES AND CHECK 
YOUR NEIGHBOR'S SUIT FOR RIPS.  BE VERY CAREFUL.  MAKE SURE YOU TAKE REST 
BREAKS.  I WANT YOU TO REST FOR TEN MINUTES EVERY HOUR.  WHEN YOU GET 
TIRED, YOU GET CARELESS."  Every time he looked into a monkey room, he saw 
a room full of eyes looking back at him.  Some of the monkeys rattled 
their cages, and the wave of noise swept up and down the room.
	Jerry decided to set up a bleed area in a small room near the 
front of the building, right next to the offices.  In the bleed area there 
was a shower with a drain hole in the floor.  They would need to use the 
drain hole for washing down blood and for rinsing down objects with 
bleach.  Every time blood went down the drain, they would pour bleach 
after it-they didn't want this thing getting into Reston sewage system.  
They found a metal examination table on wheels and rolled it into the 
bleed area.  Jerry divided the people into subteams: a bleed team (to work 
at the bleed table), a euthanasia team (to put monkeys to death), and a 
necropsy team (to open up the monkeys and take samples and bag the 
carcasses in biohazard bags).
	They got an assembly line going.  Every five minutes or so, Jerry 
Jaax would carry an unconscious monkey out of a room and down the 
corridors to the bleed area, holding the animal with its arms pinned 
behind its back.  He would lay it down on the bleed table, and then 
Captain Haines, the Green Beret, would insert a needle into the animal's 
thigh and draw off a lot of blood into various tubes.  Then he'd hand the 
unconscious animal to Major Nate Powell, and he would give it an injection 
of T-61, the euthanasia agent.  He'd put the needle right into the heart.  
When the animal was clearly dead, he would hand it to Captain Steve Denny, 
who did the necropsy.  Captain Denny opened the animal with scissors and 
snipped out parts of the liver and spleen.  The livers of these animals 
were gray, eroded, nasty looking.
	Private Charlotte Godwin stood beside Captain Denny and handed him 
tools.  She thought he looked nervous, jumpy, inside his space suit.  He 
pulled a spleen out of a monkey.  It was speckled with white spots, as 
hard as a rock, a biological bomb ticking with hot agent.  After a while, 
he handed the scissors to her and gave her a chance to open up a monkey.  
It frightened her and gave her a big rush.  She was doing a hot necropsy 
in Level 4, perhaps the most dangerous work in a space suit.  This was a 
rocket ride, and it thrilled her.  Her hands worked within a membrane's 
thickness of a death worse than any death in combat.  She found herself 
racing to finish the job.  She noticed that the monkey's eyes were open.  
It was as if the monkey was looking at her while she worked.  She wanted 
to reach out and close the monkey's eyes.  She thought, Is my face the 
last thing they see?

INSIDE

EARLY EVENING, TUESDAY

THE DATE WORE ON, and people began using up their batteries.  They could 
see that the daylight was starting to go, because some windows at the ends 
of the hallways were getting dark.  Jerry Jaax made people rest every now 
and then.  They sat on the floor with blank looks on their faces, 
exhausted, or they loaded syringes with drugs.  Meanwhile, Jerry went from 
person to person, trying to gauge the level of exhaustion.  "HOW ARE YOU 
DOING?  ARE YOU TIRED?  DO YOU WANT TO GO OUT?"
	Nobody wanted to go out.
	The team inside the building maintained radio contact with Gene 
Johnson outside the building.  He had supplied them with hand-held 
short-wave radios that operated on a military band.  He hadn't given them 
ordinary walkie-talkies because he didn't want anybody listening to the 
talk, especially the news media, who might make a tape recording of the 
chatter.  It seemed less likely that anyone would listen to these radios.
	Something went wrong with one of the soldiers' suits.  She was a 
specialist named Rhonda Williams.  Her blower cut off, and her suit began 
to go limp until it stuck to her sweaty scrub suit, and she felt 
contaminated air creeping around her.  "MY AIR'S GOING OFF," she shouted.  
She kepted working.  She couldn't leave her post.  Her battery was 
failing.  She discovered that she did not have a spare battery on her 
belt.  All the others had used their spare batteries.
	When Rhonda announced that her air was shutting down, it caused a 
commotion.  Jerry wanted to evacuate her from the building.  He ran down 
the hall to the air-lock door, where a soldier was stationed with a 
short-wave radio.  Jerry grabbed the radio, and called Gene Johnson, 
shouting through his helmet, "WE'VE GOT A LADY WHO'S LOSING HER BATTERY."
	Gene answered, "We need to get a battery and send it in with 
someone.  Can you wait?"
	"NO, SHE'S COMING OUT.  SHE'S LOSING HER AIR," Jerry said.
	Abruptly, the soldier by the door told Jerry that he had an extra 
battery.  Jerry said over the radio: "WAIT-WE HAVE AN EXTRA ONE."
	The soldier ran down the hallway to Rhonda, grinned at her, and 
said, "YOUR BATTERY IS HERE."
	People started laughing.  He clipped it to Rhonda's belt.
	She thought, Oh, my God, they're gong to unlock my old battery, 
it's going to stop my blowers.  She said, "WAIT A MINUTE!  MY AIR'S GOING 
TO GO OFF!"
	"DON'T WORRY.  IT'S JUST FOR A SECOND WHILE WE SWITCH YOU OVER," 
he said.  Rhonda was rattled and was ready to leave.  She was wondering if 
she had caught the virus during the moments when her air pressure had been 
lost.  Jerry decided to send her out with Charlotte Godwin, who seemed to 
be getting tired.  On the radio, he said to Gene, "I HAVE TWO COMING OUT."
	On Gene's side, a near panic was occurring.  A television van had 
just showed up.  Gene was appalled.  He didn't want the cameras to start 
rolling just as two women in space suits were extracted from the building. 
 He said to Jerry, "We're jammed.  We can't move them out.  We've got TV 
cameras out here."
	"I'LL SENDING THEM OUT," Jerry said.
	"All right.  Send them out," Gene said. "We'll give the cameras a 
show."
	Jerry pounded on the door of the gray area, and the decon man 
opened it.  He was a sergeant.  He wore a space suit.  He held a pump 
sprayer filled with bleach, and a flashlight.  Rhonda and Charlotte walked 
into the gray area, and the sergeant told them to hold their arms straight 
out at their sides.  He played the flashlight over their space suits, 
checking for damage or leaks.
	Rhonda noticed that he had a strange look on his face.
	"YOU HAVE A HOLE IN YOUR SUIT," he said.
	I knew this was going to happen, she thought.
	"WHERE DID YOU GET IT?" he asked.
	"I DON'T KNOW!"
	He slapped a piece of tape over the hole.  Then he washed the two 
soldiers down with bleach, spraying it all over them, and pounded on the 
door that led to the staging room.  Someone opened it, and they went out.  
Immediately the support team opened their head bubbles and peeled off 
their suits.  Their scrub suits, underneath, were soaked with sweat.  They 
began to shiver.
	"There's a television-news van out front," Gene said.
	"I had a hole in my suit," Rhonda said to him.  "Did I get the 
virus?"
	"No.  You had enough pressure in your suit to protect you the 
whole time."  He hurried them outdoors.  "Get into the van and lie down," 
he said.  "If anybody asked you any questions, keep you mouths shut."
	They couldn't find their clothes in the van.  They rolled 
themselves up in some overcoats to keep warm and lay down on the seats, 
out of sight.
	The television crew parked their van near the front door of the 
monkey house, and the reporter began to poke around, followed by a 
cameraman.  The reporter knocked on the front door and rang the buzzer-no 
answer.  He peered in the front windows-the curtains were drawn, and he 
couldn't see anything.  Well, nothing was happening in there.  This place 
was deserted.  He and the cameraman didn't notice the white vehicles 
parked behind the building, or if they noticed them it didn't seem 
interesting.  There was nothing going on here.
	The television men returned to their van and sat in it for a 
while, hoping that someone would happen or that someone would show up so 
that they could get some sound bites for the evening news, but this was 
getting to be boring, it was an awfully cold day, and the light was 
fading.  It did not occur to them to go around the side of the building 
and point their video camera toward a window.  If they had done that, they 
would have gotten enough footage to fill the entire evening news, with 
something left over for CBS's 60 minutes.  They would have gotten footage 
of soldiers in space suits smeared with Ebola blood, engaged in the first 
major biohazard mission the world ever knew, and they would have gotten 
shots of biohazard buddies coming out into the staging area in pairs and 
being stripped of their suits by the supporting team.  But the news crew 
didn't walk around the building, and so far as I know, there is no video 
footage of the Reston action.
	Meanwhile, the two women lay on their back in the van for many 
minutes.  Suddenly the television crew left.  Gene Johnson, poking his 
head around the corner of the building, reported that the coast was clear. 
 The women got dressed and then hurried off to relieve themselves in the 
wooded area behind the building.  That was where they found the 
needles-two used hypodermic syringes with needles attached to them.  The 
needles were uncapped and bare, obviously used.  It was impossible to tell 
how long they had been lying in the grass.  Some of the safety people put 
on gloves and picked up the needles, and as they searched the area, they 
found more needles in the grass.
	The last person to come out was Jerry Jaax.  He emerged around six 
in the evening, having lost between five and ten pounds of weight.  It was 
fluid loss from sweating, and his face was ashen.  His hair, instead of 
look silver, looked white.
	There was no food for the soldiers, and they were hungry and 
thirsty.  The soldiers took a vote on where to eat, and it came out in 
favor of Taco Bell.  Gene Johnson said to them, "Don't tell anyone why are 
here.  Don't answer any question."
	The caravan started up, engines roaring in the cold, and headed 
for Taco Bell.  The soldiers ordered soft tacos with many, many jumbo 
Cokes to replace the sweat they'd lost inside their space suits.  They 
also ordered a vast number of cinnamon twists-everything to do-yeah, put 
it in boxes, and hurry, please.  The employees were staring at them.  The 
soldiers looked like soldiers, even in jeans and sweat shirts-the men were 
bulked up and hard-looking, with crew cuts and metal-framed military 
eyeglasses and a few zits from too much Army food, and the women liked as 
if they could do fifty push-ups and break down a weapon.  A man came up to 
Sergeant Klages while he was waiting for his food and said, "Where were 
you doing over there?  I saw those vans."  Sergeant Klages turned his back 
on the man without saying a word.

AFTER MIDNIGHT ON the water bed in the master bedroom of Jaax house on the 
slopes of Catoctin Mountain, Nancy and Jerry Jaax caught up on the news 
while their daughter, Jaime, slept beside them.  Jerry told her that the 
day's operation had gone reasonably well and that no one had stuck himself 
or herself with a needle.  He told her he hadn't realized how lonely it is 
inside biohazard suit.
	Nancy wrapped herself around him and rested her head against his 
neck in the way they had held each other since college.  She thought he 
looked shrunken and thin.  He was physically more exhausted than she had 
seen him in years.  She picked up Jaime and carried her to bed, then 
returned and folded herself around her husband.  They fell asleep holding 
each other.

A BAD DAY

DECEMBER 6, WEDNESDAY

FOR THE PAST several days and nights, an Army scientist named Thomas 
Ksiazek had been working in his space suit in a Level 4 lab trying to 
develop a rapid test for Ebola virus in blood and tissue.  He got the test 
to work.  It was called a rapid Elisa test, and it was sensitive and easy 
to perform.  He tested urine and blood samples from Milton Frantig, the 
man who had vomited on the lawn and who was now in an isolation room at 
Fairfax Hospital.  Frantig came up clean.  His urine and blood did not 
react to the Ebola test.  It looked as if he had the flu.  This was a 
mystery.  Why weren't those guys breaking with Ebola?
	The weather warmed up and turned sunny, and the wind shifted 
around until it blew from the south.  On the second day of the massive 
nuking-Wednesday-the Army caravan flowed with commuter traffic to Reston 
and deployed behind the monkey house.  Things went more smoothly.  By 
eight o'clock in the morning, the teams had begun their insertions.  Gene 
Johnson brought a floodlight, and they set it up in the gray corridor.
	Jerry Jaax went in first and fed the monkeys.  He made his rounds 
with Sergeant Amen, checking each room, and here and there they found 
monkeys dead or in terminal shock.  In a lounge, they found some chairs, 
and dragged them into a hallway and arranged them in a semicircle so that 
the soldiers could sit on them while they took their rest breaks and 
filled up syringes.  As the day wore on, you could see exhausted soldiers 
and civilians in orange space suits, men and women, their head bubbles 
clouded with condensation, sitting on the chairs, in the hallway, loading 
syringes with T-61 and sorting boxes full of blood tubes.  Some talked 
with each other by shouting, and others just stared at the walls.
	At midmorning, Jerry Jaax was working in Room C.  He decided to 
take a break to rest and check up on his people.  He left the room in 
charge of Sergeants Amen and Klages while he went out into the hallway.  
Suddenly there was a commotion in Room C, and the monkeys in that room 
burst out in wild screeches.  Jerry ran back to the room, where he found 
the sergeants outside the door, looking in, in a state of alarm.
	"WHAT HAPPENED?"
	"A MONKEY ESCAPED, SIR."
	"AW, SHIT!" Jaax roared.
	The animal had bolted past Sergeant Amen as he opened the cage, 
and the sergeants had immediately run out of the room and shut the door 
behind them.
	A loose monkey-this was what Jerry had feared the most.  They can 
leap long distances.  He had been bitten by monkeys himself, and he knew 
what that felt like.  Those teeth went in deep.
	They looked into the room through the window in the door.  The 
whole room had exploded in activity, monkeys whirling in their cages and 
shaking them violently, giving off high, excited whoops.  There were about 
a hundred screaming monkeys in that room.  But where was the loose monkey? 
 They couldn't see it.
	They found a catching net, a pole with a baglike net at the end.  
They opened the door and edged into the room.
	The events that followed have a dreamlike quality in people's 
memories, and the memories are contradictory.  Specialist Rhonda Williams 
has a clear memory that the monkey escaped from the room.  She says she 
was sitting on a chair when it happened, that she heard a lot of shouting 
and suddenly the animal appeared and ran under her feet.  She froze in 
terror, and then burst out laughing-nervous, near-hysterical laughter.  
The animal was a small, determined male, and he was not going to let these 
people get near him with a net.
	Jerry Jaax insists that the monkey never got out of the room.  It 
is possible that the monkey ran under Specialist Williams's feet and then 
was chased back into the room again.
	The loose monkey was very frightened and the soldiers were very 
frightened.  He stayed in the room for a while, running back and forth 
across the cages.  The other monkeys apparently grew angry at this and bit 
at the monkey's toes.  The monkey's feet began to bleed, and pretty soon 
it had tracked blood all over the room.  Jerry got on the radio and 
reported that a monkey was loose and bleeding.  Gene Johnson told him to 
do whatever had to be done.  How about shooting the monkey?  Bring in a 
handgun, like an Army .45.  Jerry didn't like that idea.  Looking into the 
room, he noticed that the loose monkey was spending most of its time 
hiding behind the cages.  If you tried to shoot the monkey, you'd be 
firing into the cages, and the bullet could hit a cage or a wall and might 
ricochet inside the room.  Getting a gunshot wound in this building might 
be fatal.  He decided that the safest procedure would be to go into the 
room and capture the monkey with the net.  He took Sergeant Amen with him.
	As they entered the room, they could not see the monkey.  Jerry 
proceeded forward slowly, holding the net up, ready to swipe it at the 
monkey.  But where was it?  He could not see very well.  His faceplate was 
covered with sweat, and the light was dim in the room.  He might as well 
have been swimming underwater.  He edged slowly forward, keeping his body 
away from the cages on either side, which were filled with hysterical, 
screaming, leaping, bar-rattling monkeys.  The sound of monkeys raising 
hell was deafening.  He was afraid of being bitten by a monkey if he came 
too close to a cage.  So he stayed in the middle of the room as he went 
forward, while Sergeant Amen followed him, holding a syringe full of drugs 
on a pole.
	"BE CAREFUL, SERGEANT," he said. "DON'T GET BITTEN.  STAY BACK 
FROM THE CAGES."
	He edged his way from cage to cage, looking into each one, trying 
to see through it toward the shadowy wall behind.  Suddenly he saw a 
flicker of movement out of the corner of his eye, and he turned with the 
net, and the monkey went soaring through the air over him, making a 
twelve-foot jump from one side of the room to the other.
	"GET HIM!  HE'S OVER HERE!" he said.  He waved the net, slammed it 
around over the cages, but the monkey was gone.
	He walked through the room again, slowly.  The monkey leaped 
across the room, a huge, tail-swing leap.  This animal was airborne 
whenever it moved.  Jerry waved his net and missed.  "SON OF A BITCH!" he 
shouted.  The monkey was too fast for him.  He would spend ten or fifteen 
minutes searching the room, squinting past the cages.  If he found the 
monkey, the monkey would leap to the order side of the room.  It was a 
small monkey, built for life in the trees.  He thought.  This environment 
favors the monkey over us.  We don't have the tools to handle this 
situation.  We are not in control here-we are along for the ride.

OUTSIDE THE BUILDING, Colonel C.J. Peters stopped by to observe the 
operation.  He was dressed in Levi's and a sweater, along with sandals and 
socks, even thought it was a cold day.  With his sandals and mustache, he 
appeared to be a sixties type or some sort of a low-grade employee, may be 
a janitor.  He noticed a stranger hanging around the front of the 
building.  Who was it?  Then the man started to come around the side of 
the building.  He was obviously after something, and he was getting too 
close to the action.  C.J. hurried forward and stopped the man and asked 
him what he was doing.
	He was a reporter from The Washington Post.  "What's happening 
around here?" he asked C.J.
	"Well-aw-nothing much is happening," C.J. replied.  He was 
suddenly very glad he had not worn his colonel's uniform today-for once, 
his bad habits had paid off.  He did not encourage the reporter to come 
around to the side of the building and have a look in through the window.  
The reporter left shortly afterward, having seen and heard nothing of 
interest.  The Washington Post suspected that something funny was 
happening at the monkey house but the reporters and editors who worked on 
the story couldn't quite get to the bottom of it.

"THIS MONKEY KNOWS NETS," Jerry shouted to the sergeant.  The monkey was 
not going to let himself be caught by some fool of a human wearing a 
plastic bag.  They decided to leave him in the room overnight.  Meanwhile, 
the surviving monkeys were becoming increasingly agitated.  The teams 
killed most of the monkeys this day, working straight through until after 
dark.  Some of the soldiers began to complain that they were not being 
given enough responsibility, and so Jerry let them take over more of the 
hazardous work from the officers.  He assigned Specialist Rhonda Williams 
to duty at the euthanasia table with Major Nate Powell.  The major had a 
drugged monkey on the table, holding its arms behind its back in case it 
woke up, while Rhonda uncapped a syringe and gave the monkey a heart 
stick-plunged the needle into the chest between the ribs, aiming for the 
heart.  She pushed the plunger, sending a load of drugs into the heart, 
which killed the monkey instantly.  She pulled the needle out, and a lot 
of blood squirted out of the puncture wound.  That was a good sign; it 
meant she had punctured the heart.  If she got blood on her gloves, she 
rinsed them in a pan of bleach, and if she got blood on her space suit, 
she wiped it down with a sponge soaked in bleach.
	It was awful when she missed the heart.  She pushed the plunger, 
the poison flooded the animals's chest around the heart, and the monkey 
jumped.  It doubled up, its eyes moved, and it seemed to struggle.  This 
was only a death reflex, but she gasped and her own heart jumped.
	Then Colonel Jaax put her to work at the bleed table with Captain 
Haines, and presently she began drawing blood from unconscious monkeys.  
She inserted a needle into the animals' leg vein and drew the blood.  
Their eyes were open.  She didn't like that.  She felt they were staring 
at her.
	She was bleeding a monkey when suddenly she thought its eyes 
moved, and it seemed to be trying to sit up.  It was awake.  It looked at 
her in a daze and reached out and grabbed her by the hand, the one that 
was holding the syringe.  The monkey was very strong.  The needle came out 
of its thigh, and blood spurted out.  Then the animal started pulling her 
hand towards its mouth!  It was trying to bit her hand!  She screamed: 
"GRAB HIM, SOMEBODY, PLEASE!  HE'S GETTING UP!"  Captain Haines caught the 
monkey's arms and pinned it to the table, shouting, "WE HAVE ONE THAT'S 
AWAKE!  NEED KETAMINE!"
	The needle, in coming out of the monkey, had cut the monkey's leg 
vein.  Immediately a ball of blood the size of a baseball formed in the 
monkey's leg.  It just got bigger and bigger, the blood pouring under the 
skin, and Rhonda almost burst into tears.  She pressed her hands on the 
blood ball to stop the internal bleeding.  Through her gloves, she could 
feel the blood swelling.  A ball of Ebola blood.
	A soldier hurried over and hit the monkey with a double load of 
ketamine, and the monkey went limp.

DURING THE CRISIS, Peter Jahrling spent every day wearing a space suit in 
his lab, running tests on monkey samples, trying to determine where and 
how the virus spreading, and trying to get a pure sample of the virus 
isolated.  Meanwhile, Tom Geisbert pulled all-nighters, staring at the 
cellscapes through his microscope.
	Occassionlly they met each other in an office, and closed the door.
	"How are you feeling?"
	"Tired, but otherwise I'm okay."
	"No headache?"
	"Nope.  How are you feeling?"
	"Fine."
	They were the discoverers of the strain, and it seemed that they 
would have the chance to give it a name, provided they could isolate it, 
and provided it didn't isolate them first.
	Jahrling went home for dinner with his family, but later he had 
read his children their stories and put them to bed, he returned to the 
Institute and worked until late.  The whole Institute was lit up with 
activity, all the hot labs full of people and operating around the clock.  
Soon he had stripped nude in the locker room, and he was putting on his 
scrubs, and then he was wearing his space suit, feeling sleepy, warm, and 
full of dinner, as he faced the steel door blazzed with the red flower, 
reluctant to take another step forward.  He opened the door and went 
through to the hot side.
	He had been testing his and Geisbert's blood all along, and he 
wondered if the virus would suddenly show up in it.  He didn't think it 
was likely.  I didn't stick the flask close to my nose.  I kind of just 
waved my hand over it.  They used to do that all the time in hospital labs 
with bacteria.  It used to be standard procedure to sniff cultures in a 
lab-that was how you learned what bacteria smelled like, how you learned 
that some kinds smell like Welch's grape juice.  The question of whether 
he, Peter Jahrling, was infected with Ebola had become somewhat more 
pressing since the animal caretaker had puked on the lawn.  That guy had 
not cut himself or stuck himself with a needle.  Therefore, if that guy 
was breaking with Ebola, he might have caught it by breathing it in the 
air.
	Jahrling carried some slides containing spots of his own blood 
serum into his closet, shut the door, turned out the light.  He let his 
eyes adjust to the darkness, and had the usual struggle to see anything in 
the microscope through his faceplate.  Then the panorama swam into view.  
It was the ocean of his blood, stretching in all directions, grainy and 
mysterious, faintly glowing with green.  This was a normal glow, nothing 
to get excited about, that faint green.  If the green brightened into a 
hotter glow, that would signify that his blood was inhabited by Ebola.  
And what if his blood glowed?  How would he judge if it was really 
glowing?  How green is green?  How much do I trust my tools and my 
perceptions?  And if I'm covinced my blood is glowing, how am I going to 
report the results?  I'll need to tell C.J.  May be I won't have to go to 
the Slammer.  I could be bicontained right here in my own lab.  I'm in 
Biosafety Level 4 right now.  I'm already in isolation.  Who can I infect 
here in my lab?  Nobody.  I could live and work in here if I go positive 
for Ebola.
	Nothing glowed.  Nothing reacted to his blood.  His blood was 
normal.  Same with Tom Geisbert's blood.  As to whether their blood would 
glow tomorrow or the next day or the day after that, only time would tell, 
but he and Geisbert were climbing out of the incubation period.
	At eleven o'clock at night, he decided it was time to go home, and 
he entered the air lock and pulled the chain to start the decon cycle.  He 
was standing in gray light in the gray zone, alone with his thoughts.  He 
couldn't see much of anything in here, in the chemical mist.  He had to 
wait seven minutes for the cycle to complete itself.  His legs were 
killing him.  He was so tired he couldn't stand up.  He reached up with 
his hands and grabbed the pipes that fed chemicals into the shower, to 
hold himself up.  The warm liquid ran over his space suit.  He felt 
comfortable and safe in here, surrounded by the sloshing noises of 
virus-killing liquids and the hiss of air and the ruffling sensation 
across his back as the chemical played over his suit.  He fell asleep.
	He jerked awake when the final blast of water jets hit him, and he 
found himself slumped against the wall of the air lock, his hands still 
gripped around the pipes.  If it hadn't been for that last jet of water, 
he would not have woken up.  He would have slid down the wall and curled 
up in the corner of the air lock, and probably would have stayed there all 
night, sound asleep, while the cool, sterile air flowed through his suit 
and bathed his body, nude inside its cocoon, at the heart of the Institute.

SPECIALIST RHONDA WILLIAMS was standing in the main corridor of the monkey 
house, afraid she would end up in the Slammer.  There was no sound except 
the roar of air in her helmet.  The corridor stretched in both directions 
to infinity, strewn with cardboard boxes and trash and monkey biscuits.  
Where were the officers?  Where was Colonel Jaax?  Where was everybody?  
She saw the doors leading to the monkey rooms.  Maybe the officers were in 
there.
	Something was coming down the corridor.  It was the loose monkey.  
He was running toward her.  His eyes were staring at her.  Something 
glittered in his hand-he was holding a syringe.  He waved it at her with 
gesture that conveyed passionate revenge.  He wanted to give her an 
injection.  The syringe was hot with an unknown agent.  She started to 
run.  Her space suit slowed her down.  She kept running, but the hallway 
stretched on forever, and she couldn't reach the end.  Where was the door 
out of here?  There was no door!  There was no way out!  The monkey 
bounded toward her, its terrible eyes fixed on her-and the needle flashed 
and went into her suit ... She woke up in her barracks room.

DECON 

DECEMBER 7, THURSDAY

NANCY JAAX AWOKE at four o'clock in the morning to the sound of the 
telephone ringing.  It was her brother, calling from a pay telephone at 
the hospital in Wichita.  He said that their father was dying.  "He's 
very, very bad, and he's not going to make it," he said.  Their father was 
in cardiac failure, and the doctor had been asking if the family wanted 
him to undertake extreme lifesaving measures.  Nancy thought only briefly 
about this and told her brother not to do it.  Her father was down to 
ninety pounds, just skin and bones, and he was in pain and miserable.
	She woke up Jerry and told him that her father would probably die 
today.  She knew she would have to go home, but should she try home today? 
 She could arrive in Wichita by afternoon, and he might still be alive.  
She might be able to have a last farewell with him.  She decided not to 
fly home.  She felt that she couldn't leave her job in the middle of 
Reston crisis, that it would be a dereliction of her post.
	The telephone rang again.  It was Nancy's father calling from his 
hospital room.  "Are you coming home, Nancy?" he asked.  He sounded wheezy 
and faint.
	"I just can't get away right now, Dad.  It's my work.  I'm in the 
middle of a serious outbreak of disease."
	"I understand," he said.
	"I'll see you at Christmas, Dad."
	"I don't think I'll make it that long, but well, you never know."
	"I'm sure you will make it."
	"I love you, Nancy."
	"I love you, too."
	In the blackness before dawn, she and Jerry got dressed, she in 
her uniform, he in civilian clothes, and he headed off for the monkey 
house.  Nancy stayed at home until after the children had awaken up, and 
she fixed them some cereal.  She sent the children off on the school bus 
and drove to work.  She went to Colonel C.J. Peters and told him that her 
father was probably going to die today.
	"Go home, Nancy," he said.
	"I'm not going to do that," she replied.
	The dead monkeys began coming in after lunch.  A truck would bring 
them twice a day from Reston, and the first shipment would end up in 
Nancy's air lock while she was suiting up.  Usually there would be ten or 
twelve monkeys in hatboxes.
	The rest of the monkeys that came out of the monkey house-the vast 
majority of them, two or three tons' worth-were placed in triple biohazard 
bags, and the bags were decontaminated, taken out of the building, and 
placed in steel garbage cans.  Hazleton employees then drove them to an 
incinerator owned by the company, where the monkeys were burned at a high 
temperature, high enough to guarantee the destruction of Ebola organisms.
	Some of the monkeys had to be examined, however, to see if and 
where the virus was spreading inside the building.  Nancy would carry the 
hatboxes into suite AA-5 and work on the monkeys until after midnight with 
her partner and a civilian assistant.  They hardly spoke to one another, 
except to point to a tool or a sign of disease in a monkey.
	Thoughts about her father and her childhood came to Nancy that 
day.  Years earlier, as a girl, she had helped him during plowing season, 
driving his tractor from afternoon until late at night.  Moving at a pace 
not much faster than a mule, it plowed furrows along a strip of land a 
half a mile long.  She wore cutoff shorts and sandals.  It was loud and 
hot on the tractor, and in the emptiness of Kansas she thought about 
nothing, drowned in the roar of the engine as the sun edged down to the 
horizon and the land grew dark and the moon appeared and climbed high.  At 
ten o'clock her father would take over and plow for the rest of the night, 
and she would go to bed.  At sunrise, he would wake her up, and she would 
get back on the tractor and keep on plowing.
	"SPONGE," she mouthed to her buddy.
	He mopped up some blood from the monkey, and Nancy rinsed her 
gloves in the pan of green EnviroChem.
	Her father died that day, while Nancy worked in the hot suite.  
She flew home to Kansas and arrived by taxi on Saturday morning at her 
family's plot at a graveyard in Wichita just as the funeral service began. 
 It was a cold, rainy day, and a tiny knot of people holding umbrellas 
huddled around a preacher by a stone wall and a hole in the earth.  
Lieutenant Colonel Nancy Jaax moved forward to see more clearly, and here 
eyes rested on something that she had not quite anticipated.  It was a 
flag draped over the casket.  He had been a veteran, after all.  The sight 
broke her down, and she burst into tears.

AT FOUR O'CLOCK in the afternoon, Thursday, December 7, the last monkey 
was killed and bagged, and people began deconning out.  They had a bad 
time trying to catch the little monkey that had escaped; it took hours.  
Jerry Jaax had entered the room were it was hiding and spent two or three 
hours chasing it in circles with a net.  Finally the monkey got itself 
jammed down in a crack behind a cage with its tail sticking out, and 
Sergeant Amen hit the tail with a massive dose of anesthetic.  In about 
fifteen minutes, the monkey became still, and they dragged it out, and it 
went the way of the other monkeys, carried along in the flow of material.
	They radioed Gene Johnson to tell him that the last monkey was 
dead.  He told Sergeant Klages to explore the building, to make sure that 
there were no more live monkeys in any rooms.  Klages discovered a chest 
freezer in a storage room.  It looked sinister, and he radioed to Johnson: 
"GENE, I'VE GOT A FREEZER HERE."
	"Check it out," Johnson replied.
	Sergeant Klages lifted the lid.  He found himself staring into the 
eyes of frozen monkeys.  They were sitting in clear plastic bags.  Their 
bodies streamed with blood icicles.  They were monkeys from Room F, the 
original hot spot of the outbreak, some of monkeys that had been 
sacrificed by Dan Dalgard.  He shut the lid and called Johnson on the 
radio:
	"GENE, YOU'RE NOT GOING TO BELIEVE WHAT I'VE FOUND IN THIS 
FREEZER.  I'VE GOT TEN OR FIFTEEN MONKEYS."
	"Aw, shit, Klages!"
	"WHAT SHOULD I DO WITH THEM?"
	"I don't want any more problems with monkeys?  No more samples!  
Decon them!"
	"I ALSO FOUND SOME VIALS OF SEDATIVE."
	"Decon it, baby!  You don't know if any dirty needles have been 
stuck in those bottles.  Everything comes out of this building!  
Everything comes out!"
	Sergeant Klages and a civilian, Merhl Gibson, dragged the bags out 
of the freezer.  They tried to cram the monkeys into the hatboxes but they 
didn't fit.  They were twisted into bizarre shapes.  They left them in the 
hallway to thaw.  The decon teams would deal with them tomorrow.
	The 91-Tangos shuffled out through the air-lock corridor, two by 
two, numb and tired beyond feeling, soaked with sweat and continual fear.  
They had collected a total of thirty-five hundred clinical samples.  They 
didn't want to talk about the operation with each other or with their 
officers.
	When the team members left Fort Detrick, they noticed that Gene 
Johnson was sitting on the grass under the tree in front of the building.  
He didn't want talk to anyone, and they were afraid to talk to him.  He 
looked terrible.  His mind was a million miles away, in the devastated 
zone inside the building.  He kept going over and over what the kids had 
done.  If the guy has the needle in his right hand, you stand on his left. 
 You pin the monkey's arms behind so it can't turn around and bite you.  
Did anyone cut a finger?  So far, it looked as if all the kids had made it.
	The decon team suited up immediately while the soldiers were 
coming out of the building.  It was now after dark, but Gene Johnson 
feared Ebola so much that he did not want to let the building sit 
untouched overnight.
	The decon team was led by Merhl Gibson.  He put on a space suit 
and explored the building to get a sense of what needed to be done.  The 
rooms and halls were bloodstained and stewn with medical packaging.  
Monkey biscuits lay everywhere and crunched underfoot.  Monkey feces lay 
in loops on the floor and was squiggled in lines across the walls and 
printed in the shapes of small hands.  He had a brush and a bucket of 
bleach, and he tried to scrub a wall.
	Then he called Gene on the radio, "GENE, THE SHIT IN HERE IS LIKE 
CEMENT, IT WON'T COME OFF."
	"You do what's best.  Our orders are to clean this place up."
	"WE'LL TRY TO CHIP IT OFF," Gibson sad.
	The next day, they went to a hardware store and bought putty 
knives and steel spatulas, and the decon team went to work chipping the 
walls and floor.  They almost suffocated from the heat inside their suits.
	Milton Frantig, the man who had thrown up on the lawn, had now 
been kept in isolation at Fairfax Hospital for several days.  He was 
feeling much better, his fever had vanished, he had not developed any 
nosebleeds, and he was getting restless.  Apparently he did not have 
Ebola.  At any rate, it did not show up in his blood tests.  Apparently he 
had a mild case of flu.  The C.D.C. eventually told him he could go home.

BY DAY NINETEEN after the whiffing incident, when they hadn't had any 
bloody noses, Peter Jahrling and Tom Geisbert began to regard themselves 
as definite survivors.  The fact that Dan Dalgard and the monkey workers 
had so far shown no signs of breaking with Ebola also reassured them, 
although it was very puzzling.  What on earth was going on with this 
virus?  It killed monkeys like flies, they were dripping virus from every 
pore, yet no human being had crashed.  If the virus wasn't Ebola Zaire, 
what was it?  And where had it come from?  Jahrling believed that it must 
have come from Africa.  After all, Nurse Mayinga's blood reacted to it.  
Therefore, it must be closely related to Ebola Zaire.  It was behaving 
like the fictional Andromeda strain.  Just when we thought the world was 
coming to an end, the virus slipped away, and we survived.
	The Centers for Disease Control focused its efforts on trying to 
trace the source of the virus, and the trail eventually led back to the 
Ferlite Farms monkey-storage facility near Manila.  All of the Reston 
monkeys had come from there.  The place was a way station on their trip 
from the forests of Mindanao to Washington.  Investigators found that 
monkeys had been dying in large numbers there, too.  But it looked as 
though no Philippine monkey workers had become sick either.  If it was an 
African virus, what was it doing in the Philippines?  And why weren't 
monkey handlers dying?  Yet the virus was able to destroy a monkey.  
Something very strange was going on here.  Nature had seemed to be closing 
in on us for a kill, when she suddenly turned her face away and smiled.  
It was a Mona Lisa smile, the meaning of which no one could figure out.

DECEMBER 18, MONDAY

THE DECON TEAM scrubbed the building with bleach until they took the paint 
off the concrete floors, and still they kept scrubbing.  When they were 
satisfied that all the building's inside surfaces had been scoured, they 
move on to the final stage, the gas.  The decon team taped the exterior 
doors, windows, and vents of the building with silver duct tape.  They 
taped sheets of plastic over the exterior openings of the ventilation 
system.  They made the building airtight.  At various places inside the 
monkey house, they set out patches of paper saturated with spores of a 
harmless bacterium known as Bacillus Subtilis Niger will kill almost 
anything.
	The decon team brought thirty-nine Sunbeam electric frying pans to 
the monkey house.  Sunbeam electric frying pans are the Army's tool of 
choice for a decon job.  The team laid an electric cable along the floor 
throughout the building, strung with outlets, like a cord for 
Christmas-tree lights.  At points along the cable, they plugged in the 
Sunbeam frying pans.  They wired the cable to a master switch.  Into each 
Sunbeam frying pan they dropped a handful of disinfecting crystals.  The 
crystals were white and resembled salt.  They dialed the pans to high.  At 
1800 hours on December 18, someone threw the master switch, and the 
Sunbeams began to cook.  The crystals boiled away, releasing formaldehyde 
gas.  Since the building's doors, windows, and vents were taped shut, the 
gas had nowhere to go, and it stayed inside the building for three days.  
The gas penetrated the air ducts, soaked the offices, got into drawers in 
the desks, and got inside pencil sharpeners in the drawers.  It 
infiltrated Xerox machines and worked its way inside personal computers 
and inside the cushions of chairs and fingered down into the floor drains 
until it touched pools of lingering bleach in the water traps.  Finally 
the decon team, still wearing space suits, went back inside the building 
and collect the spore samples.  The Sunbeam treatment had killed the Niger.
	There is an old piece of wisdom in biohazard work that goes like 
this: you can never know when life is exterminated.  Life will survive 
almost any blitz.  Total, unequivocal sterilization is extremely difficult 
to achieve in practice and is almost impossible to verify afterward.  
However, a Sunbeam cookout that lasts for three days and exterminates all 
samples of Niger implies success.  The monkey house had been sterilized.  
Ebola had met opposition.  For a short while, until life could 
re-establish itself there, the Reston Primate Quarantine Unit was the only 
building in the world where nothing lived, nothing at all.

THE MOST DANGEROUS STRAIN

1990 JANUARY

THE STRAIN OF Ebola virus that had erupted near Washington went into 
hiding somewhere in the rain forest.  The cycling went on.  The cycling 
must always go on if the virus is to maintain its existance.  The Army, 
having certified that the monkey house had been nuked, returned to the 
possession of Hazleton Resrach Products.  Hazleton began buying more 
monkeys from the Philippines, from the same monkey house near Manila, and 
restocked the building with crab-eating monkeys that had been trapped in 
the rain forests of Mindanao.  Less than a month later, in the middle of 
January, some of the monkeys in Room C began dying with bloody noses.  Dan 
Dalgard called Peter Jahrling. "Looks like we're affected again," he said.
	The virus was Ebola.  It had come from the Philippines.  This 
time, since there had been no human casualties during the first outbreak, 
the Army, the C.D.C., and Hazleton jointly decided to isolate the 
monkeys-leave them alone and let the virus burn.  Dan Dalgard hoped to 
save at least some of the monkeys, and his company did not want the Army 
to come back with space suits.
	What haapened in that building was a kind of experiment.  Now they 
would see what Ebola could do naturally in a population of monkeys living 
in a confined air space, in a kind of city, as it were.  The Ebola Reston 
virus jumped quickly from room to room, and as it blossomed in the 
monkeys, it seemed to mutate spontaneously into something that looked 
quite a lot like the common cold.  But it was an Ebola cold.  The monkeys 
died with great quantities of clear mucus and green mucus running from 
their nose, mixed with blood that would not clot.  Their lungs were 
destroyed, rotten and swimming with Ebloa virus.  They had pneumonia.  
When a single animal with a nosebleed showed up in a room, generally 80 
percent of the animals died in that room shortly afterward.  The virus was 
extraordinarily infective in monkeys.  The Institute scientists suspected 
that they were seeing a mutant strain of Ebola, something new and a little 
different from what they had seen just a month before, in December, when 
the Army had nuked the monkey house.  It was frightening-it was as if 
Ebola could change its character fast.  As if a different strain could 
appear in a month's time.  The clinical symptoms of the disease served as 
a reminder of the fact that Ebola is related to certain kind of colds seen 
in human children.  It seemed that the virus could adapt quickly to new 
host, and that it could change its character rapidly as it entered a new 
population.
	bola apparently drifted through the building's air-handling ducts. 
 By January 24, it had entered Room B, and monkeys in that room started 
going into shock and dying with runny noses, red eyes, and masklike 
expressions on their faces.  In the following weeks, the infection entered 
Room I,F,E, and D, and the animals in these rooms virtually all died.  
Then, in mid-February, a Hazleton animal caretaker who will be called John 
Coleus was performing a necropsy on a dead monkey when he cut his thumb 
with a scalpel.  He had been slicing apart the liver, one of the favorite 
nesting sites of Ebola.  The scalpel blade, smeared with liver cells and 
blood, went deep into this thumb.  He had had a major exposure to Ebola.
	The liver that he had been cuting was rushed to USAMRIID for 
analysis.  Tom Geisbert looked at a piece of it under his microscope and, 
to his dismay, found that it was "incredibly hot-I mean, wall to wall with 
virus."  Everyone at the Institute thought John Coleus was going to die.  
"Around her," Peter Jahrling told me, "we were frankly fearful that this 
guy had bought the farm."  The C.D.C. decided not to put him into 
isolation.  So Coleus visited bars and drank beer with his friends.
	"Here at the Institute," Peter Jahrling said, "we were absolutely 
appalled when that guy went out to bars, drinking.  Clearly the C.D.C. 
should not have let that happen.  This was a serious virus and a serious 
situation.  We don't know a whole lot about the virus.  It could be like 
the common cold-it could have a latency period when you are shedding virus 
before you develop symptoms-and by the time you know you are sick, you 
might have infected sixteen people.  There's an awful lot we don't know 
about this virus.  We don't know where it came from, and we don't know 
what form it will take when it appears next time."
	John Coleus had a minor medical condition that required surgery.  
Doctors performed the operation while he was in the incubation period 
after his exposure to Ebola.  There is no record indicating that he bled 
excessively during the surgery.  He came through fine, and he is alive 
today, with no ill effects from his exposure.

AS FOR THE MONKEY HOUSE, the entire building died.  The Army didn't have 
to nuke it.  It was nuked by the Ebola Reston virus.  Once again, there 
were no human casualties.  However, something eerie and perhaps sinister 
occurred.  A total of four men had worked as caretakers in the monkey 
house: Jarvis Purdy, who had a heart; Milton Frantig, who had thrown up on 
the lawn; John Coleus, who had cut his thumb; and a fourth man.  All four 
men eventually tested positive for Ebola Reston virus.  They had all been 
infected with the agent.  The virus had entered their bloodstreams and 
multiplied in their cells.  Ebola proliferated in their bodies.  It cycled 
in them.  It carried on its life inside the monkey workers.  But it did 
not make them sick, even while it multiplied inside them.  If they had 
headaches or felt ill, none of them could recall it.  Eventually the virus 
cleared from their systems naturally, disappeared from the blood, and as 
of this writing none of the men was affected by it.  The are among the 
very, very few human survivors of Ebola virus.  John Coleus certainly 
caught the virus when he cut himself with a bloody scalpel, no question 
about that.  What is more worrisome is that the others had not cut 
themselves, yet the virus entered their bloodstreams.  It got there 
somehow.  Most likely it entered their blood thought contact with the 
lungs.  It infected them through the air.  When it became apparent to the 
Army researchers that three of the four men who became infected had not 
cut themselves, just about everyone at USAMRIID concluded that Ebola can 
spread through the air.
	Dr. Philip Russell-the general who made the decision to send in 
the Army to stop the virus-recently said to me that although he had been 
"scared to death" about Ebola at the time, it wasn't until afterward, when 
he understood that the virus was spreading in the air among the monkeys, 
that the true potential for disaster sank in for him.  "I was more 
frightened in retrospect," he said.  "When I saw the respiratory evidence 
coming from those monkeys, I said to myself, My God, with certain kinds of 
small changes, this virus could become one that travels in rapid 
respiratory transmission through humans.  I'm talking about the Black 
Death.  Imagine a virus with the infectiousness of influenza and the 
mortality rate of black plague in the Middle Ages-that's what we're 
talking about."
	The workers at Reston had symptomless Ebola virus.  Why didn't it 
kill them?  To this day, no one knows the answer to that question.  
Symptomless Ebola-the men had been infected with something like an Ebola 
cold.  A tiny difference in the virus's genetic code, probably resulting 
in a small structural change in the shape of one of the seven mysterious 
proteins in the virus particle, had apparently changed its effect 
tremendously in humans, rendering it mild or harmless even though it had 
destroyed the monkeys.  This strain of Ebola knew the difference between a 
monkey and a person.  And if it should mutate in some other direction... 

ONE DAY IN spring, I went to visit Colonel Nancy Jaax, to interview her 
about her work during the Reston event.  We talked in her office.  She 
wore a black military sweater with silver eagles on the shoulder 
boards-she had recently made full colonel.  A baby parrot slept in a box 
in the corner.  The parrot woke up and squeaked.
	"Are you hungry?" she asked it.  "Yeah, yeah, I know."  She pulled 
a turkey baster out of a bag and loaded it with parrot mush.  She stuck 
the baster into the parrot's beak and squeezed the baster bulb, and the 
parrot closed it eyes with satisfaction.
	She waved her hand at some filing cabinets.  "Want to look at some 
Ebola?  Take your pick."
	"You show me."
	She searched through a cabinet and removed a handful of glass 
slides, and carried them into another room, where a microscope sat on a 
table.  It had two sets of eyepieces so that two people could look into it 
at the same time.
	I sat down and stared in the microscope, into white nothingness.
	"Okay, here's a good one," she said, and placed a slide under the 
lens.
	I saw a field of cells.  Here and there, pockets of cells had 
burst and liquefied.
	"That's male reproductive tissue," she said.  "It's heavily 
infected.  This is Ebola Zaire in a monkey that we exposed through the 
lungs in 1986, in the study that Gene Johnson and I did."
	Looking at the slice of monkey testicle, I got an unpleasant 
sensation.  "You mean, it got into the monkey's lungs and moved to its-?"
	"Yeah.  it's pretty yucky," she said.  "Now I'm going to make you 
dizzy.  I'm going to show you the lung."
	The scene shifted, and we were looking at rotted pink Belgian lace.
	"This is a slice of lung tissue.  A monkey that was exposed 
through the lungs.  See how the virus bubbles up in the lung?  It's Ebola 
Zaire."
	I could see individual cells, and some of them were swollen with 
dark specks.
	"We'll go to higher magnification."
	The cells got bigger.  The dark specks became angular, shadowy 
blobs.  The blobs were bursting out of the cells, like something hatching.
	"Those are big, fat bricks," she said.
	They were Ebola crystalloids bursting out of the lungs.  The lungs 
were popping Ebola directly into the air.  My scalp crawled and I felt 
suddenly like a civilian who had seen something that maybe civilians 
should not see.
	"These lungs are very hot," she said in a matter-of-face voice.  
"You see those bricks budding directly into the air spaces of the lung?  
When you cough, this stuff comes up your throat in your sputum.  That's 
why you don't want someone who has Ebola coughing in your face."
	"My God, it knows all about lungs, doesn't it?"
	"Maybe not.  It might live in an insect, and insects don't have 
lungs.  But you see here how Ebola has adapted to this lung.  It's budding 
out of the lung, right straight into the air."
	"We're looking at a highly sophisticated organism, aren't we?"
	"You're absolutely right.  This hummer has an established life 
cycle.  You get into what-if? game.  What if it got into human lungs?  If 
it mutates, it could be a problem.  A big problem."

IN MARCH 1990, while the second outbreak at Reston was happening, the 
C.D.C. slapped a heavy set of restrictions on monkey importers, tightening 
the testing and quarantine procedures.  The C.D.C. also temporarily 
revoked the license of three companies, Hazleton Research Products, the 
Charles River Primates Corporation, and Worldwide Primates, charging these 
companies with violations of quarantine rules.  (Their licenses were later 
reinstated.  The C.D.C.'s action effectively stopped the importation of 
monkeys into the United States for several months.  The total loss to 
Hazleton ran into the millions of dollars.  Monkeys are worth money.  
Despite the C.D.C.'s action against Hazleton, scientists at USAMRIID, and 
even some at the C.D.C., gave Dalgard and his company high praise for 
making the decision to hand over the monkey facility to the Army.  "It was 
hard for Hazleton, but they did the right thing,"  Peter Jahrling said to 
me, summing up the general opinion of the experts.
	Hazleton had been renting the monkey house from a commercial 
landlord.  Not surprisingly, relations between the landlord and Hazleton 
did not flourish happily during the Army operation and the second Ebola 
outbreak.  The company vacated the building afterward, and to this day it 
stands empty.
	Peter Jahrling, a whiffer of Ebola who lived to tell about it, is 
now the principal scientist at USAMRIID.  He and Tom Geisbert, following 
tradition in the naming of new viruses, named the strain they had 
discovered Reston, after the place where it was first noticed.  In 
conversation, they sometimes refer to it casually as Ebola Reston.  One 
day in his office, Jahrling showed me a photograph of some Ebola-virus 
particles.  They resembled noddles that had been cooked al dente.  "Look 
at this honker.  Look at this long sucker here," Jahrling said, his finger 
tracing a loop.  "It's Reston-oh, I was about to say it's Reston, but it 
isn't-it's Zaire.  The point is, you can't easily tell the difference 
between the two strains by looking.  It brings you back to a philosophical 
question:  Why is the Zaire suffer hot for humans?  Why isn't Reston hot 
for humans, when the strains are so close to each other?  The Ebola Reston 
virus is almost certainly transmitted by some airborne route.  Those 
Hazleton workers who had the virus-I'm pretty sure they got it through the 
air."
	"Did we dodge a bullet?"
	"I don't think we did," Jahrling said.  "The bullet hit us.  We 
were just lucky that the bullet we took was a rubber bullet from a 
twenty-two rather than a dumdum bullet from a forty-five.  My concern is 
that people are saying, "Whew, we dodged a bullet.' And the next time they 
see Ebola in a microscope, they'll say, 'Aw, it's just Reston,' and 
they'll take it outside a containment facility.  And we'll get whacked in 
the forehead when the stuff turns out not to be Reston but its big sister."

C.J. PETERS EVENTUALLY left the Army to become the chief of the Special 
Pathogen Branch at the Centers for Disease Control.  Looking back on the 
Reston event, he said to me one day that was pretty sure Ebola had spread 
through the air, "I think the pattern of spread that we saw, and the fact 
that it spread to new rooms, suggest that Ebola aerosols were being 
generated and were present in the building," he said.  "If you look at 
pictures of lungs from a monkey with Ebola Zaire, you see that the lungs 
are fogged with Ebola.  Have you seen those pictures?"
	"Yes, Nancy Jaax showed them to me."
	"Then you know.  You can see Ebola particles clearly in the air 
spaces of the lung."
	"Did you ever try to see if you could put Ebola Reston into the 
air and spread it among monkeys that way?"  I asked.
	"No," he replied firmly.  "I just didn't think that was a good 
idea.  If anybody had found out that the Army was doing experiments to see 
if the Ebola virus had adapted to spreading in the respiratory tract, we 
would have been accused of doing offensive biological warfare-trying to 
create a doomsday germ.  So we elected not to follow it up."
	"That means you don't really know if Ebola spreads in the air."
	"That's right.  We don't know.  You have to wonder if Ebola virus 
can do that or not.  If it can, that's about the worst thing you can 
imagine."

SO THE THREE sisters-Marburg, Ebola Sudan, and Ebola Zaire-have been 
joined by a fourth sister, Reston.  A group of researchers at the Special 
Pathogens Branch of the C.D.C.-principally Antony Sanchez and Heinz 
Feldmann-have picked apart the genes of all the filoviruses.  They 
discovered that Zaire and Reston ar so much alike that it's hard to say 
how they are different.  When I met Anthony Sanchez and asked him about 
it, he said to me, "I call them kissing cousins.  But I can't put my 
finger on why Reston apparently doesn't make us sick.  Personally, I 
wouldn't feel comfortable handling it without a suit and maximum 
containment procedures."  Each virus contains seven proteins, four of 
which are completely unknown.  Something slightly different about one of 
the Reston proteins is a probably the reason the virus didn't go off in 
Washington like a bonfire.  The Army and C.D.C have never downgraded the 
safety satus of Reston virus.  It seems classified as a Level 4 hot agent, 
and if you want to shake hands with it, you had better wearing a space 
suit.  Safety experts feel that there is not enough evidence, yet, to show 
that the Reston strain is not an extremely dangerous virus.  It may be, in 
fact, the most dangerous of all the filovirus sisters, because of its 
seeming ability to travel rather easily through the air, perhaps more 
easily than the others.  A tiny change in its genetic code, and it might 
turn into a cough and take out the human race.
	Why is the Reston virus so much like Ebola Zaire, when Reston 
supposedly comes from Asia?  If the strains come from different 
continents, they should be quite different from each other.  One 
possibility is that the Reston strain originated in Africa and flew to the 
Philippines on an airplane not long ago.  In other words, Ebola has 
already entered the net and has been traveling lately.  The experts do not 
doubt that a virus can hop around the world in a matters of days.  Perhaps 
Ebola came out of Africa and landed in Asia a few years back.  
Perhaps-this is only a guess-Ebola traveled to Asia inside wild African 
animals.  There have been rumors that rain forest have been importing 
African animals illegally, releasing them into the Philippine jungle, and 
hunting them.  If Ebola lives in African game animals-in leopards or lions 
or in Cape buffalo-it might have traveled to Philippines that way.  This 
is only a guess.  Like all the other thread virus, Ebola Reston hides in a 
secret place.  It seems quite likely, however, that the enter Reston 
outbreak started with a single monkey in the Philippines.  One sick 
monkey.  That monkey was the unknown index case.  One monkey started the 
whole thing.  That monkey perhaps picked up four or five particles of 
Ebola that came from...anyone's guess.
??

 

PART FOUR

KITUM CAVE

Highway

1993 August
...

Camp
...

THE EMERGENCE OF AIDS, Ebola, and any number of other rainforest agents 
appears to be a natural consequence of the ruin of tropical biosphere.  
The emerging viruses are surfacing from ecologically damaged parts of the 
earth.  Many of them come from tatered edges of tropical rain forest, or 
they come from tropical savanna that is being settled rapidly by people.  
The tropical rain forests are the deep reservoirs of life on the planet, 
containing most of the world's plant and animal species.  The rain forests 
are also its largest reservoirs of viruses, since all living thins carry 
viruses.  When viruses come out of an ecosystem, they tend to spread in 
wave through the human population, like echoes from the dying biosphere.  
Here are the names of some emerging viruses:  Lassa. Rift Valley. 
Oropouche. Rocio. q. Guanarito. VEE. Monkeypox. Dengue. Chikungunya. The 
hantaviruses. Machupo. Junin. The rabieslike strains Mokola and Duvenhage. 
LeDantec. The Kyasnur Forst brain virus. HIV-which is very much an 
emerging virus, because its penetration of the human species is increasing 
reapidly, with no end in sight.  The Semlike Forst agent.  Grimean-Congo. 
Sinbis. O'nyongnyong. Nameless Sao Paulo. Marbury. Ebola Sudan. Ebola 
Zaire. Ebola Reston.
	In a sense, the earth is mounting an immune response against the 
human species.  It is beginning to react to the human parasite, the 
flooding infection of people, the dead spots of concrete all over the 
planet, the cancerous rot-outs in Europe, Japan and the United States, 
thick with replicating primates, the colonies enlarging and spreading and 
threatening to shock the biosphere with mass extinctions.  Perhaps the 
biosphere does not 'like' the idea of five billion humans.  Or it could 
also be said that the extreme amplification of human race, which has 
occurred only in the past hundred years or so, has suddenly produced a 
very large quantity of meat, which is sitting everywhere in the biosphere 
and may not be able to defend itself against a life form that might want 
to consume it.  Nature has interesting ways of balance itself.  The rain 
forest has its own defenses.  The earth's immune system, so to speak, has 
recognized the presence of the human species and is starting to kick in.  
The earth is attempting to rid itself of an infection by human parasite.  
Perhaps AIDS is the first step in a natural process of clearance.

AIDS IS ARGUABLY the most environmental disaster of the twentieth century. 
 The AIDS virus may well have jumped into the human race from African 
primates, from monkeys and anthropoid apes.  For example, HIV-2 (one of 
the two major strains of HIV) may be a mutant virus that jumped into us 
from an African monkey known as the sooty mangabey, perhaps when monkey 
hunters or trappers touched bloody tissue.  HIV-1 (the other strain) may 
have jumped into us from chimpanzees-perhaps when hunters butchered 
chimpanzees.  A strain of simian AIDS virus was recently isolated from a 
chimpanzee in Gabon, in West Africa, which is, so far, the closest thing 
to HIV-1 that anyone has yet found in the animal kingdom.
	The AIDS virus was first noticed in 1980 in Los Angeles by a 
doctor who realized that his gay male patients were dying of an infectious 
agent.  If anyone at the time suggested that this unknown disease in gay 
men in southern California came from wild chimpanzees in Africa, the 
medical community would have collectively burst out laughing.  No one is 
laughing now.  I find it extremely interesting to consider the idea that 
the chimpanzee is an endangered rain-forest animal and then to contemplate 
the idea that a virus that moved from chimps is suddenly not endangered at 
all.  You could say that rain-forest viruses are extremely good at looking 
after their own interests.
	The AIDS virus is a fast mutator; it changes constantly.  It is a 
hypermutant, a shape shifter, spontaneously altering its character as it 
moves through populations and through individuals.  It mutates even in the 
course of one injection, and a person who dies of HIV is usually infected 
with multiple strains, which have all arisen spontaneously in the body.  
The fact that the virus mutates rapidly means that vaccines for it will be 
very difficult to develop.  In a larger sense, it means that the AIDS 
virus is a natural survivor of changes in ecosystems.  The AIDS virus and 
other emerging viruses are surviving the wreck of the tropical biosphere 
because they can mutate faster than any changes taking place in their 
ecosystems.  They must be good at escaping trouble, if some of them have 
been around for as long as four billion years.  I tend to think of rat 
leaving a ship.
	I suspect the AIDS might not be Nature's preeminent display of 
power.  Whether the human race can actually maintain a population of five 
billion or more without a crash with a hot virus remains an open question. 
 Unanswered.  The answer lies hidden in the labyrinth of tropical 
ecosystems.  AIDS is the revenge of the rain forest.  It is only the first 
act of the revenge.
	No problem, I thought.  Of course, I'll be all right.  We'll be al 
right.  No problem at all.  Everything will be all right.  Plenty of 
people have gone inside Kitum Cave without becoming sick.  Three to 
eighteen days.  As the amplification begins, you feel nothing.  It made me 
think of Joe McCormick, the C.D.C. official who had clashed with the Army 
over the management of the Ebola Reston outbreak.  I remembered the story 
of him in Sudan, hunting Ebola virus.  At the end of a plane flight into 
deep bush, he had come face to face with Ebola in a hut full of dying 
patients, had pricked his thumb with a bloody needle, and got lucky, and 
had survived the experience.  In the end, Joe McCormick had been right 
about the Ebola Reston virus: it had not proved to be highly infectious in 
people.  Then I thought about another Joe McCormick discovery, one of the 
few breakthroughs in the treatment of Ebola virus.  In Sudan, thinking he 
was going to die of Ebola, he had discovered that a bottle of Scotch is 
the only good treatment for exposure to filovirus.

I DROVE TO the abandoned monkey house one day in autumn, to see what had 
become of it.  It was a warm day in Indian summer.  A brown haze hung over 
Washington.  I turned off the Beltway and approached the building 
discreetly.  The place was deserted and as quiet as a tomb.  Out front, a 
sweet-gum tree dropped an occasional leaf.  For LEASE signs sat in front 
of many of the offices around the parking lot.  I sensed the presence not 
of a virus but of financial illness-clinical signs of the eighties, like 
your skin peeling off after a bad fever.  I walked across the grassy area 
behind the building until I reached the insertion point, a glass door.  It 
was locked.  Shreds of silver duct tape dangled from the door's edges.  I 
looked inside and saw a floor mottled with reddish brown stains.  A sign 
on the wall said CLEAN UP YOUR OWN MESS.  Next to it, I discerned the 
air-lock corridor, the gray zone through which the soldiers had passed 
into the hot zone.  It had gray cinder-block walls: the ideal gray zone.
	My feet rustled through shred of plastic in the grass.  I found 
elderberries ripening around a rusted air-handling machine.  I heard a 
ball bounce, and saw a boy dribbling as basketball on a playground.  The 
ball cast rubbery echoes off the former monkey house.  Children's shouts 
came from the day-care center through the trees.  Exploring the back of 
the building, I came to a window and looked in.  Climbing vines had grown 
up inside the room and had pressed against the glass of the windows, 
seeking warmth and light.  Where had those vines found water inside the 
building?  The vine was Tartarian honeysuckle, a weed that grows in waste 
places and on abandoned ground.  The flowers of Tartarian honeysuckle have 
no smell.  That is, they smell like a virus; and they flourish in ruined 
habitats.  Tartarian honeysuckle reminded me of Tartarus, the land of the 
dead in Virgil's Aeneid, the underworld, where the shades of dead 
whispered in the shadows.
	I couldn't see through the tangled vines into the former hot zone. 
 It was like looking into a jungle.  I walked around to the side of the 
building and found another glass door beribboned with tape.  I pressed my 
nose against the glass and cupped my hands around my eyes to stop 
reflections, and saw a bucket smeared with a dry brown crust.  The crust 
looked like dried monkey excrement.  Whatever it was, I guessed it had 
been stirred up with Clorox bleach.  A spider had strung a web between a 
wall and the bucket of waste.  On the floor under the web, the spider had 
dropped husks of flies and yellow jackets.  The time of being autumn, the 
spider had left egg cases in its web, preparing for its own cycle of 
replication.  Life had established itself in the monkey house.  Ebola had 
risen in these rooms, flashed its color, fed, and subsided into the 
forest.  It will be back.
??